| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Milyavsky, Olga I Gan, Magan Trottier, Martin Komosa, Ofer Tabach, Faiyaz Notta, Eric Lechman, Karin G Hermans, Kolja Eppert, Zhanna Konovalova, Olga Ornatsky, Eytan Domany, M Stephen Meyn, John E Dic. A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell stem cell. vol 7. issue 2. 2010-11-12. PMID:20619763. |
our data reveal distinct physiological roles of p53 that together ensure optimal hsc function: apoptosis regulation and prevention of gammah2ax foci accumulation upon hsc self-renewal. |
2010-11-12 |
2023-08-12 |
human |
| Dongping Liu, Linda Ou, Gregory D Clemenson, Connie Chao, Marshall Eli Lutske, Gerard P Zambetti, Fred H Gage, Yang X. Puma is required for p53-induced depletion of adult stem cells. Nature cell biology. vol 12. issue 10. 2010-11-12. PMID:20818388. |
dna damage activates the tumour suppressor p53, which leads to cell-cycle arrest, senescence or apoptosis. |
2010-11-12 |
2023-08-12 |
mouse |
| Magnus G Olsson, E J Charlotta Nilsson, Sigurbjörg Rutardóttir, Jan Paczesny, Jan Pallon, Bo Akerströ. Bystander cell death and stress response is inhibited by the radical scavenger α(1)-microglobulin in irradiated cell cultures. Radiation research. vol 174. issue 5. 2010-11-12. PMID:20954860. |
a significant increase in apoptosis, oxidation markers and expression of the stress response genes heme oxygenase 1, superoxide dismutase, catalase, glutathione peroxidase 1, p21 and p53 were observed. |
2010-11-12 |
2023-08-12 |
human |
| Suresh R Volate, Brian T Kawasaki, Elaine M Hurt, John A Milner, Young S Kim, Jeffrey White, William L Farra. Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells. Molecular cancer therapeutics. vol 9. issue 2. 2010-11-10. PMID:20124455. |
gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells. |
2010-11-10 |
2023-08-12 |
human |
| A R M Ruhul Amin, Vijay S Thakur, Kalpana Gupta, Mark W Jackson, Hisashi Harada, Mukesh K Agarwal, Dong M Shin, David N Wald, Munna L Agarwa. Restoration of p53 functions protects cells from concanavalin A-induced apoptosis. Molecular cancer therapeutics. vol 9. issue 2. 2010-11-10. PMID:20124456. |
restoration of p53 functions protects cells from concanavalin a-induced apoptosis. |
2010-11-10 |
2023-08-12 |
human |
| A R M Ruhul Amin, Vijay S Thakur, Kalpana Gupta, Mark W Jackson, Hisashi Harada, Mukesh K Agarwal, Dong M Shin, David N Wald, Munna L Agarwa. Restoration of p53 functions protects cells from concanavalin A-induced apoptosis. Molecular cancer therapeutics. vol 9. issue 2. 2010-11-10. PMID:20124456. |
previously, we reported that concanavalin a (con a) induced p73-dependent apoptosis of cells lacking functional p53. |
2010-11-10 |
2023-08-12 |
human |
| A R M Ruhul Amin, Vijay S Thakur, Kalpana Gupta, Mark W Jackson, Hisashi Harada, Mukesh K Agarwal, Dong M Shin, David N Wald, Munna L Agarwa. Restoration of p53 functions protects cells from concanavalin A-induced apoptosis. Molecular cancer therapeutics. vol 9. issue 2. 2010-11-10. PMID:20124456. |
in the present study, we investigated the mechanism and role of p53 in protection from apoptosis induced by con a. |
2010-11-10 |
2023-08-12 |
human |
| A R M Ruhul Amin, Vijay S Thakur, Kalpana Gupta, Mark W Jackson, Hisashi Harada, Mukesh K Agarwal, Dong M Shin, David N Wald, Munna L Agarwa. Restoration of p53 functions protects cells from concanavalin A-induced apoptosis. Molecular cancer therapeutics. vol 9. issue 2. 2010-11-10. PMID:20124456. |
inhibition of p53 function rendered these cells sensitive to con a. con a-induced apoptosis was accompanied by upregulation of forkhead box o1a (foxo1a) and bcl-2-interacting mediator (bim), which were strongly inhibited after p53 expression and rescued after p53 ablation. |
2010-11-10 |
2023-08-12 |
human |
| A R M Ruhul Amin, Vijay S Thakur, Kalpana Gupta, Mark W Jackson, Hisashi Harada, Mukesh K Agarwal, Dong M Shin, David N Wald, Munna L Agarwa. Restoration of p53 functions protects cells from concanavalin A-induced apoptosis. Molecular cancer therapeutics. vol 9. issue 2. 2010-11-10. PMID:20124456. |
taken together, our study suggests that con a induces apoptosis of cells lacking p53 by activating foxo1a-bim signaling and that expression of p53 protects these cells by inducing g(1) arrest and by downregulating the expression of both foxo1a and bim, identifying a novel cross-talk between foxo1a and p53 transcription factors. |
2010-11-10 |
2023-08-12 |
human |
| Takuya Kudoh, Junko Kimura, Zheng-Guang Lu, Yoshio Miki, Kiyotsugu Yoshid. D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage. Experimental cell research. vol 316. issue 17. 2010-11-10. PMID:20599942. |
transcription factor p53 is activated in response to genotoxic damage and plays crucial roles in apoptosis. |
2010-11-10 |
2023-08-12 |
Not clear |
