| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Qian Liu, Fu-Jun Tian, Ying Xiong, Yan Zhao, Jian-Bo Son. Gadd45a gene silencing by RNAi promotes cell proliferation and inhibits apoptosis and senescence in skin squamous cell carcinoma through the p53 signaling pathway. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29663367. |
the results reveal that gadd45a silencing increases tumor cell proliferation and reduces apoptosis and senescence through the p53 signaling pathway in skin scc. |
2019-09-30 |
2023-08-13 |
mouse |
| J Scott Lee, Andrew Roberts, Dennis Juarez, Thanh-Trang T Vo, Shruti Bhatt, Lee-Or Herzog, Sharmila Mallya, Richard J Bellin, Suresh K Agarwal, Ahmed Hamed Salem, Tu Xu, Jia Jia, Lingxiao Li, John R Hanna, Matthew S Davids, Angela G Fleischman, Susan O'Brien, Lloyd T Lam, Joel D Leverson, Anthony Letai, Jonathan H Schatz, David A Fruma. Statins enhance efficacy of venetoclax in blood cancers. Science translational medicine. vol 10. issue 445. 2019-09-30. PMID:29899021. |
by blocking mevalonate production, hmgcr inhibition suppressed protein geranylgeranylation, resulting in up-regulation of proapoptotic protein p53 up-regulated modulator of apoptosis (puma). |
2019-09-30 |
2023-08-13 |
human |
| Tao Li, Weilin Xu, Liansheng Gao, Guoping Guan, Zhongyuan Zhang, Pingyou He, Hangzhe Xu, Linfeng Fan, Feng Yan, Gao Che. Mesencephalic astrocyte-derived neurotrophic factor affords neuroprotection to early brain injury induced by subarachnoid hemorrhage via activating Akt-dependent prosurvival pathway and defending blood-brain barrier integrity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 2. 2019-09-30. PMID:30211660. |
manf was mainly expressed in rat neurons, and its expression increased significantly at 3 h after sah induction and peaked at 24 h. stereotactic injection of rh-manf into the cerebroventricle significantly increased the level of manf, p-akt, p-mouse double minute 2 homolog (p-mdm2), and b-cell lymphoma 2 (bcl-2) in brain tissue, whereas it down-regulated the expression of p53, bcl-2-associated x protein (bax), and cleaved caspase-3, which indicated that neuronal apoptosis was remarkably suppressed. |
2019-09-30 |
2023-08-13 |
human |
| Rosi Bissinger, Elisabeth Lang, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Mehrdad Ghashghaeinia, Lisann Pelzl, Basma Sukkar, Abdulla Al Mamun Bhuyan, Madhuri S Salker, Yogesh Singh, Birgit Fehrenbacher, Hajar Fakhri, Anja T Umbach, Martin Schaller, Syed M Qadri, Florian Lan. Genetic deficiency of the tumor suppressor protein p53 influences erythrocyte survival. Apoptosis : an international journal on programmed cell death. vol 23. issue 11-12. 2019-09-30. PMID:30238335. |
the transcription factor p53 suppresses tumor growth by inducing nucleated cell apoptosis and cycle arrest. |
2019-09-30 |
2023-08-13 |
Not clear |
| Shunji Gao, Yanyan Yu, Lu Liu, Jun Meng, Guifang L. Circular RNA hsa_circ_0007059 restrains proliferation and epithelial-mesenchymal transition in lung cancer cells via inhibiting microRNA-378. Life sciences. vol 233. 2019-09-30. PMID:31351967. |
overexpressed hsa_circ_0007059 evidently restrained cell proliferation, elevated p53 and repressed cyclind1 expression, meanwhile triggered apoptosis and enhanced bax and cleaved-caspase-3 expression. |
2019-09-30 |
2023-08-13 |
Not clear |
| Yingji Jin, Yoshito Takeda, Yasushi Kondo, Lokesh P Tripathi, Sujin Kang, Hikari Takeshita, Hanako Kuhara, Yohei Maeda, Masayoshi Higashiguchi, Kotaro Miyake, Osamu Morimura, Taro Koba, Yoshitomo Hayama, Shohei Koyama, Kaori Nakanishi, Takeo Iwasaki, Satoshi Tetsumoto, Kazuyuki Tsujino, Muneyoshi Kuroyama, Kota Iwahori, Haruhiko Hirata, Takayuki Takimoto, Mayumi Suzuki, Izumi Nagatomo, Ken Sugimoto, Yuta Fujii, Hiroshi Kida, Kenji Mizuguchi, Mari Ito, Takashi Kijima, Hiromi Rakugi, Eisuke Mekada, Isao Tachibana, Atsushi Kumanogo. Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging. Scientific reports. vol 8. issue 1. 2019-09-25. PMID:29572511. |
