| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Theodoros Eleftheriadis, Georgios Pissas, Vassilios Liakopoulos, Ioannis Stefanidi. Indoleamine 2, 3-dioxygenase Up-regulates Hypoxia-inducible Factor-1α Expression by Degrading L-tryptophan but Not Its Activity in Human Alloreactive T-cells. Iranian journal of allergy, asthma, and immunology. vol 17. issue 1. 2019-09-12. PMID:29512370. |
ido increased the p53 transcriptional targets p21 and tp53-induced glycolysis and apoptosis regulator. |
2019-09-12 |
2023-08-13 |
human |
| Y Gao, H Zhu, Q Ma. Effects of neuroblastoma breakpoint family member 1 (NBPF1) gene on growth and Akt-p53-Cyclin D pathway in cutaneous squamous carcinoma cells. Neoplasma. vol 66. issue 4. 2019-09-12. PMID:31058534. |
overexpression of nbpf1 not only arrested a431 cells in g1 phase and promoted apoptosis, but also up-regulated the expressions of bax and p53 mrna and protein and down-regulated the expressions of bcl-2, survivin and cyclin d1. |
2019-09-12 |
2023-08-13 |
Not clear |
| S N Naryzhny, O K Legin. [Structural-functional diversity of p53 proteoforms]. Biomeditsinskaia khimiia. vol 65. issue 4. 2019-09-12. PMID:31436168. |
protein p53 is a transcription factor involved in a wide variety of processes: cell cycle regulation and apoptosis, signaling inside the cell, dna repair, coordination of metabolic processes, regulation of cell interactions, etc. |
2019-09-12 |
2023-08-13 |
Not clear |
| Junjun Liang, Nina Liu, Haibin Xi. Knockdown long non-coding RNA PEG10 inhibits proliferation, migration and invasion of glioma cell line U251 by regulating miR-506. General physiology and biophysics. vol 38. issue 4. 2019-09-11. PMID:31241046. |
the cell proliferation and apoptosis related p16, p53, bcl-2, bax, and pro-/cleaved-caspase-3/9, migration and invasion related-protein: matrix metalloproteinases mmp-2, mmp-9 and vimentin, and raf/mek/erk and jak1/stat3 pathways-related proteins were accessed by western blot. |
2019-09-11 |
2023-08-13 |
human |
| Lei Duan, Ricardo E Perez, Ling Chen, Lothar A Blatter, Carl G Mak. p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. Journal of molecular cell biology. vol 10. issue 4. 2019-09-10. PMID:29190376. |
p53 promotes akt and sp1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to nutlin-3a. |
2019-09-10 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Ling Chen, Lothar A Blatter, Carl G Mak. p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. Journal of molecular cell biology. vol 10. issue 4. 2019-09-10. PMID:29190376. |
the data indicate that p53 promotes akt and sp1-dependent activation of the ppp that protects cells from nutlin-3a-induced apoptosis. |
2019-09-10 |
2023-08-13 |
Not clear |
| Yang Yang, Wei Huang, Rongfang Qiu, Ruiqiong Liu, Yi Zeng, Jie Gao, Yu Zheng, Yongqiang Hou, Shuang Wang, Wenqian Yu, Shuai Leng, Dandan Feng, Yan Wan. LSD1 coordinates with the SIN3A/HDAC complex and maintains sensitivity to chemotherapy in breast cancer. Journal of molecular cell biology. vol 10. issue 4. 2019-09-10. PMID:29741645. |
transcriptional target analysis using chip-on-chip technology revealed that the lsd1/sin3a/hdac complex targets several cellular signalling pathways that are critically involved in cell proliferation, survival, metastasis, and apoptosis, especially the p53 signalling pathway. |
2019-09-10 |
2023-08-13 |
Not clear |
