| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guang-Yu Li, Ping Xie, Hui-Ying Li, Le Hao, Qian Xiong, Tong Qi. Involment of p53, Bax, and Bcl-2 pathway in microcystins-induced apoptosis in rat testis. Environmental toxicology. vol 26. issue 2. 2011-05-25. PMID:19760617. |
involment of p53, bax, and bcl-2 pathway in microcystins-induced apoptosis in rat testis. |
2011-05-25 |
2023-08-12 |
rat |
| Guang-Yu Li, Ping Xie, Hui-Ying Li, Le Hao, Qian Xiong, Tong Qi. Involment of p53, Bax, and Bcl-2 pathway in microcystins-induced apoptosis in rat testis. Environmental toxicology. vol 26. issue 2. 2011-05-25. PMID:19760617. |
the p53, bax, and bcl-2 protein play important roles in mitochondria-dependent apoptotic pathway, and this study aimed to investigate whether the p53, bax, and bcl-2 pathway is involved in microcystins-induced apoptosis in rat testis and discussed the possible mechanisms. |
2011-05-25 |
2023-08-12 |
rat |
| Nagehan O Barisik, Suheyla Bozkurt, Mahmut Gumus, Isik Kaygusuz, Nimet Karadayi, Emine Bas, Mahmut Bayik, Tulay Tecime. Expression and prognostic significance of Cox-2 and p-53 in Hodgkin lymphomas: a retrospective study. Diagnostic pathology. vol 5. 2011-05-24. PMID:20346139. |
p53 contributes to apoptosis, dna renewal and cell cycle. |
2011-05-24 |
2023-08-12 |
Not clear |
| Jose C Gomez-Sanchez, Maria Delgado-Esteban, Irene Rodriguez-Hernandez, Tomas Sobrino, Natalia Perez de la Ossa, Silvia Reverte, Juan P Bolaños, Rogelio Gonzalez-Sarmiento, Jose Castillo, Angeles Almeid. The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke. The Journal of experimental medicine. vol 208. issue 3. 2011-05-24. PMID:21357744. |
the p53 tumor suppressor protein, an important transcriptional regulator of apoptosis, naturally occurs in humans in two variants with single nucleotide polymorphisms resulting in arg or pro at residue 72. |
2011-05-24 |
2023-08-12 |
human |
| Alireza Shoae-Hassani, Shiva Sharif, Seyed Abdolreza Mortazavi Tabatabaei, Javad Verd. Could the endogenous opioid, morphine, prevent neural stem cell proliferation? Medical hypotheses. vol 76. issue 2. 2011-05-23. PMID:21051157. |
morphine induces over-expression of p53 gene that could mediate stem cell apoptosis. |
2011-05-23 |
2023-08-12 |
human |
| Antero Salminen, Johanna Ojala, Kai Kaarnirant. Apoptosis and aging: increased resistance to apoptosis enhances the aging process. Cellular and molecular life sciences : CMLS. vol 68. issue 6. 2011-05-23. PMID:21116678. |
at the molecular level, age-related resistance to apoptosis involves (1) functional deficiency in p53 network, (2) increased activity in the nf-κb-iap/jnk axis, and (3) changes in molecular chaperones, micrornas, and epigenetic regulation. |
2011-05-23 |
2023-08-12 |
Not clear |
| M B Aljabri, T Lund, A C Höper, T V Andreasen, S Al-Saad, S Lindal, K Ytrehu. Gene expression, function and ischemia tolerance in male and female rat hearts after sub-toxic levels of angiotensin II. Cardiovascular toxicology. vol 11. issue 1. 2011-05-23. PMID:21170686. |
ang ii increased expression of genes related to heart function (anf, β-mch, ankrd-1, pkc-α, pkc-δ tnf-α); fibrosis (col i-α1, col iii-α1, fn-1, timp1) and apoptosis (p53, casp-3) without changing heart weight but with 68% increase in collagen content. |
2011-05-23 |
2023-08-12 |
rat |
| Hung-Yun Lin, Cornelia B Landersdorfer, David London, Ran Meng, Chang-Uk Lim, Cassie Lin, Sharon Lin, Heng-Yuan Tang, David Brown, Brian Van Scoy, Robert Kulawy, Lurdes Queimado, George L Drusano, Arnold Louie, Faith B Davis, Shaker A Mousa, Paul J Davi. Pharmacodynamic modeling of anti-cancer activity of tetraiodothyroacetic acid in a perfused cell culture system. PLoS computational biology. vol 7. issue 2. 2011-05-23. PMID:21304935. |
fluorescence-activated cell sorting analysis of harvested cells revealed tetrac and nano-tetrac induced concentration-dependent apoptosis that was correlated with expression of pro-apoptotic proteins, such as p53, p21, pig3 and bad for nano-tetrac, while unmodified tetrac showed a different profile. |
2011-05-23 |
2023-08-12 |
human |
| Martin Chopra, Dieter Schren. Dioxin toxicity, aryl hydrocarbon receptor signaling, and apoptosis-persistent pollutants affect programmed cell death. Critical reviews in toxicology. vol 41. issue 4. 2011-05-20. PMID:21323611. |
the exact mechanisms of apoptosis inhibition by tcdd are not fully understood, but both in vivo and in vitro studies consistently showed an involvement of the tumor suppressor p53 in this effect. |
2011-05-20 |
2023-08-12 |
Not clear |
