| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Caroline Pirou, Fatemeh Montazer-Torbati, Nadège Jah, Elisabeth Delmas, Christelle Lasbleiz, Bernard Mignotte, Flore Renau. FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation. Cell death & disease. vol 8. issue 8. 2018-04-24. PMID:29048426. |
as we previously showed that fibroblast growth factor 1 (fgf1) inhibited p53-dependent apoptosis in neuron-like pc12 cells, we initiated the study of the interaction between the fgf1 and p53 pathways in neuroblastoma. |
2018-04-24 |
2023-08-13 |
mouse |
| Luke F Peterson, Miao-Chia Lo, Yihong Liu, Diane Giannola, Emilija Mitrikeska, Nicholas J Donato, Craig N Johnson, Shaomeng Wang, Jessica Mercer, Moshe Talpa. Induction of p53 suppresses chronic myeloid leukemia. Leukemia & lymphoma. vol 58. issue 9. 2018-04-23. PMID:28084835. |
the p53 protein is an important regulator of cell cycle and apoptosis. |
2018-04-23 |
2023-08-13 |
Not clear |
| Huan Shen, Li Liu, Yongjin Yang, Wenxing Xun, Kewen Wei, Guang Zen. Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling. Oncology research. vol 25. issue 7. 2018-04-23. PMID:28109089. |
knockdown of p53 blocked ba-induced increase in apoptosis, cell cycle arrest, and inhibition of cell proliferation. |
2018-04-23 |
2023-08-13 |
human |
| Sergey A Dyshlovoy, Stefanie Rast, Jessica Hauschild, Katharina Otte, Winfried H Alsdorf, Ramin Madanchi, Vladimir I Kalinin, Alexandra S Silchenko, Sergey A Avilov, Judith Dierlamm, Friedemann Honecker, Valentin A Stonik, Carsten Bokemeyer, Gunhild von Amsber. Frondoside A induces AIF-associated caspase-independent apoptosis in Burkitt lymphoma cells. Leukemia & lymphoma. vol 58. issue 12. 2018-04-23. PMID:28508718. |
nonfunctional caspases-dependent apoptosis pathways, inactivating p53 mutations and pro-survival autophagy prevent activity of conventional chemotherapy. |
2018-04-23 |
2023-08-13 |
Not clear |
| Jiho Jang, Yong Jun Huh, Hyun-Ju Cho, Boram Lee, Jaepil Park, Dong-Youn Hwang, Dong-Wook Ki. SIRT1 Enhances the Survival of Human Embryonic Stem Cells by Promoting DNA Repair. Stem cell reports. vol 9. issue 2. 2018-04-23. PMID:28689995. |
furthermore, sirt1 inhibition causes p53 activation, which eventually leads to dna damage-induced apoptosis of hescs. |
2018-04-23 |
2023-08-13 |
human |
| Jiz-Yuh Wang, Chiou-Lian Lai, Ching-Tien Lee, Chen-Yen Li. Electronegative Low-Density Lipoprotein L5 Impairs Viability and NGF-Induced Neuronal Differentiation of PC12 Cells via LOX-1. International journal of molecular sciences. vol 18. issue 8. 2018-04-23. PMID:28800073. |
l5 caused cell damage by inducing atm/h2ax-associated dna breakage as well as by activating apoptosis via lectin-like oxidized ldl receptor-1 (lox-1) signaling to p53 and ensuring cleavage of caspase-3. |
2018-04-23 |
2023-08-13 |
human |
| Arvinder Kapur, Mildred Felder, Lucas Fass, Justanjot Kaur, Austin Czarnecki, Kavya Rathi, San Zeng, Kathryn Kalady Osowski, Colin Howell, May P Xiong, Rebecca J Whelan, Manish S Patanka. Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation. Scientific reports. vol 6. 2018-04-23. PMID:27270209. |
in p53 expressing ecc-1 and ovcar-3 but not in p53-deficient skov-3 cells, citral induces g1/s cell cycle arrest and apoptosis as determined by annexin v staining and increased cleaved caspase3 and bax and decreased bcl-2. |
