| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshiyuki Mizushina, Katsumi Nishimura, Yukiko Takenaka, Toshifumi Takeuchi, Fumio Sugawara, Hiromi Yoshida, Takao Tanahash. Inhibitory effects of docosyl p-coumarate on DNA topoisomerase activity and human cancer cell growth. International journal of oncology. vol 37. issue 4. 2010-12-23. PMID:20811721. |
compound 5 (docosyl p-coumarate), which was the strongest inhibitor of topo ii and cancer cell growth in the compounds tested, halted hct116 p53(+/+) cells in g2/m phases, and induced apoptosis, although this compound did not affect the cell cycle of hct116 p53(-/-) cells. |
2010-12-23 |
2023-08-12 |
human |
| Diptiman Choudhury, Amlan Das, Abhijit Bhattacharya, Gopal Chakrabart. Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 48. issue 10. 2010-12-22. PMID:20647029. |
it has been found that the apoptosis of a549 cells by gae is mediated by up regulation of tumor suppressor gene p53 and alteration of the normal bax/bcl-2 ratio followed by down regulation of cellular pro-caspase3. |
2010-12-22 |
2023-08-12 |
human |
| Imane Abbas, Guillaume Garçon, Françoise Saint-Georges, Sylvain Billet, Anthony Verdin, Pierre Gosset, Philippe Mulliez, Pirouz Shiral. Occurrence of molecular abnormalities of cell cycle in L132 cells after in vitro short-term exposure to air pollution PM(2.5). Chemico-biological interactions. vol 188. issue 3. 2010-12-21. PMID:20850422. |
p53; bcl2; p21; cyclin d1, cyclin-dependent kinase 1; retinoblastoma protein) in l132 cells, thereby leading to the occurrence of cell proliferation and apoptosis together. |
2010-12-21 |
2023-08-12 |
human |
| Ajaikumar B Kunnumakkara, Bokyung Sung, Jayaraj Ravindran, Parmeswaran Diagaradjane, Amit Deorukhkar, Sanjit Dey, Cemile Koca, Vivek R Yadav, Zhimin Tong, Juri G Gelovani, Sushovan Guha, Sunil Krishnan, Bharat B Aggarwa. {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer research. vol 70. issue 21. 2010-12-21. PMID:20864511. |
γ-t3 inhibited the in vitro proliferation of pancreatic cancer cell lines with variable p53 status and potentiated gemcitabine-induced apoptosis. |
2010-12-21 |
2023-08-12 |
mouse |
| Mario A Pennella, Yue Liu, Jennifer L Woo, Chongwoo A Kim, Arnold J Ber. Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies. Journal of virology. vol 84. issue 23. 2010-12-20. PMID:20861261. |
oncogenic transformation by adenovirus e1a and e1b-55k requires e1b-55k inhibition of p53 activity to prevent e1a-induced apoptosis. |
2010-12-20 |
2023-08-12 |
Not clear |
| Kuladip Jana, Narayan Jana, Dipak Kumar De, Sujoy Kumar Guh. Ethanol induces mouse spermatogenic cell apoptosis in vivo through over-expression of Fas/Fas-L, p53, and caspase-3 along with cytochrome c translocation and glutathione depletion. Molecular reproduction and development. vol 77. issue 9. 2010-12-17. PMID:20803734. |
ethanol induces mouse spermatogenic cell apoptosis in vivo through over-expression of fas/fas-l, p53, and caspase-3 along with cytochrome c translocation and glutathione depletion. |
2010-12-17 |
2023-08-12 |
mouse |
| Kuladip Jana, Narayan Jana, Dipak Kumar De, Sujoy Kumar Guh. Ethanol induces mouse spermatogenic cell apoptosis in vivo through over-expression of Fas/Fas-L, p53, and caspase-3 along with cytochrome c translocation and glutathione depletion. Molecular reproduction and development. vol 77. issue 9. 2010-12-17. PMID:20803734. |
the present study has indicated that the ethanol treatment induced apoptosis in the mouse testis through the increased expression of fas/fas-l and p53, up-regulation of bax/bcl-2 ratio, cytosolic translocation of cytochrome c along with caspase-3 activation and glutathione depletion. |
2010-12-17 |
2023-08-12 |
mouse |
| Jie Wu, Jiao Sun, Yang Xu. Involvement of JNK and P53 activation in G2/M cell cycle arrest and apoptosis induced by titanium dioxide nanoparticles in neuron cells. Toxicology letters. vol 199. issue 3. 2010-12-17. PMID:20863874. |
involvement of jnk and p53 activation in g2/m cell cycle arrest and apoptosis induced by titanium dioxide nanoparticles in neuron cells. |
2010-12-17 |
2023-08-12 |
Not clear |
| Jie Wu, Jiao Sun, Yang Xu. Involvement of JNK and P53 activation in G2/M cell cycle arrest and apoptosis induced by titanium dioxide nanoparticles in neuron cells. Toxicology letters. vol 199. issue 3. 2010-12-17. PMID:20863874. |
it is suggested from our results that reactive oxygen species (ros) have a mediation effect to oxidative stress and up-regulation of jnk and p53 phosphorylation involved in mechanistic pathways of tio(2)-nps can induce apoptosis and cell cycle arrest in pc12 cells. |
2010-12-17 |
2023-08-12 |
Not clear |
| Wei-jun Mai, Jun-lun Yan, Lei Wang, Ying Zheng, Yu Xin, Wei-na Wan. Acute acidic exposure induces p53-mediated oxidative stress and DNA damage in tilapia (Oreochromis niloticus) blood cells. Aquatic toxicology (Amsterdam, Netherlands). vol 100. issue 3. 2010-12-16. PMID:20739073. |
