| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Subhasree Roy Choudhury, Surajit Karmakar, Naren L Banik, Swapan K Ra. Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification. Investigational new drugs. vol 28. issue 6. 2011-02-03. PMID:19777160. |
synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having n-myc amplification or non-amplification. |
2011-02-03 |
2023-08-12 |
human |
| Subhasree Roy Choudhury, Surajit Karmakar, Naren L Banik, Swapan K Ra. Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification. Investigational new drugs. vol 28. issue 6. 2011-02-03. PMID:19777160. |
combination therapy showed activation of caspase-8, cleavage of bid to tbid, increase in p53 and p21 expression, down regulation of anti-apoptotic mcl-1, and increase in bax:bcl-2 ratio to trigger apoptosis. |
2011-02-03 |
2023-08-12 |
human |
| J Hrebackova, J Hrabeta, T Eckschlage. Valproic acid in the complex therapy of malignant tumors. Current drug targets. vol 11. issue 3. 2011-02-03. PMID:20214599. |
the first involves apoptosis and can be both p53 dependent or independent; the second involves mechanisms other than apoptosis. |
2011-02-03 |
2023-08-12 |
Not clear |
| Andrea Hartwi. Mechanisms in cadmium-induced carcinogenicity: recent insights. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 23. issue 5. 2011-02-03. PMID:20390439. |
furthermore, cadmium induces cell proliferation, inactivates negative growth stimuli, such as the tumor suppressor protein p53, and provokes resistance towards apoptosis. |
2011-02-03 |
2023-08-12 |
Not clear |
| Olaf Merkel, Daniela Asslaber, Josefina D Piñón, Alexander Egle, Richard Grei. Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia. Cell cycle (Georgetown, Tex.). vol 9. issue 14. 2011-02-03. PMID:20581456. |
the mir-34 family was demonstrated to be induced by the tumor suppressor p53 and to elicit p53-like responses like senescence, cell cycle arrest and apoptosis depending on the cell type. |
2011-02-03 |
2023-08-12 |
human |
| Olaf Merkel, Daniela Asslaber, Josefina D Piñón, Alexander Egle, Richard Grei. Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia. Cell cycle (Georgetown, Tex.). vol 9. issue 14. 2011-02-03. PMID:20581456. |
here, we present data showing that knockdown of p53 in hct-116 cells severely reduces mir-34a induced apoptosis. |
2011-02-03 |
2023-08-12 |
human |
| Girma M Woldemichael, Thomas J Turbyville, W Marston Linehan, James B McMaho. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer research. vol 71. issue 1. 2011-02-01. PMID:21199801. |
ca also induced apoptosis in ccrcc cells by a mechanism independent of p53 or hypoxia-inducible factor 2. |
2011-02-01 |
2023-08-12 |
Not clear |
| Elena Kashuba, Mariya Yurchenko, Surya Pavan Yenamandra, Boris Snopok, Laszlo Szekely, Beatrice Bercovich, Aaron Ciechanover, George Klei. Epstein-Barr virus-encoded EBNA-5 forms trimolecular protein complexes with MDM2 and p53 and inhibits the transactivating function of p53. International journal of cancer. vol 128. issue 4. 2011-01-31. PMID:20473904. |
this may explain the tolerance of established lcls to high levels of p53 without undergoing apoptosis. |
2011-01-31 |
2023-08-12 |
Not clear |
| Kelly L Moffitt, S Lorraine Martin, Brian Walke. From sentencing to execution--the processes of apoptosis. The Journal of pharmacy and pharmacology. vol 62. issue 5. 2011-01-31. PMID:20609056. |
apoptosis occurs in three non-distinct phases--induction, effector and degradation--and can be executed through both the extrinsic and intrinsic pathways in addition to recognised sub-pathways such as the p53 and lysosomal pathways. |
2011-01-31 |
2023-08-12 |
Not clear |
| Neekkan Dey, Archita Das, Arunava Ghosh, Indu B Chatterje. Activated charcoal filter effectively reduces p-benzosemiquinone from the mainstream cigarette smoke and prevents emphysema. Journal of biosciences. vol 35. issue 2. 2011-01-31. PMID:20689178. |
the charcoal filter also prevented cytotoxicity in a549 cells as evidenced by mtt assay, apoptosis as evidenced by facs analysis, tunel assay, overexpression of bax, activation of p53 and caspase 3, as well as emphysematous lung damage in a guinea pig model as seen by histology and morphometric analysis. |
2011-01-31 |
2023-08-12 |
cattle |
| Rui Kamada, Takao Nomura, Carl W Anderson, Kazuyasu Sakaguch. Cancer-associated p53 tetramerization domain mutants: quantitative analysis reveals a low threshold for tumor suppressor inactivation. The Journal of biological chemistry. vol 286. issue 1. 2011-01-31. PMID:20978130. |
