| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yaoting Sun, Wei Liu, Changyuan Wang, Qiang Meng, Zhihao Liu, Xiaokui Huo, Xiaobo Yang, Pengyuan Sun, Huijun Sun, Xiaodong Ma, Jinyong Peng, Kexin Li. Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein. Journal of cellular physiology. vol 234. issue 4. 2020-03-16. PMID:30171603. |
finally, the combination of dmy, ond, and adr led to g2/m cell cycle arrest and apoptosis via resuming p53 function and restraining relevant proteins expression. |
2020-03-16 |
2023-08-13 |
Not clear |
| Yoshifumi Okawa, Atsushi Hoshino, Makoto Ariyoshi, Satoshi Kaimoto, Shuhei Tateishi, Kazunori Ono, Motoki Uchihashi, Eri Iwai-Kanai, Satoaki Matob. Ablation of cardiac TIGAR preserves myocardial energetics and cardiac function in the pressure overload heart failure model. American journal of physiology. Heart and circulatory physiology. vol 316. issue 6. 2020-03-16. PMID:30901275. |
tumor suppressor p53 (tp53) and its downstream target tp53-induced glycolysis and apoptosis regulator (tigar) are known to modulate cardiac metabolism and cell fate. |
2020-03-16 |
2023-08-13 |
Not clear |
| Toshiaki Tanaka, Yasukazu Hozumi, Alberto M Martelli, Mitsuyoshi Iino, Kaoru Got. Nucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53 acetylation to regulate cell fate. Biochimica et biophysica acta. Molecular cell research. vol 1866. issue 12. 2020-03-16. PMID:31634504. |
upon genotoxic stress, p53 induces target genes regulating cell cycle arrest for survival or apoptosis. |
2020-03-16 |
2023-08-13 |
Not clear |
| Youliang Wen, Yueming Gu, Xiaodong Tang, Ziwei H. PINK1 overexpression protects against cerebral ischemia through Parkin regulation. Environmental toxicology. vol 35. issue 2. 2020-03-16. PMID:31654556. |
pink1 overexpression mice after i/r injury significantly reduced apoptosis through downregulation of cytochrome c, p53 expressions compared to cerebral i/r injury rats. |
2020-03-16 |
2023-08-13 |
mouse |
| Jennifer Hüllein, Mikołaj Słabicki, Maciej Rosolowski, Alexander Jethwa, Stefan Habringer, Katarzyna Tomska, Roma Kurilov, Junyan Lu, Sebastian Scheinost, Rabea Wagener, Zhiqin Huang, Marina Lukas, Olena Yavorska, Hanne Helfrich, René Scholtysik, Kyle Bonneau, Donato Tedesco, Ralf Küppers, Wolfram Klapper, Christiane Pott, Stephan Stilgenbauer, Birgit Burkhardt, Markus Löffler, Lorenz H Trümper, Michael Hummel, Benedikt Brors, Marc Zapatka, Reiner Siebert, Markus Kreuz, Ulrich Keller, Wolfgang Huber, Thorsten Zen. MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma. Cancer research. vol 79. issue 12. 2020-03-11. PMID:31000522. |
oncogenic myc activation promotes proliferation in burkitt lymphoma, but also induces cell-cycle arrest and apoptosis mediated by p53, a tumor suppressor that is mutated in 40% of burkitt lymphoma cases. |
2020-03-11 |
2023-08-13 |
Not clear |
| V Brychtová, V Hrabal, B Vojtěše. Oncogenic Viral Protein Interactions with p53 Family Proteins. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. vol 32. issue Supplementum 3. 2020-03-11. PMID:31627709. |
viral proteins functionally inactivate p53 and deregulate the expression of proteins active during apoptosis, cell proliferation and dna damage response. |
2020-03-11 |
2023-08-13 |
human |
| Lan Wen, Lei Liu, Jinfang Li, Linyan Tong, Keming Zhang, Qinbin Zhang, Changqing L. NDRG4 protects against cerebral ischemia injury by inhibiting p53-mediated apoptosis. Brain research bulletin. vol 146. 2020-03-10. PMID:30593880. |
furthermore, ndrg4 could interact with p53, inhibiting its expression and blocking p53-mediated mitochondrial apoptosis signaling. |
2020-03-10 |
2023-08-13 |
Not clear |
| Cheng-Wei Li, Tzu-Ying Lai, Bor-Sen Che. Changes of signal transductivity and robustness of gene regulatory network in the carcinogenesis of leukemic subtypes via microarray sample data. Oncotarget. vol 9. issue 34. 2020-03-09. PMID:29805763. |
