| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X L Shu, H Xu, T T Yu, J X Zhong, T Le. Regulation of apoptosis in human gastric cancer cell line SGC-7901 by L-arginine. Panminerva medica. 2019-11-20. PMID:24642529. |
expression and activation of proteins pertinent to apoptosis (bcl2, surviving, p53, and xiap) were studied using pcr, western blot, and activity assays. |
2019-11-20 |
2023-08-12 |
human |
| X L Shu, H Xu, T T Yu, J X Zhong, T Le. Regulation of apoptosis in human gastric cancer cell line SGC-7901 by L-arginine. Panminerva medica. 2019-11-20. PMID:24642529. |
conclusion: regulation of apoptosis by l-arg via down-regulation of anti-apoptotic proteins bcl-2 and surviving, and up-regulation of pro-apoptotic protein p53 may represent the mechanism behind antitumor effects of l-arg. |
2019-11-20 |
2023-08-12 |
human |
| Angel L Pey, Clare F Megarity, David J Timso. FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1. Biochimica et biophysica acta. vol 1842. issue 11. 2019-11-20. PMID:25179580. |
nad(p)h quinone oxidoreductase 1 is involved in antioxidant defence and protection from cancer, stabilizing the apoptosis regulator p53 towards degradation. |
2019-11-20 |
2023-08-13 |
human |
| Yong He, Yu-Ting Wu, Cheng Huang, Xiao-Ming Meng, Tao-Tao Ma, Bao-Ming Wu, Feng-Yun Xu, Lei Zhang, Xiong-Wen Lv, Jun L. Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis. Biochimica et biophysica acta. vol 1842. issue 11. 2019-11-20. PMID:25201080. |
more importantly, overexpression of meg3 could activate p53 and mediate cytochrome c release, subsequently leading to caspase-3-dependent apoptosis in tgf-β1-treated lx-2 cells. |
2019-11-20 |
2023-08-13 |
mouse |
| Hao Gong, Xin Yang, Yudan Zhao, Robert B Petersen, Xinran Liu, Yang Liu, Kun Huan. Amyloidogenicity of p53: A Hidden Link Between Protein Misfolding and Cancer. Current protein & peptide science. 2019-11-20. PMID:25440023. |
the tumor suppressor p53, a transcription factor that regulates the cell cycle and apoptosis, is also amyloidogenic. |
2019-11-20 |
2023-08-13 |
Not clear |
| Manel Boussabbeh, Intidhar Ben Salem, Fadwa Neffati, Mohamed Fadhel Najjar, Hassen Bacha, Salwa Abid-Essef. Crocin Prevents Patulin-Induced Acute Toxicity in Cardiac Tissues via the Regulation of Oxidative Damage and Apoptosis. Journal of biochemical and molecular toxicology. vol 29. issue 10. 2019-11-20. PMID:26095701. |
we also demonstrated that acute administration of pat triggers apoptosis via p53 overexpression and caspase 3 activation. |
2019-11-20 |
2023-08-13 |
mouse |
| Ninu Poulose, Raghavan Raj. Sirtuin regulation in aging and injury. Biochimica et biophysica acta. vol 1852. issue 11. 2019-11-20. PMID:26303641. |
the sirt1 mediated deacetylation of targets such as pgc-1α, foxo3, p53 and nf-κb has profound effect on mitochondrial function, apoptosis and inflammation. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ya-Jun He, Kenny Kuchta, Xia Lv, Yu Lin, Guo-Rong Ye, Xu-You Liu, Hui-Dong Song, Le-Xin Wang, Yuta Kobayashi, Jian-Chang Sh. Curcumin, the main active constituent of turmeric (Curcuma longa L.), induces apoptosis in hepatic stellate cells by modulating the abundance of apoptosis-related growth factors. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 70. issue 11-12. 2019-11-20. PMID:26609862. |
