| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasushi Sasaki, Miyuki Tamura, Kousuke Takeda, Kazuhiro Ogi, Takafumi Nakagaki, Ryota Koyama, Masashi Idogawa, Hiroyoshi Hiratsuka, Takashi Tokin. Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target. Oncotarget. vol 7. issue 38. 2018-01-30. PMID:27556181. |
the p53 tumor suppressor inhibits cell growth through the activation of both cell cycle arrest and apoptosis, which maintain genome stability and prevent cancer development. |
2018-01-30 |
2023-08-13 |
human |
| Yahui Yang, Shulin Deng, Qinsong Zeng, Weilie Hu, Tianfeng Che. Highly stable selenadiazole derivatives induce bladder cancer cell apoptosis and inhibit cell migration and invasion through the activation of ROS-mediated signaling pathways. Dalton transactions (Cambridge, England : 2003). vol 45. issue 46. 2018-01-30. PMID:27711726. |
mechanistic investigation revealed that compound 1b was able to enter the cells through endocytosis and then trigger reactive oxygen species (ros) overproduction, further causing dna damage-mediated p53 phosphorylation and promoting cancer cell apoptosis by regulating the akt and mapks signaling pathways. |
2018-01-30 |
2023-08-13 |
Not clear |
| Sumino Yanase, Hitoshi Suda, Kayo Yasuda, Naoaki Ishi. Impaired p53/CEP-1 is associated with lifespan extension through an age-related imbalance in the energy metabolism of C. elegans. Genes to cells : devoted to molecular & cellular mechanisms. vol 22. issue 12. 2018-01-30. PMID:29114996. |
in the nematode caenorhabditis elegans, the mammalian tumor suppressor p53 ortholog cep-1 mediates the stress response, activates germ line apoptosis and regulates meiotic chromosome segregation. |
2018-01-30 |
2023-08-13 |
caenorhabditis_elegans |
| Gillian Borland, Anna Kilbey, Jodie Hay, Kathryn Gilroy, Anne Terry, Nancy Mackay, Margaret Bell, Alma McDonald, Ken Mills, Ewan Cameron, James C Nei. Addiction to Runx1 is partially attenuated by loss of p53 in the Eµ-Myc lymphoma model. Oncotarget. vol 7. issue 17. 2018-01-30. PMID:27056890. |
notably, despite their continued growth and tumorigenic potential, runx1null lymphoma cells displayed impaired proliferation and markedly increased sensitivity to dna damage and dexamethasone-induced apoptosis, validating runx1 function as a potential therapeutic target in myc-driven lymphomas regardless of their p53 status. |
2018-01-30 |
2023-08-13 |
human |
| Shuang Zhao, Xue-Feng Yang, Dao-Fu Shen, Yang Gao, Shuai Shi, Ji-Cheng Wu, Hong-Xu Liu, Hong-Zhi Sun, Rong-Jian Su, Hua-Chuan Zhen. The down-regulated ING5 expression in lung cancer: a potential target of gene therapy. Oncotarget. vol 7. issue 34. 2018-01-29. PMID:27409347. |
ing5 can interact with p53, thereby inhibiting cell growth and inducing apoptosis. |
2018-01-29 |
2023-08-13 |
Not clear |
| Xianyu Zhang, Ying Lu, Xin Cao, Tao Zhen, Damian Kovalovsk. Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors. Oncotarget. vol 7. issue 37. 2018-01-29. PMID:27542215. |
finally, biased myeloid differentiation of zbtb1-deficient lmpp cells was not due to increased p53-dependent apoptosis as it was not reverted by transgenic bcl2 expression or p53 deficiency. |
2018-01-29 |
2023-08-13 |
mouse |
| Jian-An Bai, Hua Jie, Sun Wei, Shidong Wang, Huarui Guo, Qiyun Tan. GART mediates the renewal of intestinal epithelial barrier via p38/p53/PUMA cascade in colitis. Apoptosis : an international journal on programmed cell death. vol 21. issue 12. 2018-01-29. PMID:27718035. |