2018-04-23 |
2023-08-13 |
human |
| Arvinder Kapur, Mildred Felder, Lucas Fass, Justanjot Kaur, Austin Czarnecki, Kavya Rathi, San Zeng, Kathryn Kalady Osowski, Colin Howell, May P Xiong, Rebecca J Whelan, Manish S Patanka. Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation. Scientific reports. vol 6. 2018-04-23. PMID:27270209. |
inhibition of p53 by pifithrin-α, attenuates citral-mediated apoptosis. |
2018-04-23 |
2023-08-13 |
human |
| Ritika Prasad, Nishant Kumar Rana, Biplob Koc. Dendrobium chrysanthum ethanolic extract induces apoptosis via p53 up-regulation in HeLa cells and inhibits tumor progression in mice. Journal of complementary & integrative medicine. vol 14. issue 2. 2018-04-18. PMID:28195549. |
dendrobium chrysanthum ethanolic extract induces apoptosis via p53 up-regulation in hela cells and inhibits tumor progression in mice. |
2018-04-18 |
2023-08-13 |
mouse |
| Wuxiang Wang, Can Zeng, Yuqin Feng, Furong Zhou, Fen Liao, Yuanfeng Liu, Shaolong Feng, Xinming Wan. The size-dependent effects of silica nanoparticles on endothelial cell apoptosis through activating the p53-caspase pathway. Environmental pollution (Barking, Essex : 1987). vol 233. 2018-04-18. PMID:29096294. |
interestingly, the enhancing phosphorylation of p53 protein (ser15), decreasing ratio of bcl-2/bax protein, and elevating activation of the downstream proteins, caspase-9, -7, -3 and parp, were also observed with the decreasing sizes of tested sinps, indicating that the p53-caspase pathway is the main way of the sinp-mediated apoptosis in huvecs and that the size is an important parameter that determines the sinps' potential to induce cellular response. |
2018-04-18 |
2023-08-13 |
human |
| Jie-Qiong Ma, Chan-Min Liu, Wei Yan. Protective effect of rutin against carbon tetrachloride-induced oxidative stress, inflammation and apoptosis in mouse kidney associated with the ceramide, MAPKs, p53 and calpain activities. Chemico-biological interactions. vol 286. 2018-04-18. PMID:29522708. |
protective effect of rutin against carbon tetrachloride-induced oxidative stress, inflammation and apoptosis in mouse kidney associated with the ceramide, mapks, p53 and calpain activities. |
2018-04-18 |
2023-08-13 |
mouse |
| Bingdong Sui, Chenghu Hu, Li Liao, Yichen Chen, Xinyi Zhang, Xin Fu, Chenxi Zheng, Meng Li, Ling Wu, Xinyi Zhao, Yan Ji. Mesenchymal progenitors in osteopenias of diverse pathologies: differential characteristics in the common shift from osteoblastogenesis to adipogenesis. Scientific reports. vol 6. 2018-04-16. PMID:27443833. |
the apoptosis and cellular senescence increased except in t1d, with up-regulation of p53 and p16 expression. |
2018-04-16 |
2023-08-13 |
Not clear |
| Guoxin Zhang, Yinyin Xie, Ying Zhou, Cong Xiang, Lai Chen, Chenxi Zhang, Xiaoshuang Hou, Jiong Chen, Hui Zong, Geng Li. p53 pathway is involved in cell competition during mouse embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 3. 2018-04-16. PMID:28049824. |
acute stresses such as dna damage are able to trigger a high level of p53 activity, leading to cell cycle arrest or apoptosis. |
2018-04-16 |
2023-08-13 |
mouse |
