| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muzi Zhang, Ming Li, Rixin Wang, Yunxia Qia. Effects of acute ammonia toxicity on oxidative stress, immune response and apoptosis of juvenile yellow catfish Pelteobagrus fulvidraco and the mitigation of exogenous taurine. Fish & shellfish immunology. vol 79. 2018-10-02. PMID:29802884. |
in addition, ammonia poisoning could induce up-regulation of antioxidant enzymes (cu/zn-sod, cat, gpx and gr), inflammatory cytokines (tnf, il-1 and il-8) and apoptosis (p53, bax, caspase 3 and caspase 9) genes transcription, suggesting that cell apoptotic and inflammation may relate to oxidative stress. |
2018-10-02 |
2023-08-13 |
cat |
| Qi Wang, Yafeng Zheng, Weijing Zhuang, Xu Lu, Xianliang Luo, Baodong Zhen. Genome-wide transcriptional changes in type 2 diabetic mice supplemented with lotus seed resistant starch. Food chemistry. vol 264. 2018-10-02. PMID:29853397. |
the analysis results of gene ontology (go) functions and kyoto encyclopedia of genes and genomes (kegg) pathways indicated that the protective effect of lsrs supplementation was most likely driven by modulating expression levels of various key factors involved in insulin secretion, insulin signal transmission, cell apoptosis, antioxidant activity and p53 signaling pathways. |
2018-10-02 |
2023-08-13 |
mouse |
| Salman Akhtar, M Kalim A Khan, Jamal M Ari. Evaluation and Elucidation Studies of Natural Aglycones for Anticancer Potential using Apoptosis-Related Markers: An In silico Study. Interdisciplinary sciences, computational life sciences. vol 10. issue 2. 2018-10-01. PMID:27709544. |
with further understanding on the functional mechanism of p53 and mdm2 in apoptosis and in our continuous search for new and potent multi-target anticancer lead compounds, we have carried out molecular docking and inhibition studies of the selected aglycones along with selected anticancer leads, against the specific apoptotic and cell cycle markers using autodock tools 4.0 and other computational softwares. |
2018-10-01 |
2023-08-13 |
Not clear |
| Li Luo, Wei Gao, Jinghui Wang, Dingxue Wang, Xiaobo Peng, Zhaoyang Jia, Ye Jiang, Gongzhuo Li, Dongxin Tang, Yajie Wan. Study on the Mechanism of Cell Cycle Checkpoint Kinase 2 (CHEK2) Gene Dysfunction in Chemotherapeutic Drug Resistance of Triple Negative Breast Cancer Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-01. PMID:29761796. |
conclusions our findings indicated that chek2 y390c mutation induced the drug resistance of tnbc cells to chemotherapeutic drugs through administrating cell apoptosis and cell cycle arrest via regulating p53 activation and chek2-p53 apoptosis pathway. |
2018-10-01 |
2023-08-13 |
Not clear |
| Mei Lin, Chenglin Zhou, Junxing Huang, Weizhong Tian, Hong Yu, Xingmao Jiang, Jun Ye, Ting Guo, Yujuan Shi, Yanhong Xiao, Xuefeng Bian, Xiaoqian Fen. The Possible Mechanisms of HSV-TK/Hyperthermia Combined with 131I-antiAFPMcAb-GCV Nanospheres to Treat Hepatoma. Analytical cellular pathology (Amsterdam). vol 2018. 2018-10-01. PMID:29854577. |
in the current study, to explore the possible mechanisms of radionuclide-gene therapy combined with mfh to treat hepatoma at tissue, cellular, and molecular levels and to provide theoretical and experimental data for its clinical application, we examined the apoptosis induction of the combination therapy and investigated the expression of the proteins related to apoptosis such as survivin, livin, bcl-2, p53, and nucleus protein ki67 involved in cell proliferation, detected vegf, and mvd involved in angiogenesis of tumor tissues and analyzed the pathologic changes after treatment. |
2018-10-01 |
2023-08-13 |
Not clear |