moreover, the inhibition of gart induced cellular apoptosis and suppressed the migration of iecs through the activation of the mekk3-mkk3-p38 mitogen-activated protein kinase (mapk) pathway, following with the dys-regulation of p53 and p53 up-regulated modulator of apoptosis (puma). |
2018-01-29 |
2023-08-13 |
Not clear |
| Alegre Flores-Pérez, Guillermo Elizond. Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Chemico-biological interactions. vol 281. 2018-01-29. PMID:29274324. |
the aim of the present study was to determine whether inhibition of ahr in hela cells resulted in an increase in p53 and apoptosis along with a decrease in cell proliferation. |
2018-01-29 |
2023-08-13 |
human |
| Alegre Flores-Pérez, Guillermo Elizond. Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Chemico-biological interactions. vol 281. 2018-01-29. PMID:29274324. |
the results demonstrate that two ahr antagonists, α-naphthoflavone (α-nf) and resveratrol, decreased cell proliferation, arrested cells in the gap 1/synthesis (g1/s) phases, and increased p53 levels and apoptosis. |
2018-01-29 |
2023-08-13 |
human |
| Weihai Liu, Zhenbiao Zhang, Guosheng Lin, Dandan Luo, Hanbin Chen, Hongmei Yang, Jiali Liang, Yuhong Liu, Jianhui Xie, Ziren Su, Hongying Ca. Tetrahydrocurcumin is more effective than curcumin in inducing the apoptosis of H22 cells via regulation of a mitochondrial apoptosis pathway in ascites tumor-bearing mice. Food & function. vol 8. issue 9. 2018-01-24. PMID:28766664. |
thc induced the apoptosis of h22 cells obviously by increasing the level of p53 and decreasing the level of murine double minute 2. |
2018-01-24 |
2023-08-13 |
mouse |
| Angustias Page, Manuel Navarro, Cristian Suarez-Cabrera, Josefa P Alameda, M Llanos Casanova, Jesús M Paramio, Ana Bravo, Angel Ramire. Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53. Oncotarget. vol 7. issue 15. 2018-01-24. PMID:26959115. |
p53 is a protein that causes cell cycle arrest, apoptosis or senescence, being crucial in the process of tumor suppression in several cell types. |
2018-01-24 |
2023-08-13 |
mouse |
| b' Iva Poto\\xc4\\x8dnjak, Dalibor Brozni\\xc4\\x87, Marija Kindl, Matija Kropek, Sanda Vladimir-Kne\\xc5\\xbeevi\\xc4\\x87, Robert Domitrovi\\xc4\\x8. Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-\\xce\\xbaB activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 107. issue Pt A. 2018-01-23. PMID:28666887.' |
induction of apoptosis and inhibition of the cell cycle in kidneys was evidenced by increased expression of p53, bax, caspase-9, and p21, proteolytic cleavage of poly (adp-ribose) polymerase (parp), with concomitant suppression of bcl-2 and cyclin d1 expression. |
2018-01-23 |
2023-08-13 |
mouse |
| Wei-Zhe Liang, Chung-Ren Jan, Shu-Shong Hs. Cytotoxic effects of gastrodin extracted from the rhizome of Gastrodia elata Blume in glioblastoma cells, but not in normal astrocytes, via the induction of oxidative stress-associated apoptosis that involved cell cycle arrest and p53 activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 107. issue Pt A. 2018-01-23. PMID:28689919. |
cytotoxic effects of gastrodin extracted from the rhizome of gastrodia elata blume in glioblastoma cells, but not in normal astrocytes, via the induction of oxidative stress-associated apoptosis that involved cell cycle arrest and p53 activation. |
2018-01-23 |
2023-08-13 |
human |