| Yun-Wei Shi, Wei Yuan, Xin Wang, Jie Gong, Shun-Xing Zhu, Lin-Lin Chai, Jia-Ling Qi, Yin-Yin Qin, Yu Gao, Yu-Ling Zhou, Xiao-Le Fan, Chun-Ya Ji, Jia-Yi Wu, Zhi-Wei Wang, Dong Li. Combretastatin A-4 efficiently inhibits angiogenesis and induces neuronal apoptosis in zebrafish. Scientific reports. vol 6. 2018-04-13. PMID:27452835. |
furthermore, it was demonstrated that the neuronal apoptosis induced by ca-4 treatment was alleviated in p53 mutants. |
2018-04-13 |
2023-08-13 |
zebrafish |
| Ting Zhang, Wan Hong He, Ling Lin Feng, Hao Guang Huan. Effect of doxorubicin-induced ovarian toxicity on mouse ovarian granulosa cells. Regulatory toxicology and pharmacology : RTP. vol 86. 2018-04-12. PMID:28219713. |
after granulosa cells were treated with doxorubicin at the final concentrations of 0, 0.4, 0.8, and 1.6 μg/ml for 24 h, cell apoptosis was detected by dapi staining or caspase-3/7 fluorescence probe; ros was determined by 2', 7'-dichlorodihydrofluorescin diacetate fluorescence probe; mitochondrial membrane potential was detected by rhodamine-123 fluorescence probe; and mrna expression levels of bax, bcl-2, p53, fshr, star, p450scc and p450arom were analyzed by rt-pcr. |
2018-04-12 |
2023-08-13 |
mouse |
| Ting Zhang, Wan Hong He, Ling Lin Feng, Hao Guang Huan. Effect of doxorubicin-induced ovarian toxicity on mouse ovarian granulosa cells. Regulatory toxicology and pharmacology : RTP. vol 86. 2018-04-12. PMID:28219713. |
results indicated that doxorubicin could induce apoptosis of granulosa cells (p < 0.01); increase ros generation (p < 0.05 or p < 0.01); decrease mitochondrial membrane potential (p < 0.05); increase mrna expression levels of bax, bcl-2, and p53 (p < 0.001); enhance mrna expression level of star (p < 0.01 or p < 0.001); and inhibit mrna expression level of p450scc in granulosa cells (p < 0.05 or p < 0.001). |
2018-04-12 |
2023-08-13 |
mouse |
| Ting Zhang, Wan Hong He, Ling Lin Feng, Hao Guang Huan. Effect of doxorubicin-induced ovarian toxicity on mouse ovarian granulosa cells. Regulatory toxicology and pharmacology : RTP. vol 86. 2018-04-12. PMID:28219713. |
in addition, cell apoptosis was regulated by bax, bcl-2, and p53, and hormone generation could be influenced by star and p450scc. |
2018-04-12 |
2023-08-13 |
mouse |
| Derong Cui, Hanbing Shang, Xiaoli Zhang, Wei Jiang, Xiaofeng Ji. Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways. Scientific reports. vol 6. 2018-04-11. PMID:27273382. |
we investigated whether autophagy and p53 signaling played a role in the apoptosis of hippocampal neurons following global cerebral ischemia-reperfusion (i/r) injury, in a rat model of 8-min asphyxial cardiac arrest (ca) and resuscitation. |
2018-04-11 |
2023-08-13 |
rat |
| Derong Cui, Hanbing Shang, Xiaoli Zhang, Wei Jiang, Xiaofeng Ji. Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways. Scientific reports. vol 6. 2018-04-11. PMID:27273382. |
the expression of tumor suppressor protein 53 (p53) and its target genes: bax, p53-upregulated modulator of apoptosis (puma), and damage-regulated autophagy modulator (dram) were upregulated following ca. |
2018-04-11 |
2023-08-13 |
rat |
| Derong Cui, Hanbing Shang, Xiaoli Zhang, Wei Jiang, Xiaofeng Ji. Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways. Scientific reports. vol 6. 2018-04-11. PMID:27273382. |
these results indicate that ca affects both autophagy and apoptosis, partially mediated by p53. |
2018-04-11 |
2023-08-13 |
rat |