the protein levels of the pro-apoptotic factors fas and p53b as well as of the anti-apoptotic factor bcl-2 were monitored by immunocytochemical abc staining after incubation with curcumin for 24 h. in the case of 20 μm curcumin, not only was the respective apoptosis index increased, but also the abundance of the pro-apoptotic factors fas and p53 were amplified, whereas that of the anti-apoptotic factor bcl-2 decreased. |
2019-11-20 |
2023-08-13 |
rat |
| Ya-Jun He, Kenny Kuchta, Xia Lv, Yu Lin, Guo-Rong Ye, Xu-You Liu, Hui-Dong Song, Le-Xin Wang, Yuta Kobayashi, Jian-Chang Sh. Curcumin, the main active constituent of turmeric (Curcuma longa L.), induces apoptosis in hepatic stellate cells by modulating the abundance of apoptosis-related growth factors. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 70. issue 11-12. 2019-11-20. PMID:26609862. |
consequently, curcumin has an up-regulating effect on pro-apoptotic factors like fas and p53 as well as a down-regulating effect of the anti-apoptotic factor bcl-2, thus inducing apoptosis in hsc. |
2019-11-20 |
2023-08-13 |
rat |
| Leyla Rohani, Derrick J Morton, Xiao-Qian Wang, Jaideep Chaudhar. Relative Stability of Wild-Type and Mutant p53 Core Domain: A Molecular Dynamic Study. Journal of computational biology : a journal of computational molecular cell biology. vol 23. issue 2. 2019-11-20. PMID:26675082. |
a tumor suppressor p53 binds to a specific dna sequence and transactivates target genes, leading to cell cycle apoptosis. |
2019-11-20 |
2023-08-13 |
human |
| Dong-Mei Wu, Shan Wang, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Shao-Hua Fan, Zi-Feng Zhang, Qun Shan, Jun Lu, Yuan-Lin Zhen. MircoRNA-1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1. Journal of cellular and molecular medicine. vol 22. issue 10. 2019-11-19. PMID:30024092. |
up-regulation of mir-1275 activated p53 signalling pathway via regulating serpine1 and therefore suppressed glioma cell proliferation, invasion and migration, whereas promoted cell apoptosis. |
2019-11-19 |
2023-08-13 |
Not clear |
| Eleonora Zorzan, Ramy Elgendy, Mery Giantin, Mauro Dacasto, Claudia Siss. Whole-Transcriptome Profiling of Canine and Human in Vitro Models Exposed to a G-Quadruplex Binding Small Molecule. Scientific reports. vol 8. issue 1. 2019-11-18. PMID:30459395. |
in both cell lines, major pathways such as cell cycle progression, kit- and myc-related pathways were negatively enriched in the aq1-treated group, while other pathways such as p53, apoptosis and hypoxia-related were positively enriched. |
2019-11-18 |
2023-08-13 |
human |
| Mannu K Walia, Scott Taylor, Patricia W M Ho, T John Martin, Carl R Walkle. Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53. Cell death & disease. vol 9. issue 9. 2019-11-15. PMID:30154459. |
normal osteoblasts (p53 wt) rapidly underwent apoptosis in response to acute elevation of camp levels or activity, whereas p53-deficient osteoblasts tolerated this aberrant camp/creb level and activity. |
2019-11-15 |
2023-08-13 |
Not clear |
| Jingfei Chen, Juchang Zhong, Yeying Liu, Yuan Huang, Fei Luo, Yingjun Zhou, Xi Pan, Shousong Cao, Lingling Zhang, Yingjie Zhang, Jiangang Wan. Purified vitexin compound 1, a new neolignan isolated compound, promotes PUMA-dependent apoptosis in colorectal cancer. Cancer medicine. vol 7. issue 12. 2019-11-14. PMID:30402948. |
here, we demonstrated that vb1 promoted apoptosis via p53-dependent induction of p53 upregulated modulator of apoptosis (puma) and further to induce bax (bcl-2-associated x protein) activation and mitochondrial dysfunction in colon cancer hct-116 and lovo cells. |
