| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria Cluzet, Marie M Devillers, Florence Petit, Stéphanie Chauvin, Charlotte M François, Frank Giton, Catherine Genestie, Nathalie di Clemente, Joëlle Cohen-Tannoudji, Céline J Guigo. Aberrant granulosa cell-fate related to inactivated p53/Rb signaling contributes to granulosa cell tumors and to FOXL2 downregulation in the mouse ovary. Oncogene. vol 39. issue 9. 2020-11-24. PMID:31745296. |
tumorigenesis was associated with the combined inactivation of p53 and rb pathways, as shown by the impaired expression of respective downstream targets regulating cell apoptosis and proliferation, i.e., bax, bak, gadd45a, ccna2, ccne1, e2f1, and orc1. |
2020-11-24 |
2023-08-13 |
mouse |
| Xinyang Li, Donglei Sun, Tianhe Zhao, Zunzhen Zhan. Long non-coding RNA ROR confers arsenic trioxide resistance to HepG2 cells by inhibiting p53 expression. European journal of pharmacology. vol 872. 2020-11-24. PMID:32017938. |
in this study, we found that cellular apoptosis was increased by arsenic trioxide in liver cancer hepg2 cells; p53 expression was also increased by arsenic trioxide at both mrna level and protein level, indicating that p53-dependent apoptosis is the main mechanism for arsenic trioxide to induce cytotoxicity in liver cancer hepg2 cells. |
2020-11-24 |
2023-08-13 |
Not clear |
| Xinyang Li, Donglei Sun, Tianhe Zhao, Zunzhen Zhan. Long non-coding RNA ROR confers arsenic trioxide resistance to HepG2 cells by inhibiting p53 expression. European journal of pharmacology. vol 872. 2020-11-24. PMID:32017938. |
through the knock-down of long non-coding rna ror by sirna, we revealed that the activated long non-coding rna ror ameliorated arsenic trioxide-induced apoptosis by inhibiting p53 expression. |
2020-11-24 |
2023-08-13 |
Not clear |
| Masahiro Uehara, Tetsuro Kusaba, Tomoharu Ida, Kunihiro Nakai, Tomohiro Nakata, Aya Tomita, Noriko Watanabe-Uehara, Kisho Ikeda, Takashi Kitani, Noriyuki Yamashita, Yuhei Kirita, Satoaki Matoba, Benjamin D Humphreys, Keiichi Tamagak. Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice. Scientific reports. vol 10. issue 1. 2020-11-23. PMID:32157166. |
analysis of isolated tubular epithelia by facs from bigenic slc34a1-creert2; r26tdtomato proximal tubular-specific reporter mice revealed that ku55933 upregulated p53 and subsequent pro-apoptotic signaling in tubular epithelia of cisplatin-treated mice, leading to marked mitochondrial injury and apoptosis. |
2020-11-23 |
2023-08-13 |
mouse |
| Xiangnan Guo, Xiaona Liu, Jingqiu Wang, Xiaoyan Fu, Jinyin Yao, Xiaodan Zhang, Sira Jackson, Jinyu Li, Wei Zhang, Dianjun Su. Pigment epithelium-derived factor (PEDF) ameliorates arsenic-induced vascular endothelial dysfunction in rats and toxicity in endothelial EA.hy926 cells. Environmental research. vol 186. 2020-11-20. PMID:32315827. |
the recovery from arsenite exposure was associated with increased levels of pedf; decreased protein levels of fas, fasl, p53, and phospho-p38; and inhibited apoptosis in aortic endothelial cells in vivo. |
2020-11-20 |
2023-08-13 |
human |
| Xiangnan Guo, Xiaona Liu, Jingqiu Wang, Xiaoyan Fu, Jinyin Yao, Xiaodan Zhang, Sira Jackson, Jinyu Li, Wei Zhang, Dianjun Su. Pigment epithelium-derived factor (PEDF) ameliorates arsenic-induced vascular endothelial dysfunction in rats and toxicity in endothelial EA.hy926 cells. Environmental research. vol 186. 2020-11-20. PMID:32315827. |
recombinant human pedf treatment (100 nm) prevented the toxic effects of arsenite (50 μm) on endothelial cells in vitro by increasing no content, decreasing reactive oxygen species (ros) levels, and inhibiting apoptosis, as well as increasing cell viability and decreasing levels of p53 and phospho-p38. |