the tumor suppressor p53, a 393-amino acid transcription factor, induces cell cycle arrest and apoptosis in response to genotoxic stress. |
2011-01-31 |
2023-08-12 |
human |
| Michael A Koldobskiy, Anutosh Chakraborty, J Kent Werner, Adele M Snowman, Krishna R Juluri, M Scott Vandiver, Seyun Kim, Shira Heletz, Solomon H Snyde. p53-mediated apoptosis requires inositol hexakisphosphate kinase-2. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 49. 2011-01-31. PMID:21078964. |
the tumor suppressor p53 responds to genotoxic stress by engaging a transcriptional program leading to cell-cycle arrest or apoptosis. |
2011-01-31 |
2023-08-12 |
Not clear |
| Michael A Koldobskiy, Anutosh Chakraborty, J Kent Werner, Adele M Snowman, Krishna R Juluri, M Scott Vandiver, Seyun Kim, Shira Heletz, Solomon H Snyde. p53-mediated apoptosis requires inositol hexakisphosphate kinase-2. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 49. 2011-01-31. PMID:21078964. |
we demonstrate that ip6k2 is required for p53-mediated apoptosis and modulates the outcome of the p53 response. |
2011-01-31 |
2023-08-12 |
Not clear |
| David Engelmann, Brigitte M Pütze. Translating DNA damage into cancer cell death-A roadmap for E2F1 apoptotic signalling and opportunities for new drug combinations to overcome chemoresistance. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 13. issue 4-5. 2011-01-28. PMID:20675184. |
the cellular transcription factor e2f1 has been identified as a tumor suppressor regulating the activities of p53 and its homologue tap73, and promoting apoptosis by the activation of a plethora of death pathways. |
2011-01-28 |
2023-08-12 |
human |
| Hiromi Ohtsuka, Akemi Sakamoto, Jing Pan, Sumina Inage, Satoshi Horigome, Hirohito Ichii, Masafumi Arima, Masahiko Hatano, Seiji Okada, Takeshi Tokuhis. Bcl6 is required for the development of mouse CD4+ and CD8α+ dendritic cells. Journal of immunology (Baltimore, Md. : 1950). vol 186. issue 1. 2011-01-27. PMID:21131418. |
the addition of a p53 inhibitor to bcl6-ko bm culture protected apoptosis, suggesting that bcl6 is required by cdc precursors for survival by controlling p53 expression. |
2011-01-27 |
2023-08-12 |
mouse |
| Cassie Lin, Dana R Crawford, Sharon Lin, Jualang Hwang, Annette Sebuyira, Ran Meng, Jennifer E Westfall, Heng-Yuan Tang, SuFan Lin, Pin-Yung Yu, Paul J Davis, Hung-Yun Li. Inducible COX-2-dependent apoptosis in human ovarian cancer cells. Carcinogenesis. vol 32. issue 1. 2011-01-27. PMID:21187340. |
our findings include the following: (i) nuclear accumulation of cox-2 in resveratrol-treated cells is blocked by the erk1/2 inhibitor, pd98059; (ii) an inhibitor of cox-2 activity, ns398, prevents accumulation of erk1/2, cox-2, activated p53 and small ubiquitin-like modifier (sumo-1) in the nucleus; (iii) apoptosis, quantitated by nucleosome enzyme-linked immunosorbent assay and the nuclear abundance of the pro-apoptotic protein, bcl-xs, were inhibited by ns398. |
2011-01-27 |
2023-08-12 |
human |
| Aparna Krishnamoorthy, Matthew E Clement, Eileen O'Leary, Joseph V Bonventre, Vishal S Vaidy. TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 118. issue 1. 2011-01-25. PMID:20702592. |
a higher baseline protein expression of caspase-3 (approximately twofold) coupled with an early onset of p53 protein activation by 48 h resulted in an increased apoptosis by 48-72 h in tim2(-/-) compared with tim2(+/+). |
2011-01-25 |
2023-08-12 |
mouse |
| Shiho Ohnishi, Manabu Futamura, Hiroki Kamino, Yasuyuki Nakamura, Noriaki Kitamura, Yuji Miyamoto, Takafumi Miyamoto, Daisuke Shinogi, Olga Goda, Hirofumi Arakaw. Identification of NEEP21, encoding neuron-enriched endosomal protein of 21 kDa, as a transcriptional target of tumor suppressor p53. International journal of oncology. vol 37. issue 5. 2011-01-25. PMID:20878061. |
these results suggest that neep21 may play a critical role in apoptosis as a mediator of p53. |
2011-01-25 |
2023-08-12 |
mouse |
| Nathan P Gomes, Joaquín M Espinos. Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes. Cell cycle (Georgetown, Tex.). vol 9. issue 17. 2011-01-24. PMID:20818159. |
the p53 transcription factor regulates the expression of genes involved in cellular responses to stress, including cell cycle arrest and apoptosis. |
2011-01-24 |
2023-08-12 |
Not clear |
| Wen-bin Zhang, Zhuo Wang, Fei Shu, Yong-hua Jin, Hong-yi Liu, Qiu-juan Wang, Yong Yan. Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition. The Journal of biological chemistry. vol 285. issue 52. 2011-01-24. PMID:20880848. |
activation of amp-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mtorc1 inhibition. |
2011-01-24 |
2023-08-12 |
human |