| Mei Lin, Chenglin Zhou, Junxing Huang, Weizhong Tian, Hong Yu, Xingmao Jiang, Jun Ye, Ting Guo, Yujuan Shi, Yanhong Xiao, Xuefeng Bian, Xiaoqian Fen. The Possible Mechanisms of HSV-TK/Hyperthermia Combined with 131I-antiAFPMcAb-GCV Nanospheres to Treat Hepatoma. Analytical cellular pathology (Amsterdam). vol 2018. 2018-10-01. PMID:29854577. |
the therapeutic mechanisms may be involved in the downregulation of ki67 expression leading to tumor cell proliferation repression and inhibition of survivin, bcl-2, p53, and livin protein expression inducing tumor cell apoptosis, negatively regulating vegf protein expression, and reducing vascular endothelial cells, which results in tumor angiogenesis inhibition and microvascular density decrease and tumor cell necrosis. |
2018-10-01 |
2023-08-13 |
Not clear |
| Hao Lin, Yifan Wang, Haoqiang Lai, Xiaoling Li, Tianfeng Che. Iron(II)-Polypyridyl Complexes Inhibit the Growth of Glioblastoma Tumor and Enhance TRAIL-Induced Cell Apoptosis. Chemistry, an Asian journal. vol 13. issue 18. 2018-10-01. PMID:29963768. |
mechanistic studies demonstrated that the synthesized complexes induced cancer-cell apoptosis through triggering the activation of p38 and p53 and inhibiting the activation of erk. |
2018-10-01 |
2023-08-13 |
mouse |
| Soo-Yeon Park, Jaesung Seo, Hyo-Kyoung Choi, Hye-Jeong Oh, Garam Guk, Yoo-Hyun Lee, Jeongmin Lee, Woo Jin Jun, Kyung-Chul Choi, Ho-Geun Yoo. Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5. Scientific reports. vol 7. 2018-09-28. PMID:28051100. |
programmed cell death 5 (pdcd5) is believed to play a crucial role in p53 activation; however, the underlying mechanism of how pdcd5 function is regulated during apoptosis remains obscure. |
2018-09-28 |
2023-08-13 |
Not clear |
| Liugen Gu, Zhenming Ge, Yamin Wang, Meiqin Shen, Ping Zha. Activating transcription factor 3 promotes intestinal epithelial cell apoptosis in Crohn's disease. Pathology, research and practice. vol 214. issue 6. 2018-09-28. PMID:29716766. |
activating transcription factor 3 (atf3) modulates apoptosis under stress via regulating the p53 pathway. |
2018-09-28 |
2023-08-13 |
mouse |
| Liugen Gu, Zhenming Ge, Yamin Wang, Meiqin Shen, Ping Zha. Activating transcription factor 3 promotes intestinal epithelial cell apoptosis in Crohn's disease. Pathology, research and practice. vol 214. issue 6. 2018-09-28. PMID:29716766. |
atf3 knockdown effectively decreased tnf-α-induced p53 and bax expression, as well as inhibited the apoptosis of ht29 cells. |
2018-09-28 |
2023-08-13 |
mouse |
| Liugen Gu, Zhenming Ge, Yamin Wang, Meiqin Shen, Ping Zha. Activating transcription factor 3 promotes intestinal epithelial cell apoptosis in Crohn's disease. Pathology, research and practice. vol 214. issue 6. 2018-09-28. PMID:29716766. |
in summary, these data indicated that atf3 might promote iec apoptosis in cd via up-regulating the stability and transcription activity of p53, implying a novel molecular target for cd therapy. |
2018-09-28 |
2023-08-13 |
mouse |
| Kazuhiko Ochiai, Daigo Azakami, Masami Morimatsu, Hinako Hirama, Shota Kawakami, Takayuki Nakagawa, Masaki Michishita, Ai S Egusa, Takanori Sasaki, Masami Watanabe, Toshinori Om. Endogenous Leu332Gln mutation in p53 disrupts the tetramerization ability in a canine mammary gland tumor cell line. Oncology reports. vol 40. issue 1. 2018-09-27. PMID:29750295. |
wild‑type p53 requires tetramerization to function as an initiator of cell cycle arrest and apoptosis. |
2018-09-27 |
2023-08-13 |
human |
| Kazutoshi Isobe, Atsushi Kakimoto, Tetuo Mikami, Kyohei Kaburaki, Hiroshi Kobayashi, Takahiro Yoshizawa, Yuta Nakano, Takashi Makino, Hajime Otsuka, Go Sano, Keishi Sugino, Susumu Sakamoto, Yujiro Takai, Naobumi Tochigi, Akira Iyoda, Sakae Homm. PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma. Oncology reports. vol 40. issue 1. 2018-09-27. PMID:29767258. |
