| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Gan, Hua Zhao, Tiegang Li, Kuijie Liu, Jiangsheng Huan. CDK1 interacts with iASPP to regulate colorectal cancer cell proliferation through p53 pathway. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069733. |
taken together, we revealed that cdk1 and iaspp was up-regulated in crc tissues and cell lines; cdk1 protein interacted with iaspp protein to affect crc cell proliferation and apoptosis through the p53 apoptosis pathway. |
2019-11-20 |
2023-08-13 |
Not clear |
| A-Rum Yoon, JinWoo Hong, Chae-Ok Yu. Adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis. Oncotarget. vol 8. issue 44. 2019-11-20. PMID:29100340. |
adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| A-Rum Yoon, JinWoo Hong, Chae-Ok Yu. Adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis. Oncotarget. vol 8. issue 44. 2019-11-20. PMID:29100340. |
in addition, western blot data showed that dcn expression activated mitochondrial apoptosis by increasing the expression level of p53. |
2019-11-20 |
2023-08-13 |
Not clear |
| Yang Kong, Lufei Zhang, Yu Huang, Tianyu He, Linshi Zhang, Xinyi Zhao, Xiaohu Zhou, Dongkai Zhou, Yingcai Yan, Jiarong Zhou, Haiyang Xie, Lin Zhou, Shusen Zheng, Weilin Wan. Corrigendum to "Pseudogene PDIA3P1 promotes cell proliferation, migration and invasion, and suppresses apoptosis in hepatocellular carcinoma by regulating the p53 pathway" [Cancer Lett. 407C (2017) 76-83]. Cancer letters. vol 414. 2019-11-20. PMID:29150093. |
corrigendum to "pseudogene pdia3p1 promotes cell proliferation, migration and invasion, and suppresses apoptosis in hepatocellular carcinoma by regulating the p53 pathway" [cancer lett. |
2019-11-20 |
2023-08-13 |
Not clear |
| Toshihiro Uchihashi, Kaori Ota, Yusuke Yabuno, Shouichi Ohno, Kohshiro Fukushima, Yoko Naito, Mikihiko Kogo, Norikazu Yabuta, Hiroshi Nojim. ELAS1 induces apoptotic death in adenocarcinoma DU145 and squamous-cell carcinoma SAS cancer cells, but not in normal KD cells. Oncotarget. vol 8. issue 49. 2019-11-20. PMID:29156763. |
because the effect of elas1 is dependent on increased stability of p53 and enhanced phosphorylation of p53-s46, we exogenously expressed wild-type p53 protein to fully promote elas1-mediated induction of apoptosis in sas cells. |
2019-11-20 |
2023-08-13 |
mouse |
| Yan Shu, Ligang Ren, Bo Xie, Zhen Liang, Jing Che. MiR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway. Oncotarget. vol 8. issue 57. 2019-11-20. PMID:29228612. |
as the results, acetylated p53 induced by dox upregulates the expression of noxa and puma followed by induction of mitochondrial apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Marie Kristin Fritsche, Andreas Knop. The Tumor Suppressor p53 in Mucosal Melanoma of the Head and Neck. Genes. vol 8. issue 12. 2019-11-20. PMID:29236030. |
abrogated activation of p53 target genes results in derogation of the apoptotic signal cascade and contributes to the strong resistance against chemotherapeutic agents activating p53 dependent apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jiahui Du, Peng Yang, Fanhua Kong, Haiyan Li. Aberrant expression of translationally controlled tumor protein (TCTP) can lead to radioactive susceptibility and chemosensitivity in lung cancer cells. Oncotarget. vol 8. issue 60. 2019-11-20. PMID:29254214. |
p53 tumor suppressor protein is important in regulating cell growth, it can induce either growth arrest or programmed cell death (apoptosis). |
2019-11-20 |
2023-08-13 |
Not clear |
| Jiahui Du, Peng Yang, Fanhua Kong, Haiyan Li. Aberrant expression of translationally controlled tumor protein (TCTP) can lead to radioactive susceptibility and chemosensitivity in lung cancer cells. Oncotarget. vol 8. issue 60. 2019-11-20. PMID:29254214. |
tctp and p53 formed a feedback signal pathway and through it to regulate the downstream akt signal pathways to make the lung cancer cells keep a higher metabolism level and protect cancer cells from apoptosis induced by outside stress. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jun Zhou, Youling Fan, Simin Tang, Huiping Wu, Jiying Zhong, Zhengxing Huang, Chengxiang Yang, Hongtao Che. Inhibition of PTEN activity aggravates cisplatin-induced acute kidney injury. Oncotarget. vol 8. issue 61. 2019-11-20. PMID:29262553. |
in summary, our study has demonstrated that inhibiting pten activity aggravates cisplatin-induced aki via apoptosis, inflammatory reaction, and p53 signaling pathway. |
2019-11-20 |
2023-08-13 |
mouse |
| Ying-Yi Luan, Min Jia, Hui Zhang, Fu-Jun Zhu, Ning Dong, Yong-Wen Feng, Ming Wu, Ya-Lin Tong, Yong-Ming Ya. The potential mechanism of extracellular high mobility group box-1 protein mediated p53 expression in immune dysfunction of T lymphocytes. Oncotarget. vol 8. issue 68. 2019-11-20. PMID:29348880. |
