| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Izabela Bialuk, Magdalena Cieślińska, Oksana Kowalczuk, Tomasz A Bonda, Jacek Nikliński, Maria M Winnick. IL-6 deficiency attenuates p53 protein accumulation in aged male mouse hippocampus. Biogerontology. vol 21. issue 1. 2020-12-11. PMID:31598806. |
taken together, attenuated p53 protein build-up, absence of enhanced apoptosis, and transcriptional up-regulation of autophagy-associated genes imply that il-6 deficiency may protect hippocampus from age-related accumulation of cellular damages. |
2020-12-11 |
2023-08-13 |
mouse |
| Jie Zhang, Min Xu, Weihua Zhou, Dejian Li, Hong Zhang, Yi Chen, Longgui Ning, Yuwei Zhang, Sha Li, Mengli Yu, Yishu Chen, Hang Zeng, Li Cen, Tianyu Zhou, Xinxin Zhou, Chao Lu, Chaohui Yu, Youming Li, Jing Sun, Xiaoni Kong, Zhe She. Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53. The Journal of biological chemistry. vol 295. issue 13. 2020-12-09. PMID:32075910. |
deficiency in the anti-apoptotic protein dj-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53. |
2020-12-09 |
2023-08-13 |
human |
| Jie Zhang, Min Xu, Weihua Zhou, Dejian Li, Hong Zhang, Yi Chen, Longgui Ning, Yuwei Zhang, Sha Li, Mengli Yu, Yishu Chen, Hang Zeng, Li Cen, Tianyu Zhou, Xinxin Zhou, Chao Lu, Chaohui Yu, Youming Li, Jing Sun, Xiaoni Kong, Zhe She. Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53. The Journal of biological chemistry. vol 295. issue 13. 2020-12-09. PMID:32075910. |
increased intestinal epithelial cell (iec) apoptosis and excessive activation of the p53 signaling pathway is a hallmark of inflammatory bowel disease (ibd), which includes ulcerative colitis (uc) and crohn's disease (cd). |
2020-12-09 |
2023-08-13 |
human |
| Jie Zhang, Min Xu, Weihua Zhou, Dejian Li, Hong Zhang, Yi Chen, Longgui Ning, Yuwei Zhang, Sha Li, Mengli Yu, Yishu Chen, Hang Zeng, Li Cen, Tianyu Zhou, Xinxin Zhou, Chao Lu, Chaohui Yu, Youming Li, Jing Sun, Xiaoni Kong, Zhe She. Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53. The Journal of biological chemistry. vol 295. issue 13. 2020-12-09. PMID:32075910. |
to determine whether dj-1 deficiency is involved in the p53 activation that results in iec apoptosis in colitis, here we performed immunostaining, real-time pcr, and immunoblotting analyses to assess dj-1 expression in human uc and cd samples. |
2020-12-09 |
2023-08-13 |
human |
| Muhammad Atif Zahoor, Xiao-Dan Yao, Bethany M Henrick, Chris P Verschoor, Alash'le Abimiku, Sophia Osawe, Kenneth L Rosentha. Expression profiling of human milk derived exosomal microRNAs and their targets in HIV-1 infected mothers. Scientific reports. vol 10. issue 1. 2020-12-09. PMID:32737406. |
diana-mir functional pathway analyses revealed that multiple biological pathways are involved including cell cycle, pathways in cancer, tgf-β signaling, foxo signaling, fatty acid biosynthesis, p53 signaling and apoptosis. |
2020-12-09 |
2023-08-13 |
human |
| Amir Imani, Nasim Maleki, Sepideh Bohlouli, Maryam Kouhsoltani, Simin Sharifi, Solmaz Maleki Diza. Molecular mechanisms of anticancer effect of rutin. Phytotherapy research : PTR. 2020-12-09. PMID:33295678. |
regulation of different cellular signaling pathways such as wnt/β-catenin, p53-independent pathway, pi3k/akt, jak/stat, mapk, p53, apoptosis as well as nf-ĸb signaling pathways helps to mediate the anticancer impacts of this agent. |
2020-12-09 |
2023-08-13 |
Not clear |
