| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sinwoo Hwang, Joo Weon Lim, Hyeyoung Ki. Inhibitory Effect of Lycopene on Amyloid-β-Induced Apoptosis in Neuronal Cells. Nutrients. vol 9. issue 8. 2018-05-08. PMID:28813012. |
however, amyloid-β did not induce apoptosis, determined by cell viability and apoptotic indices (p53, bax/bcl-2 ratio, caspase-3 cleavage), in the cells transfected with sirna for nucling. |
2018-05-08 |
2023-08-13 |
Not clear |
| Sang Tak Lee, Jong Cheol Lee, Jong Whi Kim, Soo Young Cho, Je Kyung Seong, Myeong Hee Moo. Global Changes in Lipid Profiles of Mouse Cortex, Hippocampus, and Hypothalamus Upon p53 Knockout. Scientific reports. vol 6. 2018-05-07. PMID:27819311. |
alterations of pls containing acyl chains of docosahexaenoic acid and arachidonic acid (highly enriched polyunsaturated fatty acids in the nervous system) were examined in relation to cell apoptosis upon p53 knockout. |
2018-05-07 |
2023-08-13 |
mouse |
| Sang Tak Lee, Jong Cheol Lee, Jong Whi Kim, Soo Young Cho, Je Kyung Seong, Myeong Hee Moo. Global Changes in Lipid Profiles of Mouse Cortex, Hippocampus, and Hypothalamus Upon p53 Knockout. Scientific reports. vol 6. 2018-05-07. PMID:27819311. |
comparison between sphingomyelins (sms) and cers showed that the conversion of sm to cer did not effectively progress in the hypothalamus, resulting in the accumulation of sms, possibly due to the inhibition of apoptosis caused by the lack of p53. |
2018-05-07 |
2023-08-13 |
mouse |
| Ritu Arora, Vijaya Bharti, Poonam Gaur, Sadhna Aggarwal, Manasi Mittal, Satya N Da. Operculina turpethum extract inhibits growth and proliferation by inhibiting NF-κB, COX-2 and cyclin D1 and induces apoptosis by up regulating P53 in oral cancer cells. Archives of oral biology. vol 80. 2018-05-04. PMID:28351666. |
operculina turpethum extract inhibits growth and proliferation by inhibiting nf-κb, cox-2 and cyclin d1 and induces apoptosis by up regulating p53 in oral cancer cells. |
2018-05-04 |
2023-08-13 |
Not clear |
| Chun Huang, Runqin Li, Yinglin Zhang, Jianping Gon. Amarogentin Induces Apoptosis of Liver Cancer Cells via Upregulation of p53 and Downregulation of Human Telomerase Reverse Transcriptase in Mice. Technology in cancer research & treatment. vol 16. issue 5. 2018-05-03. PMID:27402632. |
amarogentin induces apoptosis of liver cancer cells via upregulation of p53 and downregulation of human telomerase reverse transcriptase in mice. |
2018-05-03 |
2023-08-13 |
mouse |
| Zeinab Akbarnejad, Hossein Eskandary, Cristian Vergallo, Seyed Noureddin Nematollahi-Mahani, Luciana Dini, Fatemeh Darvishzadeh-Mahani, Meysam Ahmad. Effects of extremely low-frequency pulsed electromagnetic fields (ELF-PEMFs) on glioblastoma cells (U87). Electromagnetic biology and medicine. vol 36. issue 3. 2018-05-03. PMID:27874284. |
u87 cells with five experimental groups (i-v) were exposed to various elf-pemfs for 2, 4 and 24 h, as follows: (i) no exposure, control; (ii) 50 hz 100 ± 15 g; (iii) 100 hz 100 ± 15 g; (iv) 10 hz 50 ± 10 g; (v) 50 hz 50 ± 10 g. the morphology properties, cell viability and gene expression of proteins involved in cell cycle regulation (cyclin-d1 and p53) and apoptosis (caspase-3) were investigated. |
2018-05-03 |
2023-08-13 |
human |
| Bao-Cun Zhang, Ze-Jun Zhou, Li Su. pol-miR-731, a teleost miRNA upregulated by megalocytivirus, negatively regulates virus-induced type I interferon response, apoptosis, and cell cycle arrest. Scientific reports. vol 6. 2018-05-02. PMID:27311682. |
