| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kin-Hang Kok, Ting Lei, Dong-Yan Ji. Identification and validation of the cellular targets of virus-encoded microRNAs. Methods in molecular biology (Clifton, N.J.). vol 667. 2011-01-06. PMID:20827543. |
our demonstration of the targeting of p53 upregulated modulator of apoptosis (puma) by an ebv-encoded viral mirna provides one mechanism by which a viral mirna facilitates viral replication by promoting cell survival. |
2011-01-06 |
2023-08-12 |
Not clear |
| Ya-nan Xing, Xue Yang, Xiao-yan Xu, Yang Zheng, Hui-mian Xu, Yasuo Takano, Hua-chuan Zhen. The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression. Human pathology. vol 42. issue 1. 2011-01-06. PMID:21062663. |
ing5 can interact with p53, thereby inhibiting cell growth and inducing apoptosis. |
2011-01-06 |
2023-08-12 |
Not clear |
| V Dötsch, F Bernassola, D Coutandin, E Candi, G Melin. p63 and p73, the ancestors of p53. Cold Spring Harbor perspectives in biology. vol 2. issue 9. 2011-01-05. PMID:20484388. |
besides overlapping functions shared with p53 (i.e., induction of apoptosis in response to cellular stress), the existence of extensive structural variability within the family determines unique roles for p63 and p73. |
2011-01-05 |
2023-08-12 |
mouse |
| Xiaowei Gong, Aihua Liu, Xiaoyan Ming, Peng Deng, Yong Jian. UV-induced interaction between p38 MAPK and p53 serves as a molecular switch in determining cell fate. FEBS letters. vol 584. issue 23. 2011-01-05. PMID:21050851. |
upon low dose ultraviolet (uv) radiation, p38 and p53 protect the cells from apoptosis separately. |
2011-01-05 |
2023-08-12 |
Not clear |
| Takahiko Kobayashi, Junich Ishida, Manabu Musashi, Shuichi Ota, Takeshi Yoshida, Yuichi Shimizu, Makoto Chuma, Hiroshi Kawakami, Masahiro Asaka, Junji Tanaka, Masahiro Imamura, Masanobu Kobayashi, Hiroshi Itoh, Hironori Edamatsu, Leslie C Sutherland, Rainer K Brachman. p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5. International journal of cancer. vol 128. issue 2. 2011-01-04. PMID:20309933. |
our results show that rbm5 contributes to p53 transcriptional activity after dna damage and that growth suppression and apoptosis mediated by rbm5 are linked to activity of the tumor suppressor protein p53. |
2011-01-04 |
2023-08-12 |
human |
| Yan Xu, Li Liu, Jibin Liu, Yixin Zhang, Jian Zhu, Jianguo Chen, Sheng Liu, Zheng Liu, Haibin Shi, Hongbing Shen, Zhibin H. A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. International journal of cancer. vol 128. issue 2. 2011-01-04. PMID:20309940. |
the mir-34 family members are direct transcriptional targets of tumor suppressor p53, and loss of mir-34 function can impair p53-mediated cell cycle arrest and apoptosis. |
2011-01-04 |
2023-08-12 |
Not clear |
| Lu Li, Zhiling Qi, Jin Qian, Fuyong Bi, Jun Lv, Lei Xu, Ling Zhang, Hongyu Chen, Renbing Ji. Induction of apoptosis in hepatocellular carcinoma Smmc-7721 cells by vitamin K(2) is associated with p53 and independent of the intrinsic apoptotic pathway. Molecular and cellular biochemistry. vol 342. issue 1-2. 2011-01-04. PMID:20449638. |
induction of apoptosis in hepatocellular carcinoma smmc-7721 cells by vitamin k(2) is associated with p53 and independent of the intrinsic apoptotic pathway. |
2011-01-04 |
2023-08-12 |
human |
| Lu Li, Zhiling Qi, Jin Qian, Fuyong Bi, Jun Lv, Lei Xu, Ling Zhang, Hongyu Chen, Renbing Ji. Induction of apoptosis in hepatocellular carcinoma Smmc-7721 cells by vitamin K(2) is associated with p53 and independent of the intrinsic apoptotic pathway. Molecular and cellular biochemistry. vol 342. issue 1-2. 2011-01-04. PMID:20449638. |
in summary, these data suggested that vk(2) can inhibit the growth of smmc-7721 cells by induction of apoptosis involving caspase 8 activation and p53. |
2011-01-04 |
2023-08-12 |
human |
| Zhengyi Li, Yufeng Xie, Weihua Sheng, Jingcheng Miao, Jim Xiang, Jicheng Yan. Tumor-suppressive effect of adenovirus-mediated inhibitor of growth 4 gene transfer in breast carcinoma cells in vitro and in vivo. Cancer biotherapy & radiopharmaceuticals. vol 25. issue 4. 2011-01-04. PMID:20707719. |
this study further demonstrates that ad-ing4 gene transfer resulted in g2/m phase arrest and apoptosis, upregulated p21, p27, and bax, downregulated bcl-2, il-8, and ang-1, promoted cytochrome c release from mitochondria into cytosol, and activated caspase-9, caspase-3, and parp in mutant p53 mda-mb-231 breast carcinoma cells. |
2011-01-04 |
2023-08-12 |
mouse |
| Xin Liu, Jiao Su. Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 and NF-kappaB pathways. Biomaterials. vol 31. issue 32. 2011-01-04. PMID:20727582. |
moreover, inhibition of ros attenuated silica nanoparticles-induced apoptosis and inflammation and the activation of jnk, c-jun, p53 and nf-kappab. |
