| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cornelia Amalinei, Corina Cianga, Raluca Balan, Petru Cianga, Simona Giusca, Irina-Draga Carunt. Immunohistochemical analysis of steroid receptors, proliferation markers, apoptosis related molecules, and gelatinases in non-neoplastic and neoplastic endometrium. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 193. issue 1. 2011-06-22. PMID:21145716. |
our study was designed to investigate steroid receptor (er, pr) expression and its correlation with proliferative activity (pcna), apoptosis (fas, fasl, bcl-2, bax, and p53), gelatinases (mmp-2 and mmp-9) and their tissue specific inhibitor (timp-1 and timp-2) immunoexpression in endometrial carcinogenesis. |
2011-06-22 |
2023-08-12 |
Not clear |
| Wei Liu, Min Zi, Hongbo Chi, Jiawei Jin, Sukhpal Prehar, Ludwig Neyses, Elizabeth J Cartwright, Richard A Flavell, Roger J Davis, Xin Wan. Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. Journal of molecular and cellular cardiology. vol 50. issue 4. 2011-06-22. PMID:21284947. |
cell death assays revealed an increased prevalence of cardiomyocyte apoptosis in the mkk7(cko) heart, in which elevated p53 levels and attenuated expression of manganese superoxide dismutase (mnsod) were found. |
2011-06-22 |
2023-08-12 |
mouse |
| Michael S Christodoulou, Francesco Colombo, Daniele Passarella, Gabriella Ieronimo, Valentina Zuco, Michelandrea De Cesare, Franco Zunin. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorganic & medicinal chemistry. vol 19. issue 5. 2011-06-21. PMID:21324703. |
the biochemical and biological evaluations supported that compounds of the tetrahydrobenzothiazole series were inhibitors of the p53 transcriptional activity and were effective in enhancing paclitaxel-induced apoptosis. |
2011-06-21 |
2023-08-12 |
human |
| Jane M Valentine, Sonia Kumar, Abdeladim Moume. A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. BMC cancer. vol 11. 2011-06-21. PMID:21338495. |
subsequent phosphorylation of p53 by atm and atm-induced chk2 results in p53 stabilization, ultimately intensifying transcription of p53-responsive genes involved in dna repair, cell-cycle checkpoint control and apoptosis. |
2011-06-21 |
2023-08-12 |
Not clear |
| Marian Adamkov, Erika Halasova, Julius Rajcani, Marian Bencat, Desanka Vybohova, Silvia Rybarova, Stefan Galbav. Relation between expression pattern of p53 and survivin in cutaneous basal cell carcinomas. Medical science monitor : international medical journal of experimental and clinical research. vol 17. issue 3. 2011-06-21. PMID:21358596. |
the tumor suppressor gene p53 is a key regulator of cell division and/or apoptosis. |
2011-06-21 |
2023-08-12 |
Not clear |
| Maqusood Ahamed, Mohd Javed Akhtar, Maqsood A Siddiqui, Javed Ahmad, Javed Musarrat, Abdulaziz A Al-Khedhairy, Mohamad S AlSalhi, Salman A Alrokaya. Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells. Toxicology. vol 283. issue 2-3. 2011-06-21. PMID:21382431. |
to the best of our knowledge this is the first report showing that nickel ferrite nanoparticles induced apoptosis in a549 cells through ros generation and oxidative stress via p53, survivin, bax/bcl-2 and caspase pathways. |
2011-06-21 |
2023-08-12 |
human |
| Ahmed Malki, Stephen C Bergmeie. Novel quinuclidinone derivative 8a induced apoptosis in human MCF-7 breast cancer cell lines. Anticancer research. vol 31. issue 3. 2011-06-21. PMID:21498708. |
8a induced g(1) phase arrest, presumably sensitizing the breast cancer cells to apoptosis by increasing expression level of p21 and cyclin e. moreover, 8a increased expression level of erk1, p53 and bax, and it reduced expression level of akt and bcl-2. |
2011-06-21 |
2023-08-12 |
human |
| Tomoaki Tochitani, Hiroyuki Kanemitsu, Hirofumi Yamauchi, Kazuyuki Uchida, Hiroyuki Nakayam. 5-azacytidine, a chemotherapeutic drug, induces TRAIL-mediated apoptosis in mouse thymocytes in vivo. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 63. issue 3. 2011-06-17. PMID:20092982. |
5azc-induced apoptosis was observed even in the thymuses of mice deficient in p53, a critical factor in the intrinsic apoptotic pathway, and mice with mutated fas, a death receptor. |
2011-06-17 |
2023-08-12 |
mouse |
| Ailine Stolz, Norman Ertych, Holger Bastian. Tumor suppressor CHK2: regulator of DNA damage response and mediator of chromosomal stability. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 3. 2011-06-17. PMID:21088254. |
after atm-mediated phosphorylation, the activated chk2 kinase can act as a signal transducer and phosphorylate a variety of substrates, including the cdc25 phosphatases, p53, pml, e2f-1, and brca1, which has been associated with halting the cell cycle, the initiation of dna repair, and the induction of apoptosis after dna damage. |
2011-06-17 |
2023-08-12 |
human |
| Ali M Sharifi, Roshanak Ghazanfari, Neda Tekiyehmaroof, Mohammad A Sharif. Investigating the effect of lead acetate on rat bone marrow-derived mesenchymal stem cells toxicity: role of apoptosis. Toxicology mechanisms and methods. vol 21. issue 3. 2011-06-17. PMID:21244221. |
