| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dahlia M Nuñez-Hernandez, Monserrath Felix-Portillo, Alma B Peregrino-Uriarte, Gloria Yepiz-Plascenci. Cell cycle regulation and apoptosis mediated by p53 in response to hypoxia in hepatopancreas of the white shrimp Litopenaeus vannamei. Chemosphere. vol 190. 2018-02-15. PMID:28992477. |
taken together these results indicate the involvement of p53 in regulation of cell cycle and apoptosis in the white shrimp in response to hypoxia. |
2018-02-15 |
2023-08-13 |
Not clear |
| Marci Wood, Stacia Rymarchyk, Song Zheng, Yana Ce. Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6. Archives of biochemistry and biophysics. vol 638. 2018-02-14. PMID:29233643. |
taken together, this study not only suggests potential roles of sirt6 in regulating apoptosis and stress resistance via direct deacetylation of p53, but also provides lead compound for the development of potent and selective sirt6 inhibitors. |
2018-02-14 |
2023-08-13 |
Not clear |
| Nianshuang Li, Chuan Xie, Nong-Hua L. p53, a potential predictor of Helicobacter pylori infection-associated gastric carcinogenesis? Oncotarget. vol 7. issue 40. 2018-02-13. PMID:27556187. |
dysregulation of p53 by h. pylori infection contributes to gastric carcinogenesis by mediating cell proliferation and apoptosis. |
2018-02-13 |
2023-08-13 |
human |
| Alfredo Lagunas-Martínez, Enrique García-Villa, Magaly Arellano-Gaytán, Carla O Contreras-Ochoa, Jisela Dimas-González, María E López-Arellano, Vicente Madrid-Marina, Patricio Garigli. MG132 plus apoptosis antigen-1 (APO-1) antibody cooperate to restore p53 activity inducing autophagy and p53-dependent apoptosis in HPV16 E6-expressing keratinocytes. Apoptosis : an international journal on programmed cell death. vol 22. issue 1. 2018-02-12. PMID:27766434. |
mg132 plus apoptosis antigen-1 (apo-1) antibody cooperate to restore p53 activity inducing autophagy and p53-dependent apoptosis in hpv16 e6-expressing keratinocytes. |
2018-02-12 |
2023-08-13 |
Not clear |
| Alfredo Lagunas-Martínez, Enrique García-Villa, Magaly Arellano-Gaytán, Carla O Contreras-Ochoa, Jisela Dimas-González, María E López-Arellano, Vicente Madrid-Marina, Patricio Garigli. MG132 plus apoptosis antigen-1 (APO-1) antibody cooperate to restore p53 activity inducing autophagy and p53-dependent apoptosis in HPV16 E6-expressing keratinocytes. Apoptosis : an international journal on programmed cell death. vol 22. issue 1. 2018-02-12. PMID:27766434. |
we investigated whether in hpv16 e6-expressing keratinocytes (ke6 cells), the restoration of p53 levels mediated by mg132 and/or activation of the cd95 pathway through apoptosis antigen-1 (apo-1) antibody are responsible for the induction of apoptosis. |
2018-02-12 |
2023-08-13 |
Not clear |
| Alfredo Lagunas-Martínez, Enrique García-Villa, Magaly Arellano-Gaytán, Carla O Contreras-Ochoa, Jisela Dimas-González, María E López-Arellano, Vicente Madrid-Marina, Patricio Garigli. MG132 plus apoptosis antigen-1 (APO-1) antibody cooperate to restore p53 activity inducing autophagy and p53-dependent apoptosis in HPV16 E6-expressing keratinocytes. Apoptosis : an international journal on programmed cell death. vol 22. issue 1. 2018-02-12. PMID:27766434. |
finally, using pifithrin alpha we observed a decrease in apoptosis induced by mg132, and by apo-1 plus mg132, suggesting that restoration of apo-1 sensitivity occurs in part through an increase in both the levels and the activity of p53. |
2018-02-12 |
2023-08-13 |
Not clear |
| E Fadda, M G Nixo. The transient manifold structure of the p53 extreme C-terminal domain: insight into disorder, recognition, and binding promiscuity by molecular dynamics simulations. Physical chemistry chemical physics : PCCP. vol 19. issue 32. 2018-02-12. PMID:28597880. |
