| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evgeny M Makarov, Tatyana A Shtam, Roman A Kovalev, Rimma A Pantina, Elena Yu Varfolomeeva, Michael V Filato. The rare nonsense mutation in p53 triggers alternative splicing to produce a protein capable of inducing apoptosis. PloS one. vol 12. issue 9. 2017-11-03. PMID:28961258. |
the rare nonsense mutation in p53 triggers alternative splicing to produce a protein capable of inducing apoptosis. |
2017-11-03 |
2023-08-13 |
human |
| Prapaphan Budchart, Ariya Khamwut, Chomdao Sinthuvanich, Sunanta Ratanapo, Yong Poovorawan, Nattanan Panjaworayan T-Thienpraser. Partially Purified Gloriosa superba Peptides Inhibit Colon Cancer Cell Viability by Inducing Apoptosis Through p53 Upregulation. The American journal of the medical sciences. vol 354. issue 4. 2017-11-03. PMID:29078848. |
partially purified gloriosa superba peptides inhibit colon cancer cell viability by inducing apoptosis through p53 upregulation. |
2017-11-03 |
2023-08-13 |
Not clear |
| Giuseppa Pistritto, Daniela Trisciuoglio, Claudia Ceci, Alessia Garufi, Gabriella D'Oraz. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging. vol 8. issue 4. 2017-11-03. PMID:27019364. |
this review will highlight the role of the fundamental regulators of apoptosis and how their deregulation, including activation of anti-apoptotic factors (i.e., bcl-2, bcl-xl, etc) or inactivation of pro-apoptotic factors (i.e., p53 pathway) ends up in cancer cell resistance to therapies. |
2017-11-03 |
2023-08-13 |
Not clear |
| Srinivasan Periasamy, Chuan-Teng Liu, Se-Ping Chien, Ying-Chien Chen, Ming-Yie Li. Daily sesame oil supplementation mitigates ketoconazole-induced oxidative stress-mediated apoptosis and hepatic injury. The Journal of nutritional biochemistry. vol 37. 2017-11-01. PMID:27619544. |
apoptosis was evaluated by p53, caspase-3, bcl-2, bax and cyto-c expression. |
2017-11-01 |
2023-08-13 |
mouse |
| Decha Pinkaew, Abhijnan Chattopadhyay, Matthew D King, Preedakorn Chunhacha, Zhihe Liu, Heather L Stevenson, Yanjie Chen, Patuma Sinthujaroen, Owen M McDougal, Ken Fujis. Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death. Nature communications. vol 8. issue 1. 2017-11-01. PMID:28550308. |
fortilin, a pro-survival molecule, is known to inhibit apoptosis by binding and inhibiting p53, but its role in endoplasmic reticulum stress-induced apoptosis remains unknown. |
2017-11-01 |
2023-08-13 |
human |
| Jessica A Monteith, Hestia Mellert, Morgan A Sammons, Laudita A Kuswanto, Stephen M Sykes, Lois Resnick-Silverman, James J Manfredi, Shelley L Berger, Steven B McMaho. A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction. Molecular oncology. vol 10. issue 8. 2017-10-31. PMID:27341992. |
furthermore, induction of tnfaip8 is critical for the evasion of apoptosis by tumor cells expressing the k120r variant of p53. |
2017-10-31 |
2023-08-13 |
human |
| Maria Vitória C Issler, José Carlos M Mombac. MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response. PloS one. vol 12. issue 10. 2017-10-31. PMID:28968438. |
microrna-16 feedback loop with p53 and wip1 can regulate cell fate determination between apoptosis and senescence in dna damage response. |
2017-10-31 |
2023-08-13 |
Not clear |
| Maria Vitória C Issler, José Carlos M Mombac. MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response. PloS one. vol 12. issue 10. 2017-10-31. PMID:28968438. |
dna damage induces cell cycle checkpoints that activate the p53 pathway to regulate cell fate mechanisms such as apoptosis or senescence. |
2017-10-31 |
2023-08-13 |
Not clear |
| Maria Vitória C Issler, José Carlos M Mombac. MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response. PloS one. vol 12. issue 10. 2017-10-31. PMID:28968438. |
for low dna damage the pathway presents an oscillatory pattern associated with intense dna damage repair while for high damage there are no oscillations and either p53 concentration increases inducing apoptosis or the cell enters a senescence state. |
2017-10-31 |
2023-08-13 |
Not clear |
| Li Zhu, Fengjun Xiao, Yue Yu, Hua Wang, Min Fang, Yuefeng Yang, Huiyan Sun, Lisheng Wang, Yuan Shen. KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL. Anti-cancer drugs. vol 27. issue 9. 2017-10-30. PMID:27379929. |
ksp inhibitor sb743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, bcl-2, and dtl. |
2017-10-30 |
2023-08-13 |
Not clear |
| Zhantao Deng, Zhenheng Wang, Jiewen Jin, Yong Wang, Nirong Bao, Qian Gao, Jianning Zha. SIRT1 protects osteoblasts against particle-induced inflammatory responses and apoptosis in aseptic prosthesis loosening. Acta biomaterialia. vol 49. 2017-10-30. PMID:27890623. |
