| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinyue You, Jing Xi, Yiyi Cao, Jinfu Zhang, Yang Lua. 4-Bromodiphenyl Ether Induces Germ Cell Apoptosis by Induction of ROS and DNA Damage in Caenorhabditis elegans. Toxicological sciences : an official journal of the Society of Toxicology. vol 157. issue 2. 2018-03-12. PMID:28369609. |
moreover, the knockout of the mapk kinases (mutants mek-1 and sek-1) and the p53 antagonist protein abl-1 (abl-1), which are essential for stress-induced germ cell apoptosis, also abrogated the germ cell apoptosis induced by bde-3. |
2018-03-12 |
2023-08-13 |
caenorhabditis_elegans |
| Rajnish Kumar Singh, Sunil Saini, Dileep Verma, Ponnusamy Kalaiarasan, Rameshwar N K Bameza. Mitochondrial ND5 mutation mediated elevated ROS regulates apoptotic pathway epigenetically in a P53 dependent manner for generating pro-cancerous phenotypes. Mitochondrion. vol 35. 2018-03-12. PMID:28502718. |
cells over-expressing mtnd5 variant produced both peroxide as well as super-oxide ros; the generation of which was dependent on the functional status of p53; modulating epigenetically the expression of key apoptosis pathway genes. |
2018-03-12 |
2023-08-13 |
Not clear |
| Hao-Wei Cheng, Rong-Jie Chein, Ting-Jen Cheng, Pei-Shan Wu, Hsin-Yi Wu, Pei-Fang Hung, Chia-Jen Wang, Yuan-Ling Hsu, Jau-Min Wong, Ang Yuan, Chi-Huey Wong, Pan-Chyr Yang, Szu-Hua Pa. 2-anilino-4-amino-5-aroylthiazole-type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction. Cancer science. vol 109. issue 3. 2018-03-12. PMID:29285847. |
further exploration indicated that as7128 treatment could restore the transactivation ability of p53 and, thus, increase the expressions of its downstream target genes, which are related to cell cycle arrest and apoptosis. |
2018-03-12 |
2023-08-13 |
Not clear |
| Hao-Wei Cheng, Rong-Jie Chein, Ting-Jen Cheng, Pei-Shan Wu, Hsin-Yi Wu, Pei-Fang Hung, Chia-Jen Wang, Yuan-Ling Hsu, Jau-Min Wong, Ang Yuan, Chi-Huey Wong, Pan-Chyr Yang, Szu-Hua Pa. 2-anilino-4-amino-5-aroylthiazole-type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction. Cancer science. vol 109. issue 3. 2018-03-12. PMID:29285847. |
taken together, as7128 could bind to iaspp, disrupt the interaction between iaspp and p53, and result in cell cycle arrest and apoptosis. |
2018-03-12 |
2023-08-13 |
Not clear |
| Melissa Desouza-Armstrong, Peter W Gunning, Justine R Steh. Tumor suppressor tropomyosin Tpm2.1 regulates sensitivity to apoptosis beyond anoikis characterized by changes in the levels of intrinsic apoptosis proteins. Cytoskeleton (Hoboken, N.J.). vol 74. issue 6. 2018-03-09. PMID:28378936. |
moreover, tpm2.1 overexpressing cells showed elevated levels of the apoptosis proteins bak (proapoptotic), mcl-1 (prosurvival), bcl-2 (prosurvival) and phosphorylated p53 (ser392). |
2018-03-09 |
2023-08-13 |
rat |
| Jian-Tao Lin, Zong-Kun Liu, Qing-Ling Zhu, Xiao-Hui Rong, Cui-Ling Liang, Jie Wang, Dong Ma, Jing Sun, Guan-Hai Wan. Redox-responsive nanocarriers for drug and gene co-delivery based on chitosan derivatives modified mesoporous silica nanoparticles. Colloids and surfaces. B, Biointerfaces. vol 155. 2018-03-09. PMID:28407530. |
apoptosis analysis confirmed that dox and p53 could be co-delivered to the hela cells by msn-ss-cp nanocarriers and induced significant cell apoptosis. |
2018-03-09 |
2023-08-13 |
Not clear |
| Jian-Tao Lin, Wen-Jia Pan, Jun-Ai Zhang, Wei Wang, Jia Zhong, Jia-Min Su, Tong Li, Ying Zou, Guan-Hai Wan. Photoenhanced gene transfection by a curcumin loaded CS-g-PZLL micelle. Materials science & engineering. C, Materials for biological applications. vol 78. 2018-03-09. PMID:28575972. |