epigenetic regulation of erk and genetic mutation of p53 could lead to the repressed apoptosis, cell cycle arrest and dna repair in leukemic cells. |
2020-03-09 |
2023-08-13 |
Not clear |
| Fernando M Simabuco, Mirian G Morale, Isadora C B Pavan, Ana P Morelli, Fernando R Silva, Rodrigo E Tamur. p53 and metabolism: from mechanism to therapeutics. Oncotarget. vol 9. issue 34. 2020-03-09. PMID:29805774. |
conversely, induction of p53 expression may regulate differently the tumor cell metabolism, inducing senescence, autophagy and apoptosis, which are dependent on the regulation of the pi3k/akt/mtor pathway and/or ros induction. |
2020-03-09 |
2023-08-13 |
Not clear |
| Takahiro Fukazawa, Keiji Tanimoto, Looniva Shrestha, Takeshi Imura, Shinya Takahashi, Taijiro Sueda, Nobuyuki Hirohashi, Eiso Hiyama, Louis Yug. Simulated microgravity enhances CDDP-induced apoptosis signal via p53-independent mechanisms in cancer cells. PloS one. vol 14. issue 7. 2020-03-09. PMID:31323026. |
we reasoned that signaling regulated by p53 may be involved because of its role in apoptosis. |
2020-03-09 |
2023-08-13 |
human |
| Samah R Khalil, Sabry M Abdel-Motal, Mohamed Abd-Elsalam, Noura E Abd El-Hameed, Ashraf Awa. Restoring strategy of ethanolic extract of Moringa oleifera leaves against Tilmicosin-induced cardiac injury in rats: Targeting cell apoptosis-mediated pathways. Gene. vol 730. 2020-03-09. PMID:31812513. |
the co-administration of mo ethanolic extract with til considerably modulates the expression of apoptosis pathway-encoding genes (bcl-2, caspase-3, bax, p53, apoptosis-inducing factor, and apaf-1), particularly in the high-dose group. |
2020-03-09 |
2023-08-13 |
rat |
| Weijie Zhong, Xin Xu, Zhigang Zhu, Li Yang, Hong Du, Zhongjun Xia, Zhaohu Yuan, Huabao Xiong, Qinghua Du, Yaming Wei, Qingshan L. Increased interleukin-17A levels promote rituximab resistance by suppressing p53 expression and predict an unfavorable prognosis in patients with diffuse large B cell lymphoma. International journal of oncology. vol 52. issue 5. 2020-03-06. PMID:29512700. |
we then examined the effects of il-17a on the apoptosis and proliferation of, and p53 expression in dlbcl cells, and found that il-17a prevented rituximab-induced apoptosis and promoted the proliferation of dlbcl cells by suppressing p53 expression in vitro. |
2020-03-06 |
2023-08-13 |
Not clear |
| Weijie Zhong, Xin Xu, Zhigang Zhu, Li Yang, Hong Du, Zhongjun Xia, Zhaohu Yuan, Huabao Xiong, Qinghua Du, Yaming Wei, Qingshan L. Increased interleukin-17A levels promote rituximab resistance by suppressing p53 expression and predict an unfavorable prognosis in patients with diffuse large B cell lymphoma. International journal of oncology. vol 52. issue 5. 2020-03-06. PMID:29512700. |
on the whole, our data indicate that rituximab promotes th17 and il-17+foxp3+ treg cells to secrete il-17a, which in turn promotes rituximab resistance, partially by suppressing p53 expression and inhibiting rituximab-induced dlbcl cell apoptosis. |
2020-03-06 |
2023-08-13 |
Not clear |
| Parvaneh Mehrbod, Sudharsana R Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K M Glover, Affan A Sher, Kevin M Coombs, Saeid Ghavam. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections. Virulence. vol 10. issue 1. 2020-03-05. PMID:30966844. |
abbreviation: aids: acquired immunodeficiency syndrome; atf6: activating transcription factor 6; atg6: autophagy-specific gene 6; bag3: bcl associated athanogene 3; bak: bcl-2-anatagonist/killer1; bax; bcl-2: associated x protein; bcl-2: b cell lymphoma 2x; bip: chaperon immunoglobulin heavy chain binding protein; card: caspase recruitment domain; cart: combination antiretroviral therapy; ccr5: c-c chemokine receptor type 5; cd4: cluster of differentiation 4; chop: c/ebp homologous protein; cxcr4: c-x-c chemokine receptor type 4; cyto c: cytochrome c; dcs: dendritic cells; edem1: er-degradation enhancing-a-mannosidase-like protein 1; env: envelope; er: endoplasmic