| Subburayan Karthikeyan, Sugeerappa Laxmanappa Hoti, Yasin Nazeer, Harsha Vasudev Hegd. Glaucarubinone sensitizes KB cells to paclitaxel by inhibiting ABC transporters via ROS-dependent and p53-mediated activation of apoptotic signaling pathways. Oncotarget. vol 7. issue 27. 2018-01-22. PMID:27304668. |
importantly, glu and/or ptx triggered apoptosis through the activation of pro-apoptotic proteins such as p53, bax, and caspase-9. |
2018-01-22 |
2023-08-13 |
human |
| Razmik Mirzayans, Bonnie Andrais, Piyush Kumar, David Murra. Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome. International journal of molecular sciences. vol 18. issue 5. 2018-01-22. PMID:28452953. |
significance of wild-type p53 signaling in suppressing apoptosis in response to chemical genotoxic agents: impact on chemotherapy outcome. |
2018-01-22 |
2023-08-13 |
human |
| Dayun Feng, Bao Wang, Yulong Ma, Wei Shi, Kai Tao, Weijun Zeng, Qing Cai, Zhiguo Zhang, Huaizhou Qi. The Ras/Raf/Erk Pathway Mediates the Subarachnoid Hemorrhage-Induced Apoptosis of Hippocampal Neurons Through Phosphorylation of p53. Molecular neurobiology. vol 53. issue 8. 2018-01-22. PMID:26497030. |
the ras/raf/erk pathway mediates the subarachnoid hemorrhage-induced apoptosis of hippocampal neurons through phosphorylation of p53. |
2018-01-22 |
2023-08-13 |
Not clear |
| Dayun Feng, Bao Wang, Yulong Ma, Wei Shi, Kai Tao, Weijun Zeng, Qing Cai, Zhiguo Zhang, Huaizhou Qi. The Ras/Raf/Erk Pathway Mediates the Subarachnoid Hemorrhage-Induced Apoptosis of Hippocampal Neurons Through Phosphorylation of p53. Molecular neurobiology. vol 53. issue 8. 2018-01-22. PMID:26497030. |
both p53 small interfering rna (sirna) and pd98059 reduced the oxyhb-induced apoptosis. |
2018-01-22 |
2023-08-13 |
Not clear |
| Man Liu, Guoren Huang, Thomas T Y Wang, Xiangjun Sun, Liangli Lucy Y. 3-MCPD 1-Palmitate Induced Tubular Cell Apoptosis In Vivo via JNK/p53 Pathways. Toxicological sciences : an official journal of the Society of Toxicology. vol 151. issue 1. 2018-01-22. PMID:27008853. |
additionally, p53 knockout attenuated the apoptosis, and the apoptosis-related protein bax expression and cleaved caspase-3 activation induced by mpe in the p53 knockout c57bl/6 mice, whereas jnk inhibitor sp600125 but not erk inhibitor u0126 inhibited mpe-induced apoptosis, supporting the conclusion that jnk/p53 might play a critical role in the tubular cell apoptosis induced by mpe and other 3-mcpd fatty acid esters. |
2018-01-22 |
2023-08-13 |
mouse |
| Jin Gu Cho, Seho Park, Chae Hyun Lim, Hong Sook Kim, Seung Yong Song, Tae-Young Roh, Jong-Hyuk Sung, Wonhee Suh, Seok-Jin Ham, Key-Hwan Lim, Sang Gyu Par. ZNF224, Krüppel like zinc finger protein, induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a. Oncotarget. vol 7. issue 21. 2018-01-18. PMID:27105517. |
mir-663a antagonist abolished znf224-mediated suppression of p21 and p53, resulting in the enhanced apoptosis by cpt. |
2018-01-18 |
2023-08-13 |
human |
| Jin Gu Cho, Seho Park, Chae Hyun Lim, Hong Sook Kim, Seung Yong Song, Tae-Young Roh, Jong-Hyuk Sung, Wonhee Suh, Seok-Jin Ham, Key-Hwan Lim, Sang Gyu Par. ZNF224, Krüppel like zinc finger protein, induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a. Oncotarget. vol 7. issue 21. 2018-01-18. PMID:27105517. |
consequently, znf224 increases cell survival and decreases apoptosis by decreasing the expression of p53 and p21 via mir-663a as a transcriptional activator. |
2018-01-18 |
2023-08-13 |
human |