| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akiko Horiuchi, Cuiju Wang, Norihiko Kikuchi, Ryosuke Osada, Toshio Nikaido, Ikuo Konish. BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer Cells. Biomarker insights. vol 1. 2011-07-14. PMID:19690636. |
however, cisplatin treatment under suppression of brca1 showed a significantly increased apoptosis along with up-regulation of p53 and p21 in a2780 cells. |
2011-07-14 |
2023-08-12 |
Not clear |
| Akiko Horiuchi, Cuiju Wang, Norihiko Kikuchi, Ryosuke Osada, Toshio Nikaido, Ikuo Konish. BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer Cells. Biomarker insights. vol 1. 2011-07-14. PMID:19690636. |
accordingly, reduced expression of brca1 enhances the cisplatin sensitivity and apoptosis via up-regulation of p53 and p21, but does not affect the paclitaxel sensitivity. |
2011-07-14 |
2023-08-12 |
Not clear |
| Eun Jeong Choi, Woong Shick Ah. Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells. Nutrition research and practice. vol 2. issue 4. 2011-07-14. PMID:20016737. |
the kaempferol-induced apoptosis was associated with the up-regulation of p53. |
2011-07-14 |
2023-08-12 |
human |
| Eun Jeong Choi, Woong Shick Ah. Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells. Nutrition research and practice. vol 2. issue 4. 2011-07-14. PMID:20016737. |
kaempferol inhibits cell proliferation by disrupting the cell cycle, which is strongly associated with the induction of arrest at g2/m phase and may induce apoptosis via p53 phosphorylation in human breast carcinoma mda-mb-453 cells. |
2011-07-14 |
2023-08-12 |
human |
| Young Sun Kim, Hong Joon Lee, Chorong Jang, Ho-Shik Kim, Young-Jin Ch. Knockdown of RCAN1.4 Increases Susceptibility to FAS-mediated and DNA-damage-induced Apoptosis by Upregulation of p53 Expression. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 13. issue 6. 2011-07-14. PMID:20054496. |
knockdown of rcan1.4 increases susceptibility to fas-mediated and dna-damage-induced apoptosis by upregulation of p53 expression. |
2011-07-14 |
2023-08-12 |
human |
| Young Sun Kim, Hong Joon Lee, Chorong Jang, Ho-Shik Kim, Young-Jin Ch. Knockdown of RCAN1.4 Increases Susceptibility to FAS-mediated and DNA-damage-induced Apoptosis by Upregulation of p53 Expression. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 13. issue 6. 2011-07-14. PMID:20054496. |
our results suggest that enhanced expression and activation of p53 was responsible for the upregulation of bax and the increased sensitivity to apoptosis, which could be reversed by p53 knockdown. |
2011-07-14 |
2023-08-12 |
human |
| Hiroyasu Takita, Shin Yoneya, Peter L Gehlbach, Lisa L Wei, Keisuke Mor. An empty E1, E3, E4 adenovirus vector protects photoreceptors from light-induced degeneration. Journal of ocular biology, diseases, and informatics. vol 1. issue 1. 2011-07-14. PMID:20072633. |
semiquantitative assessment of messenger ribonucleic acid (mrna) for the apoptosis related genes: p50, p65, ikba, caspase-1, caspase-3, bad, c-jun, bax, bak, bcl-2, c-fos, and p53 using quantitative reverse transcriptase polymerase chain reaction was performed on eyes following 12 h of light exposure. |
2011-07-14 |
2023-08-12 |
mouse |
| Zhen Wang, Yi Su. Targeting p53 for Novel Anticancer Therapy. Translational oncology. vol 3. issue 1. 2011-07-14. PMID:20165689. |
p53 plays a critical role in tumor suppression mainly by inducing growth arrest, apoptosis, and senescence, as well as by blocking angiogenesis. |
2011-07-14 |
2023-08-12 |
human |
| Eric R Wagner, Bai-Cheng He, Liang Chen, Guo-Wei Zuo, Wenli Zhang, Qiong Shi, Qing Luo, Xiaoji Luo, Bo Liu, Jinyong Luo, Farbod Rastegar, Connie J He, Yawen Hu, Barrett Boody, Hue H Luu, Tong-Chuan He, Zhong-Liang Deng, Rex C Haydo. Therapeutic Implications of PPARgamma in Human Osteosarcoma. PPAR research. vol 2010. 2011-07-14. PMID:20182546. |
although dysregulation of tumor suppressor genes and oncogenes, such as rb, p53, and the genes critical to cell cycle control, genetic stability, and apoptosis have been identified in os, consensus genetic changes that lead to os development are poorly understood. |
2011-07-14 |
2023-08-12 |
human |
| Srilata Bagchi, Pradip Raychaudhur. Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage. Cell division. vol 5. 2011-07-14. PMID:20205757. |