2011-01-04 |
2023-08-12 |
human |
| Jacky Chung, Joanne Lau, Lynn S Cheng, R Ian Grant, Fiona Robinson, Troy Ketela, Patricia P Reis, Olga Roche, Suzanne Kamel-Reid, Jason Moffat, Michael Ohh, Bayardo Perez-Ordonez, David R Kaplan, Meredith S Irwi. SATB2 augments ΔNp63α in head and neck squamous cell carcinoma. EMBO reports. vol 11. issue 10. 2011-01-04. PMID:20829881. |
furthermore, satb2 expression positively correlates with hnscc chemoresistance, and rna interference-mediated knockdown of endogenous satb2 re-sensitizes hnscc cells to chemotherapy- and γ-irradiation-induced apoptosis, irrespective of p53 status. |
2011-01-04 |
2023-08-12 |
Not clear |
| Assaad A Eid, Bridget M Ford, Karen Block, Balakuntalam S Kasinath, Yves Gorin, Goutam Ghosh-Choudhury, Jeffrey L Barnes, Hanna E Abbou. AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20861022. |
amp-activated protein kinase (ampk) negatively regulates nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. |
2010-12-30 |
2023-08-12 |
mouse |
| Assaad A Eid, Bridget M Ford, Karen Block, Balakuntalam S Kasinath, Yves Gorin, Goutam Ghosh-Choudhury, Jeffrey L Barnes, Hanna E Abbou. AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20861022. |
we also identified the tumor suppressor protein p53 as a mediator of podocyte apoptosis in cells exposed to hg. |
2010-12-30 |
2023-08-12 |
mouse |
| Assaad A Eid, Bridget M Ford, Karen Block, Balakuntalam S Kasinath, Yves Gorin, Goutam Ghosh-Choudhury, Jeffrey L Barnes, Hanna E Abbou. AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20861022. |
our results uncover a novel function of ampk that integrates metabolic input to nox4 and provide new insight for activation of p53 to induce podocyte apoptosis. |
2010-12-30 |
2023-08-12 |
mouse |
| Verónica A Codelia, Matías Cisterna, Alejandra R Alvarez, Ricardo D Moren. p73 participates in male germ cells apoptosis induced by etoposide. Molecular human reproduction. vol 16. issue 10. 2010-12-28. PMID:20519366. |
the aim of this study was to evaluate the participation of p73, a member of the p53 family, in apoptosis induced by etoposide in male germ cells. |
2010-12-28 |
2023-08-12 |
rat |
| Verónica A Codelia, Matías Cisterna, Alejandra R Alvarez, Ricardo D Moren. p73 participates in male germ cells apoptosis induced by etoposide. Molecular human reproduction. vol 16. issue 10. 2010-12-28. PMID:20519366. |
these results support the notion that the c-abl/p73 pathway is activated in germ cells after etoposide treatment, triggering apoptosis, possibly assisting p53. |
2010-12-28 |
2023-08-12 |
rat |
| Yaling Cui, Xiaolan Gong, Yanmei Duan, Na Li, Renping Hu, Huiting Liu, Mengmeng Hong, Min Zhou, Ling Wang, Han Wang, Fashui Hon. Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles. Journal of hazardous materials. vol 183. issue 1-3. 2010-12-28. PMID:20724067. |
60 days of tio(2) nps exposure, hepatocyte apoptosis in the liver could be observed, which was followed by increased reactive oxygen species accumulation, and decreased the stress-related gene expression levels of superoxide dismutase, catalase, glutathione peroxidase, metallothionein, heat shock protein 70, glutathione s transferase, p53, and transferrin; and the significant enhancement of the cytochrome p450 1a expression level. |
2010-12-28 |
2023-08-12 |
mouse |
| Debora Russo, Laura Ottaggio, Ilaria Penna, Giorgia Foggetti, Gilberto Fronza, Alberto Inga, Paola Menichin. PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells. Biochemical and biophysical research communications. vol 402. issue 2. 2010-12-28. PMID:20946886. |
prima-1 has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in cells expressing mutant p53. |
2010-12-28 |
2023-08-12 |
Not clear |
| Debora Russo, Laura Ottaggio, Ilaria Penna, Giorgia Foggetti, Gilberto Fronza, Alberto Inga, Paola Menichin. PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells. Biochemical and biophysical research communications. vol 402. issue 2. 2010-12-28. PMID:20946886. |
studies on subcellular distribution of the mutant p53 protein upon treatment with prima-1met, a methylated form of prima-1, have suggested that redistribution of mutant p53 to nucleoli may play a role in prima-1 induced apoptosis. |
2010-12-28 |
2023-08-12 |
Not clear |
| Angelo Peschiaroli, Flavia Scialpi, Francesca Bernassola, El Said El Sherbini, Gerry Melin. The E3 ubiquitin ligase WWP1 regulates ΔNp63-dependent transcription through Lys63 linkages. Biochemical and biophysical research communications. vol 402. issue 2. 2010-12-28. PMID:20951678. |
the transcription factor p63, a member of the p53 family, plays a crucial role in epithelial development and tumorigenesis through the regulation of epithelial progenitor cell proliferation, differentiation and apoptosis. |
2010-12-28 |
2023-08-12 |
human |