| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhichun Liu, Jingwu Sun, Bin Liu, Mengjie Zhao, Entao Xing, Cunshu Dan. miRNA‑222 promotes liver cancer cell proliferation, migration and invasion and inhibits apoptosis by targeting BBC3. International journal of molecular medicine. vol 42. issue 1. 2018-09-24. PMID:29693134. |
microrna (mir)‑222 was predicted to target b‑cell lymphoma-2 (bcl‑2) binding component 3 (bbc3, also known as p53 upregulated modulator of apoptosis) by a bioinformatics analysis with targetscan, which was verified by a dual‑luciferase reporter assay system. |
2018-09-24 |
2023-08-13 |
Not clear |
| Ying Gao, Junfeng Yin, Gary O Rankin, Yi Charlie Che. Kaempferol Induces G2/M Cell Cycle Arrest via Checkpoint Kinase 2 and Promotes Apoptosis via Death Receptors in Human Ovarian Carcinoma A2780/CP70 Cells. Molecules (Basel, Switzerland). vol 23. issue 5. 2018-09-24. PMID:29734760. |
chk2 was not responsible for kaempferol-induced apoptosis and up-regulation of p53. |
2018-09-24 |
2023-08-13 |
human |
| Bo Liu, Lv Yang, Xiu-Juan Li, Rou Li, Wei Sun, Xiao-Yi Chen, Jun-Chao Li. Expression and significance of ASPP2 in squamous carcinoma of esophagus. The Kaohsiung journal of medical sciences. vol 34. issue 6. 2018-09-24. PMID:29747775. |
to study the significance of apoptosis stimulating protein of p53 2 (aspp2) expression in esophageal squamous cell carcinoma (escc), immunohistochemistry s-p method was used to examine the expression of aspp2 in 136 cases of escc, 35 cases of high grade intraepithelial neoplasia (hgin), 29 cases of low grade intraepithelial neoplasia (lgin) and 37 cases of normal esophageal epithelium (nee). |
2018-09-24 |
2023-08-13 |
human |
| Jun Yang, Linna Li, Chengwang Xu, Dexuan Yang, Shanshan Wang, Shoujun Yua. CT‑1042, a novel anticancer agent, exhibits effects by activating p53 and inhibiting survivin. Oncology reports. vol 39. issue 6. 2018-09-21. PMID:29620221. |
in addition, ct‑1042 induced mitochondrial‑mediated apoptosis by activating p53 and bax, as well as inhibiting bcl‑2 and survivin. |
2018-09-21 |
2023-08-13 |
human |
| Ying-Hui Kong, Su-Ping X. Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis. Oncology reports. vol 39. issue 6. 2018-09-20. PMID:29693192. |
consistently, p21, p53 upregulated modulator of apoptosis (puma), bax and caspase-3 were highly induced by sr to enhance the apoptotic response for preventing skin cancer. |
2018-09-20 |
2023-08-13 |
mouse |
| Pedro Brandão, Joana B Loureiro, Sylvie Carvalho, Meriem Hadjer Hamadou, Sara Cravo, Joana Moreira, Daniela Pereira, Andreia Palmeira, Madalena Pinto, Lucília Saraiva, Honorina Cidad. Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity. European journal of medicinal chemistry. vol 156. 2018-09-18. PMID:30041135. |
in colon cancer cells, it was also shown that the growth inhibitory effect of prenylchalcone 2e was associated with the induction of cell cycle arrest, apoptosis, and increased protein expression levels of p53 transcriptional targets. |
2018-09-18 |
2023-08-13 |
human |
| Dan-Dan Li, Zhi Luo, Shi-Cheng Ling, Kun Wu, Guang-Hui Chen, Jie Chen. Mitochondrial apoptotic pathway mediated the Zn-induced lipolysis in yellow catfish Peteobagrus fulvidraco. Chemosphere. vol 208. 2018-09-18. PMID:30068034. |