the apoptosis assay showed that the complex could induce a more significant apoptosis to hela cells than that of curcumin or p53 used alone, and the curcumin loaded micelle inducing apoptosis was best after irradiation. |
2018-03-09 |
2023-08-13 |
Not clear |
| Irfan Khan, Koteswara Rao Garikapati, Anver Basha Shaik, Venkata Krishna Kanth Makani, Abdul Rahim, Mohd Adil Shareef, V Ganga Reddy, Manika Pal-Bhadra, Ahmed Kamal, C Ganesh Kuma. Design, synthesis and biological evaluation of 1, 4-dihydro indeno[1,2-c] pyrazole linked oxindole analogues as potential anticancer agents targeting tubulin and inducing p53 dependent apoptosis. European journal of medicinal chemistry. vol 144. 2018-03-09. PMID:29268127. |
design, synthesis and biological evaluation of 1, 4-dihydro indeno[1,2-c] pyrazole linked oxindole analogues as potential anticancer agents targeting tubulin and inducing p53 dependent apoptosis. |
2018-03-09 |
2023-08-13 |
human |
| Jhih-Syuan Wang, Chia-Yi Tseng, Ming-Wei Cha. Diesel Exhaust Particles Contribute to Endothelia Apoptosis via Autophagy Pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 156. issue 1. 2018-03-06. PMID:28013216. |
after 12 h of dep exposure, huvec reduced mdm2 expression leading to increased p53 expression, which triggered apoptosis and ultimately resulted in endothelial dysfunction. |
2018-03-06 |
2023-08-13 |
human |
| Seul-Ki Kwon, Madhuri Saindane, Kwang-Hyun Bae. p53 stability is regulated by diverse deubiquitinating enzymes. Biochimica et biophysica acta. Reviews on cancer. vol 1868. issue 2. 2018-03-06. PMID:28801249. |
in such responses, p53 activates specific transcriptional targets that control cell cycle arrest, dna repair, angiogenesis, autophagy, metabolism, migration, aging, senescence, and apoptosis. |
2018-03-06 |
2023-08-13 |
human |
| Ping-Ping Gan, Yang-Ying Zhou, Mei-Zuo Zhong, Yun Peng, Li Li, Jian-Huang L. Endoplasmic Reticulum Stress Promotes Autophagy and Apoptosis and Reduces Chemotherapy Resistance in Mutant p53 Lung Cancer Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 44. issue 1. 2018-03-06. PMID:29130967. |
endoplasmic reticulum stress promotes autophagy and apoptosis and reduces chemotherapy resistance in mutant p53 lung cancer cells. |
2018-03-06 |
2023-08-13 |
Not clear |
| Ping-Ping Gan, Yang-Ying Zhou, Mei-Zuo Zhong, Yun Peng, Li Li, Jian-Huang L. Endoplasmic Reticulum Stress Promotes Autophagy and Apoptosis and Reduces Chemotherapy Resistance in Mutant p53 Lung Cancer Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 44. issue 1. 2018-03-06. PMID:29130967. |
during this study we aimed to investigate the involvement of endoplasmic reticulum stress (ers) in autophagy, apoptosis, and chemotherapy resistance of mutant p53 lc cells. |
2018-03-06 |
2023-08-13 |
Not clear |
| Chulwon Kim, Il Ho Lee, Ho Bong Hyun, Jong-Chan Kim, Rajendra Gyawali, Seok-Geun Lee, Junhee Lee, Sung-Hoon Kim, Bum Sang Shim, Somi K Cho, Kwang Seok Ah. Supercritical Fluid Extraction of Citrus iyo Hort. ex Tanaka Pericarp Inhibits Growth and Induces Apoptosis Through Abrogation of STAT3 Regulated Gene Products in Human Prostate Cancer Xenograft Mouse Model. Integrative cancer therapies. vol 16. issue 2. 2018-03-06. PMID:27185319. |
this correlated with an increase in apoptosis as indicated by an increase in the expression of p53 and p21 proteins, the sub-g1 arrest, and caspase-3-induced parp cleavage. |
2018-03-06 |
2023-08-13 |
mouse |
| Xiuyan Feng, Han Han, Dan Zou, Jiaming Zhou, Weiqiang Zho. Suberoylanilide hydroxamic acid-induced specific epigenetic regulation controls Leptin-induced proliferation of breast cancer cell lines. Oncotarget. vol 8. issue 2. 2018-03-05. PMID:27926517. |
