| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen-Chen Ren, Li Yang, Ling Liu, Yan-Nan Chen, Guo-Mei Cheng, Xiao-An Zhang, Hui Li. Effects of shRNA-mediated silencing of PSMA7 on cell proliferation and vascular endothelial growth factor expression via the ubiquitin-proteasome pathway in cervical cancer. Journal of cellular physiology. vol 234. issue 5. 2020-03-30. PMID:29247526. |
compared with the blank and nc groups, the psma7-shrna1 and psma7-shrna2 groups all had decreased expression levels of psma7, ubiquitin, p53, and vegf as well as decreased cell proliferation, 20s proteasomes activity, and cell number in the s phase, increased p27 expression, cell apoptosis and cell number in the g0/g1 phase. |
2020-03-30 |
2023-08-13 |
human |
| Seo-Hyun Choi, Dong-In Koh, Su-Yeon Cho, Min-Kyeong Kim, Kyung-Sup Kim, Man-Wook Hu. Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis. The Journal of biological chemistry. vol 294. issue 35. 2020-03-30. PMID:31296660. |
temporal and differential regulation of kaiso-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis. |
2020-03-30 |
2023-08-13 |
Not clear |
| Seo-Hyun Choi, Dong-In Koh, Su-Yeon Cho, Min-Kyeong Kim, Kyung-Sup Kim, Man-Wook Hu. Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis. The Journal of biological chemistry. vol 294. issue 35. 2020-03-30. PMID:31296660. |
transcriptional regulator kaiso plays a critical role in cell cycle arrest and apoptosis through modulation of p53 acetylation by histone acetyltransferase p300. |
2020-03-30 |
2023-08-13 |
Not clear |
| Seo-Hyun Choi, Dong-In Koh, Su-Yeon Cho, Min-Kyeong Kim, Kyung-Sup Kim, Man-Wook Hu. Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis. The Journal of biological chemistry. vol 294. issue 35. 2020-03-30. PMID:31296660. |
kaiso potently stimulates apoptosis in cells expressing wt p53, but not in p53-mutant or p53-null cells. |
2020-03-30 |
2023-08-13 |
Not clear |
| Keyi Li, Mengqiu Huang, Pengfei Xu, Meng Wang, Shuangyan Ye, Qianli Wang, Sisi Zeng, Xi Chen, Wenwen Gao, Jianping Chen, Qianbing Zhang, Zhuo Zhong, Yang Sun, Qiuzhen Li. Microcystins-LR induced apoptosis via S-nitrosylation of GAPDH in colorectal cancer cells. Ecotoxicology and environmental safety. vol 190. 2020-03-27. PMID:31901813. |
chip assay showed that the nuclear gadph increased p53 transcript of a panner of apoptosis related genes. |
2020-03-27 |
2023-08-13 |
human |
| Chengyuan Tang, Zhengwei Ma, Jiefu Zhu, Zhiwen Liu, Yuxue Liu, Yu Liu, Juan Cai, Zheng Don. P53 in kidney injury and repair: Mechanism and therapeutic potentials. Pharmacology & therapeutics. vol 195. 2020-03-25. PMID:30347214. |
p53, a well-known tumor suppressor, plays a critical role in aki and subsequent kidney repair through the regulation of various cell biologic processes, including apoptosis, cell cycle arrest, and autophagy. |
2020-03-25 |
2023-08-13 |
Not clear |
| Suresh K Verma, Kumari Nisha, Pritam Kumar Panda, Paritosh Patel, Puja Kumari, M A Mallick, Biplab Sarkar, Biswadeep Da. Green synthesized MgO nanoparticles infer biocompatibility by reducing in vivo molecular nanotoxicity in embryonic zebrafish through arginine interaction elicited apoptosis. The Science of the total environment. vol 713. 2020-03-24. PMID:31951838. |
molecular toxicity investigation revealed that the toxic effects of mgo np was mainly due to the influential dysregulation in oxidative stress leading to apoptosis because of the accumulation and internalization of nanoparticles and their interaction with cellular proteins like sod1 and p53, thereby affecting structural integrity and functionality. |
2020-03-24 |
2023-08-13 |
human |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasiri, Jie Zhen. Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch. Journal of theoretical biology. vol 462. 2020-03-23. PMID:30439375. |
the activation of apoptosis by p53 involves the intrinsic apoptotic pathway to eliminate stressed cells that contain dna lesions. |
2020-03-23 |
2023-08-13 |
Not clear |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasiri, Jie Zhen. Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch. Journal of theoretical biology. vol 462. 2020-03-23. PMID:30439375. |
we focus on modelling the mechanism of p53 activation of apoptosis in response to sustained high dna double-strand breaks. |
2020-03-23 |
2023-08-13 |
Not clear |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasiri, Jie Zhen. Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch. Journal of theoretical biology. vol 462. 2020-03-23. PMID:30439375. |
building on previous models (chong et al., 2015; zhang et al., 2009a), we developed a mathematical model that incorporated the molecular interactions in the core regulation of p53 and the apoptosis initiation module involving puma, bcl2 and bax. |