reticulum; fasr: fas receptor;g2: gap 2; g2/m: gap2/mitosis; gfap: glial fibrillary acidic protein; gp120: glycoprotein120; gp41: glycoprotein41; hand: hiv associated neurodegenerative disease; hek: human embryonic kidney; hela: human cervical epithelial carcinoma; hiv: human immunodeficiency virus; ips-1: ifn-β promoter stimulator 1; ire-1: inositol requiring enzyme 1; irgm: immunity related gtpase family m protein; lamp2a: lysosome associated membrane protein 2a; lc3: microtubule associated light chain 3; mda5: melanoma differentiation associated gene 5; mef: mouse embryonic fibroblast; mmp: mitochondrial membrane permeabilization; nef: negative regulatory factor; oasis: old astrocyte specifically induced substrate; pamp: pathogen-associated molecular pattern; perk: pancreatic endoplasmic reticulum kinase; prr: pattern recognition receptor; puma: p53 upregulated modulator of apoptosis; rig-i: retinoic acid-inducible gene-i; tat: transactivator protein of hiv; tlr: toll-like receptor; ulk1: unc51 like autophagy activating kinase 1; upr: unfolded protein response; vpr: viral protein regulatory; xbp1: x-box binding protein 1. |
2020-03-05 |
2023-08-13 |
mouse |
| Erin L Britt, Sarina Raman, Kendall Leek, Casey H Sheehy, Sung W Kim, Hisashi Harad. Combination of fenretinide and ABT-263 induces apoptosis through NOXA for head and neck squamous cell carcinoma treatment. PloS one. vol 14. issue 7. 2020-03-03. PMID:31276572. |
here, we demonstrated that combination of ectopic noxa expression and abt-263 enhanced apoptosis in p53-inactive, p53 wild-type, and human papillomavirus (hpv)-positive hnscc cell lines. |
2020-03-03 |
2023-08-13 |
human |
| Erin L Britt, Sarina Raman, Kendall Leek, Casey H Sheehy, Sung W Kim, Hisashi Harad. Combination of fenretinide and ABT-263 induces apoptosis through NOXA for head and neck squamous cell carcinoma treatment. PloS one. vol 14. issue 7. 2020-03-03. PMID:31276572. |
furthermore, a retinoid derivative and an endoplasmic reticulum stress inducer, fenretinide, induced noxa, and combination of fenretinide and abt-263 strongly induced apoptosis in hnscc cells regardless of the hpv or p53 statuses. |
2020-03-03 |
2023-08-13 |
human |
| Chengguo Su, Yuzhou Chen, Yunfei Chen, Yin Zhou, Lianbo Li, Qunwen Lu, Huahui Liu, Xiaochao Luo, Jun Zh. Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats. Molecular medicine reports. vol 20. issue 5. 2020-03-03. PMID:31545441. |
effect of electroacupuncture at the st36 and gb39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats. |
2020-03-03 |
2023-08-13 |
mouse |
| Chengguo Su, Yuzhou Chen, Yunfei Chen, Yin Zhou, Lianbo Li, Qunwen Lu, Huahui Liu, Xiaochao Luo, Jun Zh. Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats. Molecular medicine reports. vol 20. issue 5. 2020-03-03. PMID:31545441. |
p53 and mouse double minute 2 homolog (mdm2) serve key regulatory roles in the apoptosis of synovial cells. |
2020-03-03 |
2023-08-13 |
mouse |
| Chengguo Su, Yuzhou Chen, Yunfei Chen, Yin Zhou, Lianbo Li, Qunwen Lu, Huahui Liu, Xiaochao Luo, Jun Zh. Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats. Molecular medicine reports. vol 20. issue 5. 2020-03-03. PMID:31545441. |
in addition, the expression levels of the apoptosis‑associated proteins, bax, phorbol‑12‑myristate‑13‑acetate‑induced protein 1 (noxa) and p53 upregulated modulator of apoptosis (puma), were determined by western blot analysis. |
2020-03-03 |
2023-08-13 |
mouse |
| Chengguo Su, Yuzhou Chen, Yunfei Chen, Yin Zhou, Lianbo Li, Qunwen Lu, Huahui Liu, Xiaochao Luo, Jun Zh. Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats. Molecular medicine reports. vol 20. issue 5. 2020-03-03. PMID:31545441. |
taken together, these results demonstrated that ea performed on the st36 and gb39 acupoints led to a significant amelioration in aa injury of model rats, by regulating the p53 signaling pathway and inducing apoptosis. |
2020-03-03 |
2023-08-13 |
mouse |