| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark E Stearns, Min Wan. Synergistic Effects of the Green Tea Extract Epigallocatechin-3-gallate and Taxane in Eradication of Malignant Human Prostate Tumors. Translational oncology. vol 4. issue 3. 2011-07-14. PMID:21633670. |
egcg combined with taxane also had an additive effect to increase the expression of apoptotic genes, (p53, p73, p21, and caspase 3) and the percent apoptosis observed in vitro and in tumor modeling studies in severe combined immunodeficient mice. |
2011-07-14 |
2023-08-12 |
mouse |
| Ehab Tousson, Bassem M Rafat, Mohamed Hessien, Ahmed A El Barbary, Ahmed Sam. P53 and Bcl2 apoptosis proteins in meso-2,3-dimercaptosuccinic acid treated lead-intoxicated rabbits. Toxicology and industrial health. vol 27. issue 3. 2011-07-12. PMID:21112928. |
p53 and bcl2 apoptosis proteins in meso-2,3-dimercaptosuccinic acid treated lead-intoxicated rabbits. |
2011-07-12 |
2023-08-12 |
Not clear |
| Ehab Tousson, Bassem M Rafat, Mohamed Hessien, Ahmed A El Barbary, Ahmed Sam. P53 and Bcl2 apoptosis proteins in meso-2,3-dimercaptosuccinic acid treated lead-intoxicated rabbits. Toxicology and industrial health. vol 27. issue 3. 2011-07-12. PMID:21112928. |
the effect of this treatment was investigated by measuring 2 of the apoptosis proteins p53 and bcl2. |
2011-07-12 |
2023-08-12 |
Not clear |
| Ehab Tousson, Bassem M Rafat, Mohamed Hessien, Ahmed A El Barbary, Ahmed Sam. P53 and Bcl2 apoptosis proteins in meso-2,3-dimercaptosuccinic acid treated lead-intoxicated rabbits. Toxicology and industrial health. vol 27. issue 3. 2011-07-12. PMID:21112928. |
our data indicate that exposure to rabbits to pb(ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic bcl2 proteins. |
2011-07-12 |
2023-08-12 |
Not clear |
| b' Bojana Zegura, Alja Straser, Metka Filipi\\xc4\\x8. Genotoxicity and potential carcinogenicity of cyanobacterial toxins - a review. Mutation research. vol 727. issue 1-2. 2011-07-12. PMID:21277993.' |
in addition, cyn increased the expression of p53 regulated genes involved in cell cycle arrest, dna damage repair, and apoptosis. |
2011-07-12 |
2023-08-12 |
human |
| Wei Qiu, Bin Wu, Xinwei Wang, Monica E Buchanan, Miguel D Regueiro, Douglas J Hartman, Robert E Schoen, Jian Yu, Lin Zhan. PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. The Journal of clinical investigation. vol 121. issue 5. 2011-07-12. PMID:21490394. |
we therefore investigated the role of p53-upregulated modulator of apoptosis (puma), a p53 target and proapoptotic bh3-only protein, in colitis and iec apoptosis, using patient samples and mouse models of uc. |
2011-07-12 |
2023-08-12 |
mouse |
| Wei Qiu, Bin Wu, Xinwei Wang, Monica E Buchanan, Miguel D Regueiro, Douglas J Hartman, Robert E Schoen, Jian Yu, Lin Zhan. PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. The Journal of clinical investigation. vol 121. issue 5. 2011-07-12. PMID:21490394. |
absence of puma, but neither absence of p53 nor that of another bh3-only protein (bid), relieved dss- and tnbs-induced colitis and inhibited iec apoptosis. |
2011-07-12 |
2023-08-12 |
mouse |
| S Häcker, S Karl, I Mader, S Cristofanon, T Schweitzer, J Krauss, S Rutkowski, K-M Debatin, S Fuld. Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation. Oncogene. vol 30. issue 19. 2011-07-12. PMID:21562496. |
combined treatment with ms-275 and doxorubicin or vp16 cooperates to promote binding of p53 to bax and p53-dependent bax activation, resulting in enhanced loss of mitochondrial membrane potential, cytochrome c release and caspase-dependent apoptosis. |
2011-07-12 |
2023-08-12 |
Not clear |
| Telma Cristina Esteves, Sebastian Thomas Balbach, Martin Johannes Pfeiffer, Marcos Jesus Araúzo-Bravo, Diana Claire Klein, Martina Sinn, Michele Boian. Somatic cell nuclear reprogramming of mouse oocytes endures beyond reproductive decline. Aging cell. vol 10. issue 1. 2011-07-11. PMID:20969722. |
although apoptosis-related genes were down-regulated in climacteric ooplasts, and reprogramming by transcription factors (direct-induced pluripotency) benefits from the inhibition of p53-mediated apoptosis, reprogramming capacity of young ooplasts was not improved by blocking p53. |
2011-07-11 |
2023-08-12 |
mouse |
