| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francis O Enane, Yogen Saunthararajah, Murray Kor. Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells. Cell death & disease. vol 9. issue 9. 2019-11-11. PMID:30190481. |
however, master regulators of apoptosis (e.g., p53, p16/cdkn2a) are frequently genetically inactivated in cancers, resulting in multidrug resistance. |
2019-11-11 |
2023-08-13 |
Not clear |
| Jiawang Zhou, Ziqian Li, Junjie Zhang, Hongsheng Wang, Sheng Yin, Jun D. 8-Acetonyldihydronitidine inhibits the proliferation of human colorectal cancer cells via activation of p53. European journal of pharmacology. vol 854. 2019-11-11. PMID:30928633. |
moreover, pifithrin-α, the p53 inhibitor, markedly reversed the above responses induced by 8-ahn, and small interfering rna-mediated knockdown of tp53 also significantly decreased 8-ahn-induced cell apoptosis. |
2019-11-11 |
2023-08-13 |
human |
| Jiawang Zhou, Ziqian Li, Junjie Zhang, Hongsheng Wang, Sheng Yin, Jun D. 8-Acetonyldihydronitidine inhibits the proliferation of human colorectal cancer cells via activation of p53. European journal of pharmacology. vol 854. 2019-11-11. PMID:30928633. |
in summary, 8-ahn displays an antitumor effect through cell cycle arrest and apoptosis in colorectal cells via activating p53, which suggests that 8-ahn, exerted a therapeutic potential against colorectal cancer cells, and may be regarded as an effective lead compound. |
2019-11-11 |
2023-08-13 |
human |
| Xiao-Yun Liu, Fei-Ran Zhang, Jin-Yan Shang, Ying-Ying Liu, Xiao-Fei Lv, Jia-Ni Yuan, Ting-Ting Zhang, Kai Li, Xiao-Chun Lin, Xiu Liu, Qingqing Lei, Xiao-Dong Fu, Jia-Guo Zhou, Si-Jia Lian. Renal inhibition of miR-181a ameliorates 5-fluorouracil-induced mesangial cell apoptosis and nephrotoxicity. Cell death & disease. vol 9. issue 6. 2019-11-08. PMID:29795190. |
in conclusion, these results demonstrate that mir-181a increases p53 protein expression and transcriptional activity by targeting birc6 and promotes 5-fu-induced apoptosis in mesangial cells. |
2019-11-08 |
2023-08-13 |
Not clear |
| Bilge Debelec-Butuner, Mustafa Kotmakci, Ezgi Oner, Gulseren Ozduman, Ayse Gulten Kantarc. Nutlin3a-Loaded Nanoparticles Show Enhanced Apoptotic Activity on Prostate Cancer Cells. Molecular biotechnology. vol 61. issue 7. 2019-11-08. PMID:31028604. |
stabilization of the p53 protein, which is responsible for the regulation of apoptosis mechanism in the cell, is therefore an important therapeutic goal. |
2019-11-08 |
2023-08-13 |
Not clear |
| Bilge Debelec-Butuner, Mustafa Kotmakci, Ezgi Oner, Gulseren Ozduman, Ayse Gulten Kantarc. Nutlin3a-Loaded Nanoparticles Show Enhanced Apoptotic Activity on Prostate Cancer Cells. Molecular biotechnology. vol 61. issue 7. 2019-11-08. PMID:31028604. |
nutlin3a inhibits the degradation of the p53 protein, triggers p53-mediated apoptosis in cancer cells and enhances the effectiveness of chemotherapeutics. |
2019-11-08 |
2023-08-13 |
Not clear |
| Bilge Debelec-Butuner, Mustafa Kotmakci, Ezgi Oner, Gulseren Ozduman, Ayse Gulten Kantarc. Nutlin3a-Loaded Nanoparticles Show Enhanced Apoptotic Activity on Prostate Cancer Cells. Molecular biotechnology. vol 61. issue 7. 2019-11-08. PMID:31028604. |
physicochemical characterization was performed and activity of apoptosis induction on wild-type p53 expressing lncap prostate cancer cell line was evaluated. |