in vivo and in vitro studies revealed that pol-mir-731 (i) specifically suppresses the expression of interferon regulatory factor 7 (irf7) and cellular tumor antigen p53 in a manner that depended on the integrity of the pol-mir-731 complementary sequences in the 3' untranslated regions of irf7 and p53, (ii) disrupts megalocytivirus-induced type i interferon response through irf7, (iii) inhibits megalocytivirus-induced splenocyte apoptosis and cell cycle arrest through p53. |
2018-05-02 |
2023-08-13 |
Not clear |
| Hao Luo, Lu Zhai, Hui Yang, Longmei Xu, Jiaxian Liu, Hairong Liang, Huanwen Tan. Dichloroacetonitrile induces cytotoxicity through oxidative stress-mediated and p53-dependent apoptosis pathway in LO2 cells. Toxicology mechanisms and methods. vol 27. issue 8. 2018-05-02. PMID:28573904. |
furthermore, dcan might activate oxidative stress-mediated apoptosis pathway via up-regulation of p53 expression and caspase-3 activity. |
2018-05-02 |
2023-08-13 |
Not clear |
| Hao Luo, Lu Zhai, Hui Yang, Longmei Xu, Jiaxian Liu, Hairong Liang, Huanwen Tan. Dichloroacetonitrile induces cytotoxicity through oxidative stress-mediated and p53-dependent apoptosis pathway in LO2 cells. Toxicology mechanisms and methods. vol 27. issue 8. 2018-05-02. PMID:28573904. |
therefore, we conclude that dcan may activate apoptotic signals via p53 up-regulation and oxidative stress-mediated apoptosis in lo2 cells. |
2018-05-02 |
2023-08-13 |
Not clear |
| E Pujade-Laurain. New treatments in ovarian cancer. Annals of oncology : official journal of the European Society for Medical Oncology. vol 28. issue suppl_8. 2018-05-02. PMID:29232465. |
even more ambitious are drug targeting the driver p53 mutation or the pathway which inhibit tumor cell apoptosis. |
2018-05-02 |
2023-08-13 |
Not clear |
| Jinyan Zhao, Yuchen Zhang, Yun Wan, Haixia Hu, Zhenfeng Hon. Pien Tze Huang Gan Bao attenuates carbon tetrachloride‑induced hepatocyte apoptosis in rats, associated with suppression of p53 activation and oxidative stress. Molecular medicine reports. vol 16. issue 3. 2018-04-30. PMID:28713991. |
pien tze huang gan bao attenuates carbon tetrachloride‑induced hepatocyte apoptosis in rats, associated with suppression of p53 activation and oxidative stress. |
2018-04-30 |
2023-08-13 |
rat |
| Jinyan Zhao, Yuchen Zhang, Yun Wan, Haixia Hu, Zhenfeng Hon. Pien Tze Huang Gan Bao attenuates carbon tetrachloride‑induced hepatocyte apoptosis in rats, associated with suppression of p53 activation and oxidative stress. Molecular medicine reports. vol 16. issue 3. 2018-04-30. PMID:28713991. |
in conclusion, silymarin and pzh‑gb treatment prevented the deleterious effects on liver functions by attenuation of oxidative stress, inflammation and mitochondrial apoptosis via the p53 signaling pathway. |
2018-04-30 |
2023-08-13 |
rat |
| Cristiana Perrotta, Federico Buonanno, Silvia Zecchini, Alessio Giavazzi, Francesca Proietti Serafini, Elisabetta Catalani, Laura Guerra, Maria Cristina Belardinelli, Simona Picchietti, Anna Maria Fausto, Simone Giorgi, Enrico Marcantoni, Emilio Clementi, Claudio Ortenzi, Davide Cervi. Climacostol reduces tumour progression in a mouse model of melanoma via the p53-dependent intrinsic apoptotic programme. Scientific reports. vol 6. 2018-04-26. PMID:27271364. |
in addition, it significantly improved the survival of transplanted mice, decreased tumour weight, induced a remarkable reduction of viable cells inside the tumour, activated apoptosis and up-regulated the p53 signalling network. |
2018-04-26 |
2023-08-13 |
mouse |
