| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Myung Kim, Misun Won, Chung-Sook Chung, Semi Kim, Hyeon Joo Yim, Sang-Hun Jung, ShinWu Jeon. JNK-mediated transcriptional upregulation of RhoB is critical for apoptosis of HCT-116 colon cancer cells by a novel diarylsulfonylurea derivative. Apoptosis : an international journal on programmed cell death. vol 15. issue 12. 2011-03-09. PMID:20683666. |
here, we report a new diarylsulfonylurea derivative, lb2a, that upregulates rhob, thereby inducing potent apoptosis in hct-116 human colon cancer cells independently of p53 status. |
2011-03-09 |
2023-08-12 |
mouse |
| Prabakaran Ravichandran, Sudhakar Baluchamy, Bindhu Sadanandan, Ramya Gopikrishnan, Santosh Biradar, Vani Ramesh, Joseph C Hall, Govindarajan T Rames. Multiwalled carbon nanotubes activate NF-κB and AP-1 signaling pathways to induce apoptosis in rat lung epithelial cells. Apoptosis : an international journal on programmed cell death. vol 15. issue 12. 2011-03-09. PMID:20694747. |
furthermore, mwcnt activated several death related proteins including apoptosis inducing factor, p53, p21 and bax. |
2011-03-09 |
2023-08-12 |
rat |
| Adrien Decorsière, Anne Cayrel, Stéphan Vagner, Stefania Millevo. Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3'-end processing and function during DNA damage. Genes & development. vol 25. issue 3. 2011-03-09. PMID:21289067. |
importantly, this interaction is critical for p53 expression and contributes to p53-mediated apoptosis. |
2011-03-09 |
2023-08-12 |
Not clear |
| Adrien Decorsière, Anne Cayrel, Stéphan Vagner, Stefania Millevo. Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3'-end processing and function during DNA damage. Genes & development. vol 25. issue 3. 2011-03-09. PMID:21289067. |
our results uncover the existence of a specific rescue mechanism of 3'-end processing regulation allowing stress-induced p53 accumulation and function in apoptosis. |
2011-03-09 |
2023-08-12 |
Not clear |
| Levin Böhlig, Maik Friedrich, Kurt Engelan. p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins. Nucleic acids research. vol 39. issue 2. 2011-03-07. PMID:20833636. |
the tumor suppressor p53 is a central regulator of cell-cycle arrest and apoptosis by acting as a transcription factor to regulate numerous genes. |
2011-03-07 |
2023-08-12 |
human |
| Katharina Schlereth, Joël P Charles, Anne C Bretz, Thorsten Stiew. Life or death: p53-induced apoptosis requires DNA binding cooperativity. Cell cycle (Georgetown, Tex.). vol 9. issue 20. 2011-03-07. PMID:20948308. |
these intermolecular interactions enable cooperative binding of p53 to less perfect response elements in the genome, which are present in many target genes essential for apoptosis. |
2011-03-07 |
2023-08-12 |
Not clear |
| Fei Wang, Xueqi Fu, Xia Chen, Xinbin Chen, Yunfeng Zha. Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells. PloS one. vol 5. issue 10. 2011-03-07. PMID:20976134. |
the tumor suppressor p53 is known to be able to trigger apoptosis in response to dna damage, oncogene activation, and certain chemotherapeutic drugs. |
2011-03-07 |
2023-08-12 |
Not clear |
| Fei Wang, Xueqi Fu, Xia Chen, Xinbin Chen, Yunfeng Zha. Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells. PloS one. vol 5. issue 10. 2011-03-07. PMID:20976134. |
in addition to its transcriptional activation, a fraction of p53 translocates to mitochondria at the very early stage of apoptosis, which eventually contributes to the loss of mitochondrial membrane potential, generation of reactive oxygen species (ros), cytochrome c release, and caspase activation. |
2011-03-07 |
2023-08-12 |
Not clear |
| Fei Wang, Xueqi Fu, Xia Chen, Xinbin Chen, Yunfeng Zha. Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells. PloS one. vol 5. issue 10. 2011-03-07. PMID:20976134. |
since mitochondrial uncoupling has been suggested to contribute to cancer development, herein, we studied whether p53 mitochondrial translocation and subsequent apoptosis were affected by mitochondrial uncoupling using chemical protonophores, and further verified the results using a sirna approach in murine skin epidermal jb6 cells. |
2011-03-07 |
2023-08-12 |
Not clear |
| Fei Wang, Xueqi Fu, Xia Chen, Xinbin Chen, Yunfeng Zha. Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells. PloS one. vol 5. issue 10. 2011-03-07. PMID:20976134. |
our results showed that mitochondrial uncoupling blocked p53 mitochondrial translocation induced by 12-o-tetradecanoylphorbol 13-acetate (tpa), a known tumor promoter to induce p53-mediated apoptosis in skin carcinogenesis. |
