| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruth Villalonga-Planells, Llorenç Coll-Mulet, Fina Martínez-Soler, Esther Castaño, Juan-Jose Acebes, Pepita Giménez-Bonafé, Joan Gil, Avelina Tortos. Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme. PloS one. vol 6. issue 4. 2011-07-20. PMID:21483692. |
nutlin-3a-induced apoptosis and senescence were firmly dependent on the presence of functional p53, as revealed by the fact that glioblastoma cells with knockdown p53 with specific sirna, or cells with mutated or functionally impaired p53 pathway, were completely insensitive to the drug. |
2011-07-20 |
2023-08-12 |
human |
| Nashi Widodo, Yasuomi Takagi, Bhupal G Shrestha, Tetsuro Ishii, Sunil C Kaul, Renu Wadhw. Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses. Cancer letters. vol 262. issue 1. 2011-07-19. PMID:18191020. |
p53 signaling, gm-cfs signaling, death receptor signaling, apoptosis signaling and g2-m dna damage regulation pathway. |
2011-07-19 |
2023-08-12 |
mouse |
| Zhenhua Zhang, Weiliang Zhu, Jian Zhang, Linlang Gu. Tyrosine kinase Etk/BMX protects nasopharyngeal carcinoma cells from apoptosis induced by radiation. Cancer biology & therapy. vol 11. issue 7. 2011-07-19. PMID:21339702. |
the purpose of this study was to investigate whether etk/bmx is involved in the apoptosis induced by irradiation in npc cells and correlated with the apoptosis associated proteins such as p53, bcl-2, bcl-x(l) and bak. |
2011-07-19 |
2023-08-12 |
Not clear |
| Zhenhua Zhang, Weiliang Zhu, Jian Zhang, Linlang Gu. Tyrosine kinase Etk/BMX protects nasopharyngeal carcinoma cells from apoptosis induced by radiation. Cancer biology & therapy. vol 11. issue 7. 2011-07-19. PMID:21339702. |
our results suggested that etk/bmx may play a role in protection of npc cells from apoptosis, and both p53 and bcl-2 may be involved in radiation-induced apoptosis through etk/bmx pathway in npc cells. |
2011-07-19 |
2023-08-12 |
Not clear |
| Di Chen, Jiping Tang, Nikan H Khatibi, Mei Zhu, Yingbo Li, Chengyuan Wang, Rong Jiang, Liu Tu, Shali Wan. Treatment with Z-ligustilide, a component of Angelica sinensis, reduces brain injury after a subarachnoid hemorrhage in rats. The Journal of pharmacology and experimental therapeutics. vol 337. issue 3. 2011-07-19. PMID:21398513. |
additional testing was done to evaluate for apoptosis using tdt-mediated dutp-biotin nick end labeling staining as well as immunohistochemistry and western blotting to identify key proapoptotic/survival proteins, i.e., p53, bax, bcl-2, and cleaved caspase-3. |
2011-07-19 |
2023-08-12 |
rat |
| Amar Deep Sharma, Nidhi Narain, Eva-Maria Händel, Marcus Iken, Nishant Singhal, Toni Cathomen, Michael P Manns, Hans R Schöler, Michael Ott, Tobias Cant. MicroRNA-221 regulates FAS-induced fulminant liver failure. Hepatology (Baltimore, Md.). vol 53. issue 5. 2011-07-19. PMID:21400558. |
we additionally demonstrate that mir-221 regulates hepatic expression of p53 up-regulated modulator of apoptosis (puma), a well-known proapoptotic member of the bcl2 protein family. |
2011-07-19 |
2023-08-12 |
mouse |
| Maki Tokumoto, Yasuyuki Fujiwara, Akinori Shimada, Tatsuya Hasegawa, Yoshiyuki Seko, Hisamitsu Nagase, Masahiko Sato. Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo. The Journal of toxicological sciences. vol 36. issue 2. 2011-07-19. PMID:21467746. |
in addition, cd induced phosphorylation of p53 and caused apoptosis in the nrk-52e cells. |
2011-07-19 |
2023-08-12 |
mouse |
| Maki Tokumoto, Yasuyuki Fujiwara, Akinori Shimada, Tatsuya Hasegawa, Yoshiyuki Seko, Hisamitsu Nagase, Masahiko Sato. Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo. The Journal of toxicological sciences. vol 36. issue 2. 2011-07-19. PMID:21467746. |
these results suggest that the cd-induced accumulation of p53 may be due to inhibition of p53 degradation through the down-regulation of ube2d family genes, and that cd induces p53-dependent apoptosis in renal tubular cells. |
2011-07-19 |
2023-08-12 |
mouse |
| Shih-Yen Weng, Chia-Yu Yang, Chao-Chin Li, Te-Ping Sun, Shu-Yun Tung, Jeffrey Jong-Young Yen, Ting-Fen Tsai, Chun-Ming Chen, Sung Ho Chen, Michael Hsiao, Pei-Hsin Huang, Hsin-Fang Yang-Ye. Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer. Journal of hepatology. vol 54. issue 4. 2011-07-15. PMID:21146511. |
the tumor suppressor protein p53 plays an important role in apoptosis control as well as other cellular responses. |
2011-07-15 |
2023-08-12 |
Not clear |
| Shih-Yen Weng, Chia-Yu Yang, Chao-Chin Li, Te-Ping Sun, Shu-Yun Tung, Jeffrey Jong-Young Yen, Ting-Fen Tsai, Chun-Ming Chen, Sung Ho Chen, Michael Hsiao, Pei-Hsin Huang, Hsin-Fang Yang-Ye. Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer. Journal of hepatology. vol 54. issue 4. 2011-07-15. PMID:21146511. |