zn significantly reduced triglyceride (tg) content, increased the activities of carnitine palmitoyltransferase 1 (cpt i), hormone-sensitive lipase (hsl) and adipose tag lipase (atgl), and the transcriptional levels of p53, cycs and caspase 3b of the hepatocytes; these zn-induced effects on tg contents, activities of cpt i, hsl and atgl, and mrna levels of p53, cycs and caspase 3b could partly be reversed by z-vad-fmk, suggesting that zn induced the mitochondrial-mediated apoptosis and reduced lipid accumulation. |
2018-09-18 |
2023-08-13 |
Not clear |
| Yawei Li, Na Xu, Wenhe Zhu, Lei Wang, Bin Liu, Jianxu Zhang, Zhigang Xie, Wensen Li. Nanoscale Melittin@Zeolitic Imidazolate Frameworks for Enhanced Anticancer Activity and Mechanism Analysis. ACS applied materials & interfaces. vol 10. issue 27. 2018-09-17. PMID:29920061. |
the mechanism is well investigated by a series of transcriptome analysis, which indicates that mlt@zif-8 nps can regulate the expression of 3383 genes, and the pi3k/akt-regulated p53 pathway is involved in mlt@zif-8 nps induced a549 cells apoptosis. |
2018-09-17 |
2023-08-13 |
Not clear |
| Bo Yu, Kaibiao Jiang, Jidong Zhan. MicroRNA-124 suppresses growth and aggressiveness of osteosarcoma and inhibits TGF-β-mediated AKT/GSK-3β/SNAIL-1 signaling. Molecular medicine reports. vol 17. issue 5. 2018-09-13. PMID:29488603. |
flow cytometry assays indicated that mir‑124 transfection attenuated apoptosis resistance of osteosarcoma to tunicamycin, potentially via the downregulation of p53 and bcl‑2 apoptosis regulator expression. |
2018-09-13 |
2023-08-13 |
mouse |
| Zi-Ling Wang, Lin-Bo Chen, Zhu Qiu, Xiong-Bin Chen, Ying Liu, Jing Li, Lu Wang, Ya-Ping Wan. Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms. Molecular medicine reports. vol 17. issue 5. 2018-09-13. PMID:29512726. |
the present study further investigated the effects of rg1 on the volume of serum testosterone, the testicular index, testicular microscopic structures, the senescence of spermatogenetic cells, the apoptosis of spermatogenetic cells, the activity of the antioxidant enzymes, the levels of inflammatory cytokines, and the levels of s‑phase kinase‑associated protein (p19), cyclin‑dependent kinase inhibitor 1 (p21) and cellular tumor antigen p53 (p53) in d‑gal‑induced aging mice. |
2018-09-13 |
2023-08-13 |
mouse |
| Zi-Ling Wang, Lin-Bo Chen, Zhu Qiu, Xiong-Bin Chen, Ying Liu, Jing Li, Lu Wang, Ya-Ping Wan. Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms. Molecular medicine reports. vol 17. issue 5. 2018-09-13. PMID:29512726. |
the percentage of senescence‑associated β‑galactosidase‑positive cells, the level of apoptosis and the volume of methane dicarboxylic aldehyde, tumor necrosis factor‑α, interleukin (il)‑1β and il‑6 in testicular tissues were significantly decreased, and the expression of p19, p53 and p21 was downregulated due to the treatment with rg1. |
2018-09-13 |
2023-08-13 |
mouse |
| Lesca M Holdt, Anika Stahringer, Kristina Sass, Garwin Pichler, Nils A Kulak, Wolfgang Wilfert, Alexander Kohlmaier, Andreas Herbst, Bernd H Northoff, Alexandros Nicolaou, Gabor Gäbel, Frank Beutner, Markus Scholz, Joachim Thiery, Kiran Musunuru, Knut Krohn, Matthias Mann, Daniel Teupse. Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nature communications. vol 7. 2018-09-12. PMID:27539542. |
as a consequence, circanril induces nucleolar stress and p53 activation, resulting in the induction of apoptosis and inhibition of proliferation, which are key cell functions in atherosclerosis. |
2018-09-12 |
2023-08-13 |
human |
| Wei Wang, Fan-Bin Meng, Zhen-Xing Wang, Xiao Li, Dong-Sheng Zho. Selenocysteine inhibits human osteosarcoma cells growth through triggering mitochondrial dysfunction and ROS-mediated p53 phosphorylation. Cell biology international. vol 42. issue 5. 2018-09-10. PMID:29323455. |
