| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miguel Chenlo, Iria A Rodriguez-Gomez, Ramon Serramito, Angela R Garcia-Rendueles, Rocío Villar-Taibo, Eva Fernandez-Rodriguez, Sihara Perez-Romero, Maria Suarez-Fariña, Alfredo Garcia-Allut, Jose M Cabezas-Agricola, Javier Rodriguez-Garcia, Pamela V Lear, Rosa M Alvarez-San Martin, Cristina Alvarez-Escola, Ignacio Bernabeu, Clara V Alvare. Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly. EBioMedicine. vol 43. 2019-11-25. PMID:30975543. |
the ret/pit1/p14arf/p53 pathway regulates apoptosis in normal pituitary somatotrophs whereas the ret/gdnf pathway regulates survival, controlling pit1 levels and blocking p14arf (arf) and p53 expression. |
2019-11-25 |
2023-08-13 |
rat |
| Ashfaq Ur Rehman, Mueed Ur Rahman, Taaha Arshad, Hai-Feng Che. Allosteric Modulation of Intrinsically Disordered Proteins. Advances in experimental medicine and biology. vol 1163. 2019-11-21. PMID:31707710. |
the similar mechanism has been implemented on adenovirus 5 early region 1a and tumor apoptosis protein p53 in correspondence with other partners in binary and ternary complexes, which are the subject of the current review. |
2019-11-21 |
2023-08-13 |
human |
| Buttyan, Shabsigh, Perlman, Colombe. Regulation of Apoptosis in the Prostate Gland by Androgenic Steroids. Trends in endocrinology and metabolism: TEM. vol 10. issue 2. 2019-11-20. PMID:10322394. |
there is now evidence for a critical cell signaling pathway, regulated by c-fos expression, necessary for castration-induced apoptosis, as well as evidence that this signaling initiates an abrupt and transient alteration in the synthesis of fas antigen, p53, bax and bcl-2 proteins in the androgen receptor-expressing prostate epithelial cells, the cellular compartment that appears to be the most affected by castration. |
2019-11-20 |
2023-08-12 |
Not clear |
| Miku. Pathology of prostate cancer. Old problems and new facts. Advances in clinical pathology : the official journal of Adriatic Society of Pathology. vol 1. issue 1. 2019-11-20. PMID:10352466. |
the value of novel methods (p53, bcl-2, apoptosis, microvessel density, interphase cytogenetics, androgen receptor mutation, neuroendocrine cells, e-cadherin) remains to be proved. |
2019-11-20 |
2023-08-12 |
human |
| Kataoka, Tsuru. Physician Education: Apoptosis. The oncologist. vol 1. issue 6. 2019-11-20. PMID:10388021. |
the tumor suppressor gene p53 plays a very important role in apoptosis induced by damage to dna. |
2019-11-20 |
2023-08-12 |
mouse |
| Kataoka, Tsuru. Physician Education: Apoptosis. The oncologist. vol 1. issue 6. 2019-11-20. PMID:10388021. |
this has been demonstrated by studying resistance to apoptosis of cells derived from p53 knockout mice [2]. |
2019-11-20 |
2023-08-12 |
mouse |
| Hal. p53: The Challenge of Linking Basic Science and Patient Management. The oncologist. vol 3. issue 4. 2019-11-20. PMID:10388108. |
loss of p53 function is associated with loss of normal cell cycle control, diminished apoptosis, and genomic instability and is strongly associated with the neoplastic phenotype. |
2019-11-20 |
2023-08-12 |
human |
| Amsterdam, Gold, Hosokawa, Yoshida, Sasson, Jung, Kotsuj. Crosstalk Among Multiple Signaling Pathways Controlling Ovarian Cell Death. Trends in endocrinology and metabolism: TEM. vol 10. issue 7. 2019-11-20. PMID:10461171. |
moreover, crosstalk between p53 and extracellular matrix components such as laminin, fibronectin and basic fibroblast growth factor, between camp- and p53-generated signals and between steroid hormones and bcl-2, can explain some of the fine tuning that controls ovarian steroidogenesis and apoptosis. |
2019-11-20 |
2023-08-12 |
human |
| Yin, Tamaki, Kokunai, Yasuo, Yonezaw. Bromocriptine-induced apoptosis in pituitary adenoma cells: relationship to p53 and bcl-2 expression. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 6. issue 4. 2019-11-20. PMID:10844757. |
bromocriptine-induced apoptosis in pituitary adenoma cells: relationship to p53 and bcl-2 expression. |
2019-11-20 |
2023-08-12 |
Not clear |
| Yin, Tamaki, Kokunai, Yasuo, Yonezaw. Bromocriptine-induced apoptosis in pituitary adenoma cells: relationship to p53 and bcl-2 expression. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 6. issue 4. 2019-11-20. PMID:10844757. |
decreased expression of bcl-2 and accumulation of wild-type p53 were associated with bromocriptine induced apoptosis in pituitary adenoma cells. |
2019-11-20 |
2023-08-12 |
Not clear |
| Yin, Tamaki, Kokunai, Yasuo, Yonezaw. Bromocriptine-induced apoptosis in pituitary adenoma cells: relationship to p53 and bcl-2 expression. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 6. issue 4. 2019-11-20. PMID:10844757. |
