| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Masuelli, Monica Benvenuto, Enrica Di Stefano, Rosanna Mattera, Massimo Fantini, Giuseppina De Feudis, Enrico De Smaele, Ilaria Tresoldi, Maria Gabriella Giganti, Andrea Modesti, Roberto Be. Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line. Oncotarget. vol 8. issue 21. 2018-03-22. PMID:28159921. |
cur-mediated apoptosis was supported by the increase of bax/bcl-2 ratio, increase of p53 expression, activation of caspase 9, cleavage of parp-1, increase of the percentage of cells in the sub g1 phase which was reduced (mm-f1 and #40a) or abolished (mm-b1 and h-meso-1) after mm cells incubation with the apoptosis inhibitor z-vad-fmk. |
2018-03-22 |
2023-08-13 |
mouse |
| Simona Catalani, Francesco Palma, Serafina Battistelli, Barbara Nuvoli, Rossella Galati, Serena Benedett. Reduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir. Toxicology in vitro : an international journal published in association with BIBRA. vol 41. 2018-03-22. PMID:28223140. |
similarly, the increase of the pro-apoptotic proteins p53, cytochrome c and caspase-3, the decrease of the survival protein bcl-x, and the increment of bax/bcl-2 ratio revealed the occurrence of apoptosis in cdv-treated ftc-133. |
2018-03-22 |
2023-08-13 |
human |
| Chunping Yao, Xiujuan Cao, Zheng Fu, Jing Tian, Wei Dong, Jin Xu, Kang An, Limin Zhai, Jinming Y. Boschniakia Rossica Polysaccharide Triggers Laryngeal Carcinoma Cell Apoptosis by Regulating Expression of Bcl-2, Caspase-3, and P53. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-22. PMID:28455995. |
boschniakia rossica polysaccharide triggers laryngeal carcinoma cell apoptosis by regulating expression of bcl-2, caspase-3, and p53. |
2018-03-22 |
2023-08-13 |
human |
| Philipp J Hohensinner, Nikol Takacs, Christoph Kaun, Barbara Thaler, Konstantin A Krychtiuk, Stefan Pfaffenberger, Arezu Aliabadi, Andreas Zuckermann, Kurt Huber, Johann Wojt. Urokinase plasminogen activator protects cardiac myocytes from oxidative damage and apoptosis via hOGG1 induction. Apoptosis : an international journal on programmed cell death. vol 22. issue 8. 2018-03-21. PMID:28643198. |
in addition, upa was reported to stabilize p53, a key cell cycle control, dna repair and apoptosis initiation protein. |
2018-03-21 |
2023-08-13 |
human |
| Przemysław Sitarek, Ewa Skała, Monika Toma, Marzena Wielanek, Janusz Szemraj, Tomasz Skorski, Adam J Białas, Tomasz Sakowicz, Tomasz Kowalczyk, Maciej Radek, Halina Wysokińska, Tomasz Śliwińsk. Transformed Root Extract of Leonurus sibiricus Induces Apoptosis through Intrinsic and Extrinsic Pathways in Various Grades of Human Glioma Cells. Pathology oncology research : POR. vol 23. issue 3. 2018-03-20. PMID:28032310. |
tr root extract induces apoptosis on various grades (i-iii) of human glioma cells by the generation of reactive oxygen species (ros) along with concurrent loss of mitochondrial membrane potential, enhanced s and g2/m phases of the cell cycle, and altered mrna levels of bax, bcl-2, p53, cas-3, cas-8 and cas-9 factors involved in apoptosis. |
2018-03-20 |
2023-08-13 |
human |
| Ulkan Kilic, Ahmet Burak Caglayan, Mustafa Caglar Beker, Mehmet Yalcin Gunal, Berrak Caglayan, Esra Yalcin, Taha Kelestemur, Reyhan Zeynep Gundogdu, Burak Yulug, Bayram Yılmaz, Bilal Ersen Kerman, Ertugrul Kili. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox biology. vol 12. 2018-03-20. PMID:28395173. |