the p53 tumour suppressor is a transcription activator that signals for cell cycle arrest and apoptosis. |
2018-02-12 |
2023-08-13 |
Not clear |
| Sajita Shah, Chaemin Lee, Hyukjae Choi, Jaya Gautam, Hyeonjin Jang, Geum Jin Kim, Yu-Jeong Lee, Chhabi Lal Chaudhary, Sang Won Park, Tae-Gyu Nam, Jung-Ae Kim, Byeong-Seon Jeon. 5-Hydroxy-7-azaindolin-2-one, a novel hybrid of pyridinol and sunitinib: design, synthesis and cytotoxicity against cancer cells. Organic & biomolecular chemistry. vol 14. issue 21. 2018-02-12. PMID:27145715. |
signaling pathway-associated transcription factor reporter assay and western blot analyses revealed that apoptosis induction in mda-mb-231 human breast cancer cells by 6f is mainly mediated through the p53 increase and down-regulation of phospho-signal transducer and activator of transcription 3 (stat3) and its target gene products, cyclin d, bcl-2, and survivin. |
2018-02-12 |
2023-08-13 |
human |
| Ling-Yu Yang, Nigel H Greig, Ya-Ni Huang, Tsung-Hsun Hsieh, David Tweedie, Qian-Sheng Yu, Barry J Hoffer, Yu Luo, Yu-Chieh Kao, Jia-Yi Wan. Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury. Neurobiology of disease. vol 96. 2018-02-09. PMID:27553877. |
p53, p53 upregulated modulator of apoptosis (puma), 4-hydroxynonenal (4-hne), cyclooxygenase-iv (cox iv), annexin v and neun were visualized by double immunofluorescence staining with cell-specific markers. |
2018-02-09 |
2023-08-13 |
rat |
| Haruna Furukawa, Tomoki Makino, Makoto Yamasaki, Koji Tanaka, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Dok. PRIMA-1 induces p53-mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation. Cancer science. vol 109. issue 2. 2018-02-09. PMID:29168598. |
prima-1 (p53 re-activation and induction of massive apoptosis) has recently been reported to restore the function of mutant tp53; however, its antitumor effect and mechanism in escc remain unclear. |
2018-02-09 |
2023-08-13 |
Not clear |
| Mohammad Reza Sam, Mohammad Esmaeillou, Mohammad Ali Shokrgoza. Fish-Oil-Derived DHA-mediated Enhancement of Apoptosis in Acute Lymphoblastic Leukemia Cells is Associated with Accumulation of p53, Downregulation of Survivin, and Caspase-3 Activation. Nutrition and cancer. vol 69. issue 1. 2018-02-08. PMID:27880058. |
fish-oil-derived dha-mediated enhancement of apoptosis in acute lymphoblastic leukemia cells is associated with accumulation of p53, downregulation of survivin, and caspase-3 activation. |
2018-02-08 |
2023-08-13 |
Not clear |
| Mohammad Reza Sam, Mohammad Esmaeillou, Mohammad Ali Shokrgoza. Fish-Oil-Derived DHA-mediated Enhancement of Apoptosis in Acute Lymphoblastic Leukemia Cells is Associated with Accumulation of p53, Downregulation of Survivin, and Caspase-3 Activation. Nutrition and cancer. vol 69. issue 1. 2018-02-08. PMID:27880058. |
in this study, we investigated the alterations of the p53 and survivin expression and induction of apoptosis in dha-treated molt-4 cells that serve as a model for all cells. |
2018-02-08 |
2023-08-13 |
Not clear |
| Mohammad Hasanzadeh, Nasrin Shadjo. (Nano)-materials and methods of signal enhancement for genosensing of p53 tumor suppressor protein: Novel research overview. Materials science & engineering. C, Materials for biological applications. vol 76. 2018-02-08. PMID:28482509. |
p53 plays an important role in cell cycle control and apoptosis. |
2018-02-08 |
2023-08-13 |
Not clear |
| Yao-Min Chen, Yu Liu, Hai-Yan Wei, Ke-Zhen Lv, Pei-Fen F. Large intergenic non-coding RNA-ROR reverses gemcitabine-induced autophagy and apoptosis in breast cancer cells. Oncotarget. vol 7. issue 37. 2018-02-06. PMID:27449099. |