these findings show that bromocriptine activated wild-type p53 and suppressed bcl-2 favouring occurrence of apoptosis in pituitary adenoma cells. |
2019-11-20 |
2023-08-12 |
Not clear |
| Seftel, Maclennan, Chen, Liu, Ferguson, Deoreo, Levine, Hampel, Ho-Chan. Loss of TGFbeta, Apoptosis, and Bcl-2 in Erectile Dysfunction and Upregulation of p53 and HIF-1alpha in Diabetes-Associated Erectile Dysfunction. Molecular urology. vol 3. issue 2. 2019-11-20. PMID:10851311. |
loss of tgfbeta, apoptosis, and bcl-2 in erectile dysfunction and upregulation of p53 and hif-1alpha in diabetes-associated erectile dysfunction. |
2019-11-20 |
2023-08-12 |
human |
| Wu, Li. Deltamethrin induces delayed apoptosis and altered expression of p53 and bax in rat brain. Environmental toxicology and pharmacology. vol 8. issue 3. 2019-11-20. PMID:10925071. |
deltamethrin induces delayed apoptosis and altered expression of p53 and bax in rat brain. |
2019-11-20 |
2023-08-12 |
rat |
| Wu, Li. Deltamethrin induces delayed apoptosis and altered expression of p53 and bax in rat brain. Environmental toxicology and pharmacology. vol 8. issue 3. 2019-11-20. PMID:10925071. |
to determine whether molecular characteristics of apoptosis is involved in neurodegeneration in rat brain after deltamethrin treatment, we investigated the effects of deltamethrin on the mrna expression of p53 and bax and their correlation with deltamethrin-induced apoptotic cell death in rat brain. |
2019-11-20 |
2023-08-12 |
rat |
| Wu, Li. Deltamethrin induces delayed apoptosis and altered expression of p53 and bax in rat brain. Environmental toxicology and pharmacology. vol 8. issue 3. 2019-11-20. PMID:10925071. |
these results indicate that (1) deltamethrin induces delayed apoptotic cell death, which may play an important role in deltamethrin-elicited neurodegeneration; (2) deltamethrin leads to the persistent increase of p53 and bax mrna levels, which may contribute to delayed apoptosis in rat brain following deltamethrin treatment. |
2019-11-20 |
2023-08-12 |
rat |
| A F. Olumi, N Weidner, J C. Prest. p53 immunoreactivity correlates with Ki-67 and bcl-2 expression in renal cell carcinoma. Urologic oncology. vol 6. issue 2. 2019-11-20. PMID:11166623. |
this study assessed the relation of proliferation, inhibition of apoptosis, and the p53 tumor suppressor protein expression in clear renal cell carcinoma (rcc). |
2019-11-20 |
2023-08-12 |
Not clear |
| A F. Olumi, N Weidner, J C. Prest. p53 immunoreactivity correlates with Ki-67 and bcl-2 expression in renal cell carcinoma. Urologic oncology. vol 6. issue 2. 2019-11-20. PMID:11166623. |
immunostaining of paraffin tissue sections was carried out for four different markers: a) ki-67, a marker for cellular proliferation; b) p53/do7, c) p53/pab240, antibodies for the p53 protein; and d) bcl-2, a marker for inhibition of apoptosis (programmed cell death). |
2019-11-20 |
2023-08-12 |
Not clear |
| K. Mujoo, L. Zhang, J. Klostergaard, N. J. Donat. Emergence of cisplatin-resistant cells from the OVCAR-3 ovarian carcinoma cell line with p53 mutations, altered tumorigenicity, and increased apoptotic sensitivity to p53 gene replacement. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 10. issue 2. 2019-11-20. PMID:11240661. |
c-1 cells had a p53 gene mutation (codon 266) that was not detected in the parental ovcar-3 cell line, and infection of c-1 cells with p53-adenovirus (rad-p53) caused greater apoptosis and gene transduction than that observed in the similarly infected parental population. |
2019-11-20 |
2023-08-12 |
mouse |
| V. E. Von Gruenigen, J. D. O'Boyle, R. L. Coleman, D. Wilson, D. S. Miller, J. M. Mathi. Efficacy of intraperitoneal adenovirus-mediated p53 gene therapy in ovarian cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 9. issue 5. 2019-11-20. PMID:11240795. |
adenovirus-mediated introduction of the wild-type p53 gene in the ovarian cancer cell line resulted in transient high levels of p53 protein for 24-48 h. cell cycle analysis revealed g1 arrest, as well as the appearance of apoptosis. |
2019-11-20 |
2023-08-12 |
mouse |
| Kalliopi P. Siziopikou, Stuart J. Schnit. MIB-1 Proliferation Index in Ductal Carcinoma In Situ of the Breast: Relationship to the Expression of the Apoptosis-Regulating Proteins bcl-2 and p53. The breast journal. vol 6. issue 6. 2019-11-20. PMID:11348399. |
in contrast, 14 cases showed "aberrant" combinations of bcl-2 and p53 expression suggesting dysregulated control of apoptosis. |
2019-11-20 |
2023-08-12 |
Not clear |