| Xiao-Qian Li, Qian Yu, Wen-Fei Tan, Zai-Li Zhang, Hong M. MicroRNA-125b mimic inhibits ischemia reperfusion-induced neuroinflammation and aberrant p53 apoptotic signalling activation through targeting TP53INP1. Brain, behavior, and immunity. vol 74. 2019-09-10. PMID:30193876. |
among these roles, we investigated whether mir-125b and its downstream targets regulated the p53 signalling network and participated in both inflammation and apoptosis. |
2019-09-10 |
2023-08-13 |
Not clear |
| Cristina Rodríguez, María E Ramos-Araque, Marta Domínguez-Martínez, Tomás Sobrino, Irene Sánchez-Morán, Jesús Agulla, María Delgado-Esteban, José C Gómez-Sánchez, Juan P Bolaños, José Castillo, Angeles Almeid. Single-Nucleotide Polymorphism 309T>G in the MDM2 Promoter Determines Functional Outcome After Stroke. Stroke. vol 49. issue 10. 2019-09-10. PMID:30355102. |
background and purpose- the e3 ubiquitin ligase mdm2 (murine double minute 2) is the main negative regulator of the p53 protein-a key player in neuronal apoptosis after ischemia. |
2019-09-10 |
2023-08-13 |
mouse |
| Cristina Rodríguez, María E Ramos-Araque, Marta Domínguez-Martínez, Tomás Sobrino, Irene Sánchez-Morán, Jesús Agulla, María Delgado-Esteban, José C Gómez-Sánchez, Juan P Bolaños, José Castillo, Angeles Almeid. Single-Nucleotide Polymorphism 309T>G in the MDM2 Promoter Determines Functional Outcome After Stroke. Stroke. vol 49. issue 10. 2019-09-10. PMID:30355102. |
disruption of the mdm2-p53 interaction with nutlin-3a, or mdm2 knockdown by sirna, triggered p53 accumulation, which increased neuronal susceptibility to oxygen and glucose deprivation-induced apoptosis. |
2019-09-10 |
2023-08-13 |
mouse |
| José Romo-Yáñez, Mauricio Domínguez-Castro, Josiff S Flores-Reyes, Higinio Estrada-Juárez, Ismael Mancilla-Herrera, Jessica Hernández-Pineda, María Luisa Bazan-Tejeda, Mónica Aguinaga-Ríos, Enrique Reyes-Muño. Hyperglycemia differentially affects proliferation, apoptosis, and BNIP3 and p53 mRNA expression of human umbilical cord Wharton's jelly cells from non-diabetic and diabetic pregnancies. Biochemical and biophysical research communications. vol 508. issue 4. 2019-09-10. PMID:30554659. |
hyperglycemia differentially affects proliferation, apoptosis, and bnip3 and p53 mrna expression of human umbilical cord wharton's jelly cells from non-diabetic and diabetic pregnancies. |
2019-09-10 |
2023-08-13 |
human |
| Haiyan Wen, Siqi Zhou, Jinchun Son. Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells. Biochemical and biophysical research communications. vol 508. issue 4. 2019-09-10. PMID:30573364. |
further analyses suggested that magnolol-induced apoptosis was related to the abnormal expression of p53, bax, bcl-2, cytochrome c and caspase activation. |
2019-09-10 |
2023-08-13 |
human |
| Jing Song, Yaqi Wang, Xiao Yuan, Qiuxia Ji, Cunhui Fan, Hongmei Zhao, Wenjing Hao, Dapeng Re. Stretching magnitude-dependent inactivation of AKT by ROS led to enhanced p53 mitochondrial translocation and myoblast apoptosis. Molecular biology of the cell. vol 30. issue 10. 2019-09-10. PMID:30865562. |
stretching magnitude-dependent inactivation of akt by ros led to enhanced p53 mitochondrial translocation and myoblast apoptosis. |
2019-09-10 |
2023-08-13 |
Not clear |
| Jing Song, Yaqi Wang, Xiao Yuan, Qiuxia Ji, Cunhui Fan, Hongmei Zhao, Wenjing Hao, Dapeng Re. Stretching magnitude-dependent inactivation of AKT by ROS led to enhanced p53 mitochondrial translocation and myoblast apoptosis. Molecular biology of the cell. vol 30. issue 10. 2019-09-10. PMID:30865562. |
knocking down endogenous p53 by shrna abrogated hms-induced apoptosis. |