2019-11-08 |
2023-08-13 |
Not clear |
| Bilge Debelec-Butuner, Mustafa Kotmakci, Ezgi Oner, Gulseren Ozduman, Ayse Gulten Kantarc. Nutlin3a-Loaded Nanoparticles Show Enhanced Apoptotic Activity on Prostate Cancer Cells. Molecular biotechnology. vol 61. issue 7. 2019-11-08. PMID:31028604. |
in addition, induction rate of apoptosis by nanoparticles was higher than nutlin3a solution in dmso, proving this nanoparticle formulation is a promising candidate for increasing the efficiency of nutlin3a for p53(+) cancer cases. |
2019-11-08 |
2023-08-13 |
Not clear |
| Pravat Kumar Parida, Barun Mahata, Abhisek Santra, Sohini Chakraborty, Zhumur Ghosh, Sanghamitra Raha, Anup Kumar Misra, Kaushik Biswas, Kuladip Jan. Inhibition of cancer progression by a novel trans-stilbene derivative through disruption of microtubule dynamics, driving G2/M arrest, and p53-dependent apoptosis. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29670107. |
moreover, z-dan-11-mediated apoptosis of cancer cells is through a partial p53-dependent pathway, since both hct116 p53 |
2019-11-07 |
2023-08-13 |
Not clear |
| Florian Schubert, Juliane Rapp, Prisca Brauns-Schubert, Lisa Schlicher, Kerstin Stock, Manuela Wissler, Martina Weiß, Céline Charvet, Christoph Borner, Ulrich Maure. Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29686375. |
thus, the suppression of gsk-3 is the key function of pi3k signaling in order to prevent the induction of puma by foxo3a and p53 and thereby apoptosis upon growth factor withdrawal. |
2019-11-07 |
2023-08-13 |
Not clear |
| Ying Shen, Wenling Tu, Yunqiang Liu, Xiling Yang, Qiang Dong, Bo Yang, Jinyan Xu, Yuanlong Yan, Xue Pei, Mohan Liu, Wenming Xu, Yuan Yan. TSPY1 suppresses USP7-mediated p53 function and promotes spermatogonial proliferation. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29748603. |
we demonstrated that the promotion of p53 degradation by tspy1 influenced the activity of p53 target molecules (cdk1, p21, and bax) to expedite the g2/m phase transition and decrease cell apoptosis, accelerating cell proliferation. |
2019-11-07 |
2023-08-13 |
mouse |
| Lin Yang, Jieying Zhou, Fei Meng, Chengyu Fu, Xiaoqian Zou, Jinfeng Liu, Chengwan Zhang, Renxiang Tan, Zhiyu Li, Qinglong Guo, Libin We. G1 phase cell cycle arrest in NSCLC in response to LZ-106, an analog of enoxacin, is orchestrated through ROS overproduction in a P53-dependent manner. Carcinogenesis. vol 40. issue 1. 2019-11-07. PMID:30239617. |
here, we substantiated the involvement of p53 activation in intracellular reactive oxygen species (ros) generation upon lz-106 treatment and related p53 to the ros-induced viability inhibition and apoptosis, which was exhibited in the previous research. |
2019-11-07 |
2023-08-13 |
mouse |
| Adi Sagiv, Amir Bar-Shai, Naama Levi, Miki Hatzav, Lior Zada, Yossi Ovadya, Lior Roitman, Gal Manella, Ofer Regev, Julia Majewska, Ezra Vadai, Raya Eilam, Sara W Feigelson, Michael Tsoory, Michel Tauc, Ronen Alon, Valery Krizhanovsk. p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence. Cell reports. vol 22. issue 13. 2019-11-05. PMID:29590616. |
the tumor suppressor p53 limits tumorigenesis by inducing apoptosis, cell cycle arrest, and senescence. |
2019-11-05 |
2023-08-13 |
mouse |