the results showed that acute acid stress induced upregulation of atm, p53 and p21, associated with increasing of dna damage and apoptosis in blood cells. |
2010-12-16 |
2023-08-12 |
Not clear |
| Viktor Shtilbans, Maoxin Wu, David E Burstei. Evaluation of apoptosis in cytologic specimens. Diagnostic cytopathology. vol 38. issue 9. 2010-12-15. PMID:20229589. |
p53 undergoes oncogenic alteration more than any other protein; its immunocytochemical detection almost always connotes loss of its physiologic role as an inducer of apoptosis in response to a damaged genome. |
2010-12-15 |
2023-08-12 |
Not clear |
| Xiaojun Xia, Eunmi Park, Bigang Liu, Jami Willette-Brown, Wanghua Gong, Jiming Wang, David Mitchell, Susan M Fischer, Yinling H. Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis. The American journal of pathology. vol 176. issue 5. 2010-12-15. PMID:20304950. |
at an early stage of carcinogenesis, an increase in uvb-induced p53 mutations as well as macrophage recruitment and mitogenic activity, and a decrease in uvb-induced apoptosis, were detected in ikkalpha(+/-) compared with those in ikkalpha(+/+) skin. |
2010-12-15 |
2023-08-12 |
mouse |
| Sz-Hsien Yu, Pei-Ming Yang, Chih-Wen Peng, Yi-Chu Yu, Shu-Jun Chi. Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis. Cancer letters. vol 300. issue 1. 2010-12-15. PMID:20974518. |
fisetin-induced apoptosis in hct116 cells as indicated by tunel assay, annexin v-fitc/pi double staining, ser15-phosphorylation of p53, and cleavages of procaspase-3 and parp. |
2010-12-15 |
2023-08-12 |
human |
| Houli Cao, Qian Feng, Wei Xu, Xiaorong Li, Zhuang Kang, Yanqin Ren, Linfang D. Genipin induced apoptosis associated with activation of the c-Jun NH2-terminal kinase and p53 protein in HeLa cells. Biological & pharmaceutical bulletin. vol 33. issue 8. 2010-12-14. PMID:20686229. |
genipin induced apoptosis associated with activation of the c-jun nh2-terminal kinase and p53 protein in hela cells. |
2010-12-14 |
2023-08-12 |
human |
| Devapregasan Moodley, Girish M Mody, Anil A Chuturgoo. Functional analysis of the p53 codon 72 polymorphism in black South Africans with rheumatoid arthritis--a pilot study. Clinical rheumatology. vol 29. issue 10. 2010-12-13. PMID:20532936. |
the p53 tumor-suppressor protein plays an integral role in apoptosis. |
2010-12-13 |
2023-08-12 |
Not clear |
| Devapregasan Moodley, Girish M Mody, Anil A Chuturgoo. Functional analysis of the p53 codon 72 polymorphism in black South Africans with rheumatoid arthritis--a pilot study. Clinical rheumatology. vol 29. issue 10. 2010-12-13. PMID:20532936. |
polymorphisms at codon 72 of p53 (arginine (arg72) to proline transition) confers differences in mitochondrial translocation and apoptosis inducing capabilities of p53 in vitro. |
2010-12-13 |
2023-08-12 |
Not clear |
| Devapregasan Moodley, Girish M Mody, Anil A Chuturgoo. Functional analysis of the p53 codon 72 polymorphism in black South Africans with rheumatoid arthritis--a pilot study. Clinical rheumatology. vol 29. issue 10. 2010-12-13. PMID:20532936. |
there was no significant difference in pl apoptosis and mitochondrial depolarization based on p53 codon 72 genotype. |
2010-12-13 |
2023-08-12 |
Not clear |
| Devapregasan Moodley, Girish M Mody, Anil A Chuturgoo. Functional analysis of the p53 codon 72 polymorphism in black South Africans with rheumatoid arthritis--a pilot study. Clinical rheumatology. vol 29. issue 10. 2010-12-13. PMID:20532936. |
we conclude that p53 codon 72 genotype does not influence pl apoptosis or mitochondrial depolarization and is not associated with clinical markers of disease in ra. |
2010-12-13 |
2023-08-12 |
Not clear |
| Angelos Tsipis, Anna Maria Athanassiadou, Pauline Athanassiadou, Nikolaos Kavantzas, George Agrogiannis, Efstratios Patsouri. Apoptosis-related factors p53, bcl-2 and the defects of force transmission in dilated cardiomyopathy. Pathology, research and practice. vol 206. issue 9. 2010-12-10. PMID:20591580. |
on the other hand, increased expression of p53 is associated with progressive loss of myocytes by apoptosis in heart failure, and increased expression of bcl-2 represents a possible compensatory antiapoptotic mechanism. |
2010-12-10 |
2023-08-12 |
Not clear |
| Sergio Perez-Alvarez, Maria D Cuenca-Lopez, Raquel M Melero-Fernández de Mera, Elena Puerta, Andonis Karachitos, Piotr Bednarczyk, Hanna Kmita, Norberto Aguirre, Maria F Galindo, Joaquin Jordá. Methadone induces necrotic-like cell death in SH-SY5Y cells by an impairment of mitochondrial ATP synthesis. Biochimica et biophysica acta. vol 1802. issue 11. 2010-12-10. PMID:20691259. |
furthermore, no participation of known protein regulators of apoptosis such as bcl-x(l) and p53 was observed. |
2010-12-10 |
2023-08-12 |
human |