moreover, cell cycle real-time pcr array and proteome profiler antibody array confirmed that leptin and saha treatment significantly changed the expressions of factors associated with cell cycle regulation and apoptosis including p53 and p21waf1/cip1.in dna-chip analysis, we found that acetylation levels binding with p21waf1/cip1 promoters are regulated in a manner specific to histone type, lysine residue and selective promoter regions. |
2018-03-05 |
2023-08-13 |
Not clear |
| Xinyun Ye, Wenjin Wei, Zhengyu Zhang, Chunming He, Ruijin Yang, Jinshi Zhang, Zhiwu Wu, Qianliang Huang, Qiuhua Jian. Identification of microRNAs associated with glioma diagnosis and prognosis. Oncotarget. vol 8. issue 16. 2018-03-05. PMID:28060761. |
ten signaling pathways showed the strongest association with glioma development and progression: the p53 pathway feedback loops 2, interleukin signaling pathway, toll receptor signaling pathway, parkinson's disease, notch signaling pathway, cadherin signaling pathway, apoptosis signaling pathway, vegf signaling pathway, alzheimer disease-amyloid secretase pathway, and the fgf signaling pathway. |
2018-03-05 |
2023-08-13 |
Not clear |
| Yan-Ling Hu, Xiao-Shan Li, Shu Xiong, Qiang Ma, Dan Liu, Zhong-Quan Shi, Jing Tang, Xian-Cai Rao, Fu-Quan Hu, Guo-Li L. The inhibiting effect of the transcription factor p53 on dengue virus infection by activating the type I interferon. Oncotarget. vol 8. issue 15. 2018-03-05. PMID:28212581. |
the dv infection was inhibited by the transcription factor p53 by activating type i interferon pathway other than promoting the cell apoptosis. |
2018-03-05 |
2023-08-13 |
human |
| Yanping Feng, Fang Liu, Zhixiang Du, Dongjie Zhao, Jianxin Cheng, Wei Gu. Wip1 regulates SKOV3 cell apoptosis through the p38 MAPK signaling pathway. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28440479. |
western blot analysis was performed to determine expression of tumor protein 53 (p53), cleaved caspase‑3, caspase‑3, bcl2 associated x (bax), bcl2 apoptosis regulator (bcl‑2), p38 mitogen‑activated protein kinase (p38 mapk) and phosphorylated (p)‑p38 mapk. |
2018-03-05 |
2023-08-13 |
human |
| Yanping Feng, Fang Liu, Zhixiang Du, Dongjie Zhao, Jianxin Cheng, Wei Gu. Wip1 regulates SKOV3 cell apoptosis through the p38 MAPK signaling pathway. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28440479. |
the present study demonstrated that wip1 silencing promotes apoptosis of human ovarian cancer skov3 cells by activation of the p38 mapk signaling pathways and through subsequent upregulation of p53, and cleaved caspase‑3/caspase‑3 and bax/bcl‑2 protein ratios. |
2018-03-05 |
2023-08-13 |
human |
| Ping Chen, Jing-Yang Zhang, Bei-Bei Sha, Yan-Er Ma, Tao Hu, Yang-Cheng Ma, Hao Sun, Jian-Xiang Shi, Zi-Ming Dong, Pei L. Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450. Oncotarget. vol 8. issue 16. 2018-03-05. PMID:28460467. |
western blot results showed the expression of cell cycle regulatory protein p21 and p53 increased and three apoptosis related proteins that participate in mitochondrial apoptotic pathway, namely, bim, cyt-c and cparp, also increased in luteolin treated cells compared with control groups. |
2018-03-05 |
2023-08-13 |
mouse |
| Jana Cesnekova, Jana Spacilova, Hana Hansikova, Josef Houstek, Jiri Zeman, Lukas Stibure. LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis. Oncotarget. vol 7. issue 30. 2018-03-01. PMID:27323408. |
lace1 interacts with p53 and mediates its mitochondrial translocation and apoptosis. |
2018-03-01 |
2023-08-13 |
Not clear |