2020-11-20 |
2023-08-13 |
human |
| Xiangnan Guo, Xiaona Liu, Jingqiu Wang, Xiaoyan Fu, Jinyin Yao, Xiaodan Zhang, Sira Jackson, Jinyu Li, Wei Zhang, Dianjun Su. Pigment epithelium-derived factor (PEDF) ameliorates arsenic-induced vascular endothelial dysfunction in rats and toxicity in endothelial EA.hy926 cells. Environmental research. vol 186. 2020-11-20. PMID:32315827. |
our findings suggest that pedf protects endothelial cells from arsenic-induced ved by increasing no release and inhibiting apoptosis, where p53 and p38mapk are its main targets. |
2020-11-20 |
2023-08-13 |
human |
| Yuanxin Zhang, Pengcheng Li, Jiamin Rong, Yakun Ge, Chenming Hu, Xu Bai, Wei Sh. Small molecule CDS-3078 induces G Experimental and therapeutic medicine. vol 20. issue 6. 2020-11-20. PMID:33209128. |
small molecule cds-3078 induces g the tumor suppressor p53 serves important roles in cell cycle arrest and apoptosis, and its activation increases the sensitivity of cancer cells to radiotherapy or chemotherapy. |
2020-11-20 |
2023-08-13 |
Not clear |
| Xinghua Zhang, Yunshu Su, Huiqing Lin, Xiaoli Ya. The impacts of ubiquilin 1 (UBQLN1) knockdown on cells viability, proliferation, and apoptosis are mediated by p53 in A549 lung cancer cells. Journal of thoracic disease. vol 12. issue 10. 2020-11-20. PMID:33209421. |
the impacts of ubiquilin 1 (ubqln1) knockdown on cells viability, proliferation, and apoptosis are mediated by p53 in a549 lung cancer cells. |
2020-11-20 |
2023-08-13 |
human |
| Ali M Ethaeb, Mohammad A Mohammad, Yahya Madkhali, Sophie Featherby, Anthony Maraveyas, John Greenman, Camille Ettelai. Accumulation of tissue factor in endothelial cells promotes cellular apoptosis through over-activation of Src1 and involves β1-integrin signalling. Apoptosis : an international journal on programmed cell death. vol 25. issue 1-2. 2020-11-19. PMID:31654241. |
accumulation of tissue factor (tf) within cells leads to cellular apoptosis mediated through p38 and p53 pathways. |
2020-11-19 |
2023-08-13 |
human |
| Vishal Kumar Gupta, Pradip Kumar Jaiswara, Pratishtha Sonker, Shiv Govind Rawat, Rajan Kumar Tiwari, Ajay Kuma. Lysophosphatidic acid promotes survival of T lymphoma cells by altering apoptosis and glucose metabolism. Apoptosis : an international journal on programmed cell death. vol 25. issue 1-2. 2020-11-19. PMID:31867678. |
observations of this investigation suggest that lpa supports survival of t lymphoma cells via altering apoptosis and glucose metabolism through changing the level of reactive species, namely nitric oxide and reactive oxygen species along with expression of various survival and glucose metabolism regulatory molecules, including hypoxia-inducible factor 1-alpha, p53, bcl2, and glucose transporter 3, hexokinase ii, pyruvate kinase muscle isozyme 2, monocarboxylate transporter 1, pyruvate dehydrogenase kinase 1. |
2020-11-19 |
2023-08-13 |
Not clear |
| Lu Guo, Jum Soon Kang, Nam Jun Kang, Young Whan Cho. S-petasin induces apoptosis and inhibits cell migration through activation of p53 pathway signaling in melanoma B16F10 cells and A375 cells. Archives of biochemistry and biophysics. vol 692. 2020-11-19. PMID:32763235. |
s-petasin induces apoptosis and inhibits cell migration through activation of p53 pathway signaling in melanoma b16f10 cells and a375 cells. |
2020-11-19 |
2023-08-13 |
Not clear |
| Chanchan Xiao, Fanbiao Mei, Guanhua Ren, Long Long, Maojian Chen, Xiang Fang, Jilin Li, Kezhi Li, Yanping Tang, Tianren Huang, Wei Den. Synergistic Effect of MC-LR and C-Terminal Truncated HBx on HepG2 Cells and Their Effects on PP2A Mediated Downstream Target of MAPK Signaling Pathway. Frontiers in genetics. vol 11. 2020-11-17. PMID:33193609. |
