| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zachariah Chee Ken Chan, Kok Hoong Leong, Huda Salah Kareem, Anwar Norazit, Suzita Mohd Noor, Azhar Ariffi. Activation of death receptor, DR5 and mitochondria-mediated apoptosis by a 3,4,5-trimethoxybenzyloxy derivative in wild-type and p53 mutant colorectal cancer cell lines. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 3. 2021-01-25. PMID:31641820. |
activation of death receptor, dr5 and mitochondria-mediated apoptosis by a 3,4,5-trimethoxybenzyloxy derivative in wild-type and p53 mutant colorectal cancer cell lines. |
2021-01-25 |
2023-08-13 |
human |
| Zachariah Chee Ken Chan, Kok Hoong Leong, Huda Salah Kareem, Anwar Norazit, Suzita Mohd Noor, Azhar Ariffi. Activation of death receptor, DR5 and mitochondria-mediated apoptosis by a 3,4,5-trimethoxybenzyloxy derivative in wild-type and p53 mutant colorectal cancer cell lines. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 3. 2021-01-25. PMID:31641820. |
a previous study focused on its antioxidant mechanism, whereas in this study, we investigated the cytotoxicity of a series of 28 analogues and the mechanism of apoptosis of the most cytotoxic compound against wild-type (hct-116) and p53 mutant (ht-29) colorectal cancer cell lines. |
2021-01-25 |
2023-08-13 |
human |
| Yifan Chen, Tianzheng Y. Involvement of p53 in the Responses of Cardiac Muscle Cells to Heat Shock Exposure and Heat Acclimation. Journal of cardiovascular translational research. vol 13. issue 6. 2021-01-25. PMID:32314164. |
these results suggest that p53 plays a role in heat-induced apoptosis in cardiac muscle cells. |
2021-01-25 |
2023-08-13 |
mouse |
| Qian Wu, Xianhui Ning, Shuai Jiang, Li Su. Transcriptome analysis reveals seven key immune pathways of Japanese flounder (Paralichthys olivaceus) involved in megalocytivirus infection. Fish & shellfish immunology. vol 103. 2021-01-25. PMID:32413472. |
weighted co-expression network analysis (wgcna) was used to identify 16 key immune degs belonging to seven immune pathways (rig-i-like receptor signaling pathway, jak-stat signaling pathway, tlr signaling pathway, cytokine-cytokine receptor interaction, phagosome, apoptosis, and p53 signaling pathway). |
2021-01-25 |
2023-08-13 |
Not clear |
| Hojat Anbara, Mohammad Taghi Sheibani, Mazdak Razi, Mehdi Kia. Insight into the mechanism of aspartame-induced toxicity in male reproductive system following long-term consumption in mice model. Environmental toxicology. vol 36. issue 2. 2021-01-25. PMID:32951320. |
also, it decreased attenuated testicular histomorphometric indices (tubular differentiation index, spermiogenesis index, and repopulation index), and steroidogenic foci, while increased mrna damages and apoptosis rate, downregulated antiapoptotic (bcl-2) and upregulated proapoptotic (p53, bax, and caspase-3) mediators respectively in testis. |
2021-01-25 |
2023-08-13 |
mouse |
| Xiangxuan Zhao, Wei Sun, Ying Ren, Zaiming L. Therapeutic potential of p53 reactivation in cervical cancer. Critical reviews in oncology/hematology. vol 157. 2021-01-22. PMID:33276182. |
accumulating studies have demonstrated that restoration of p53 activity can induce cell cycle arrest and apoptosis, eliminate radio- and chemotherapy resistance, and inhibit tumor growth in cc cells. |
2021-01-22 |
2023-08-13 |
Not clear |
| Hye Young Cho, Roshan Jha, Ameeq Ui Mushtaq, Sung Ho Oh, Young Ho Jeo. Structural insight into the interaction between p53 TAD1 and AIMP2-DX2 by NMR. Biochemical and biophysical research communications. vol 527. issue 3. 2021-01-19. PMID:32448505. |