taken together, our data strongly indicated that hmgb1 might enhance p53 expression, which was associated with both the proliferative activity as well as apoptosis of t cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Kevin Y Guo, Lili Han, Xinyu Li, Andrew V Yang, Jiaxiong Lu, Shan Guan, Hui Li, Yang Yu, Yanling Zhao, Jianhua Yang, Hong Zhan. Novel proteasome inhibitor delanzomib sensitizes cervical cancer cells to doxorubicin-induced apoptosis via stabilizing tumor suppressor proteins in the p53 pathway. Oncotarget. vol 8. issue 69. 2019-11-20. PMID:29371974. |
novel proteasome inhibitor delanzomib sensitizes cervical cancer cells to doxorubicin-induced apoptosis via stabilizing tumor suppressor proteins in the p53 pathway. |
2019-11-20 |
2023-08-13 |
human |
| Se Hoon Hong, Dae-Hee Lee, Young-Sun Lee, Min Jee Jo, Yoon A Jeong, William T Kwon, Haroon A Choudry, David L Bartlett, Yong J Le. Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression. Oncotarget. vol 8. issue 70. 2019-11-20. PMID:29383150. |
moreover, erastin and art induced endoplasmic reticulum (er) stress and promoted p53 upregulated modulator of apoptosis (puma) expression via c/ebp-homologous protein (chop). |
2019-11-20 |
2023-08-13 |
mouse |
| Shih-Yao Chen, Ai-Li Shiau, Chao-Liang Wu, Chrong-Reen Wan. P53-derived hybrid peptides induce apoptosis of synovial fibroblasts in the rheumatoid joint. Oncotarget. vol 8. issue 70. 2019-11-20. PMID:29383169. |
in synovial fibroblasts (sfs) from rheumatoid arthritis (ra), mutant p53 can lead to the transformation-like features with resistance to the apoptosis induction. |
2019-11-20 |
2023-08-13 |
human |
| Xin Jiang, Yaqiong Hong, Di Zhao, Xinxin Meng, Lijing Zhao, Yanwei Du, Zan Wang, Yan Zheng, Lu Cai, Hongyu Jian. Low dose radiation prevents doxorubicin-induced cardiotoxicity. Oncotarget. vol 9. issue 1. 2019-11-20. PMID:29416617. |
pretreatment of dox-treated mice with ldr also decreased dox-induced cardiac cell apoptosis (tunel staining and cleaved caspase-3) and mitochondrial apoptotic pathway (increased p53, bax, and caspase-9 expression and decreased bcl2 expression and ΔΨm dissipation). |
2019-11-20 |
2023-08-13 |
mouse |
| Antonella Muscella, Carla Vetrugno, Luca Giulio Cossa, Giovanna Antonaci, Amilcare Barca, Sandra Angelica De Pascali, Francesco Paolo Fanizzi, Santo Marsigliant. Correction: Apoptosis by [Pt(O,O'-acac)(γ-acac)(DMS)] requires PKC-δ mediated p53 activation in malignant pleural mesothelioma. PloS one. vol 13. issue 2. 2019-11-20. PMID:29432478. |
correction: apoptosis by [pt(o,o'-acac)(γ-acac)(dms)] requires pkc-δ mediated p53 activation in malignant pleural mesothelioma. |
2019-11-20 |
2023-08-13 |
Not clear |
| Venu Venkatarame Gowda Saralamma, Ho Jeong Lee, Suchismita Raha, Won Sup Lee, Eun Hee Kim, Sang Joon Lee, Jeong Doo Heo, Chungkil Won, Chang Keun Kang, Gon Sup Ki. Inhibition of IAP's and activation of p53 leads to caspase-dependent apoptosis in gastric cancer cells treated with Scutellarein. Oncotarget. vol 9. issue 5. 2019-11-20. PMID:29464049. |
inhibition of iap's and activation of p53 leads to caspase-dependent apoptosis in gastric cancer cells treated with scutellarein. |
2019-11-20 |
2023-08-13 |
human |
| Venu Venkatarame Gowda Saralamma, Ho Jeong Lee, Suchismita Raha, Won Sup Lee, Eun Hee Kim, Sang Joon Lee, Jeong Doo Heo, Chungkil Won, Chang Keun Kang, Gon Sup Ki. Inhibition of IAP's and activation of p53 leads to caspase-dependent apoptosis in gastric cancer cells treated with Scutellarein. Oncotarget. vol 9. issue 5. 2019-11-20. PMID:29464049. |
it's imperative to understand apoptosis, which provides the basis for novel targeted therapies that can induce cancer cell death or sensitize them to cytotoxic agents by regulating key factors like iaps, mdm2, p53, caspases and much more. |
2019-11-20 |
2023-08-13 |
human |
| Venu Venkatarame Gowda Saralamma, Ho Jeong Lee, Suchismita Raha, Won Sup Lee, Eun Hee Kim, Sang Joon Lee, Jeong Doo Heo, Chungkil Won, Chang Keun Kang, Gon Sup Ki. Inhibition of IAP's and activation of p53 leads to caspase-dependent apoptosis in gastric cancer cells treated with Scutellarein. Oncotarget. vol 9. issue 5. 2019-11-20. PMID:29464049. |
this study demonstrated that the scutellarein on ags and snu-484 cells significantly inhibits cell proliferation and induces apoptotic cell death via down regulating mdm2 and activated the tumor suppresser protein p53, subsequently down regulating the iap family proteins (ciap1, ciap2, and xiap) leading to caspase-dependent apoptosis in ags and snu-484 cells. |
2019-11-20 |
2023-08-13 |
human |
| Ning Kon, Donglai Wang, Tongyuan Li, Le Jiang, Li Qiang, Wei G. Inhibition of Mdmx (Mdm4) Oncotarget. vol 9. issue 7. 2019-11-20. PMID:29484110. |
inhibition of mdmx (mdm4) although cell-cycle arrest, senescence and apoptosis remain as major canonical activities of p53 in tumor suppression, the emerging role of p53 in metabolism has been a topic of great interest. |
2019-11-20 |
2023-08-13 |
Not clear |