| J-J Lee, B C Kim, M-J Park, Y-S Lee, Y-N Kim, B L Lee, J-S Le. PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell death and differentiation. vol 18. issue 4. 2011-07-11. PMID:21072054. |
furthermore, transfection with wild-type (wt) pten or akt small interfering rna induced a change from premature senescence to apoptosis and depletion of p53 or p21 prevented ir-induced premature senescence in u87 cells. |
2011-07-11 |
2023-08-12 |
human |
| Ying Huang, Zakaria Rachid, Bertrand J Jean-Claud. MGMT is a molecular determinant for potency of the DNA-EGFR-combi-molecule ZRS1. Molecular cancer research : MCR. vol 9. issue 3. 2011-07-11. PMID:21263032. |
in addition, the p53 pathway was activated by dna damage in both cell lines, but apoptosis was significantly more pronounced in a427 cells. |
2011-07-11 |
2023-08-12 |
human |
| Hae Mi Joo, Ji Young Kim, Jae Boon Jeong, Ki Moon Seong, Seon Young Nam, Kwang Hee Yang, Cha Soon Kim, Hee Sun Kim, Meeseon Jeong, Sungkwan An, Young Woo Ji. Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2. European journal of cell biology. vol 90. issue 5. 2011-07-11. PMID:21333377. |
we observed that rfp2 formed a complex with mdm2, a negative regulator of the p53 tumor suppressor, and akt, a regulator of apoptosis inhibition at the cellular level. |
2011-07-11 |
2023-08-12 |
Not clear |
| Hae Mi Joo, Ji Young Kim, Jae Boon Jeong, Ki Moon Seong, Seon Young Nam, Kwang Hee Yang, Cha Soon Kim, Hee Sun Kim, Meeseon Jeong, Sungkwan An, Young Woo Ji. Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2. European journal of cell biology. vol 90. issue 5. 2011-07-11. PMID:21333377. |
thus, these data suggest that irradiation causes rfp2 overexpression, which enhances ionizing radiation-induced apoptosis by increasing p53 stability and decreasing akt kinase activity through mdm2 and akt degradation. |
2011-07-11 |
2023-08-12 |
Not clear |
| Shichuan Zhang, Hirohiko Yajima, Hoangdinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J Chen, Benjamin P C Che. Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. The Journal of cell biology. vol 193. issue 2. 2011-07-11. PMID:21482716. |
in addition, increased apoptosis in the intestinal crypt and epidermal hyperpigmentation indicate the presence of elevated genotoxic stress and p53 activation. |
2011-07-11 |
2023-08-12 |
mouse |
| Yong-Jig Cho, Peng Lian. S-phase-coupled apoptosis in tumor suppression. Cellular and molecular life sciences : CMLS. vol 68. issue 11. 2011-07-07. PMID:21437646. |
over-replication, under-replication, as well as dna damage in a cell all induce the activation of checkpoint control pathways such as atm/atr, chk kinases, and the tumor suppressor protein p53, which provide "damage controls" via either dna repairs or apoptosis. |
2011-07-07 |
2023-08-12 |
Not clear |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. Apoptosis : an international journal on programmed cell death. vol 16. issue 1. 2011-07-05. PMID:20812030. |
mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and e2f1-mediated expression of puma and siva-1. |
2011-07-05 |
2023-08-12 |
human |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. Apoptosis : an international journal on programmed cell death. vol 16. issue 1. 2011-07-05. PMID:20812030. |
camptothecin (cpt) and nutlin-3 caused apoptosis by increasing p53 protein and its activation in intestinal epithelial cells (iec-6). |
2011-07-05 |
2023-08-12 |
human |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. Apoptosis : an international journal on programmed cell death. vol 16. issue 1. 2011-07-05. PMID:20812030. |
we studied the effectiveness of these inducers on apoptosis in human colon cancer cells (caco2) lacking p53 expression. |
2011-07-05 |
2023-08-12 |
human |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. Apoptosis : an international journal on programmed cell death. vol 16. issue 1. 2011-07-05. PMID:20812030. |
the absence of p53 expression, higher basal bcl-xl and lower bax proteins prevented cpt-induced apoptosis. |
2011-07-05 |
2023-08-12 |
human |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. Apoptosis : an international journal on programmed cell death. vol 16. issue 1. 2011-07-05. PMID:20812030. |
nutlin-3-mediated degradation of mdm2 caused the accumulation of p73, which induced the expression of p53 up-regulated modulator of apoptosis (puma). |
2011-07-05 |
2023-08-12 |
human |