importantly, sirna knockdown of cd9 and cd81 in lung epithelial cells additively decreased sirt1 and foxo3a expression, but reciprocally upregulated the expression of p21 and p53, leading to reduced cell proliferation and elevated apoptosis. |
2019-09-25 |
2023-08-13 |
mouse |
| Maria Mrakovcic, Leopold F Fröhlic. p53-Mediated Molecular Control of Autophagy in Tumor Cells. Biomolecules. vol 8. issue 2. 2019-09-23. PMID:29561758. |
accordingly, we recently identified p53 as a molecular hub that regulates autophagy and apoptosis in histone deacetylase inhibitor-treated uterine sarcoma cells. |
2019-09-23 |
2023-08-13 |
human |
| Olga Fedorova, Alexandra Daks, Varvara Petrova, Alexey Petukhov, Larissa Lezina, Oleg Shuvalov, Pavel Davidovich, Darya Kriger, Ekaterina Lomert, Dmitry Tentler, Victor Kartsev, Burhan Uyanik, Vyacheslav Tribulovich, Oleg Demidov, Gerry Melino, Nickolai A Barle. Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis. Cell cycle (Georgetown, Tex.). vol 17. issue 15. 2019-09-20. PMID:30109812. |
novel isatin-derived molecules activate p53 via interference with mdm2 to promote apoptosis. |
2019-09-20 |
2023-08-13 |
human |
| Olga Fedorova, Alexandra Daks, Varvara Petrova, Alexey Petukhov, Larissa Lezina, Oleg Shuvalov, Pavel Davidovich, Darya Kriger, Ekaterina Lomert, Dmitry Tentler, Victor Kartsev, Burhan Uyanik, Vyacheslav Tribulovich, Oleg Demidov, Gerry Melino, Nickolai A Barle. Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis. Cell cycle (Georgetown, Tex.). vol 17. issue 15. 2019-09-20. PMID:30109812. |
in response to various forms of genotoxic stress p53 stimulates expression of genes whose products induce cell cycle arrest and/or apoptosis. |
2019-09-20 |
2023-08-13 |
human |
| Rashideh N Mobaraki, Maryam Karimi, Fatemeh Alikarami, Elham Farhadi, Ali Amini, Davood Bashash, Mostafa Paridar, Parviz Kokhaei, Mohammad R Rezvani, Ahmad Kazemi, Majid Saf. RITA induces apoptosis in p53-null K562 leukemia cells by inhibiting STAT5, Akt, and NF-κB signaling pathways. Anti-cancer drugs. vol 29. issue 9. 2019-09-20. PMID:30157040. |
reactivation of p53 and induction of tumor cell apoptosis (rita) is a promising anticancer small molecule that reactivates p53 and induces exclusive apoptosis in tumor cells. |
2019-09-20 |
2023-08-13 |
Not clear |
| Lei Zho. P53 and Apoptosis in the Drosophila Model. Advances in experimental medicine and biology. vol 1167. 2019-09-20. PMID:31520351. |
p53 and apoptosis in the drosophila model. |
2019-09-20 |
2023-08-13 |
human |
| Sadia Afrin, Francesca Giampieri, Tamara Y Forbes-Hernández, Massimiliano Gasparrini, Adolfo Amici, Danila Cianciosi, Josè L Quiles, Maurizio Battin. Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. Free radical biology & medicine. vol 126. 2019-09-19. PMID:30056083. |
compared to 5-fu alone, mh synergistically enhanced the chemotherapeutic effects of 5-fu, by reducing cell proliferation through the suppression of egfr, her2, p-akt and p-mtor expression, and promoting apoptosis by the modulation pro-apoptotic (p53, bax, cyto c, fasl caspase-3, -8, -9 and cleave-parp) and anti-apoptotic (bcl-2) markers. |
2019-09-19 |
2023-08-13 |
human |
| Michio Iwata, Lisa Hirose, Hiroshi Kohara, Jiyuan Liao, Ryusuke Sawada, Sayaka Akiyoshi, Kenzaburo Tani, Yoshihiro Yamanish. Pathway-Based Drug Repositioning for Cancers: Computational Prediction and Experimental Validation. Journal of medicinal chemistry. vol 61. issue 21. 2019-09-19. PMID:30371064. |