in addition, melatonin decreased apoptosis through reduced p53 phosphorylation by the pi3k/akt pathway. |
2018-03-20 |
2023-08-13 |
mouse |
| Daniel Menendez, Julie M Lowe, Joyce Snipe, Michael A Resnic. Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells. Oncotarget. vol 7. issue 38. 2018-03-19. PMID:27533082. |
furthermore, restoration of wt p53 activity for loss-of-function p53 mutants by the p53 reactivating drug rita restored p53 regulation of tlr3 gene expression and enhanced dna damage-induced apoptosis via tlr3 signaling. |
2018-03-19 |
2023-08-13 |
human |
| Theophilos Tzaridis, Till Milde, Kristian W Pajtler, Sebastian Bender, David T W Jones, Simone Müller, Andrea Wittmann, Magdalena Schlotter, Andreas E Kulozik, Peter Lichter, V Peter Collins, Olaf Witt, Marcel Kool, Andrey Korshunov, Stefan M Pfister, Hendrik Wit. Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma. Oncotarget. vol 7. issue 38. 2018-03-19. PMID:27556362. |
transcriptome analyses of high-dose (100 nm), low-dose (5 nm) and non-treated cells revealed re-expression of p53 dependent genes including p53 upregulated modulator of apoptosis (puma) after low-dose treatment. |
2018-03-19 |
2023-08-13 |
Not clear |
| Juhyun Song, Oh Yoen Ki. Melatonin Modulates Neuronal Cell Death Induced by Endoplasmic Reticulum Stress under Insulin Resistance Condition. Nutrients. vol 9. issue 6. 2018-03-19. PMID:28604593. |
apoptosis cell death signaling markers (cleaved poly [adp-ribose] polymerase 1 (parp), p53, and bax) and er stress markers (phosphorylated eif2α (p-eif2α), atf4, chop, |
2018-03-19 |
2023-08-13 |
Not clear |
| Mans Broekgaarden, Ruud Weijer, Alebert C van Wijk, Ruud C Cox, Maarten R Egmond, Ron Hoebe, Thomas M van Gulik, Michal Hege. Photodynamic Therapy with Liposomal Zinc Phthalocyanine and Tirapazamine Increases Tumor Cell Death via DNA Damage. Journal of biomedical nanotechnology. vol 13. issue 2. 2018-03-19. PMID:29377650. |
tpz induces dna double strand breaks (dsbs) under hypoxic conditions and subsequent apoptosis via p53 signaling. |
2018-03-19 |
2023-08-13 |
Not clear |
| Hanzhang Zhu, Jingrui Wang, Junjie Yin, Bei Lu, Qijun Yang, Yafeng Wan, Changku Ji. Downregulation of PRAME Suppresses Proliferation and Promotes Apoptosis in Hepatocellular Carcinoma Through the Activation of P53 Mediated Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 45. issue 3. 2018-03-19. PMID:29439259. |
downregulation of prame suppresses proliferation and promotes apoptosis in hepatocellular carcinoma through the activation of p53 mediated pathway. |
2018-03-19 |
2023-08-13 |
Not clear |
| Jingjin Liu, Yongshun Wang, Jinjin Cui, Meng Sun, Zhongyue Pu, Chao Wang, Wenjuan Du, Xinxin Liu, Jian Wu, Jingbo Hou, Shuo Zhang, Bo Y. miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit Stem cell research & therapy. vol 8. issue 1. 2018-03-16. PMID:28583208. |
mir199a-3p regulates p53 by targeting cables1 in mouse cardiac c-kit micrornas (mirnas) have emerged as crucial factors that regulate proliferation and apoptosis of cardiac c-kit |
2018-03-16 |
2023-08-13 |
mouse |
| Lalitha Devi, Himesh Makala, Lavanya Pothana, Khemlal Nirmalkar, Sandeep Goe. Comparative efficacies of six different media for cryopreservation of immature buffalo (Bubalus bubalis) calf testis. Reproduction, fertility, and development. vol 28. issue 7. 2018-03-15. PMID:25482277. |