| Huayi Li, Wenxin Zhang, Kunming Zhao, Dong Zhao, Shanliang Zheng, Ying H. A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells. The Journal of biological chemistry. vol 295. issue 12. 2020-12-08. PMID:32005663. |
the oncogene inhibitor of the apoptosis-stimulating protein of p53 (iaspp) plays essential roles in regulating cellular drug response by inhibiting apoptosis. |
2020-12-08 |
2023-08-13 |
mouse |
| Peng Wang, Chun Wang, Chunying Li. Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration. Oncology letters. vol 21. issue 1. 2020-12-08. PMID:33281970. |
investigations into the mechanism revealed that the expression levels of phosphorylated ataxia telangiectasia-mutated (atm) were considerably activated by dioscin, which significantly upregulated the expression levels of p53 to activate mitochondrial apoptosis signaling. |
2020-12-08 |
2023-08-13 |
human |
| Changbing Wang, Haiyang Chen, Danyang Chen, Mingqi Zhao, Zhengfang Lin, Min Guo, Tiantian Xu, Yi Chen, Liang Hua, Tao Lin, Ying Tang, Bing Zhu, Yinghua L. The Inhibition of H1N1 Influenza Virus-Induced Apoptosis by Surface Decoration of Selenium Nanoparticles with β-Thujaplicin through Reactive Oxygen Species-Mediated AKT and p53 Signaling Pathways. ACS omega. vol 5. issue 47. 2020-12-08. PMID:33283112. |
the inhibition of h1n1 influenza virus-induced apoptosis by surface decoration of selenium nanoparticles with β-thujaplicin through reactive oxygen species-mediated akt and p53 signaling pathways. |
2020-12-08 |
2023-08-13 |
mouse |
| Katarzyna A Roszkowska, Slawomir Gizinski, Maria Sady, Zdzislaw Gajewski, Maciej B Olszewsk. Gain-of-Function Mutations in p53 in Cancer Invasiveness and Metastasis. International journal of molecular sciences. vol 21. issue 4. 2020-12-07. PMID:32079237. |
its activity is generally antiproliferative and when the cell is damaged beyond repair or intensely stressed the p53 protein contributes to apoptosis. |
2020-12-07 |
2023-08-13 |
human |
| Deepa, Anil Mittal, Shashank Taxak, Vibha Tandon, Uttam Pat. Oxygen-releasing manganese clay hybrid complex triggers p53-mediated cancer cell death in hypoxia. Biochemical pharmacology. vol 178. 2020-12-07. PMID:32450254. |
the induction of apoptosis by mhc is higher in p53 wt/wt cells when it is compared with p53 mt/mt cells. |
2020-12-07 |
2023-08-13 |
Not clear |
| Deepa, Anil Mittal, Shashank Taxak, Vibha Tandon, Uttam Pat. Oxygen-releasing manganese clay hybrid complex triggers p53-mediated cancer cell death in hypoxia. Biochemical pharmacology. vol 178. 2020-12-07. PMID:32450254. |
the released oxygen from mhc triggers apoptosis via p53 activation through its enhanced homo-oligomerization, post-translational modifications and nuclear localization. |
2020-12-07 |
2023-08-13 |
Not clear |
| Yuxin Che, Yang Yang, Jinguo Suo, Yujing An, Xuelian Wan. Induction of systemic immune responses and reversion of immunosuppression in the tumor microenvironment by a therapeutic vaccine for cervical cancer. Cancer immunology, immunotherapy : CII. vol 69. issue 12. 2020-12-07. PMID:32607768. |
the expression of the cell proliferation indicator ki67, apoptosis regulatory protein p53 and angiogenesis marker cd31 was significantly decreased in the vaccine group. |
2020-12-07 |
2023-08-13 |
mouse |
| Beata Hat, Joanna Jaruszewicz-Błońska, Tomasz Lipniack. Model-based optimization of combination protocols for irradiation-insensitive cancers. Scientific reports. vol 10. issue 1. 2020-12-07. PMID:32724100. |
alternations in the p53 regulatory network may render cancer cells resistant to the radiation-induced apoptosis. |