2019-09-10 |
2023-08-13 |
Not clear |
| Yu Wang, Hongjing Zhao, Menghao Guo, Yizhi Shao, Juanjuan Liu, Guangshun Jiang, Mingwei Xin. Arsenite renal apoptotic effects in chickens co-aggravated by oxidative stress and inflammatory response. Metallomics : integrated biometal science. vol 10. issue 12. 2019-09-09. PMID:30516227. |
it was further noted that arsenic-induced mitochondrial damage was accompanied by accumulation of p53 initiated mitochondrial apoptosis pathway in nephrocyte, eventually elevating the apoptosis rate (up to 9.1 folds) compared to that of the control groups. |
2019-09-09 |
2023-08-13 |
chicken |
| Wencheng Xu, Xiaoqin Wang, Yuanchao Tu, Hiroshi Masaki, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hiran. Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells. Chemico-biological interactions. vol 310. 2019-09-09. PMID:31255635. |
as the important markers of apoptosis, p53 and bax were both upregulated by the treatment of tet and cep. |
2019-09-09 |
2023-08-13 |
human |
| Zsofia Turi, Marketa Senkyrikova, Martin Mistrik, Jiri Bartek, Pavel Moudr. Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells. Cell cycle (Georgetown, Tex.). vol 17. issue 1. 2019-09-05. PMID:29143558. |
perturbation of ribosome biogenesis leads to the activation of p53 tumor suppressor protein promoting processes like cell cycle arrest, apoptosis or senescence. |
2019-09-05 |
2023-08-13 |
human |
| Aiqing Ma, Xianhua Da. The relationship between DNA single-stranded damage response and double-stranded damage response. Cell cycle (Georgetown, Tex.). vol 17. issue 1. 2019-09-05. PMID:29157089. |
here, we present a hybrid numerical model of p53 response and a hybrid numerical model of dna damage repair exploring dna damage repair and apoptosis mechanisms when dna single-stranded breaks and dna double-stranded breaks exist simultaneously. |
2019-09-05 |
2023-08-13 |
Not clear |
| Aiqing Ma, Xianhua Da. The relationship between DNA single-stranded damage response and double-stranded damage response. Cell cycle (Georgetown, Tex.). vol 17. issue 1. 2019-09-05. PMID:29157089. |
firstly, when two kinds of damage are present at the same time, the response of p53 is graded, it means that p53 responds to single-stranded breaks preferentially; secondly, dna single-stranded breaks are repaired preferentially, and single-stranded breaks and double-stranded breaks can be repaired simultaneously after most of single-stranded breaks having been repaired; moreover, single-stranded breaks are more likely to cause apoptosis, because the accumulation of p53 in dna single-stranded breaks is faster than it in dna double-stranded breaks and single-stranded breaks has lower threshold of apoptosis. |
2019-09-05 |
2023-08-13 |
Not clear |
| João Crispim Encarnação, Ana Salomé Pires, Renata Alexandra Amaral, Telmo José Gonçalves, Mafalda Laranjo, João Eduardo Casalta-Lopes, Ana Cristina Gonçalves, Ana Bela Sarmento-Ribeiro, Ana Margarida Abrantes, Maria Filomena Botelh. Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells. The Journal of nutritional biochemistry. vol 56. 2019-09-04. PMID:29587241. |
results demonstrate that milimolar concentrations of butyrate has an anti-proliferative effect in all three colon cancer cell lines under study, leading to a decrease on cell viability, expression of p21, p53 and β-catenin, being able to modulate p-glycoprotein activity and to induce apoptosis by modulation of bax/bcl-2 ratio. |
2019-09-04 |
2023-08-13 |
Not clear |