| Lan Ma, Hai-Jun Yu, Sheng-Wei Gan, Rui Gong, Ke-Jie Mou, Jun Xue, Shan-Quan Su. p53-Mediated oligodendrocyte apoptosis initiates demyelination after compressed spinal cord injury by enhancing ER-mitochondria interaction and E2F1 expression. Neuroscience letters. vol 644. 2018-04-26. PMID:28237798. |
in this study, after successfully establishing a rat csci model using a custom-made compressor, we investigated the pathological changes, mbp expression, as well as apoptosis-related protein (p53, active caspase-3) expression to determine whether or not apoptosis and demyelination occurred after injury. |
2018-04-26 |
2023-08-13 |
rat |
| Lan Ma, Hai-Jun Yu, Sheng-Wei Gan, Rui Gong, Ke-Jie Mou, Jun Xue, Shan-Quan Su. p53-Mediated oligodendrocyte apoptosis initiates demyelination after compressed spinal cord injury by enhancing ER-mitochondria interaction and E2F1 expression. Neuroscience letters. vol 644. 2018-04-26. PMID:28237798. |
these results demonstrated that over-expression of p53 could mediate oligodendrocyte apoptosis thus resulting in demyelination in two ways; by enhancing er-mitochondria interaction and by triggering the e2f1 mediated apoptosis pathway. |
2018-04-26 |
2023-08-13 |
rat |
| Yang Chen, Tianyong Gao, Yanwei Wang, Guangcan Yan. Investigating the Influence of Magnesium Ions on p53-DNA Binding Using Atomic Force Microscopy. International journal of molecular sciences. vol 18. issue 7. 2018-04-26. PMID:28754018. |
p53 is a tumor suppressor protein that plays a significant role in apoptosis and senescence, preserving genomic stability, and preventing oncogene expression. |
2018-04-26 |
2023-08-13 |
human |
| Wenting Lu, Tengteng Yu, Shuang Liu, Saisai Li, Shouyun Li, Jia Liu, Yingxi Xu, Haiyan Xing, Zheng Tian, Kejing Tang, Qing Rao, Jianxiang Wang, Min Wan. FHL2 interacts with iASPP and impacts the biological functions of leukemia cells. Oncotarget. vol 8. issue 25. 2018-04-25. PMID:28402264. |
iaspp is an inhibitory member of apoptosis-stimulating proteins of p53 (aspp) family, which inhibits p53-dependent apoptosis. |
2018-04-25 |
2023-08-13 |
Not clear |
| Abhishek Basu, Arin Bhattacharjee, Prosenjit Ghosh, Amalesh Samanta, Sudin Bhattachary. Sensitizing effects of an organovanadium compound during adjuvant therapy with cyclophosphamide in a murine tumor model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-25. PMID:28711021. |
further studies revealed that vc-iv sensitized tumor cells to cyclophosphamide therapy by down-regulating the anti-apoptotic protein bcl-2 and by up-regulating molecules like p53, bax, cytochrome c, caspases, which led to parp cleavage and apoptosis. |
2018-04-25 |
2023-08-13 |
Not clear |
| Yansheng Wang, Changqing Liu, Jianchun Wang, Yang Zhang, Linlin Che. Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway. Oncology reports. vol 38. issue 3. 2018-04-25. PMID:28714021. |
we found that iodine-131 reduced cell proliferation, induced apoptosis, induced p53, pidd, t-bid (mitochondria) protein expression, suppressed cytochrome c (mitochondria) protein expression, and increased bax protein expression, and promoted caspase-2, -3 and -9 expression levels in human cardiac muscle cells. |
2018-04-25 |
2023-08-13 |
human |
| Ying Bai, Yuan Zhang, Jun Hua, Xiangyu Yang, Xiaotian Zhang, Ming Duan, Xinjian Zhu, Wenhui Huang, Jie Chao, Rongbin Zhou, Gang Hu, Honghong Ya. Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse. Scientific reports. vol 6. 2018-04-24. PMID:27767041. |
mir-143, which targets p53 unregulated modulator of apoptosis (puma), increased the permeability of human brain endothelial cells and concomitantly decreased the expression of tight junction proteins (tjps). |
2018-04-24 |
2023-08-13 |
human |