| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying-Chao Lin, Chao-Ming Hung, Jia-Chun Tsai, Jang-Chang Lee, Yi-Lin Sophia Chen, Chyou-Wei Wei, Jung-Yie Kao, Tzong-Der Wa. Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK). Journal of agricultural and food chemistry. vol 58. issue 17. 2010-12-10. PMID:20698539. |
furthermore, hispidulin blocked the progression of the cell cycle at the g1 phase and induced apoptosis by inducing p53 expression and further upregulating p21 expression in gbm cells. |
2010-12-10 |
2023-08-12 |
human |
| Hui-Juan Zhang, Michelle Kwan-Yee Siu, Li-Li Jiang, Victor Chun-Yin Mak, Hextan Yuen-Sheung Ngan, Annie Nga-Yin Cheun. Overexpression of the Parkinson disease protein DJ-1 and its regulator PTEN in gestational trophoblastic disease. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. vol 29. issue 5. 2010-12-10. PMID:20736773. |
a significant negative correlation was found between dj-1 and the apoptosis resistant gene bcl-2 (p=0.031), whereas a positive correlation was shown between pten and wild-type p53 (p=0.019). |
2010-12-10 |
2023-08-12 |
human |
| Subramanian Balakrishnan, Shanmugam Manoharan, Linsa Mary Alias, Madavan R Nirma. Effect of curcumin and ferulic acid on modulation of expression pattern of p53 and bcl-2 proteins in 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Indian journal of biochemistry & biophysics. vol 47. issue 1. 2010-12-10. PMID:21086748. |
the modulating effect of curcumin and ferulic acid was investigated on expression pattern of apoptosis regulatory p53 and bcl-2 proteins in oral squamous cell carcinoma (oscc). |
2010-12-10 |
2023-08-12 |
Not clear |
| Xiarong Dong, Jihua Dong, Gang Pen. Growth-inhibiting and apoptosis-inducing effects of Tanshinone II A on human gastric carcinoma cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 6. 2010-12-07. PMID:18231749. |
to explore the effects of tanshinone ii a on the proliferation, apoptosis and gene expression of p53 and bcl-2 in human gastric carcinoma mkn-45 cells. |
2010-12-07 |
2023-08-12 |
human |
| Xiarong Dong, Jihua Dong, Gang Pen. Growth-inhibiting and apoptosis-inducing effects of Tanshinone II A on human gastric carcinoma cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 6. 2010-12-07. PMID:18231749. |
this resulted in apoptosis of mkn-45 cells and the apoptosis rate was as high as 43.91% after treatment with 2.0 microg/ml tanshinone ii a for 96 h. it was also found that tanshinone ii a up-regulated expression of p53 gene and down-regulated expression of bcl-2 gene. |
2010-12-07 |
2023-08-12 |
human |
| Meisong Lu, Lan Xiao, Zhimin L. The relationship between p38MAPK and apoptosis during paclitaxel resistance of ovarian cancer cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 6. 2010-12-07. PMID:18231754. |
moreover, p38mapk-mediated apoptosis in paclitaxel-resistant ovarian carcinoma cells depends on the activation of p53. |
2010-12-07 |
2023-08-12 |
human |
| Bruce K Carney, Lynne Cassimeri. Stathmin/oncoprotein 18, a microtubule regulatory protein, is required for survival of both normal and cancer cell lines lacking the tumor suppressor, p53. Cancer biology & therapy. vol 9. issue 9. 2010-12-07. PMID:20200495. |
our results demonstrate that stathmin is required for cell survival in cells lacking p53, suggesting that stathmin depletion could be used therapeutically to induce apoptosis in tumors without functional p53. |
2010-12-07 |
2023-08-12 |
human |
| Xi-Ming Yuan, Ehab Osman, Sayem Miah, Shahram Nour Mohammad Zadeh, Lihua Xu, Claes Forssell, Wei L. p53 expression in human carotid atheroma is significantly related to plaque instability and clinical manifestations. Atherosclerosis. vol 210. issue 2. 2010-12-06. PMID:20060114. |
the expression of p53 has been associated with dna damage, cell senescence, proliferation and apoptosis in human atherosclerotic plaques. |
2010-12-06 |
2023-08-12 |
human |
| Xi-Ming Yuan, Ehab Osman, Sayem Miah, Shahram Nour Mohammad Zadeh, Lihua Xu, Claes Forssell, Wei L. p53 expression in human carotid atheroma is significantly related to plaque instability and clinical manifestations. Atherosclerosis. vol 210. issue 2. 2010-12-06. PMID:20060114. |
we also investigated p53 expression and its relation to apoptosis and apoptosis-related cathepsin l and ferritin in the carotid lesions. |
2010-12-06 |
2023-08-12 |
human |
| Shreya Datta, Megan E Bucks, Dipankar Koley, Pei Xin Lim, Sergey N Savino. Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system. Bioorganic & medicinal chemistry. vol 18. issue 16. 2010-12-06. PMID:20638853. |
the restoration of the p53 function, rendered suppressed or dormant by these negative regulators, establishes, therefore, a unique opportunity for a targeted induction of apoptosis in cancers that retain wild-type p53. |
