| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Han Liu, Ali Pedram, Jin Kyung Ki. Oestrogen prevents cardiomyocyte apoptosis by suppressing p38α-mediated activation of p53 and by down-regulating p53 inhibition on p38β. Cardiovascular research. vol 89. issue 1. 2011-04-04. PMID:20724307. |
oestrogen prevents cardiomyocyte apoptosis by suppressing p38α-mediated activation of p53 and by down-regulating p53 inhibition on p38β. |
2011-04-04 |
2023-08-12 |
Not clear |
| Han Liu, Ali Pedram, Jin Kyung Ki. Oestrogen prevents cardiomyocyte apoptosis by suppressing p38α-mediated activation of p53 and by down-regulating p53 inhibition on p38β. Cardiovascular research. vol 89. issue 1. 2011-04-04. PMID:20724307. |
an attractive downstream target is p53, a well-known mediator of apoptosis and a substrate of p38α mapk. |
2011-04-04 |
2023-08-12 |
Not clear |
| Pattamawadee Yanatatsaneeji, Nakarin Kitkumthorn, Chutintorn Dhammawipark, Jierada Rabalert, Vyomesh Patel, Apiwat Mutirangur. Codon72 polymorphism in the p53 tumor suppressor gene in oral lichen planus lesions in a Thai population. Asian Pacific journal of cancer prevention : APJCP. vol 11. issue 4. 2011-04-04. PMID:21133638. |
this fas pathway and the action of p53 tumour suppressor gene are important in producing apoptosis. |
2011-04-04 |
2023-08-12 |
Not clear |
| Abhik Saha, Adebowale Bamidele, Masanao Murakami, Erle S Robertso. EBNA3C attenuates the function of p53 through interaction with inhibitor of growth family proteins 4 and 5. Journal of virology. vol 85. issue 5. 2011-04-04. PMID:21177815. |
a colony formation assay as well as an apoptosis assay showed that ebna3c nullified the negative regulatory effects on cell proliferation induced by coupled expression of p53 in the presence of either ing4 or ing5 in saos-2 (p53(-/-)) cells. |
2011-04-04 |
2023-08-12 |
human |
| Rui Meng, Hui-yun Xu, Sheng-meng Di, Dong-yan Shi, Ai-rong Qian, Jin-fu Wang, Peng Shan. Human mesenchymal stem cells are sensitive to abnormal gravity and exhibit classic apoptotic features. Acta biochimica et biophysica Sinica. vol 43. issue 2. 2011-04-04. PMID:21266543. |
the pifithrin-α, an specific inhibitor of p53, inhibited the apoptosis and prevented the disruption of cytoskeleton induced by abnormal gravity. |
2011-04-04 |
2023-08-12 |
human |
| Xin Liu, Yang Xue, Jiao Su. Indirect induction of endothelial cell injury by PU- or PTFE-mediated activation of monocytes. Journal of biomaterials science. Polymer edition. vol 21. issue 13. 2011-04-01. PMID:20557688. |
then, we assessed the apoptosis rate of the huvecs and determined the expression of no, inducible nitric oxide synthase (inos), and apoptosis-related proteins (p53, bax, bcl-2) in the huvecs. |
2011-04-01 |
2023-08-12 |
human |
| Xin Liu, Yang Xue, Jiao Su. Indirect induction of endothelial cell injury by PU- or PTFE-mediated activation of monocytes. Journal of biomaterials science. Polymer edition. vol 21. issue 13. 2011-04-01. PMID:20557688. |
after culturing with the supernatants of the pu- or ptfe-stimulated thp-1 cells, the apoptosis rate, no production and expression of inos, p53 and bax in the huvecs were up-regulated, while bcl-2 expression was down-regulated. |
2011-04-01 |
2023-08-12 |
human |
| Xin Liu, Yang Xue, Jiao Su. Indirect induction of endothelial cell injury by PU- or PTFE-mediated activation of monocytes. Journal of biomaterials science. Polymer edition. vol 21. issue 13. 2011-04-01. PMID:20557688. |
in conclusion, the release of ros by pu- or ptfe-treated thp-1 cells may induce inos expression and cause apoptosis in huvecs via the p53, bax and bcl-2 proteins. |
2011-04-01 |
2023-08-12 |
human |
| Jean-Sébastien Guerrini, Véronique Bouvard, Evelyne Oswald, Angel Alonso, Jean-Luc Prétet, Massimo Tommasino, Christiane Mougin, François Aubi. E6 and E7 proteins from different beta-papillomaviruses types do not interfere in UVB-induced apoptosis of HaCaT keratinocytes. Experimental dermatology. vol 20. issue 1. 2011-04-01. PMID:21158941. |
hacat keratinocytes transduced with both e6 and e7 genes of seven beta-hpv types (hpv5, hpv8, hpv14, hpv24, hpv36, hpv38 and hpv49) did not demonstrate any inhibition of uvb-induced apoptosis, even after p53 reactivation through prima-1. |
2011-04-01 |
2023-08-12 |
Not clear |
| L Bastin-Coyette, S Cardoen, C Smal, E de Viron, A Arts, R Amsailale, E Van Den Neste, F Bontemp. Nucleoside analogs induce proteasomal down-regulation of p21 in chronic lymphocytic leukemia cell lines. Biochemical pharmacology. vol 81. issue 5. 2011-04-01. PMID:21168391. |