finally, it might be concluded that lead acetate could induce cell toxicity and apoptosis in mscs, causing instability in mitochondria and in turn activation of the intrinsic pathway including over-expression of bax, caspase 9 and caspase 3, leading to dna damage and activation of p53. |
2011-06-17 |
2023-08-12 |
rat |
| Chen Chen, Natalia Gorlatova, Zvi Kelman, Osnat Herzber. Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 16. 2011-06-17. PMID:21464285. |
transcription factor p63, a p53 family member, plays a role in epithelial cell development, cell cycle arrest, apoptosis, and tumorigenesis. |
2011-06-17 |
2023-08-12 |
Not clear |
| Christophe Hennequin, Laurent Quero, Vincent Favaudo. [DNA repair and tumour radiosensitivity: focus on ATM gene]. Bulletin du cancer. vol 98. issue 3. 2011-06-17. PMID:21466987. |
atm plays a major role in the cellular response to ionizing radiation: it induced dna repair, cell cycle arrest, and apoptosis via induction of p53. |
2011-06-17 |
2023-08-12 |
Not clear |
| Min-Bin Chen, Wen-Xiang Shen, Yun Yang, Xiao-Yang Wu, Jin-Hua Gu, Pei-Hua L. Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell. Journal of cellular physiology. vol 226. issue 7. 2011-06-17. PMID:21506122. |
ampk activation is involved in vincristine induced p53 phosphorylation and stabilization, the latter is known to mediate melanoma cell apoptosis. |
2011-06-17 |
2023-08-12 |
Not clear |
| Hadar Benyamini, Assaf Friedle. The ASPP interaction network: electrostatic differentiation between pro- and anti-apoptotic proteins. Journal of molecular recognition : JMR. vol 24. issue 2. 2011-06-16. PMID:20623514. |
the c-terminal ankyrin repeats and sh3 domain (ank-sh3) mediate the interactions of the aspp proteins with major apoptosis regulators such as p53, bcl-2, and nfκb. |
2011-06-16 |
2023-08-12 |
Not clear |
| Tomasz Ociepa, Eliza Maloney, Elżbieta Kamieńska, Mariusz Wysocki, Andrzej Kurylak, Michał Matysiak, Tomasz Urasiński, Elżbieta Urasińska, Wenancjusz Domagał. Simultaneous assessment of p53 and MDM2 expression in leukemic cells in response to initial prednisone therapy in children with acute lymphoblastic leukemia. Polish journal of pathology : official journal of the Polish Society of Pathologists. vol 61. issue 4. 2011-06-16. PMID:21290342. |
p53 plays a crucial role in triggering apoptosis of all in response to prednisone treatment. |
2011-06-16 |
2023-08-12 |
Not clear |
| Tomasz Ociepa, Eliza Maloney, Elżbieta Kamieńska, Mariusz Wysocki, Andrzej Kurylak, Michał Matysiak, Tomasz Urasiński, Elżbieta Urasińska, Wenancjusz Domagał. Simultaneous assessment of p53 and MDM2 expression in leukemic cells in response to initial prednisone therapy in children with acute lymphoblastic leukemia. Polish journal of pathology : official journal of the Polish Society of Pathologists. vol 61. issue 4. 2011-06-16. PMID:21290342. |
mdm2 is the endogenous inhibitor of apoptosis that downregulates the functional activity of p53 protein. |
2011-06-16 |
2023-08-12 |
Not clear |
| André Schuster, Tobias Schilling, Vincenzo De Laurenzi, Andreas F Koch, Sarah Seitz, Frank Staib, Andreas Teufel, Snorri S Thorgeirsson, Peter Galle, Gerry Melino, Wolfgang Stremmel, Peter H Krammer, Martina Mülle. ΔNp73β is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria. Cell cycle (Georgetown, Tex.). vol 9. issue 13. 2011-06-15. PMID:20581467. |
p73 belongs to the p53 family of transcription factors known to regulate cell cycle and apoptosis. |
2011-06-15 |
2023-08-12 |
Not clear |
| Ramamurthi Vidya Priyadarsini, Govindarajah Vinothini, Ramalingam Senthil Murugan, Palrasu Manikandan, Siddavaram Nagin. The flavonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors. Nutrition and cancer. vol 63. issue 2. 2011-06-14. PMID:21294050. |
we analyzed the expression of markers associated with cell proliferation and survival (pcna, p21, p53, cyclin d1, gst-p), apoptosis (fas, fas-l, bcl-2 family proteins, cytochrome-c, apaf-1, caspases, parp, survivin, cflip, api1), invasion (mmps, timp-2, reck), angiogenesis (plgf, vegf, vegf receptors, hif-1α), as well as the epigenetic markers (hdac-1, dnmt1) by immunohistochemical, western blot, and rt-pcr analyses. |
2011-06-14 |
2023-08-12 |
Not clear |
| T Engel, K Tanaka, E M Jimenez-Mateos, A Caballero-Caballero, J H M Prehn, D C Henshal. Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus. Cell death & disease. vol 1. 2011-06-14. PMID:21368852. |
the p53 tumor suppressor is a multifunctional protein, which regulates cell cycle, differentiation, dna repair and apoptosis. |
2011-06-14 |
2023-08-12 |
mouse |
| Wen-Horng Wang, Leo L Studach, Ourania M Andrisan. Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication. Hepatology (Baltimore, Md.). vol 53. issue 4. 2011-06-14. PMID:21480320. |
knockdown of znf198 and suz12 by small interfering rna (sirna) reduced p53 stability and dna repair, rescued px-expressing hepatocytes from dna damage-induced apoptosis, and increased px-induced polyploidy and oncogenic transformation, suggesting znf198 and suz12 have a role in px-mediated transformation. |
2011-06-14 |
2023-08-12 |
human |