importantly, mg-63 human osteosarcoma xenograft growth in nude mice was significantly suppressed in vivo through triggering apoptosis and p53 phosphorylation. |
2018-09-10 |
2023-08-13 |
mouse |
| Hai Li, Qi Gao, Yuhao Shao, Bangyao Sun, Fengjie Wang, Yangyang Qiao, Nana Wang, Shengwang Li. Gallid Herpesvirus 1 Initiates Apoptosis in Uninfected Cells through Paracrine Repression of p53. Journal of virology. vol 92. issue 18. 2018-09-10. PMID:29950417. |
gallid herpesvirus 1 initiates apoptosis in uninfected cells through paracrine repression of p53. |
2018-09-10 |
2023-08-13 |
Not clear |
| Meili Tian, Shuang Yang, Xinpeng Ya. Icariin reduces human colon carcinoma cell growth and metastasis by enhancing p53 activities. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 51. issue 10. 2018-09-07. PMID:30088538. |
moreover, small interfering rna (sirna) plasmid was used to examine the role of p53 in icariin-induced apoptosis in hct116 cells. |
2018-09-07 |
2023-08-13 |
human |
| Yanbing Wang, Shicai Sun, Jianting Xu, Yang Luo, Ying Xin, Xin Zha. MicroRNA-381 suppresses the proliferation of osteosarcoma cells through LRH-1/Wnt/β-catenin signaling pathway. Oncology reports. vol 39. issue 2. 2018-09-05. PMID:29207112. |
downregulation of microrna-381 using anti-microrna-381 mimics increased cell proliferation, decreased ldh activity and apoptosis, and inhibited caspase‑3/9 activities, bax/bcl-2 and p53 protein expression in vitro osteosarcoma cells through upregulation of lrh-1/wnt/β-catenin signaling pathway. |
2018-09-05 |
2023-08-13 |
Not clear |
| Yanbing Wang, Shicai Sun, Jianting Xu, Yang Luo, Ying Xin, Xin Zha. MicroRNA-381 suppresses the proliferation of osteosarcoma cells through LRH-1/Wnt/β-catenin signaling pathway. Oncology reports. vol 39. issue 2. 2018-09-05. PMID:29207112. |
overexpression of microrna-381 using microrna-381 mimics inhibited cell proliferation, induced apoptosis and increased ldh activity, caspase‑3/9 activities, expression of bax/bcl-2 and p53 protein in osteosarcoma of in vitro model through downregulation of lrh-1/wnt/β-catenin signaling pathway. |
2018-09-05 |
2023-08-13 |
Not clear |
| Vasilis P Androutsopoulos, Demetrios A Spandido. Anticancer pyridines induce G2/M arrest and apoptosis via p53 and JNK upregulation in liver and breast cancer cells. Oncology reports. vol 39. issue 2. 2018-09-05. PMID:29207138. |
anticancer pyridines induce g2/m arrest and apoptosis via p53 and jnk upregulation in liver and breast cancer cells. |
2018-09-05 |
2023-08-13 |
human |
| Xiya Zhang, Ying Wang, Tony Velkov, Shusheng Tang, Chongshan Da. T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 114. 2018-09-05. PMID:29432840. |
taken together, these novel findings suggest that t-2 toxin-induced neurotoxicity in n2a cells involves oxidative stress, mitochondrial dysfunction and apoptosis via the inhibition of the nrf2/ho-1 and activation of p53 pathway. |
2018-09-05 |
2023-08-13 |
mouse |
| Si-Wei Wang, Yi Xu, Yuan-Yuan Weng, Xue-Yu Fan, Yong-Feng Bai, Xiao-Yan Zheng, Li-Jun Lou, Feng Zhan. Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 114. 2018-09-05. PMID:29471006. |
astilbin significantly decreased reactive oxygen species (ros) accumulation and alleviated ros-induced activation of p53, mapks and akt signaling cascades, which in turn attenuated cisplatin-induced hek-293 cell apoptosis. |
2018-09-05 |
2023-08-13 |
mouse |