p53 is the most studied tumor suppressor and a key transcriptional factor, with discrete domains that regulate cellular pathways such as apoptosis, angiogenesis, cell-cycle arrest, dna repair, and senescence. |
2021-01-19 |
2023-08-13 |
Not clear |
| Somayeh Afsah Vakili, Ajay George, Seyed Abdulmajid Ayatollahi, Miquel Martorell, Elise Adrian Ostrander, Bahare Salehi, Natália Martins, Javad Sharifi-Ra. Phenolic compounds, saponins and alkaloids on cancer progression: emphasis on p53 expression and telomere length. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 4. 2021-01-19. PMID:32583791. |
in particular, the tumour suppressor protein p53 loss or inactivation can lead to activation of telomerase enzyme, which can make cells unable to detect dna damages that spurs apoptosis. |
2021-01-19 |
2023-08-13 |
Not clear |
| Yousef Faridvand, Parinaz Haddadi, Vahid Vahedian, Samira Nozari, Hamid Reza Nejabati, Masoud Pezeshkian, Abbas Afrasiabi, Nasser Safaie, Ahmadreza Jodati, Mohammad Nour. Human Amnion Membrane Proteins Prevent Doxorubicin-Induced Oxidative Stress Injury and Apoptosis in Rat H9c2 Cardiomyocytes. Cardiovascular toxicology. vol 20. issue 4. 2021-01-18. PMID:32086724. |
moreover, expression profiling of apoptosis-related genes (p53, bcl-2, and bax) and annexin v by flow cytometry were used for cell apoptosis detection. |
2021-01-18 |
2023-08-13 |
human |
| Jiaming Zheng, Liling Zhuo, Di Ran, Yonggang Ma, Tongwang Luo, Hongyan Zhao, Ruilong Song, Hui Zou, Jiaqiao Zhu, Jianhong Gu, Jianchun Bian, Yan Yuan, Zongping Li. Cadmium induces apoptosis via generating reactive oxygen species to activate mitochondrial p53 pathway in primary rat osteoblasts. Toxicology. vol 446. 2021-01-14. PMID:33031904. |
cadmium induces apoptosis via generating reactive oxygen species to activate mitochondrial p53 pathway in primary rat osteoblasts. |
2021-01-14 |
2023-08-13 |
rat |
| Jiaming Zheng, Liling Zhuo, Di Ran, Yonggang Ma, Tongwang Luo, Hongyan Zhao, Ruilong Song, Hui Zou, Jiaqiao Zhu, Jianhong Gu, Jianchun Bian, Yan Yuan, Zongping Li. Cadmium induces apoptosis via generating reactive oxygen species to activate mitochondrial p53 pathway in primary rat osteoblasts. Toxicology. vol 446. 2021-01-14. PMID:33031904. |
however, pretreatment with the ros scavenger n-acetyl-l-cysteine (nac) or the p53 transcription specific inhibitor pft-α suppressed cd-induced apoptosis. |
2021-01-14 |
2023-08-13 |
rat |
| Jiaming Zheng, Liling Zhuo, Di Ran, Yonggang Ma, Tongwang Luo, Hongyan Zhao, Ruilong Song, Hui Zou, Jiaqiao Zhu, Jianhong Gu, Jianchun Bian, Yan Yuan, Zongping Li. Cadmium induces apoptosis via generating reactive oxygen species to activate mitochondrial p53 pathway in primary rat osteoblasts. Toxicology. vol 446. 2021-01-14. PMID:33031904. |
our results indicate that cd can induce apoptosis in osteoblasts by increasing the generation of ros and activating the mitochondrial p53 signaling pathway, and this mechanism requires the transcriptional activation of p53. |
2021-01-14 |
2023-08-13 |
rat |
| Yomna I Mahmoud, Aya M M Shehata, Nagui H Fares, Asmaa A Mahmou. Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis. Life sciences. vol 265. 2021-01-14. PMID:33253720. |
spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis. |
2021-01-14 |
2023-08-13 |
Not clear |
| Le Thi Nhu Ngoc, Se-Myo Park, Jung-Hwa Oh, Ho Yun Shin, Moon Il Kim, Hyun Uk Lee, Kyung-Bok Lee, Kug-Seung Lee, Ju-Young Moon, Oh-Hyeok Kwon, Hee Young Yang, Young-Chul Le. Cerium Aminoclay-A Potential Hybrid Biomaterial for Anticancer Therapy. ACS biomaterials science & engineering. vol 5. issue 11. 2021-01-14. PMID:33405676. |
