| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenjie Bao, Ming Chen, Xu Zhao, Ravjiv Kumar, Clemens Spinnler, Minna Thullberg, Natalia Issaeva, Galina Selivanova, Staffan Strömbla. PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo. Cell cycle (Georgetown, Tex.). vol 10. issue 2. 2011-04-28. PMID:21239882. |
although p53 is not frequently mutated in melanoma, it is inactivated by integrin αv-mediated signaling, as we previously demonstrated 1, which may account, at least partially, for increased apoptosis resistance of malignant melanoma. |
2011-04-28 |
2023-08-12 |
human |
| Wenjie Bao, Ming Chen, Xu Zhao, Ravjiv Kumar, Clemens Spinnler, Minna Thullberg, Natalia Issaeva, Galina Selivanova, Staffan Strömbla. PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo. Cell cycle (Georgetown, Tex.). vol 10. issue 2. 2011-04-28. PMID:21239882. |
in this study we addressed the question whether functional restoration of p53 by apr-246 (prima-1met), which can reactivate mutant p53 and induce massive apoptosis in cancer cells, is able to restore the function of inactive p53 in melanoma. |
2011-04-28 |
2023-08-12 |
human |
| Wenjie Bao, Ming Chen, Xu Zhao, Ravjiv Kumar, Clemens Spinnler, Minna Thullberg, Natalia Issaeva, Galina Selivanova, Staffan Strömbla. PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo. Cell cycle (Georgetown, Tex.). vol 10. issue 2. 2011-04-28. PMID:21239882. |
moreover, apr-246 triggered melanoma cell apoptosis that was mediated by p53 and caspase 9. |
2011-04-28 |
2023-08-12 |
human |
| Dimitrios J Stravopodis, Panagiotis K Karkoulis, Eumorphia G Konstantakou, Sophia Melachroinou, Angeliki Thanasopoulou, Gerasimos Aravantinos, Lukas H Margaritis, Ema Anastasiadou, Gerassimos E Voutsina. Thymidylate synthase inhibition induces p53-dependent and p53-independent apoptotic responses in human urinary bladder cancer cells. Journal of cancer research and clinical oncology. vol 137. issue 2. 2011-04-27. PMID:20425122. |
in the present study, we have investigated the effects of 5-fu treatment on apoptosis induction in wild-type and mutant p53 urinary bladder cancer cells. |
2011-04-27 |
2023-08-12 |
human |
| Rachel Damico, Tiffany Simms, Bo S Kim, Zenar Tekeste, Henry Amankwan, Mahendra Damarla, Paul M Hassou. p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor. American journal of respiratory cell and molecular biology. vol 44. issue 3. 2011-04-27. PMID:20448056. |
p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor. |
2011-04-27 |
2023-08-12 |
human |
| Rachel Damico, Tiffany Simms, Bo S Kim, Zenar Tekeste, Henry Amankwan, Mahendra Damarla, Paul M Hassou. p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor. American journal of respiratory cell and molecular biology. vol 44. issue 3. 2011-04-27. PMID:20448056. |
using the p53 inhibitor, pifithrin-α (pft-α), and rna interference (rnai) directed at p53, we demonstrate that p53 function and expression are required for cse-mediated apoptosis. |
2011-04-27 |
2023-08-12 |
human |
| Rachel Damico, Tiffany Simms, Bo S Kim, Zenar Tekeste, Henry Amankwan, Mahendra Damarla, Paul M Hassou. p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor. American journal of respiratory cell and molecular biology. vol 44. issue 3. 2011-04-27. PMID:20448056. |
finally, we demonstrate that mif is a negative regulator of p53 expression in response to cse, placing mif upstream of p53 as an antagonist of cse-induced apoptosis. |
2011-04-27 |
2023-08-12 |
human |
| Yanze Li, Haruka Matsumori, Yuji Nakayama, Mitsuhiko Osaki, Hirotada Kojima, Akihiro Kurimasa, Hisao Ito, Seiichi Mori, Motonobu Katoh, Mitsuo Oshimura, Toshiaki Inou. SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis. Genes to cells : devoted to molecular & cellular mechanisms. vol 16. issue 1. 2011-04-27. PMID:21059157. |
sirt2 down-regulation in hela can induce p53 accumulation via p38 mapk activation-dependent p300 decrease, eventually leading to apoptosis. |
2011-04-27 |
2023-08-12 |
Not clear |
| Yanze Li, Haruka Matsumori, Yuji Nakayama, Mitsuhiko Osaki, Hirotada Kojima, Akihiro Kurimasa, Hisao Ito, Seiichi Mori, Motonobu Katoh, Mitsuo Oshimura, Toshiaki Inou. SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis. Genes to cells : devoted to molecular & cellular mechanisms. vol 16. issue 1. 2011-04-27. PMID:21059157. |
the apoptosis was caused by p53 accumulation, which is mediated by p38 mapk activation-dependent degradation of p300 and the subsequent mdm2 degradation. |
2011-04-27 |
2023-08-12 |
Not clear |
| Jong-Lyel Roh, Sung Koo Kang, Il Minn, Joseph A Califano, David Sidransky, Wayne M Koc. p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. Oral oncology. vol 47. issue 1. 2011-04-27. PMID:21109480. |
high-dose treatment with p53ra small molecules also induced apoptosis in cell lines independent of p53 or mdm2 expression. |