one of their most important mechanisms of action is the activation of p53, leading to apoptosis through the intrinsic pathway. |
2011-04-01 |
2023-08-12 |
Not clear |
| Rocky Cipriano, John T Patton, Lindsey D Mayo, Mark W Jackso. Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis. Cell cycle (Georgetown, Tex.). vol 9. issue 7. 2011-03-31. PMID:20305378. |
inactivation of p53 signaling by p73 or pten ablation results in a transformed phenotype that remains susceptible to nutlin-3 mediated apoptosis. |
2011-03-31 |
2023-08-12 |
Not clear |
| Rocky Cipriano, John T Patton, Lindsey D Mayo, Mark W Jackso. Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis. Cell cycle (Georgetown, Tex.). vol 9. issue 7. 2011-03-31. PMID:20305378. |
however, despite the transformed phenotype conferred by p53 inactivation following p73 or pten loss, p53 could be fully activated by nutlin-3, resulting in efficient caspase-mediated apoptosis. |
2011-03-31 |
2023-08-12 |
Not clear |
| Baozong Li, Qian Cheng, Zhenyu Li, Jiandong Che. p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors. Cell cycle (Georgetown, Tex.). vol 9. issue 7. 2011-03-31. PMID:20372076. |
here we show that disruption of p53-mdm2 binding using the mdm2-specific inhibitor nutlin activates p53 in tgct cells and is sufficient to induce strong apoptosis. |
2011-03-31 |
2023-08-12 |
Not clear |
| Baozong Li, Qian Cheng, Zhenyu Li, Jiandong Che. p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors. Cell cycle (Georgetown, Tex.). vol 9. issue 7. 2011-03-31. PMID:20372076. |
furthermore, tgct cells are unique in having a strong apoptosis response to p53. |
2011-03-31 |
2023-08-12 |
Not clear |
| Kazumichi Yonenaga, Satoru Nishizawa, Yuko Fujihara, Yukiyo Asawa, Kanazawa Sanshiro, Satoru Nagata, Tsuyoshi Takato, Kazuto Hosh. The optimal conditions of chondrocyte isolation and its seeding in the preparation for cartilage tissue engineering. Tissue engineering. Part C, Methods. vol 16. issue 6. 2011-03-31. PMID:20412008. |
results regarding expression of the p53, tumor necrosis factor-α, and interleukin-1β genes, as well as apoptosis enzyme-linked immunosorbent assay results, show that excessive collagenase exposure may decrease chondrocyte viability or activity. |
2011-03-31 |
2023-08-12 |
Not clear |
| L V Moskvina, P G Mal'ko. [Current views of the molecular mechanisms of gastric cancer progression]. Arkhiv patologii. vol 72. issue 4. 2011-03-31. PMID:21086643. |
traditional markers of proliferation and apoptosis, such as ki-67, p53, and bcl-2, may be further used to estimate the rate of tumor growth. |
2011-03-31 |
2023-08-12 |
Not clear |
| Bo Liu, Shiwei Yan, Qi Wan. Intrinsic noise and Hill dynamics in the p53 system. Journal of theoretical biology. vol 269. issue 1. 2011-03-30. PMID:20974153. |
the p53 feedback loop can induce cellular senescence, cell cycle arrest and apoptosis in response to various stresses, including dna damage, hypoxia and nutrient deprivation. |
2011-03-30 |
2023-08-12 |
Not clear |
| Anutosh Chakraborty, J Kent Werner, Michael A Koldobskiy, Asif K Mustafa, Krishna R Juluri, Joseph Pietropaoli, Adele M Snowman, Solomon H Snyde. Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 6. 2011-03-30. PMID:21262846. |
the inositol pyrophosphate, diphosphoinositol pentakisphosphate, regulates p53 and protein kinase akt signaling, and its aberrant increase in cells has been implicated in apoptosis and insulin resistance. |
2011-03-30 |
2023-08-12 |
Not clear |
| Hua-chuan Zheng, Pu Xia, Xiao-yan Xu, Hiroyuki Takahashi, Yasuo Takan. The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas. Human pathology. vol 42. issue 3. 2011-03-29. PMID:21193223. |
inhibitor of growth 5, a tumor suppressor protein, can interact with p53, thereby inhibiting cell growth and inducing apoptosis. |
2011-03-29 |
2023-08-12 |
Not clear |
| Hsin-Yi Tseng, Chen Chen Jiang, Amanda Croft, Kwang Hong Tay, Rick Francis Thorne, Fan Yang, Hao Liu, Peter Hersey, Xu Dong Zhan. Contrasting effects of nutlin-3 on TRAIL- and docetaxel-induced apoptosis due to upregulation of TRAIL-R2 and Mcl-1 in human melanoma cells. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159614. |
wild-type p53 is commonly expressed in melanoma but does not appear to be effective in the induction of apoptosis. |
2011-03-28 |
2023-08-12 |
human |