mammalian cells activate the pathways of p53 to induce apoptosis of cells harboring irreparable dna damages. |
2011-07-14 |
2023-08-12 |
Not clear |
| Srilata Bagchi, Pradip Raychaudhur. Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage. Cell division. vol 5. 2011-07-14. PMID:20205757. |
while p53 induces expression of various pro-apoptotic genes and directly participates in the disruption of mitochondrial membrane polarization, it also increases expression of the cell cycle inhibitor p21 that is a dominant inhibitor of caspase-activation and apoptosis. |
2011-07-14 |
2023-08-12 |
Not clear |
| Eswar Shankar, Chandreyi Basu, Brett Adkins, Wolfram Siede, Alakananda Bas. NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner. Journal of molecular signaling. vol 5. 2011-07-14. PMID:20459745. |
the tumor suppressor protein p53 plays a critical role in dna damage-induced apoptosis. |
2011-07-14 |
2023-08-12 |
Not clear |
| James N Tsoporis, Forough Mohammadzadeh, Thomas G Parke. Intracellular and Extracellular Effects of S100B in the Cardiovascular Response to Disease. Cardiovascular psychiatry and neurology. vol 2010. 2011-07-14. PMID:20672023. |
s100b induces apoptosis by an extracellular mechanism via interaction with the receptor for advanced glycation end products and activating erk1/2 and p53 signaling. |
2011-07-14 |
2023-08-12 |
mouse |
| Virginie Lamy, Souad Bousserouel, Francine Gossé, Carole Minker, Annelise Lobstein, Francis Rau. p53 Activates Either Survival or Apoptotic Signaling Responses in Lupulone-Treated Human Colon Adenocarcinoma Cells and Derived Metastatic Cells. Translational oncology. vol 3. issue 5. 2011-07-14. PMID:20885891. |
because p53 plays a central role in the response to cellular stresses by upregulating the transcription of several genes controlling apoptosis, we aimed to study the involvement of p53 on lupulone-triggered apoptosis. |
2011-07-14 |
2023-08-12 |
human |
| Young Jin Moon, Daniel A Brazeau, Marilyn E Morri. Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2011-07-14. PMID:20953429. |
induction of p57 kip2, p53, brca2, il-2, and atf-2 would be expected to decrease cellular proliferation and increase tumor suppression and/or apoptosis. |
2011-07-14 |
2023-08-12 |
human |
| Nicolas Dejeans, Jeanette A M Maier, Igor Tauveron, Dragan Milenkovic, Andrzej Mazu. Modulation of gene expression in endothelial cells by hyperlipaemic postprandial serum from healthy volunteers. Genes & nutrition. vol 5. issue 3. 2011-07-14. PMID:21052530. |
taken together, the transcriptomic results and pathway analysis showed that postprandial serum promotes apoptosis in huvecs, potentially through the activation of the p53 network. |
2011-07-14 |
2023-08-12 |
human |
| Jordi Muntané, Manuel De la Mat. Nitric oxide and cancer. World journal of hepatology. vol 2. issue 9. 2011-07-14. PMID:21161018. |
the multiple actions of no in the tumor environment is related to heterogeneous cell responses with particular attention in the regulation of the stress response mediated by the hypoxia inducible factor-1 and p53 generally leading to growth arrest, apoptosis or adaptation. |
2011-07-14 |
2023-08-12 |
human |
| Sanna-Maria Hede, Inga Nazarenko, Monica Nistér, Mikael S Lindströ. Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors. Journal of oncology. vol 2011. 2011-07-14. PMID:21209724. |
p53 is well-known for its ability to induce cell cycle arrest, apoptosis, senescence, or differentiation following cellular stress. |
2011-07-14 |
2023-08-12 |
Not clear |
| Shingo Matsushima, Naoyuki Okita, Misako Oku, Wataru Nagai, Masaki Kobayashi, Yoshikazu Higam. An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts. Biochemical and biophysical research communications. vol 407. issue 3. 2011-07-14. PMID:21419099. |
nutlin-3a (nutlin) is an mdm2 inhibitor and is potent to stabilize p53, which is a tumor-suppressor involved in various biological processes such as cell cycle regulation, dna repair, and apoptosis. |
2011-07-14 |
2023-08-12 |
mouse |
| Chindo Hicks, Antonio Pannuti, Lucio Miel. Associating GWAS Information with the Notch Signaling Pathway Using Transcription Profiling. Cancer informatics. vol 10. 2011-07-14. PMID:21584266. |
additionally, we identified other snp-associated biological pathways relevant to breast cancer, including the p53, apoptosis and map kinase pathways. |
2011-07-14 |
2023-08-12 |
Not clear |