both pharmacological activation and overexpression of sirt1 dramatically reduced the particle-induced expression of inflammatory cytokines and osteoblast apoptosis through nf-κb and p53 signaling, respectively. |
2017-10-30 |
2023-08-13 |
Not clear |
| Idha Kurtsdotter, Danijal Topcic, Alexandra Karlén, Bhumica Singla, Daniel W Hagey, Maria Bergsland, Peter Siesjö, Monica Nistér, Joseph W Carlson, Veronique Lefebvre, Oscar Persson, Johan Holmberg, Jonas Muh. SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells. Cancer research. vol 77. issue 18. 2017-10-30. PMID:28687615. |
consistently, restoring high levels of sox5/6/21 in human primary glioblastoma cells enabled expression of cdk inhibitors and decreased p53 protein turnover, which blocked their tumorigenic capacity through cellular senescence and apoptosis. |
2017-10-30 |
2023-08-13 |
mouse |
| Sun Young Park, Seon Yeong Chae, Jin Oh Park, Kyu Jin Lee, Geuntae Par. Kalopanacis Cortex extract-capped gold nanoparticles activate NRF2 signaling and ameliorate damage in human neuronal SH-SY5Y cells exposed to oxygen-glucose deprivation and reoxygenation. International journal of nanomedicine. vol 12. 2017-10-30. PMID:28790819. |
western blot analysis indicated that the ogd/r-induced cellular apoptosis and simultaneous increases in the expression of cleaved caspase-3, p53, p21, and b-cell lymphoma 2-associated x protein were reversed by kc-gns. |
2017-10-30 |
2023-08-13 |
human |
| Peng Li, Evan Wuthrick, Jeff A Rappaport, Crystal Kraft, Jieru E Lin, Glen Marszalowicz, Adam E Snook, Tingting Zhan, Terry M Hyslop, Scott A Waldma. GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. Cancer research. vol 77. issue 18. 2017-10-30. PMID:28916678. |
in turn, p53 activation prevented cell death by selectively limiting mitotic catastrophe, but not apoptosis. |
2017-10-30 |
2023-08-13 |
Not clear |
| Anabela La Colla, Andrea Vasconsuelo, Lorena Milanesi, Lucía Pronsat. 17β-Estradiol Protects Skeletal Myoblasts From Apoptosis Through p53, Bcl-2, and FoxO Families. Journal of cellular biochemistry. vol 118. issue 1. 2017-10-30. PMID:27249370. |
17β-estradiol protects skeletal myoblasts from apoptosis through p53, bcl-2, and foxo families. |
2017-10-30 |
2023-08-13 |
Not clear |
| Elsa R Flore. Commentary on "Apoptosis, p53, and Tumor Cell Sensitivity to Anticancer Agents". Cancer research. vol 76. issue 23. 2017-10-26. PMID:27909063. |
commentary on "apoptosis, p53, and tumor cell sensitivity to anticancer agents". |
2017-10-26 |
2023-08-13 |
Not clear |
| Jason Ear, Jessica Hsueh, Melinda Nguyen, QingHua Zhang, Victoria Sung, Rajesh Chopra, Kathleen M Sakamoto, Shuo Li. A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure. Journal of genetics and genomics = Yi chuan xue bao. vol 43. issue 5. 2017-10-25. PMID:27216296. |
targeted disruption of rps14 causes an increase in p53 activity and p53-mediated apoptosis, similar to what is observed with other ribosomal proteins. |
2017-10-25 |
2023-08-13 |
zebrafish |
| Paola Di Lello, Lionel Rougé, Borlan Pan, Till Maure. (1)H, (13)C and (15)N backbone resonance assignment for the 40.5 kDa catalytic domain of Ubiquitin Specific Protease 7 (USP7). Biomolecular NMR assignments. vol 10. issue 2. 2017-10-24. PMID:27386854. |
consequently, usp7 has emerged as an attractive oncology target because its inhibition stabilizes p53, thereby promoting p53-dependent apoptosis in cancer cells. |
2017-10-24 |
2023-08-13 |
Not clear |
| Zunzhe Wang, Xing Rong, Bihui Luo, Shanshan Qin, Lili Lu, Xiuli Zhang, Yeying Sun, Qin Hu, Chunxiang Zhan. A Natural Model of Mouse Cardiac Myocyte Senescence. Journal of cardiovascular translational research. vol 9. issue 5-6. 2017-10-23. PMID:27631884. |
in this study, we have demonstrated that the senescence of mouse cardiomyocytes occurred with the extended culture time as shown by the increased β-galactosidase staining, increased p53 expression, decreased telomere activity, shorted telomere length, increased production of ros, increased cell apoptosis, and impaired mitochondrial ΔΨm. |
2017-10-23 |
2023-08-13 |
mouse |
| Upasana Sahu, Himakshi Sidhar, Pankaj S Ghate, Gopal M Advirao, Sathees C Raghavan, Ranjit K Gir. A Novel Anticancer Agent, 8-Methoxypyrimido[4',5':4,5]thieno(2,3-b) Quinoline-4(3H)-One Induces Neuro 2a Neuroblastoma Cell Death through p53-Dependent, Caspase-Dependent and -Independent Apoptotic Pathways. PloS one. vol 8. issue 6. 2017-10-23. PMID:23824039. |
mptq-mediated apoptosis is associated with increased phosphorylation of p53 at ser15 and ser20 which correlates with the hyperphosphorylation of ataxia-telangiectasia mutated protein (atm). |
2017-10-23 |
2023-08-12 |
mouse |