similarity in expression of pro-apoptosis proteins transcription factor tumour protein p53 (tp53) and bcl2-associated x protein (bax) in d20s20 cryopreserved tissues to that of fcc (p>0.05) suggested lower apoptosis and dna damage as key reasons for superior cryopreservation. |
2018-03-15 |
2023-08-13 |
cattle |
| Mi Jung Kwon, So Young Kang, Eun Sook Nam, Seong Jin Cho, Young-Soo Rh. HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma. BioMed research international. vol 2017. 2018-03-14. PMID:28607924. |
homeodomain-interacting protein kinase 2 (hipk2) is a central regulator of p53, which participates in apoptosis during the dna damage response. |
2018-03-14 |
2023-08-13 |
human |
| Miao Sun, Gao Si, Hai-Shen Sun, Fu-Chun S. Inhibition of CREPT restrains gastric cancer growth by regulation of cycle arrest, migration and apoptosis via ROS-regulated p53 pathway. Biochemical and biophysical research communications. vol 496. issue 4. 2018-03-14. PMID:29402413. |
inhibition of crept restrains gastric cancer growth by regulation of cycle arrest, migration and apoptosis via ros-regulated p53 pathway. |
2018-03-14 |
2023-08-13 |
human |
| Miao Sun, Gao Si, Hai-Shen Sun, Fu-Chun S. Inhibition of CREPT restrains gastric cancer growth by regulation of cycle arrest, migration and apoptosis via ROS-regulated p53 pathway. Biochemical and biophysical research communications. vol 496. issue 4. 2018-03-14. PMID:29402413. |
intriguingly, suppressing p53 expressions significantly abolished crept silence-induced apoptosis, and reduction of cell viability. |
2018-03-14 |
2023-08-13 |
human |
| Lin Fang, Qian Cheng, Jingjing Zhao, Yan Ge, Qi Zhu, Min Zhao, Jie Zhang, Qi Zhang, Liantao Li, Junjie Liu, Junnian Zhen. A p53-independent apoptotic mechanism of adenoviral mutant E1A was involved in its selective antitumor activity for human cancer. Oncotarget. vol 7. issue 30. 2018-03-13. PMID:27340782. |
e1a and me1a had accumulated inactive p53, decreased the expression of mdm2, cdkn1a (also named p21), increased p21's nuclear distribution and induced tumor cell apoptosis in a p53-indenpent manner. |
2018-03-13 |
2023-08-13 |
mouse |
| Joana Soares, Margarida Espadinha, Liliana Raimundo, Helena Ramos, Ana Sara Gomes, Sara Gomes, Joana B Loureiro, Alberto Inga, Flávio Reis, Célia Gomes, Maria M M Santos, Lucília Saraiv. DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties. Molecular oncology. vol 11. issue 6. 2018-03-13. PMID:28296148. |
dimp53-1 caused growth inhibition, mediated by p53 stabilization and upregulation of p53 transcriptional targets involved in cell cycle arrest and apoptosis, in wt p53-expressing tumor cells, including mdm2- or mdmx-overexpressing cells. |
2018-03-13 |
2023-08-13 |
mouse |
| Xiang Yan, Han S. YM155 Down-Regulates Survivin and Induces P53 Up-Regulated Modulator of Apoptosis (PUMA)-Dependent in Oral Squamous Cell Carcinoma Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-13. PMID:28435150. |
ym155 down-regulates survivin and induces p53 up-regulated modulator of apoptosis (puma)-dependent in oral squamous cell carcinoma cells. |
2018-03-13 |
2023-08-13 |
human |
| Zhipeng Qu, Jian Cui, Yuka Harata-Lee, Thazin Nwe Aung, Qianjin Feng, Joy M Raison, Robert Daniel Kortschak, David L Adelso. Identification of candidate anti-cancer molecular mechanisms of Compound Kushen Injection using functional genomics. Oncotarget. vol 7. issue 40. 2018-03-12. PMID:27602759. |
cki may also induce apoptosis in mcf-7 cells via a p53 independent mechanism. |
2018-03-12 |
2023-08-13 |
human |