then we investigated the function of mc-lr and cthbx using the molecular biology approaches, including enzyme-linked immunosorbent assay, clone formation assay, scratch wound testing, transwell assays, carried out flow cytometry respectively to examine cell cycle and apoptosis in each group, and detected the related proteins of hbx, mek/erk/jnk/p38 in mitogen-activated protein kinase (mapk) pathway and the downstream proteins such as cdc2, cdc25c, and p53 by western blotting. |
2020-11-17 |
2023-08-13 |
human |
| Tong Lin, Caijun Liang, Wenya Peng, Yuqin Qiu, Lisheng Pen. Mechanisms of Core Chinese Herbs against Colorectal Cancer: A Study Based on Data Mining and Network Pharmacology. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-11-17. PMID:33193800. |
various cancer-associated signaling pathways, including micrornas, tnf, apoptosis, pi3k-akt, and p53, were involved. |
2020-11-17 |
2023-08-13 |
Not clear |
| Lizhi Gu, Hong Sun, Zhuan Ya. lncRNA ZEB1-AS1 is downregulated in diabetic lung and regulates lung cell apoptosis. Experimental and therapeutic medicine. vol 20. issue 6. 2020-11-17. PMID:33193839. |
zeb1-as1 in lung cells was downregulated by high glucose treatment, and overexpression of zeb1-as1 resulted in inhibited lung cancer cell apoptosis and downregulated p53. |
2020-11-17 |
2023-08-13 |
Not clear |
| Lizhi Gu, Hong Sun, Zhuan Ya. lncRNA ZEB1-AS1 is downregulated in diabetic lung and regulates lung cell apoptosis. Experimental and therapeutic medicine. vol 20. issue 6. 2020-11-17. PMID:33193839. |
p53 overexpression attenuated the effects of zeb1-as1 overexpression on lung cell apoptosis. |
2020-11-17 |
2023-08-13 |
Not clear |
| Lizhi Gu, Hong Sun, Zhuan Ya. lncRNA ZEB1-AS1 is downregulated in diabetic lung and regulates lung cell apoptosis. Experimental and therapeutic medicine. vol 20. issue 6. 2020-11-17. PMID:33193839. |
in conclusion, the present study demonstrated that zeb1-as1 was downregulated in patients with dl and regulates lung cancer cell apoptosis by downregulating p53. |
2020-11-17 |
2023-08-13 |
Not clear |
| Ana Peterlin, Karolina Počivavšek, Danijel Petrovič, Borut Peterli. The Role of microRNAs in Heart Failure: A Systematic Review. Frontiers in cardiovascular medicine. vol 7. 2020-11-17. PMID:33195446. |
gene set enrichment analysis, based on the gene targets of micrornas presented in the included studies, showed that gene targets of differentially expressed micrornas were enriched in the mapk, tgfβ, pi3k-akt, and il-2 signaling pathways, as well as apoptosis pathway, p53 activity regulation, and angiogenesis pathway. |
2020-11-17 |
2023-08-13 |
Not clear |
| Ibraheem M Attafi, Saleh A Bakheet, Hesham M Korash. The role of NF-κB and AhR transcription factors in lead-induced lung toxicity in human lung cancer A549 cells. Toxicology mechanisms and methods. vol 30. issue 3. 2020-11-16. PMID:31682781. |
in the current study, treatment of a549 cells with pb significantly induced cell apoptosis as evidenced by increasing a) the percentage of cells underwent apoptosis determined by flow cytometry and b) p53 mrna level. |
2020-11-16 |
2023-08-13 |
human |
| Lingqi Yu, Jie Zheng, Junying Li, Yuzhen Wang, Xiaoyan Lu, Xiaohui Fa. Integrating serum exosomal microRNA and liver microRNA profiles disclose the function role of autophagy and mechanisms of Fructus Meliae Toosendan-induced hepatotoxicity in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 123. 2020-11-16. PMID:31855734. |
moreover, in vivo validation studies suggested that the protein expression levels of pten, p-akt, p53, and bax were indeed regulated in the mouse liver after high-dose fmt administration, indicating hepatocyte apoptosis may be mediated by these three pathways mentioned above. |
2020-11-16 |
2023-08-13 |
mouse |