| L Song, M Gao, W Dong, M Hu, J Li, X Shi, Y Hao, Y Li, C Huan. p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response. Oncogene. vol 30. issue 11. 2011-05-19. PMID:21057544. |
inducible acetylation of p53 at lysine residues has a great impact on regulating the transactivation of this protein, which is associated with cell growth arrest and/or apoptosis under various stress conditions. |
2011-05-19 |
2023-08-12 |
mouse |
| L Song, M Gao, W Dong, M Hu, J Li, X Shi, Y Hao, Y Li, C Huan. p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response. Oncogene. vol 30. issue 11. 2011-05-19. PMID:21057544. |
depletion of p85α in mouse embryonic fibroblasts significantly impairs uvb-induced apoptosis, as well as p53 transactivation and acetylation at lys370 (lys373 of human p53); however, the accumulation, nuclear translocation and phosphorylation of p53 are not affected. |
2011-05-19 |
2023-08-12 |
mouse |
| L Song, M Gao, W Dong, M Hu, J Li, X Shi, Y Hao, Y Li, C Huan. p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response. Oncogene. vol 30. issue 11. 2011-05-19. PMID:21057544. |
moreover, ablation of p53 acetylation at lys370 by site-directed mutagenesis dramatically suppresses uvb-induced expression of the specific p53-responsive gene as well as cell apoptosis. |
2011-05-19 |
2023-08-12 |
mouse |
| Nadine S Jahchan, Kunxin Lu. SnoN in mammalian development, function and diseases. Current opinion in pharmacology. vol 10. issue 6. 2011-05-18. PMID:20822955. |
as a crucial negative regulator of transforming growth factor-β (tgf-β) signaling and also an activator of p53, it plays an important role in regulating cell proliferation, senescence, apoptosis, and differentiation. |
2011-05-18 |
2023-08-12 |
mouse |
| Ki Sa Sung, Yun-Ah Lee, Eui Tae Kim, Seung-Rock Lee, Jin-Hyun Ahn, Cheol Yong Cho. Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53. Experimental cell research. vol 317. issue 7. 2011-05-18. PMID:21192925. |
pml-nuclear body (nb) is required for hipk2-mediated p53 phosphorylation at ser46 and induction of apoptosis. |
2011-05-18 |
2023-08-12 |
Not clear |
| Ki Sa Sung, Yun-Ah Lee, Eui Tae Kim, Seung-Rock Lee, Jin-Hyun Ahn, Cheol Yong Cho. Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53. Experimental cell research. vol 317. issue 7. 2011-05-18. PMID:21192925. |
these results suggest that sim-mediated hipk2 targeting to pml-nbs is crucial for hipk2-mediated p53 activation and induction of apoptosis. |
2011-05-18 |
2023-08-12 |
Not clear |
| Wen-Jun Duan, Qi-Sheng Li, Ming-Yu Xia, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways. Biological & pharmaceutical bulletin. vol 34. issue 1. 2011-05-16. PMID:21212516. |
pifithrin-α (pft-α), a specific inhibitor of p53, reduced autophagy and reversed silibinin's growth-inhibitory effect; besides, pft-α decreased the activation of caspase-3, a crucial executor of apoptosis. |
2011-05-16 |
2023-08-12 |
human |
| Hong Wu, Scott L Pomeroy, Manuel Ferreira, Natalia Teider, Juliana Mariani, Keiichi I Nakayama, Shigetsugu Hatakeyama, Victor A Tron, Linda F Saltibus, Leo Spyracopoulos, Roger P Len. UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. Nature medicine. vol 17. issue 3. 2011-05-16. PMID:21317885. |
ube4b promotes p53 polyubiquitination and degradation and inhibits p53-dependent transactivation and apoptosis. |
2011-05-16 |
2023-08-12 |
mouse |
| Poh Choo How, Dennis Shield. Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway. The Journal of biological chemistry. vol 286. issue 10. 2011-05-11. PMID:21147777. |
ctf-induced apoptosis is transcription dependent and mediated by the tumor suppressor, p53. |
2011-05-11 |
2023-08-12 |
Not clear |
| Ali Tebbi, Olivier Guittet, Marie-Hélène Cottet, Marie-Françoise Vesin, Michel Lepoivr. TAp73 induction by nitric oxide: regulation by checkpoint kinase 1 (CHK1) and protection against apoptosis. The Journal of biological chemistry. vol 286. issue 10. 2011-05-11. PMID:21212274. |
nitric oxide (no) is a potent activator of the p53 tumor suppressor protein, thereby inducing cell cycle arrest and apoptosis. |
2011-05-11 |
2023-08-12 |
mouse |
| Tao Liu, Lin Li, WenFeng Yang, Hui Jia, MingKai Xu, JianBin Bi, ZeLiang Li, XianKui Liu, ZhenHua Li, HongWei Jing, ChuiZe Kon. iASPP is important for bladder cancer cell proliferation. Oncology research. vol 19. issue 3-4. 2011-05-10. PMID:21473288. |
inhibitor of apoptosis stimulatory protein phosphatase (iaspp) is a key inhibitor of p53 conserved from worm to human and is associated with cell proliferation and carcinogenesis in a variety of human cancers. |
2011-05-10 |
2023-08-12 |
human |