its anticancer mechanism has been fully demonstrated through apoptosis assays; herein ceac induced high-level apoptosis (16%), which promoted the expression of proapoptotic proteins (bax, p53, and caspase 9) in tumor cells. |
2021-01-14 |
2023-08-13 |
mouse |
| Mao Xu, Meng Feng, Hang Peng, Zhuang Qian, Liting Zhao, Shufang W. Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1/P53/P21 pathway in surgery-induced osteoarthritis. Biochemical and biophysical research communications. vol 528. issue 1. 2021-01-13. PMID:32499111. |
we also observed that chondrocyte apoptosis and p53 increased in osteoarthritis (oa) progression with a declining expression of sirt1 in human cartilage. |
2021-01-13 |
2023-08-13 |
mouse |
| Sang-Soo Kim, Joe B Harford, Manish Moghe, Antonina Rait, Esther H Chan. Combination with SGT-53 overcomes tumor resistance to a checkpoint inhibitor. Oncoimmunology. vol 7. issue 10. 2021-01-12. PMID:30288347. |
the tumor suppressor p53 responds to genotoxic and oncogenic stresses by inducing cell cycle arrest and apoptosis. |
2021-01-12 |
2023-08-13 |
mouse |
| Cheng-Wei Wu, Shannon N Tessier, Kenneth B Store. Dehydration stress alters the mitogen-activated-protein kinase signaling and chaperone stress response in Xenopus laevis. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 246-247. 2021-01-12. PMID:32497588. |
in the brain tissue, most proteins remain unchanged with the exception of the apoptosis regulating p53 transcription factor, which showed a significant decrease in its activating phosphorylation residue under dehydration. |
2021-01-12 |
2023-08-13 |
xenopus_laevis |
| Yongqiang Wang, Zenghong Huang, Christopher Z Chen, Chengfei Liu, Christopher P Evans, Allen C Gao, Fangjian Zhou, Hong-Wu Che. Therapeutic Targeting of MDR1 Expression by RORγ Antagonists Resensitizes Cross-Resistant CRPC to Taxane via Coordinated Induction of Cell Death Programs. Molecular cancer therapeutics. vol 19. issue 2. 2021-01-11. PMID:31712394. |
our mechanistic analyses revealed that combined treatment with rorγ antagonists and taxane elicited a robust synergy in killing the resistant cells, which involves a coordinated alteration of p53, myc, and e2f-controlled programs critical for both intrinsic and extrinsic apoptosis, survival, and cell growth. |
2021-01-11 |
2023-08-13 |
Not clear |
| Shi-Jing Wang, Heng Chen, Li-Jing Tang, Hua Tu, Bin Liu, Nian-Sheng Li, Xiu-Ju Luo, Jun Pen. Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury. Canadian journal of physiology and pharmacology. vol 98. issue 5. 2021-01-11. PMID:31825666. |
consistently, hypoxia/reoxygenation (h/r) treated cardiac (h9c2) cells displayed cellular injury (apoptosis and necrosis), upregulation of total and mitochondrial protein levels of mul1 and p53, and enhanced interactions between p53 and sumo1 concomitant with mitochondrial dysfunctions (an increase in mitochondrial membrane potential and reactive oxygen species production with a decrease in atp production); these phenomena were attenuated by knockdown of mul1 expression. |
2021-01-11 |
2023-08-13 |
rat |
| Zahra Motamedi, Sayed Asadollah Amini, Elham Raeisi, Yves Lemoigne, Esfandiar Heidaria. Combined Effects of Protocatechuic Acid and 5-Fluorouracil on p53 Gene Expression and Apoptosis in Gastric Adenocarcinoma Cells. Turkish journal of pharmaceutical sciences. vol 17. issue 6. 2021-01-11. PMID:33389946. |
combined effects of protocatechuic acid and 5-fluorouracil on p53 gene expression and apoptosis in gastric adenocarcinoma cells. |
2021-01-11 |
2023-08-13 |
Not clear |