| Ya-Ju Sung, Ting-Yu Kao, Cheng-Liang Kuo, Chi-Chen Fan, An Ning Cheng, Wei-Cheng Fang, Han-Yu Chou, Yu-Kang Lo, Chung-Hsing Chen, Shih Sheng Jiang, I-Shou Chang, Chun-Hua Hsu, Jin-Ching Lee, Alan Yueh-Luen Le. Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity. Cell death & disease. vol 9. issue 6. 2019-11-05. PMID:29899330. |
mitochondrial lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity. |
2019-11-05 |
2023-08-13 |
Not clear |
| Ya-Ju Sung, Ting-Yu Kao, Cheng-Liang Kuo, Chi-Chen Fan, An Ning Cheng, Wei-Cheng Fang, Han-Yu Chou, Yu-Kang Lo, Chung-Hsing Chen, Shih Sheng Jiang, I-Shou Chang, Chun-Hua Hsu, Jin-Ching Lee, Alan Yueh-Luen Le. Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity. Cell death & disease. vol 9. issue 6. 2019-11-05. PMID:29899330. |
accumulating evidences indicate that various stresses induce transportation of p53 to mitochondria and activate apoptosis in a transcription-independent manner. |
2019-11-05 |
2023-08-13 |
Not clear |
| Ya-Ju Sung, Ting-Yu Kao, Cheng-Liang Kuo, Chi-Chen Fan, An Ning Cheng, Wei-Cheng Fang, Han-Yu Chou, Yu-Kang Lo, Chung-Hsing Chen, Shih Sheng Jiang, I-Shou Chang, Chun-Hua Hsu, Jin-Ching Lee, Alan Yueh-Luen Le. Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity. Cell death & disease. vol 9. issue 6. 2019-11-05. PMID:29899330. |
here we found that increased lon interacts with p53 in mitochondrial matrix and restrains the apoptosis induced by p53 under oxidative stress by rescuing the loss of mitochondrial membrane potential (Δψm) and the release of cytochrome c and smac/diablo. |
2019-11-05 |
2023-08-13 |
Not clear |
| Ya-Ju Sung, Ting-Yu Kao, Cheng-Liang Kuo, Chi-Chen Fan, An Ning Cheng, Wei-Cheng Fang, Han-Yu Chou, Yu-Kang Lo, Chung-Hsing Chen, Shih Sheng Jiang, I-Shou Chang, Chun-Hua Hsu, Jin-Ching Lee, Alan Yueh-Luen Le. Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity. Cell death & disease. vol 9. issue 6. 2019-11-05. PMID:29899330. |
the atpase mutant (k529r) of chaperone lon decreases the interaction with p53 and fails to inhibit apoptosis. |
2019-11-05 |
2023-08-13 |
Not clear |
| Guanghui Wang, Fenglong Bie, Xiao Qu, Xudong Yang, Shaorui Liu, Yu Wang, Cuicui Huang, Kai Wang, Jiajun D. Expression profiling of ubiquitin-related genes in LKB1 mutant lung adenocarcinoma. Scientific reports. vol 8. issue 1. 2019-11-04. PMID:30185829. |
sh3rf1 can influence cell cycle, apoptosis, dna replication and the p53 signaling pathway. |
2019-11-04 |
2023-08-13 |
Not clear |
| Hong-Qiang Chen, Ji Zhao, Yan Li, Yu-Jing Huang, Dong-Jiao Chen, Li-Xiong He, Ling-Qiao Wang, Chuan-Fen Zheng, Jia Wang, Jia Cao, Wei-Qun Shu, Jin-Yi Liu, Wen-Bin Li. Epigenetic inactivation of LHX6 mediated microcystin-LR induced hepatocarcinogenesis via the Wnt/β-catenin and P53 signaling pathways. Environmental pollution (Barking, Essex : 1987). vol 252. issue Pt A. 2019-10-31. PMID:31151060. |
in addition, we found that up-regulation of p53 and bax resulted in apoptosis, and that down-regulation of ctnnb1 and mmp7 led to migration of mc-lr treated l02 cells. |
2019-10-31 |
2023-08-13 |
human |
| Joana F A Valente, João A Queiroz, Fani Sous. p53 as the Focus of Gene Therapy: Past, Present and Future. Current drug targets. vol 19. issue 15. 2019-10-30. PMID:29336259. |
p53 is implicated in a number of known cellular functions, including dna damage repair, cell cycle arrest in g1/s and g2/m and apoptosis, being an interesting target for cancer treatment. |
2019-10-30 |
2023-08-13 |
Not clear |