| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Xia, D Knezevic, L T Vassile. p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation. Oncogene. vol 30. issue 3. 2011-02-17. PMID:20871630. |
p21(waf1/cip1) is a p53 transcription target implicated in both major functions of the tumor suppressor--cell cycle arrest and apoptosis. |
2011-02-17 |
2023-08-12 |
Not clear |
| Young-Ho Lee, Mark T Bedford, Michael R Stallcu. Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes & development. vol 25. issue 2. 2011-02-17. PMID:21245169. |
tumor suppression by p53 and brca1 involves regulation of cell cycle, apoptosis, and dna repair and is influenced by transcriptional coactivators and post-translational modifications. |
2011-02-17 |
2023-08-12 |
Not clear |
| Boyan Bonev, Angela Pisco, Nancy Papalopul. MicroRNA-9 reveals regional diversity of neural progenitors along the anterior-posterior axis. Developmental cell. vol 20. issue 1. 2011-02-16. PMID:21238922. |
hairy1 mediates the effects of mir-9 on proliferation, through fgf8 signaling in the forebrain and wnt signaling in the hindbrain, but affects apoptosis only in the forebrain, via the p53 pathway. |
2011-02-16 |
2023-08-12 |
Not clear |
| Tongsen Zheng, Xianzhi Meng, Jiabei Wang, Xi Chen, Dalong Yin, Yingjian Liang, Xuan Song, Shangha Pan, Hongchi Jiang, Lianxin Li. PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. Journal of cellular biochemistry. vol 111. issue 1. 2011-02-14. PMID:20506484. |
suppression of pten expression with sirna significantly reduced the p53 and p21 levels and activated akt, resulting in decreased apoptosis and increased cell survival. |
2011-02-14 |
2023-08-12 |
mouse |
| Tongsen Zheng, Xianzhi Meng, Jiabei Wang, Xi Chen, Dalong Yin, Yingjian Liang, Xuan Song, Shangha Pan, Hongchi Jiang, Lianxin Li. PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. Journal of cellular biochemistry. vol 111. issue 1. 2011-02-14. PMID:20506484. |
in conclusion, our results suggest that fty720 induces a significant increase of pten, which inhibits p-akt and mdm2, and then increases the level of p53, thereby inducing g1 phase arrest and apoptosis. |
2011-02-14 |
2023-08-12 |
mouse |
| Manasi Das, Sanjeeb K Saho. Epithelial cell adhesion molecule targeted nutlin-3a loaded immunonanoparticles for cancer therapy. Acta biomaterialia. vol 7. issue 1. 2011-02-14. PMID:20727991. |
expression of p53, p21, epcam, and c-myc proteins involved in cell cycle regulation and apoptosis were investigated by western blotting. |
2011-02-14 |
2023-08-12 |
Not clear |
| Nayoung Kim, Sami Kukkonen, Sumeet Gupta, Anna Aldovin. Association of Tat with promoters of PTEN and PP2A subunits is key to transcriptional activation of apoptotic pathways in HIV-infected CD4+ T cells. PLoS pathogens. vol 6. issue 9. 2011-02-14. PMID:20862322. |
apoptosis in hiv-1-infected cd4+ primary t cells is triggered by the alteration of the pi3k and p53 pathways, which converge on the foxo3a transcriptional activator. |
2011-02-14 |
2023-08-12 |
Not clear |
| Keisuke Shinada, Tadasuke Tsukiyama, Takuya Sho, Fumihiko Okumura, Masahiro Asaka, Shigetsugu Hatakeyam. RNF43 interacts with NEDL1 and regulates p53-mediated transcription. Biochemical and biophysical research communications. vol 404. issue 1. 2011-02-14. PMID:21108931. |
in addition, we found that rnf43 also interacts with p53 and that rnf43 suppresses transcriptional activity of p53 in h1299 cells and attenuates apoptosis induced by ultraviolet irradiation. |
2011-02-14 |
2023-08-12 |
human |
| Aymone Gurtner, Paola Fuschi, Fabio Martelli, Isabella Manni, Simona Artuso, Giacoma Simonte, Valeria Ambrosino, Annalisa Antonini, Valentina Folgiero, Rita Falcioni, Ada Sacchi, Giulia Piaggi. Transcription factor NF-Y induces apoptosis in cells expressing wild-type p53 through E2F1 upregulation and p53 activation. Cancer research. vol 70. issue 23. 2011-02-10. PMID:20952509. |
transcription factor nf-y induces apoptosis in cells expressing wild-type p53 through e2f1 upregulation and p53 activation. |
2011-02-10 |
2023-08-12 |
Not clear |
| Aymone Gurtner, Paola Fuschi, Fabio Martelli, Isabella Manni, Simona Artuso, Giacoma Simonte, Valeria Ambrosino, Annalisa Antonini, Valentina Folgiero, Rita Falcioni, Ada Sacchi, Giulia Piaggi. Transcription factor NF-Y induces apoptosis in cells expressing wild-type p53 through E2F1 upregulation and p53 activation. Cancer research. vol 70. issue 23. 2011-02-10. PMID:20952509. |
here we show that unrestricted nf-y activity leads to apoptosis in an e2f1- and wild-type p53 (wtp53)-dependent manner. |
2011-02-10 |
2023-08-12 |
Not clear |
| Philip J Coates, M Virginia C L Appleyard, Karen Murray, Caroline Ackland, June Gardner, Douglas C Brown, Dougal J A Adamson, Lee B Jordan, Colin A Purdie, Alastair J Munro, Eric G Wright, John A Dewar, Alastair M Thompso. Differential contextual responses of normal human breast epithelium to ionizing radiation in a mouse xenograft model. Cancer research. vol 70. issue 23. 2011-02-10. PMID:21084272. |