correlations of pd-l1 mrna expression with bim, p53 upregulated modular of apoptosis (puma), human epidermal growth factor receptor 2 (her2), mesenchymal-epithelial transition (met), egfr, and vascular endothelial growth factor a (vegfa) were determined. |
2018-09-27 |
2023-08-13 |
human |
| Shanshan Shen, Chunyang Li, Mingjia Dai, Xuebing Ya. Induction of Huh‑7 cell apoptosis by HCV core proteins via CK1α‑p53‑Bid signaling pathway. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620268. |
electron microscopy indicated that p53 knockdown decreased hcv core protein and trail‑induced cell apoptosis. |
2018-09-26 |
2023-08-13 |
human |
| Dan Gu, Lulin Huang, Xia Chen, Qianhu Wu, Kan Din. Structural characterization of a galactan from Ophiopogon japonicus and anti-pancreatic cancer activity of its acetylated derivative. International journal of biological macromolecules. vol 113. 2018-09-25. PMID:29518447. |
in addition, the cells apoptosis was triggered since cleaved caspase-3 and fasl were activated while p53, p21, bax expression were up-regulated by roh05a as well. |
2018-09-25 |
2023-08-13 |
Not clear |
| M R Sam, R S Pourpa. Regulation of p53 and survivin by prodigiosin compound derived from Serratia marcescens contribute to caspase-3-dependent apoptosis in acute lymphoblastic leukemia cells. Human & experimental toxicology. vol 37. issue 6. 2018-09-24. PMID:28681618. |
regulation of p53 and survivin by prodigiosin compound derived from serratia marcescens contribute to caspase-3-dependent apoptosis in acute lymphoblastic leukemia cells. |
2018-09-24 |
2023-08-13 |
Not clear |
| M R Sam, R S Pourpa. Regulation of p53 and survivin by prodigiosin compound derived from Serratia marcescens contribute to caspase-3-dependent apoptosis in acute lymphoblastic leukemia cells. Human & experimental toxicology. vol 37. issue 6. 2018-09-24. PMID:28681618. |
wt-p53 molt-4 cells were treated with 100 to 600 nm prodigiosin, after which, viability, cell proliferation rates, survivin and p53 protein levels, caspase-3 activation, and apoptosis were evaluated. |
2018-09-24 |
2023-08-13 |
Not clear |
| M R Sam, R S Pourpa. Regulation of p53 and survivin by prodigiosin compound derived from Serratia marcescens contribute to caspase-3-dependent apoptosis in acute lymphoblastic leukemia cells. Human & experimental toxicology. vol 37. issue 6. 2018-09-24. PMID:28681618. |
p53 and survivin as molecular targets of prodigiosin contribute to caspase-3-dependent apoptosis in all cells and this compound represents an attractive p53- and survivin-modulating agent in all. |
2018-09-24 |
2023-08-13 |
Not clear |
| P Zhang, Xy Zhan. Stimulatory effects of curcumin and quercetin on posttranslational modifications of p53 during lung carcinogenesis. Human & experimental toxicology. vol 37. issue 6. 2018-09-24. PMID:28681665. |
the present study concludes that prophylactic treatment with curcumin and quercetin induces apoptosis in the lungs by modulation of p53 posttranslational modifications. |
2018-09-24 |
2023-08-13 |
mouse |
| Shubhadeep Roychoudhury, Marek Halenar, Katarina Michalcova, Sangeeta Nath, Miroslava Kacaniova, Adriana Kolesarov. Green tea extract affects porcine ovarian cell apoptosis. Reproductive biology. vol 18. issue 1. 2018-09-24. PMID:29396284. |
in conclusion, our results indicate the impact of green tea extract at the highest dose used in this study on ovarian apoptosis through pathway that includes activation of caspase-3 and p53. |
2018-09-24 |
2023-08-13 |
Not clear |