untreated mda-mb-231 cell lines strongly expressed linc-ror, but linc-ror knockdown decreased cell viability and expression of p62 and p53 while increasing apoptosis. |
2018-02-06 |
2023-08-13 |
Not clear |
| Guillaume Renner, Fanny Noulet, Marie-Cécile Mercier, Laurence Choulier, Nelly Etienne-Selloum, Jean-Pierre Gies, Maxime Lehmann, Isabelle Lelong-Rebel, Sophie Martin, Monique Dontenwil. Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells. Oncotarget. vol 7. issue 38. 2018-02-06. PMID:27613837. |
however, blockade of beta-catenin by xav939 (tankyrase inhibitor leading to beta-catenin degradation) did not synergize with p53 activation aiming to cell apoptosis as was the case with integrin antagonists. |
2018-02-06 |
2023-08-13 |
Not clear |
| Hiroyuki Morita, Issei Komur. Heart Failure as an Aging-Related Phenotype. International heart journal. vol 59. issue 1. 2018-02-06. PMID:29332923. |
on the other hand, p53 induces the apoptosis of cardiomyocytes in the failing heart. |
2018-02-06 |
2023-08-13 |
Not clear |
| Sang Yun Ha, Jeong Hoon Kim, Jung Wook Yang, Jimin Kim, Binnari Kim, Cheol-Keun Par. The Overexpression of CCAR1 in Hepatocellular Carcinoma Associates with Poor Prognosis. Cancer research and treatment. vol 48. issue 3. 2018-02-05. PMID:26511806. |
cell division cycle and apoptosis regulator 1 (ccar1) plays a dynamic role in regulation of cell growth and apoptosis by serving as a cofactor of steroid/thyroid nuclear receptors, β-catenin, and p53 in a variety of cell types including different cancer cells. |
2018-02-05 |
2023-08-13 |
Not clear |
| Mohd Kamil, Ejazul Haque, Safia Irfan, Saba Sheikh, Adria Hasan, Aamir Nazir, Mohtashim Lohani, Snober S Mi. ER chaperone GRP78 regulates autophagy by modulation of p53 localization. Frontiers in bioscience (Elite edition). vol 9. 2018-01-31. PMID:27814589. |
its anti-apoptotic and pro-autophagic activity makes it an intriguing target to study the relationship between grp78 and p53, which is also a major regulator of apoptosis and autophagy. |
2018-01-31 |
2023-08-13 |
human |
| Chengfu Yuan, Changdong Wang, Junjie Wang, Vikas Kumar, Firoz Anwar, Fangxiang Xiao, Gohar Mushtaq, Yufei Liu, Mohammad Amjad Kamal, Ding Yua. Inhibition on the growth of human MDA-MB-231 breast cancer cells in vitro and tumor growth in a mouse xenograft model by Se-containing polysaccharides from Pyracantha fortuneana. Nutrition research (New York, N.Y.). vol 36. issue 11. 2018-01-31. PMID:27865619. |
in vitro studies showed that treatment of triple negative breast cancer (tnbc) mda-mb-231 cells with se-pfps (1) inhibited cell growth dose-dependently by arresting cells at g2 phase via inhibiting cdc25c-cyclinb1/cdc2 pathway; (2) caused apoptosis associated with increased p53, bax, puma and noxa, decreased bcl2, increased bax/bcl2 ratio and increased activities of caspases 3/9, suggesting its effect on p53-mediated cytochrome c-caspase pathway. |
2018-01-31 |
2023-08-13 |
mouse |
| Malte Kriegs, Ulla Kasten-Pisula, Britta Riepen, Konstantin Hoffer, Nina Struve, Laura Myllynen, Friederike Braig, Mascha Binder, Thorsten Rieckmann, Reidar Grénman, Cordula Petersen, Ekkehard Dikomey, Kai Rothkam. Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests. Oncotarget. vol 7. issue 29. 2018-01-30. PMID:27281611. |
because egfr targeting in combination with radiotherapy is used to treat head and neck squamous cell carcinomas (hnscc) which are predominantly p53 mutated, we tested the effects of egfr targeting on cellular radiosensitivity, proliferation, apoptosis, dna repair and cell cycle control using a large panel of hnscc cell lines. |
2018-01-30 |
2023-08-13 |
Not clear |