2020-03-23 |
2023-08-13 |
Not clear |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasiri, Jie Zhen. Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch. Journal of theoretical biology. vol 462. 2020-03-23. PMID:30439375. |
(2013) suggested that one of the components in the p53 pathway may control a threshold activation of apoptosis. |
2020-03-23 |
2023-08-13 |
Not clear |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasiri, Jie Zhen. Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch. Journal of theoretical biology. vol 462. 2020-03-23. PMID:30439375. |
we hypothesized that atm auto-activation is the component that controls p53 threshold activation of apoptosis with atm's multi-site autophosphorylation depending on damage intensity. |
2020-03-23 |
2023-08-13 |
Not clear |
| Yu Wang, Jing Nan Wang, Xue Zhun Chen, Qi Xing Hu, Qi Qing Liu, Gang W. Heat stress-induced expression of Bulletin of entomological research. vol 110. issue 2. 2020-03-23. PMID:31559929. |
heat stress-induced expression of p53, dna damage regulated gene (pdrg) and apoptosis-stimulating p53 protein 2 (aspp2) are p53-related genes which can promote apoptosis. |
2020-03-23 |
2023-08-13 |
Not clear |
| Lu Gan, Menghuan Guo, Jing Si, Jinhua Zhang, Zhiyuan Liu, Jin Zhao, Fang Wang, Junfang Yan, Hongyan Li, Hong Zhan. Protective effects of phenformin on zebrafish embryonic neurodevelopmental toxicity induced by X-ray radiation. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2020-03-23. PMID:31713449. |
in addition, expression levels of multiple genes related to neural development and apoptosis (sod2, bdnf, ache, p53, bax, and bcl-2) were compared by rt-pcr and associated protein expression levels by western blotting. |
2020-03-23 |
2023-08-13 |
cat |
| Meng Wang, Xin Wang, Yuan Li, Qiang Xiao, Xiao-Hai Cui, Guo-Dong Xiao, Ji-Chang Wang, Chong-Wen Xu, Hong Ren, Dapeng Li. Nutlin-3-Induced Sensitization of Non-Small Cell Lung Cancer Stem Cells to Axitinib-Induced Apoptosis Through Repression of Akt1/Wnt Signaling. Oncology research. vol 27. issue 9. 2020-03-20. PMID:30832755. |
nutlin-3 induction of p53 expression was used to test its role in controlling the cell division pattern and apoptosis of nsclc cells. |
2020-03-20 |
2023-08-13 |
Not clear |
| Meng Wang, Xin Wang, Yuan Li, Qiang Xiao, Xiao-Hai Cui, Guo-Dong Xiao, Ji-Chang Wang, Chong-Wen Xu, Hong Ren, Dapeng Li. Nutlin-3-Induced Sensitization of Non-Small Cell Lung Cancer Stem Cells to Axitinib-Induced Apoptosis Through Repression of Akt1/Wnt Signaling. Oncology research. vol 27. issue 9. 2020-03-20. PMID:30832755. |
increased p53 expression stimulated the induction of apoptosis by axitinib and promoted asymmetric cell division (acd) of nsclc cscs. |
2020-03-20 |
2023-08-13 |
Not clear |
| Souvik Roy, Anweshan Sil, Tania Chakrabort. Potentiating apoptosis and modulation of p53, Bcl2, and Bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30246261. |
potentiating apoptosis and modulation of p53, bcl2, and bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer. |
2020-03-18 |
2023-08-13 |
human |
| Zhi Zhao, Jian-Zhong Guan, Min Wu, Gui-Hua Lai, Zhong-Lian Zh. Downregulation of microRNA-23b protects against ischemia-reperfusion injury via p53 signaling pathway by upregulating MDM4 in rats. Journal of cellular biochemistry. vol 120. issue 3. 2020-03-18. PMID:30537038. |
our results indicate that silencing mir-23b could act to attenuate iri and reduce the apoptosis of articular chondrocytes through inactivation of the p53 signaling pathway by upregulating mdm4, which provide basic therapeutic considerations for a novel target against iri. |
2020-03-18 |
2023-08-13 |
rat |
| Fei-Fei Feng, Peng Cheng, Chao Sun, Hui Wang, Wei Wan. Inhibitory effects of polyphyllins I and VII on human cisplatin-resistant NSCLC via p53 upregulation and CIP2A/AKT/mTOR signaling axis inhibition. Chinese journal of natural medicines. vol 17. issue 10. 2020-03-18. PMID:31703757. |
further examination of the mechanism revealed that the ppi and ppvii significantly upregulated the p53, induced caspase-dependent apoptosis and suppressed the cip2a/akt/mtor pathway. |
2020-03-18 |
2023-08-13 |
human |
| Enze Li, Yi Sun, Guixiang Lv, Yongning Li, Zhiguo Zhang, Zheng Hu, Wenwu Ca. Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis. The international journal of biochemistry & cell biology. vol 113. 2020-03-17. PMID:30660690. |
the increased ros production up-regulated the expression of p53 and bax, and down-regulated bcl-2 expression, which led to the activation of caspase-3, ultimately initiated cell apoptosis. |
2020-03-17 |
2023-08-13 |
mouse |