2011-04-27 |
2023-08-12 |
human |
| Motonobu Saito, Kensuke Kumamoto, Ana I Robles, Izumi Horikawa, Bungo Furusato, Shu Okamura, Akiteru Goto, Taro Yamashita, Makoto Nagashima, Tin-Lap Lee, Vanessa J Baxendale, Owen M Rennert, Seiichi Takenoshita, Jun Yokota, Isabell A Sesterhenn, Glenwood E Trivers, S Perwez Hussain, Curtis C Harri. Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PloS one. vol 5. issue 11. 2011-04-27. PMID:21124965. |
ing2 also functionally interacts with the tumor suppressor protein p53 to regulate cellular senescence, apoptosis and dna damage response in vitro, and is thus expected to modulate carcinogenesis and aging. |
2011-04-27 |
2023-08-12 |
mouse |
| Motonobu Saito, Kensuke Kumamoto, Ana I Robles, Izumi Horikawa, Bungo Furusato, Shu Okamura, Akiteru Goto, Taro Yamashita, Makoto Nagashima, Tin-Lap Lee, Vanessa J Baxendale, Owen M Rennert, Seiichi Takenoshita, Jun Yokota, Isabell A Sesterhenn, Glenwood E Trivers, S Perwez Hussain, Curtis C Harri. Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PloS one. vol 5. issue 11. 2011-04-27. PMID:21124965. |
their testes showed degeneration of seminiferous tubules, meiotic arrest before pachytene stage with incomplete meiotic recombination, induction of p53, and enhanced apoptosis. |
2011-04-27 |
2023-08-12 |
mouse |
| Jolijn W Groeneweg, Yvonne A R White, David Kokel, Randall T Peterson, Lawrence R Zukerberg, Inna Berin, Bo R Rueda, Antony W Woo. cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish. Molecular reproduction and development. vol 78. issue 1. 2011-04-26. PMID:21268180. |
suppression of p53 expression in cables1 morphants partially rescued both apoptosis and the behavioral phenotype, suggesting that the phenotype of cables1 morphants is due in part to p53-dependent apoptosis. |
2011-04-26 |
2023-08-12 |
zebrafish |
| Wei Li, Yong Liu, Xue-Xia Li, Yang Yu, Jing-Jing Wu, Qing Wang, Hong Huo, Li-Ming Wang, Ling Yan. MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status. Planta medica. vol 77. issue 1. 2011-04-25. PMID:20607649. |
mapks are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status. |
2011-04-25 |
2023-08-12 |
human |
| M K Lee, W M Tong, Z Q Wang, K Sabapath. Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo. Cell death and differentiation. vol 18. issue 2. 2011-04-25. PMID:20671749. |
p53 activation, stability, localization and ability to induce apoptosis, cell-cycle arrest and prevent centrosome amplification are not compromised in p53(s312a/s312a) cells. |
2011-04-25 |
2023-08-12 |
mouse |
| M Aoubala, F Murray-Zmijewski, M P Khoury, K Fernandes, S Perrier, H Bernard, A-C Prats, D P Lane, J-C Bourdo. p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage. Cell death and differentiation. vol 18. issue 2. 2011-04-25. PMID:20689555. |
we have previously reported that the human p53 gene encodes at least nine different p53 isoforms, including Δ133p53α, which can modulate p53 transcriptional activity and apoptosis. |
2011-04-25 |
2023-08-12 |
human |
| M Aoubala, F Murray-Zmijewski, M P Khoury, K Fernandes, S Perrier, H Bernard, A-C Prats, D P Lane, J-C Bourdo. p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage. Cell death and differentiation. vol 18. issue 2. 2011-04-25. PMID:20689555. |
we report here that in response to a low dose of doxorubicin (which induces cell cycle arrest without promoting apoptosis), p53 directly transactivates the human p53 internal promoter, inducing Δ133p53α protein expression. |
2011-04-25 |
2023-08-12 |
human |
| M Aoubala, F Murray-Zmijewski, M P Khoury, K Fernandes, S Perrier, H Bernard, A-C Prats, D P Lane, J-C Bourdo. p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage. Cell death and differentiation. vol 18. issue 2. 2011-04-25. PMID:20689555. |
therefore, endogenous Δ133p53α does not exclusively function in a dominant-negative manner toward p53, but differentially regulates cell cycle arrest and apoptosis. |
2011-04-25 |
2023-08-12 |
human |
| Jing Li, Yongyi Cheng, Weixing Qu, Yi Sun, Zhiping Wang, Hanzhang Wang, Binqiang Tia. Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells. Basic & clinical pharmacology & toxicology. vol 108. issue 2. 2011-04-25. PMID:21054790. |
fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of nf-kappa b pathways in bladder cancer cells. |
2011-04-25 |
2023-08-12 |
human |
| Jing Li, Yongyi Cheng, Weixing Qu, Yi Sun, Zhiping Wang, Hanzhang Wang, Binqiang Tia. Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells. Basic & clinical pharmacology & toxicology. vol 108. issue 2. 2011-04-25. PMID:21054790. |
in the present study, we report that fisetin-induced apoptosis in human bladder cancer is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of nf-kappa b activity, causing a change in the ratio of pro- and anti-apoptotic proteins. |
2011-04-25 |
2023-08-12 |
human |