2011-03-07 |
2023-08-12 |
Not clear |
| Fei Wang, Xueqi Fu, Xia Chen, Xinbin Chen, Yunfeng Zha. Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells. PloS one. vol 5. issue 10. 2011-03-07. PMID:20976134. |
altogether, our data suggest that mitochondrial uncoupling may serve as an important regulator of p53 mitochondrial translocation and p53-mediated apoptosis during early tumor promotion. |
2011-03-07 |
2023-08-12 |
Not clear |
| Sergey V Prykhozhi. In the absence of Sonic hedgehog, p53 induces apoptosis and inhibits retinal cell proliferation, cell-cycle exit and differentiation in zebrafish. PloS one. vol 5. issue 10. 2011-03-07. PMID:21042410. |
in the absence of sonic hedgehog, p53 induces apoptosis and inhibits retinal cell proliferation, cell-cycle exit and differentiation in zebrafish. |
2011-03-07 |
2023-08-12 |
zebrafish |
| Patricia A J Muller, Karen H Vousden, Jim C Norma. p53 and its mutants in tumor cell migration and invasion. The Journal of cell biology. vol 192. issue 2. 2011-03-07. PMID:21263025. |
loss of p53 function is well known to influence cell cycle checkpoint controls and apoptosis. |
2011-03-07 |
2023-08-12 |
human |
| Matteo Becatti, Francesca Prignano, Claudia Fiorillo, Leonardo Pescitelli, Paolo Nassi, Torello Lotti, Niccolò Tadde. The involvement of Smac/DIABLO, p53, NF-kB, and MAPK pathways in apoptosis of keratinocytes from perilesional vitiligo skin: Protective effects of curcumin and capsaicin. Antioxidants & redox signaling. vol 13. issue 9. 2011-03-04. PMID:20085492. |
the involvement of smac/diablo, p53, nf-kb, and mapk pathways in apoptosis of keratinocytes from perilesional vitiligo skin: protective effects of curcumin and capsaicin. |
2011-03-04 |
2023-08-12 |
Not clear |
| Qin-Sheng Dai, Wei Liu, Xiao-Bing Wang, Na Lu, Dan-Dan Gong, Ling-Yi Kong, Qing-Long Gu. NCPMF-60 induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20948430. |
these results suggested that ncpmf-60 indeed activated the p53 pathway, which may contribute to its induction of cell cycle arrest and apoptosis in hepg2 cells. |
2011-03-04 |
2023-08-12 |
human |
| Qin-Sheng Dai, Wei Liu, Xiao-Bing Wang, Na Lu, Dan-Dan Gong, Ling-Yi Kong, Qing-Long Gu. NCPMF-60 induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20948430. |
collectively, our findings show that cell cycle arrest and apoptosis induced by ncpmf-60 was associated with the activation of p53 pathway and the inhibition of cdk-activating kinase activity in hepg2 cells. |
2011-03-04 |
2023-08-12 |
human |
| HongYan Li, LiXia Pan, KeMian Go. Depletion of ribosomal protein L8 impairs Drosophila development and is associated with apoptosis. Science China. Life sciences. vol 53. issue 9. 2011-03-04. PMID:21104369. |
rt-pcr analyses of the transcription level of genes that are known to be key factors in apoptosis (p53, hid, reaper, dark, dcp-1) and cell cycle regulation (cdc45, mcm3, cyclin b, incenp) in l8-deficient s2 cells, were consistent with their role in apoptosis induction and cell cycle arrest. |
2011-03-04 |
2023-08-12 |
drosophila_melanogaster |
| HongYan Li, LiXia Pan, KeMian Go. Depletion of ribosomal protein L8 impairs Drosophila development and is associated with apoptosis. Science China. Life sciences. vol 53. issue 9. 2011-03-04. PMID:21104369. |
these results indicate that depletion of l8 strongly impairs drosophila development, and that this depletion is associated with cell proliferation arrest and apoptosis, in which p53 may play a central role. |
2011-03-04 |
2023-08-12 |
drosophila_melanogaster |
| Subhan Dudekula, Ming-Hui Lee, Li-Jin Hsu, Shean-Jen Chen, Nan-Shan Chan. Zfra is a small wizard in the mitochondrial apoptosis. Aging. vol 2. issue 12. 2011-03-04. PMID:21212468. |
remarkably, overexpressed zfra induces apoptosis via the mitochondrial pathway, which involves suppression of bcl-2 and bcl-xl expression (without causing cytochrome c release), counteracting the apoptotic function of tumor suppressor p53 and wwox, and dissipation of mitochondrial membrane potential for ultimately leading to cell death. |
2011-03-04 |
2023-08-12 |
Not clear |
| Subhan Dudekula, Ming-Hui Lee, Li-Jin Hsu, Shean-Jen Chen, Nan-Shan Chan. Zfra is a small wizard in the mitochondrial apoptosis. Aging. vol 2. issue 12. 2011-03-04. PMID:21212468. |
control of cellular aging and apoptosis by zfra, p53 and wwox is discussed. |
2011-03-04 |
2023-08-12 |
Not clear |