this study was initially aimed to examine whether p53 was involved in mcl-1 deficiency-induced apoptosis of hepatocytes. |
2011-07-15 |
2023-08-12 |
Not clear |
| Xiaozhong Yu, Jaspreet S Sidhu, Sungwoo Hong, Joshua F Robinson, Rafael A Ponce, Elaine M Faustma. Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 120. issue 2. 2011-07-15. PMID:21252392. |
the tumor suppressor oncoprotein, p53, is a critical regulator of stress-induced growth arrest and apoptosis. |
2011-07-15 |
2023-08-12 |
mouse |
| Xiaozhong Yu, Jaspreet S Sidhu, Sungwoo Hong, Joshua F Robinson, Rafael A Ponce, Elaine M Faustma. Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 120. issue 2. 2011-07-15. PMID:21252392. |
in the present study, we investigate the role of p53 to determine sensitivity to cadmium (cd) and whether induction of stress signaling responses and perturbation of the ups are involved in cd-induced cytotoxicity and apoptosis. |
2011-07-15 |
2023-08-12 |
mouse |
| Xiaozhong Yu, Jaspreet S Sidhu, Sungwoo Hong, Joshua F Robinson, Rafael A Ponce, Elaine M Faustma. Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 120. issue 2. 2011-07-15. PMID:21252392. |
our study suggests that cd-mediated cytotoxicity and induction of stress signaling responses, elevated accumulation of hmw-polyub conjugates, and resulting apoptosis are all dependent on p53 status. |
2011-07-15 |
2023-08-12 |
mouse |
| Michael A Wrid. Lens fibre cell differentiation and organelle loss: many paths lead to clarity. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 366. issue 1568. 2011-07-15. PMID:21402582. |
apoptosis signalling and proteolytic pathways have been implicated in both lens fibre cell differentiation and organelle loss, including the bcl-2 and inhibitor of apoptosis families, tumour necrosis factors, p53 and its regulators (such as mdm2) and proteolytic enzymes, including caspases, cathepsins, calpains and the ubiquitin-proteasome pathway. |
2011-07-15 |
2023-08-12 |
mouse |
| Xin-Hai Pei, Feng Bai, Zhijun Li, Matthew D Smith, Gabrielle Whitewolf, Ran Jin, Yue Xion. Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Cancer research. vol 71. issue 8. 2011-07-15. PMID:21487039. |
ectopic expression of wild-type cul9, but not a point mutant cul9 deficient in p53 binding, promotes apoptosis. |
2011-07-15 |
2023-08-12 |
mouse |
| Luca Giliberto, Dawang Zhou, Richard Weldon, Elena Tamagno, Pasquale De Luca, Massimo Tabaton, Luciano D'Adami. Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role. Molecular neurodegeneration. vol 3. 2011-07-14. PMID:18764939. |
furthermore, p53 has been implicated in aid mediated susceptibility to apoptosis. |
2011-07-14 |
2023-08-12 |
mouse |
| Diogo André Pilger, Patrícia Luciana da Costa Lopez, Fábio Segal, Sandra Leistner-Sega. Analysis of R213R and 13494 g-->a polymorphisms of the p53 gene in individuals with esophagitis, intestinal metaplasia of the cardia and Barrett's Esophagus compared with a control group. Genomic medicine. vol 1. issue 1-2. 2011-07-14. PMID:18923929. |
protein p53 is the tumor suppressor involved in cell cycle control and apoptosis. |
2011-07-14 |
2023-08-12 |
Not clear |
| Minaxi Jhawer, David Kelsen, Manish Sha. Incorporation of biologic therapies in the management of gastroesophageal cancers. Gastrointestinal cancer research : GCR. vol 1. issue 2 Suppl. 2011-07-14. PMID:19343157. |
such targets include cell growth regulators (human epidermal growth factor like receptor, ki-67), vascular modulators (vascular endothelial growth factor), cell cycle checkpoint modulators (p16, p21, cyclin d1, cyclindependent kinases), apoptosis promoters (p53, bax, bcl-2), and cell proliferators, tissue invasion and metastasis potentiators (matrix metalloproteinase, e-cadherin, gastrin 17). |
2011-07-14 |
2023-08-12 |
human |
| Howard A Levine, Michael W Smiley, Anna L Tucker, Marit Nilsen-Hamilto. A mathematical model for the onset of avascular tumor growth in response to the loss of p53 function. Cancer informatics. vol 2. 2011-07-14. PMID:19458766. |
the wild type p53 protein regulates apoptosis, cell expression of growth factor and matrix metalloproteinase, which are regulatory functions that many mutant p53 proteins do not possess. |
2011-07-14 |
2023-08-12 |
Not clear |
| Akiko Horiuchi, Cuiju Wang, Norihiko Kikuchi, Ryosuke Osada, Toshio Nikaido, Ikuo Konish. BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer Cells. Biomarker insights. vol 1. 2011-07-14. PMID:19690636. |
brca1 expression is an important biomarker for chemosensitivity: suppression of brca1 increases the apoptosis via up-regulation of p53 and p21 during cisplatin treatment in ovarian cancer cells. |
2011-07-14 |
2023-08-12 |
Not clear |