ionizing radiation induced dose-dependent p53 stabilization and p53 phosphorylation, together with the induction of p21(cdkn1a) and apoptosis of normal breast epithelium. |
2011-02-10 |
2023-08-12 |
mouse |
| Sebastian Bauer, Thomas Mühlenberg, Michael Leahy, Mathias Hoiczyk, Thomas Gauler, Martin Schuler, Leendert Looijeng. Therapeutic potential of Mdm2 inhibition in malignant germ cell tumours. European urology. vol 57. issue 4. 2011-02-09. PMID:19560254. |
murine double minute 2 (mdm2) inhibitors enhance apoptosis in tumours harbouring wild-type p53. |
2011-02-09 |
2023-08-12 |
Not clear |
| Yun-Wen Chen, Isabelle Chenier, Shiao-Ying Chang, Stella Tran, Julie R Ingelfinger, Shao-Ling Zhan. High glucose promotes nascent nephron apoptosis via NF-kappaB and p53 pathways. American journal of physiology. Renal physiology. vol 300. issue 1. 2011-02-09. PMID:20962117. |
high glucose promotes nascent nephron apoptosis via nf-kappab and p53 pathways. |
2011-02-09 |
2023-08-12 |
mouse |
| Yun-Wen Chen, Isabelle Chenier, Shiao-Ying Chang, Stella Tran, Julie R Ingelfinger, Shao-Ling Zhan. High glucose promotes nascent nephron apoptosis via NF-kappaB and p53 pathways. American journal of physiology. Renal physiology. vol 300. issue 1. 2011-02-09. PMID:20962117. |
the present study investigated whether the nascent nephron apoptosis promoted by high glucose is mediated via the transcription factor nf-κb and p53 signaling pathways. |
2011-02-09 |
2023-08-12 |
mouse |
| Yun-Wen Chen, Isabelle Chenier, Shiao-Ying Chang, Stella Tran, Julie R Ingelfinger, Shao-Ling Zhan. High glucose promotes nascent nephron apoptosis via NF-kappaB and p53 pathways. American journal of physiology. Renal physiology. vol 300. issue 1. 2011-02-09. PMID:20962117. |
in vitro, high-glucose (25 mm) induced ros generation and significantly increased mk4 cell apoptosis and caspase-3 activity via activation of nf-κb pathway, with p53 phosphorylation and nuclear translocation compared with normal glucose (5 mm). |
2011-02-09 |
2023-08-12 |
mouse |
| Yun-Wen Chen, Isabelle Chenier, Shiao-Ying Chang, Stella Tran, Julie R Ingelfinger, Shao-Ling Zhan. High glucose promotes nascent nephron apoptosis via NF-kappaB and p53 pathways. American journal of physiology. Renal physiology. vol 300. issue 1. 2011-02-09. PMID:20962117. |
our data demonstrate that high glucose-induced nascent nephron apoptosis is mediated, at least in part, via ros generation and the activation of nf-κb and p53 pathways. |
2011-02-09 |
2023-08-12 |
mouse |
| Ahmed Kamal, D Dastagiri, M Janaki Ramaiah, J Surendranadha Reddy, E Vijaya Bharathi, Chatla Srinivas, S N C V L Pushpavalli, Dhananjaya Pal, Manika Pal-Bhadr. Synthesis of imidazothiazole-chalcone derivatives as anticancer and apoptosis inducing agents. ChemMedChem. vol 5. issue 11. 2011-02-08. PMID:20836120. |
moreover, these compounds elicit the characteristic features of apoptosis such as enhancement in the levels of p53, p21, and p27, suppression of nf-κb, and up-regulation of caspase-9. |
2011-02-08 |
2023-08-12 |
Not clear |
| Ning Gao, Boyang Shang, Xiumin Zhang, Cong Shen, Rong Xu, Hongzhang Xu, Ruxian Chen, Qiyang H. Potent antitumor actions of the new antibiotic boningmycin through induction of apoptosis and cellular senescence. Anti-cancer drugs. vol 22. issue 2. 2011-02-08. PMID:20948431. |
low concentrations of boningmycin led to a senescent phenotype with an increase in senescence-associated β-galactosidase activity and the time-dependent increase of p21, p27, and p53 expressions from 48 to120 h. taken together, the results showed that boningmycin exhibits potent antitumor actions through the induction of apoptosis and cellular senescence. |
2011-02-08 |
2023-08-12 |
mouse |
| Vincent Kam Wai Wong, Simon Shiu Fai Cheung, Ting Li, Zhi-Hong Jiang, Jing-Rong Wang, Hang Dong, Xiao Qin Yi, Hua Zhou, Liang Li. Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF-κB signaling. Journal of cellular biochemistry. vol 111. issue 4. 2011-02-07. PMID:20665661. |
eag also induced mapk and p53 signaling in llc-1 cells, which suppressed cyclin b-cdc2 complex and in turn induced g2-m arrest and apoptosis. |
2011-02-07 |
2023-08-12 |
mouse |
| Xueya Zhang, Haobo Huang, Zhenshu Xu, Rong Zha. 2-Methoxyestradiol blocks cell-cycle progression at the G2/M phase and induces apoptosis in human acute T lymphoblastic leukemia CEM cells. Acta biochimica et biophysica Sinica. vol 42. issue 9. 2011-02-07. PMID:20732853. |
moreover, the expression level of p21 protein was upregulated, whereas bcl-2 and dysfunctional p53 protein were downregulated, which also contributed to 2-me2-induced apoptosis. |
2011-02-07 |
2023-08-12 |
human |