| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hsin-Yi Tseng, Chen Chen Jiang, Amanda Croft, Kwang Hong Tay, Rick Francis Thorne, Fan Yang, Hao Liu, Peter Hersey, Xu Dong Zhan. Contrasting effects of nutlin-3 on TRAIL- and docetaxel-induced apoptosis due to upregulation of TRAIL-R2 and Mcl-1 in human melanoma cells. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159614. |
however, we found in this study that blockade of the interaction of p53 and mdm2 by the mdm2 antagonist nutlin-3 in melanoma cells did not induce apoptosis, even though it upregulated p53 and its proapoptotic targets. |
2011-03-28 |
2023-08-12 |
human |
| Zhen-Yu He, Chuan-Bing Shi, Hao Wen, Fang-Long Li, Bao-Lin Wang, Jie Wan. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer investigation. vol 29. issue 3. 2011-03-28. PMID:21314329. |
we conclude that the curcumin treatment improves the general health of patients with colorectal cancer via the mechanism of increased p53 molecule expression in tumor cells and consequently speeds up tumor cell apoptosis. |
2011-03-28 |
2023-08-12 |
Not clear |
| Eunjin Park, Insun Hwang, Jie-Young Song, Youngheun Je. Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice. Acta histochemica. vol 113. issue 1. 2011-03-25. PMID:19767060. |
in addition, apg significantly inhibited irradiation-induced apoptosis by decreasing the amount of pro-apoptotic p53 and bax as well as augmenting that of anti-apoptotic bcl-2 at 24h after irradiation. |
2011-03-25 |
2023-08-12 |
mouse |
| Feng-Lang Lin, Jue-Liang Hsu, Chang-Hung Chou, Wen-Jun Wu, Chi-I Chang, Hung-Jen Li. Activation of p38 MAPK by damnacanthal mediates apoptosis in SKHep 1 cells through the DR5/TRAIL and TNFR1/TNF-α and p53 pathways. European journal of pharmacology. vol 650. issue 1. 2011-03-24. PMID:20951126. |
activation of p38 mapk by damnacanthal mediates apoptosis in skhep 1 cells through the dr5/trail and tnfr1/tnf-α and p53 pathways. |
2011-03-24 |
2023-08-12 |
Not clear |
| Zoltan Derdak, Charles H Lang, Kristine A Villegas, Ming Tong, Nicholas M Mark, Suzanne M de la Monte, Jack R Wand. Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. Journal of hepatology. vol 54. issue 1. 2011-03-24. PMID:20961644. |
activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. |
2011-03-24 |
2023-08-12 |
rat |
| Atsushi Ito, Hisako Nakano, Kunio Shinohar. Role of wild-type p53 in apoptotic and non-apoptotic cell death induced by X-irradiation and heat treatment in p53-mutated mouse M10 cells. Journal of radiation research. vol 51. issue 6. 2011-03-24. PMID:20972365. |
the sensitizing effects of wild-type p53 on x-ray-induced cell death and on heat-induced apoptosis in m10, a radiosensitive and trp53 (mouse p53 gene)-mutated lymphoma cell line which dies through necrosis by x-irradiation, were investigated using three m10 derived transfectants with wild-type tp53 (human p53 gene). |
2011-03-24 |
2023-08-12 |
mouse |
| Snjezana Mardesic Brakus, Danijela Kalibovic Govorko, Katarina Vukojevic, Ivana Alujevic Jakus, Dominko Carev, Josko Petricevic, Mirna Saraga-Babi. Apoptotic and anti-apoptotic factors in early human mandible development. European journal of oral sciences. vol 118. issue 6. 2011-03-24. PMID:21083614. |
the regulators of apoptosis bcl-2, bax, caspase-3, p53, and hsp70 were analyzed immunohistochemically in the developing human mandible of eight human conceptuses from weeks 5 to 10 of gestation. |
2011-03-24 |
2023-08-12 |
human |
| Jonathan Shloush, John E Vlassov, Ian Engson, Shili Duan, Vivian Saridakis, Sirano Dhe-Paganon, Brian Raught, Yi Sheng, Cheryl H Arrowsmit. Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2. The Journal of biological chemistry. vol 286. issue 6. 2011-03-24. PMID:21084285. |
the tumor suppressor p53 maintains genome stability and prevents malignant transformation by promoting cell cycle arrest and apoptosis. |
2011-03-24 |
2023-08-12 |
Not clear |
| Luyang Sun, Lei Shi, Feng Wang, Peiwei Huangyang, Wenzhe Si, Jie Yang, Zhi Yao, Yongfeng Shan. Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization. The Journal of biological chemistry. vol 286. issue 6. 2011-03-24. PMID:21127074. |
significantly, inhibition of csn-associated kinase activity or knockdown of csn5 impairs jfk-promoted p53 degradation, enhances p53-dependent transcription, and promotes cell growth suppression, g(1) arrest, and apoptosis. |
2011-03-24 |
2023-08-12 |
human |
| Hestia S Mellert, Timothy J Stanek, Stephen M Sykes, Frank J Rauscher, David C Schultz, Steven B McMaho. Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis. The Journal of biological chemistry. vol 286. issue 6. 2011-03-24. PMID:21148320. |
cancer cells carry inherent genetic damage, but avoid arrest and apoptosis by inactivating p53. |
2011-03-24 |
2023-08-12 |
human |
| Hestia S Mellert, Timothy J Stanek, Stephen M Sykes, Frank J Rauscher, David C Schultz, Steven B McMaho. Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis. The Journal of biological chemistry. vol 286. issue 6. 2011-03-24. PMID:21148320. |