2020-12-07 |
2023-08-13 |
Not clear |
| Surinder M Soond, Lyudmila V Savvateeva, Vladimir A Makarov, Neonila V Gorokhovets, Paul A Townsend, Andrey A Zamyatni. Making Connections: p53 and the Cathepsin Proteases as Co-Regulators of Cancer and Apoptosis. Cancers. vol 12. issue 11. 2020-12-07. PMID:33266503. |
making connections: p53 and the cathepsin proteases as co-regulators of cancer and apoptosis. |
2020-12-07 |
2023-08-13 |
Not clear |
| Anita Ramesh, R Vimal Chander, Chitra Srinivasan, Srinivasan Vengadassalapath. Prevalence of Angiogenesis, Proliferation, and Apoptosis Markers of Cervical Cancer and Their Correlation with Clinicopathological Parameters. Journal of oncology. vol 2020. 2020-12-07. PMID:33273920. |
the aim of the study is to investigate the expression of angiogenesis (vegf and pdgf), angiogenesis inhibitor markers (angiostatin and endostatin), proliferation (ki67), and apoptosis markers (p53 and p16) of cervical cancer in indian population and to correlate them with the clinicopathological profile. |
2020-12-07 |
2023-08-13 |
Not clear |
| Stanislav Rodkin, Andrey Khaitin, Maria Pitinova, Valentina Dzreyan, Valeria Guzenko, Mikhail Rudkovskii, Svetlana Sharifulina, Anatoly Uzdensk. The Localization of p53 in the Crayfish Mechanoreceptor Neurons and Its Role in Axotomy-Induced Death of Satellite Glial Cells Remote from the Axon Transection Site. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-12-04. PMID:31823284. |
protein p53 is a key regulator of diverse cell functions including stress response, dna repair, proliferation, and apoptosis. |
2020-12-04 |
2023-08-13 |
Not clear |
| Stanislav Rodkin, Andrey Khaitin, Maria Pitinova, Valentina Dzreyan, Valeria Guzenko, Mikhail Rudkovskii, Svetlana Sharifulina, Anatoly Uzdensk. The Localization of p53 in the Crayfish Mechanoreceptor Neurons and Its Role in Axotomy-Induced Death of Satellite Glial Cells Remote from the Axon Transection Site. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-12-04. PMID:31823284. |
axotomy-induced apoptosis of remote glial cells increased in the presence of p53 activators wr-1065 and nutlin-3 but reduced by pifithrin-α that inhibits transcriptional activity of p53. |
2020-12-04 |
2023-08-13 |
Not clear |
| Stanislav Rodkin, Andrey Khaitin, Maria Pitinova, Valentina Dzreyan, Valeria Guzenko, Mikhail Rudkovskii, Svetlana Sharifulina, Anatoly Uzdensk. The Localization of p53 in the Crayfish Mechanoreceptor Neurons and Its Role in Axotomy-Induced Death of Satellite Glial Cells Remote from the Axon Transection Site. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-12-04. PMID:31823284. |
pifithrin-μ that inhibits p53 effect on mitochondria increased axotomy-induced apoptosis of remote glial cells but reduced their necrosis. |
2020-12-04 |
2023-08-13 |
Not clear |
| Stanislav Rodkin, Andrey Khaitin, Maria Pitinova, Valentina Dzreyan, Valeria Guzenko, Mikhail Rudkovskii, Svetlana Sharifulina, Anatoly Uzdensk. The Localization of p53 in the Crayfish Mechanoreceptor Neurons and Its Role in Axotomy-Induced Death of Satellite Glial Cells Remote from the Axon Transection Site. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-12-04. PMID:31823284. |
therefore, axotomy-induced apoptosis of remote glial cells was associated with p53 effect on transcription processes, whereas glial necrosis was rather associated with transcription-independent p53 effect on mitochondria. |
2020-12-04 |
2023-08-13 |
Not clear |