2010-12-06 |
2023-08-12 |
Not clear |
| Ahmed Kamal, J Surendranadha Reddy, M Janaki Ramaiah, E Vijaya Bharathi, D Dastagiri, M Kashi Reddy, S N C V L Pushpavalli, Manika Pal-Bhadr. Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents. Bioorganic & medicinal chemistry letters. vol 20. issue 17. 2010-12-06. PMID:20673627. |
these compounds showed the characteristic features of apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of parp. |
2010-12-06 |
2023-08-12 |
Not clear |
| Liam P Tuffy, Caoimhín G Concannon, Beatrice D'Orsi, Matthew A King, Ina Woods, Heinrich J Huber, Manus W Ward, Jochen H M Preh. Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition. Molecular and cellular biology. vol 30. issue 23. 2010-12-06. PMID:20921277. |
previously we demonstrated that stabilization of p53 and activation of its target gene, puma (p53-upregulated mediator of apoptosis), mediated proteasome inhibitor-induced apoptosis in cancer cells. |
2010-12-06 |
2023-08-12 |
mouse |
| Kakajan Komurov, Michael A White, Prahlad T Ra. Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data. PLoS computational biology. vol 6. issue 8. 2010-12-03. PMID:20808879. |
we also present netwalk analysis of microarray gene expression data from mcf7 cells exposed to different doses of doxorubicin, which reveals a switch-like pattern in the p53 regulated network in cell cycle arrest and apoptosis. |
2010-12-03 |
2023-08-12 |
Not clear |
| Marina Zemskova, Michael B Lilly, Ying-Wei Lin, Jin H Song, Andrew S Kraf. p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase. Molecular cancer research : MCR. vol 8. issue 8. 2010-12-02. PMID:20647331. |
in these 22rv1 cells, the induction of p53 protein was associated not only with senescence but also with a significant level of apoptosis. |
2010-12-02 |
2023-08-12 |
human |
| b' James M Angelastro, Michael W Lam\\xc3\\xa. Overexpression of CD133 promotes drug resistance in C6 glioma cells. Molecular cancer research : MCR. vol 8. issue 8. 2010-12-02. PMID:20663862.' |
although p53 was upregulated in cd133-overexpressing glioma cells treated with dna-damaging agents, apoptosis seems to be p53 independent. |
2010-12-02 |
2023-08-12 |
rat |
| Young Bong Choi, John Nichola. Bim nuclear translocation and inactivation by viral interferon regulatory factor. PLoS pathogens. vol 6. issue 8. 2010-12-02. PMID:20700448. |
contributors include the four viral interferon regulatory factors (virfs 1-4), which function in dominant negative fashion to block cellular irf activities in addition to targeting irf signaling-induced proteins such as p53 and inhibiting other inducers of apoptosis such as tgfbeta receptor-activated smad transcription factors. |
2010-12-02 |
2023-08-12 |
human |
| Drew D Dudgeon, Sunita Shinde, Yun Hua, Tong Ying Shun, John S Lazo, Christopher J Strock, Kenneth A Giuliano, D Lansing Taylor, Patricia A Johnston, Paul A Johnsto. Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits. Journal of biomolecular screening. vol 15. issue 7. 2010-12-01. PMID:20639499. |
in hct116 cells with wild-type (wt) p53, the mbnas enhanced p53 protein levels, increased the expression of p53 target genes, caused a cell cycle arrest in g1, induced apoptosis, and inhibited cell proliferation with an ic(50) ~4 microm. |
2010-12-01 |
2023-08-12 |
Not clear |
| Drew D Dudgeon, Sunita Shinde, Yun Hua, Tong Ying Shun, John S Lazo, Christopher J Strock, Kenneth A Giuliano, D Lansing Taylor, Patricia A Johnston, Paul A Johnsto. Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits. Journal of biomolecular screening. vol 15. issue 7. 2010-12-01. PMID:20639499. |
unlike nutlin-3, however, mbnas also increased the percentage of apoptosis in p53 null cells and exhibited similar potencies for growth inhibition in isogenic cell lines null for p53 or p21. |
2010-12-01 |
2023-08-12 |
Not clear |
| Peng Gao, Jie Zhen. High-risk HPV E5-induced cell fusion: a critical initiating event in the early stage of HPV-associated cervical cancer. Virology journal. vol 7. 2010-12-01. PMID:20846406. |
it is proposed that oncogenic virus-induced cell fusion may contribute to oncogenesis if p53 or apoptosis is perturbed simultaneously. |
2010-12-01 |
2023-08-12 |
human |
| C Auw-Hädrich, N Göbel, G Illerhau. [Infectious agents in ocular adnexal tumours]. Klinische Monatsblatter fur Augenheilkunde. vol 227. issue 7. 2010-11-30. PMID:20535664. |
inactivation of p53 by mutation of its dna, which leads to elevation of defective p53 protein and inhibition of apoptosis, allows oncogenic by-chance mutations to become effective. |
2010-11-30 |
2023-08-12 |
Not clear |