specifically, acetylation of p53 at lysine 120, a dna-binding domain residue mutated in human cancer, is essential for triggering apoptosis. |
2011-03-24 |
2023-08-12 |
human |
| G Alkistis Frentzou, Mary E W Collier, Anne-Marie L Seymour, Camille Ettelai. Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor. Molecular and cellular biochemistry. vol 345. issue 1-2. 2011-03-23. PMID:20730477. |
in contrast, elevated concentrations of rtf (52 ng/ml) induced cellular apoptosis as indicated by increased caspase-3 activity and nuclear localisation of p53. |
2011-03-23 |
2023-08-12 |
rat |
| Faris Q Alenz. Cell type specific expression of the apoptosis stimulating protein (ASPP-2) in human tissues. Acta microbiologica et immunologica Hungarica. vol 57. issue 4. 2011-03-23. PMID:21183427. |
apoptosis stimulating proteins of p53 (aspp-l and aspp-2) are a novel family of proteins that have been found to co-stimulate p53 activation of bax (bcl-2 associated protein x) inducing caspase-mediated apoptosis. |
2011-03-23 |
2023-08-12 |
mouse |
| Lynnette Fernández-Cuesta, Suresh Anaganti, Pierre Hainaut, Magali Olivie. Estrogen levels act as a rheostat on p53 levels and modulate p53-dependent responses in breast cancer cell lines. Breast cancer research and treatment. vol 125. issue 1. 2011-03-21. PMID:20221692. |
this reduction in p53 protein levels resulted in reduced p53-dependent responses induced by dna damage in p53 wild-type cells, lowering the capacity of doxorubicine to induce apoptosis. |
2011-03-21 |
2023-08-12 |
Not clear |
| Bulent Karabulut, Burcak Karaca, Harika Atmaca, Asli Kisim, Selim Uzunoglu, Canfeza Sezgin, Ruchan Usl. Regulation of apoptosis-related molecules by synergistic combination of all-trans retinoic acid and zoledronic acid in hormone-refractory prostate cancer cell lines. Molecular biology reports. vol 38. issue 1. 2011-03-21. PMID:20349282. |
while expression of proapoptotic genes such as tumor necrosis factor receptor superfamily (tnfrsf), bad, bax, fas, fadd are induced with the exposure of the combination, expression of antiapoptotic genes or proteins such as members of inhibitor apoptosis family (iaps), mcl-1, ltbr, p53 and bcl-2 are reduced. |
2011-03-21 |
2023-08-12 |
human |
| Xia Lei, Bo Liu, Weinong Han, Mei Ming, Yu-Ying H. UVB-Induced p21 degradation promotes apoptosis of human keratinocytes. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. vol 9. issue 12. 2011-03-21. PMID:20931139. |
our results suggest a distinct mechanism of p21 degradation in keratinocytes by uvb, and this p21 degradation may significantly enhance uvb-induced apoptosis of premalignant keratinocytes with a p53 defect to eliminate damaged cells and therefore prevent skin cancer development. |
2011-03-21 |
2023-08-12 |
mouse |
| Rui Kang, Daolin Tang, Michael T Loze, Herbert J Ze. Apoptosis to autophagy switch triggered by the MHC class III-encoded receptor for advanced glycation endproducts (RAGE). Autophagy. vol 7. issue 1. 2011-03-21. PMID:20978368. |
rage inhibits apoptosis ("programmed cell death") by a p53 transcription-independent pathway during the response to chemotherapeutic agents. |
2011-03-21 |
2023-08-12 |
Not clear |
| Xia Li, Ying Zhao, William K K Wu, Shanshan Liu, Min Cui, Hongxiang Lo. Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. Life sciences. vol 88. issue 7-8. 2011-03-18. PMID:21163271. |
solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma u2os cells. |
2011-03-18 |
2023-08-12 |
human |
| Valentina Turinetto, Paola Porcedda, Valentina Minieri, Luca Orlando, Erica Lantelme, Lisa Accomasso, Antonio Amoroso, Mario De Marchi, Laura Zannini, Domenico Delia, Claudia Giachin. A novel defect in mitochondrial p53 accumulation following DNA damage confers apoptosis resistance in Ataxia Telangiectasia and Nijmegen Breakage Syndrome T-cells. DNA repair. vol 9. issue 11. 2011-03-17. PMID:20947454. |
a novel defect in mitochondrial p53 accumulation following dna damage confers apoptosis resistance in ataxia telangiectasia and nijmegen breakage syndrome t-cells. |
2011-03-17 |
2023-08-12 |
Not clear |
| Valentina Turinetto, Paola Porcedda, Valentina Minieri, Luca Orlando, Erica Lantelme, Lisa Accomasso, Antonio Amoroso, Mario De Marchi, Laura Zannini, Domenico Delia, Claudia Giachin. A novel defect in mitochondrial p53 accumulation following DNA damage confers apoptosis resistance in Ataxia Telangiectasia and Nijmegen Breakage Syndrome T-cells. DNA repair. vol 9. issue 11. 2011-03-17. PMID:20947454. |
we have previously shown that whereas t-cells from normal individuals undergo accumulation of p53 and apoptosis when treated with the genotoxic agent actinomycin d (actd), those from ataxia telangiectasia (at) and nijmegen breakage syndrome (nbs) patients resist actd-induced apoptosis [1]. |
2011-03-17 |
2023-08-12 |
Not clear |