| Xi-Yong Yu, Yong-Jian Geng, Jia-Liang Liang, Qiu-Xiong Lin, Shu-Guang Lin, Saidan Zhang, Yangxin L. High levels of glucose induce apoptosis in cardiomyocyte via epigenetic regulation of the insulin-like growth factor receptor. Experimental cell research. vol 316. issue 17. 2010-11-10. PMID:20633551. |
the effects of hg on reduced expression of igf-1r and increased apoptosis were blocked by silencing p53 with small interference rna but not by non-targeting scrambled sirna. |
2010-11-10 |
2023-08-12 |
rat |
| Jianmin Xu, Laura Timares, Clay Heilpern, Zhiping Weng, Changzhao Li, Hui Xu, Joseph G Pressey, Craig A Elmets, Levy Kopelovich, Mohammad Atha. Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis. Cancer research. vol 70. issue 16. 2010-11-10. PMID:20682800. |
targeting wild-type and mutant p53 with small molecule cp-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis. |
2010-11-10 |
2023-08-12 |
Not clear |
| Jianmin Xu, Laura Timares, Clay Heilpern, Zhiping Weng, Changzhao Li, Hui Xu, Joseph G Pressey, Craig A Elmets, Levy Kopelovich, Mohammad Atha. Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis. Cancer research. vol 70. issue 16. 2010-11-10. PMID:20682800. |
apoptosis induced by cp-31398 occurred with translocation of p53 to mitochondria, leading to altered mitochondrial membrane potential, cytochrome c release, and reactive oxygen species release. |
2010-11-10 |
2023-08-12 |
Not clear |
| Paola Palozza, Maria Colangelo, Rossella Simone, Assunta Catalano, Alma Boninsegna, Paola Lanza, Giovanni Monego, Franco O Ranellett. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. Carcinogenesis. vol 31. issue 10. 2010-11-10. PMID:20699249. |
these effects were also accompanied by an arrest of cell cycle progression and by apoptosis induction, as evidenced by a decrease in cyclin d1 and phospho-akt levels and by an increase in p21, p27 and p53 levels and in bax:bcl-2 ratio. |
2010-11-10 |
2023-08-12 |
Not clear |
| Maria Menichincheri, Clara Albanese, Cristina Alli, Dario Ballinari, Alberto Bargiotti, Marina Caldarelli, Antonella Ciavolella, Alessandra Cirla, Maristella Colombo, Francesco Colotta, Valter Croci, Roberto D'Alessio, Matteo D'Anello, Antonella Ermoli, Francesco Fiorentini, Barbara Forte, Arturo Galvani, Patrizia Giordano, Antonella Isacchi, Katia Martina, Antonio Molinari, Jürgen K Moll, Alessia Montagnoli, Paolo Orsini, Fabrizio Orzi, Enrico Pesenti, Antonio Pillan, Fulvia Roletto, Alessandra Scolaro, Marco Tatò, Marcellino Tibolla, Barbara Valsasina, Mario Varasi, Paola Vianello, Daniele Volpi, Corrado Santocanale, Ermes Vanott. Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding. Journal of medicinal chemistry. vol 53. issue 20. 2010-11-09. PMID:20873740. |
cdc7 inhibition through sirna or prototype small molecules causes p53 independent apoptosis in tumor cells while reversibly arresting cell cycle progression in primary fibroblasts. |
2010-11-09 |
2023-08-12 |
Not clear |
| Yingqun Wan. JimMY on the stage: Linking DNA damage with cell adhesion and motility. Cell adhesion & migration. vol 4. issue 2. 2010-11-04. PMID:20574148. |
tumor suppressor p53 is a key intermediate in dna damage response by inducing cell cycle arrest to allow repair or promoting apoptosis to eliminate irreparably damaged cells. |
2010-11-04 |
2023-08-12 |
Not clear |
| Xiao-Peng Zhang, Feng Liu, Wei Wan. Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage. The Journal of biological chemistry. vol 285. issue 41. 2010-11-04. PMID:20685653. |
for irreparable dna damage, growth arrest is overcome by growth factors, and activated p53 and e2f1 cooperate to initiate apoptosis. |
2010-11-04 |
2023-08-12 |
Not clear |
| Xiao-Peng Zhang, Feng Liu, Wei Wan. Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage. The Journal of biological chemistry. vol 285. issue 41. 2010-11-04. PMID:20685653. |
we showed that e2f1 promotes apoptosis by up-regulating the proapoptotic cofactors of p53 and procaspases. |
2010-11-04 |
2023-08-12 |
Not clear |
| Danielle B Ulanet, Douglas Hanaha. Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms. PloS one. vol 5. issue 8. 2010-11-04. PMID:20805995. |
despite inhibition of p53 by tag in this mouse pnet model, concomitant disruption of arf via genetic knockout resulted in a significantly accelerated pathway to tumor formation that was surprisingly not driven by alterations in tumor cell proliferation or apoptosis, but rather via earlier activation of the angiogenic switch. |
2010-11-04 |
2023-08-12 |
mouse |
| Danupon Nantajit, Ming Fan, Nadire Duru, Yunfei Wen, John C Reed, Jian Jian L. Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808790. |
the mitochondrial kinase activity of cyclin b1/cdk1 was found to specifically phosphorylate p53 at ser-315 residue, leading to enhanced mitochondrial atp production and reduced mitochondrial apoptosis. |
2010-11-04 |
2023-08-12 |
mouse |