we analyzed chemically induced gene expression data of 1112 drugs on 66 human cell lines and searched for drugs that inactivate pathways involved in the growth of cancer cells (cell cycle) and activate pathways that contribute to the death of cancer cells (e.g., apoptosis and p53 signaling). |
2019-09-19 |
2023-08-13 |
human |
| Foo Kit Cheah, Kok Hoong Leong, Noel Francis Thomas, Hui Kee Chin, Azhar Ariffin, Khalijah Awan. Resveratrol analogue, (E)-N-(2-(4-methoxystyryl) phenyl) furan-2-carboxamide induces G Apoptosis : an international journal on programmed cell death. vol 23. issue 5-6. 2019-09-17. PMID:29754265. |
the results show that cs causes apoptosis via the activation of an extrinsic pathway leading to caspase activation and cell cycle arrest from activated p53. |
2019-09-17 |
2023-08-13 |
Not clear |
| Zinaida Dedeić, Gopinath Sutendra, Ying Hu, Kathryn Chung, Elizabeth A Slee, Michael J White, Felix Y Zhou, Robert D Goldin, David J P Ferguson, Debra McAndrew, Jurgen E Schneider, Xin L. Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders. Cell death and differentiation. vol 25. issue 7. 2019-09-16. PMID:29352264. |
previous studies showed that inhibitor of apoptosis stimulating p53 protein (iaspp) regulates desmosome integrity at cell-cell junctions and transcription in the nucleus, and its deficiency causes cardiocutaneous disorder in mice, cattle, and humans. |
2019-09-16 |
2023-08-13 |
mouse |
| Min Zhang, Yanhong Zhang, Enshun Xu, Shakur Mohibi, Danielle Michelle de Anda, Yuqian Jiang, Jin Zhang, Xinbin Che. Rbm24, a target of p53, is necessary for proper expression of p53 and heart development. Cell death and differentiation. vol 25. issue 6. 2019-09-16. PMID:29358667. |
activation of p53-dependent apoptosis is critical for tumor suppression but aberrant activation of p53 also leads to developmental defects and heart failure. |
2019-09-16 |
2023-08-13 |
mouse |
| Min Zhang, Yanhong Zhang, Enshun Xu, Shakur Mohibi, Danielle Michelle de Anda, Yuqian Jiang, Jin Zhang, Xinbin Che. Rbm24, a target of p53, is necessary for proper expression of p53 and heart development. Cell death and differentiation. vol 25. issue 6. 2019-09-16. PMID:29358667. |
we also showed that the heart developmental defect in rbm24-null mice can be partially rescued by p53 deficiency through decreased apoptosis in the heart. |
2019-09-16 |
2023-08-13 |
mouse |
| Eric R Wolf, Ciarán P McAtarsney, Kristin E Bredhold, Amber M Kline, Lindsey D May. Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK. Science signaling. vol 11. issue 524. 2019-09-16. PMID:29615516. |
mutations in the dna-binding domain of p53, which are commonly seen in cancers, result in conformational changes that enable p53 to interact with and inhibit p73, thereby suppressing apoptosis. |
2019-09-16 |
2023-08-13 |
Not clear |
| Toshiaki Tanaka, Ken Iseki, Ken Tanaka, Tomoyuki Nakano, Mitsuyoshi Iino, Kaoru Got. DGKζ ablation engenders upregulation of p53 level in the spleen upon whole-body ionizing radiation. Advances in biological regulation. vol 67. 2019-09-12. PMID:29079355. |
in a cellular model of doxorubicin-induced dna damage, overexpression of wild-type dgkζ suppresses p53 protein induction and reduces apoptosis, whereas knockdown of dgkζ upregulates p53 protein level and promotes apoptosis. |
2019-09-12 |
2023-08-13 |
mouse |
| Toshiaki Tanaka, Ken Iseki, Ken Tanaka, Tomoyuki Nakano, Mitsuyoshi Iino, Kaoru Got. DGKζ ablation engenders upregulation of p53 level in the spleen upon whole-body ionizing radiation. Advances in biological regulation. vol 67. 2019-09-12. PMID:29079355. |
our results reveal that p53 protein is induced robustly in the spleen of dgkζ-ko mice upon exposure to ionizing radiation, thereby promoting apoptosis in this organ. |
2019-09-12 |
2023-08-13 |
mouse |