2019-11-14 |
2023-08-13 |
Not clear |
| Jingfei Chen, Juchang Zhong, Yeying Liu, Yuan Huang, Fei Luo, Yingjun Zhou, Xi Pan, Shousong Cao, Lingling Zhang, Yingjie Zhang, Jiangang Wan. Purified vitexin compound 1, a new neolignan isolated compound, promotes PUMA-dependent apoptosis in colorectal cancer. Cancer medicine. vol 7. issue 12. 2019-11-14. PMID:30402948. |
deficiency in p53, puma, or bax abrogated vb1-induced apoptosis and promoted cell survival in hct-116 cells. |
2019-11-14 |
2023-08-13 |
Not clear |
| Silvia Zecchini, Francesca Proietti Serafini, Elisabetta Catalani, Matteo Giovarelli, Marco Coazzoli, Ilaria Di Renzo, Clara De Palma, Cristiana Perrotta, Emilio Clementi, Federico Buonanno, Claudio Ortenzi, Enrico Marcantoni, Anna Rita Taddei, Simona Picchietti, Anna Maria Fausto, Davide Cervi. Dysfunctional autophagy induced by the pro-apoptotic natural compound climacostol in tumour cells. Cell death & disease. vol 10. issue 1. 2019-11-14. PMID:30584259. |
since the activation of p53 system is at the molecular crossroad regulating both the anti-autophagic action of climacostol and its role in the apoptosis induction, it might be important to explore the dual targeting of autophagy and apoptosis with agents acting on p53 for the selective killing of tumours. |
2019-11-14 |
2023-08-13 |
mouse |
| Kaitlyn Beyfuss, Avigail T Erlich, Matthew Triolo, David A Hoo. The Role of p53 in Determining Mitochondrial Adaptations to Endurance Training in Skeletal Muscle. Scientific reports. vol 8. issue 1. 2019-11-13. PMID:30279494. |
our results confirm that p53 is important for regulating mitochondrial content and function, as well as proteins within the autophagy and apoptosis pathways. |
2019-11-13 |
2023-08-13 |
mouse |
| Ziyi Wang, Kai Yang, Qiuyu Zheng, Chenting Zhang, Haiyang Tang, Aleksandra Babicheva, Qian Jiang, Meichan Li, Yuqin Chen, Shane G Carr, Kang Wu, Qian Zhang, Angela Balistrieri, Christina Wang, Shanshan Song, Ramon J Ayon, Ankit A Desai, Stephen M Black, Joe G N Garcia, Ayako Makino, Jason X-J Yuan, Wenju Lu, Jian Wan. Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension. American journal of physiology. Lung cellular and molecular physiology. vol 316. issue 1. 2019-11-12. PMID:30358436. |
the tumor-suppressive role of p53, a transcription factor that regulates the expression of many genes, has been linked to cell cycle arrest, apoptosis, and senescence. |
2019-11-12 |
2023-08-13 |
Not clear |
| Emilie Lukášová, Martina Řezáčová, Alena Bačíková, Ludmila Šebejová, Jiřina Vávrová, Stanislav Kozube. Distinct cellular responses to replication stress leading to apoptosis or senescence. FEBS open bio. vol 9. issue 5. 2019-11-12. PMID:30982228. |
in contrast, a lymphoid cancer cell line wsu-nhl (wt-p53) lacking la/c and expressing low levels of lb1 died after several hours, while lines mec-1 and su-dhl-4, both with mutated p53, and su-dhl-4 with mutations in la/c, died at different rates by apoptosis. |
2019-11-12 |
2023-08-13 |
Not clear |
| Emilie Lukášová, Martina Řezáčová, Alena Bačíková, Ludmila Šebejová, Jiřina Vávrová, Stanislav Kozube. Distinct cellular responses to replication stress leading to apoptosis or senescence. FEBS open bio. vol 9. issue 5. 2019-11-12. PMID:30982228. |
our results show that, in addition to being influenced by p53 mutation status, the response to rs (apoptosis or senescence) may also be influenced by lamin a/c and lb1 status. |
2019-11-12 |
2023-08-13 |
Not clear |