| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. Apoptosis : an international journal on programmed cell death. vol 16. issue 1. 2011-07-05. PMID:20812030. |
in summary, apoptosis in caco2 cells lacking functional p53 occurred following the disruption of mdm2 binding with p73 and rb leading to the expression of pro-apoptotic proteins, puma, noxa, and siva-1. |
2011-07-05 |
2023-08-12 |
human |
| Mi Hee Lee, Dong-Wook Han, Suong-Hyu Hyon, Jong-Chul Par. Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3-O-gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB. Apoptosis : an international journal on programmed cell death. vol 16. issue 1. 2011-07-05. PMID:20963498. |
apoptosis of human fibrosarcoma ht-1080 cells by epigallocatechin-3-o-gallate via induction of p53 and caspases as well as suppression of bcl-2 and phosphorylated nuclear factor-κb. |
2011-07-05 |
2023-08-12 |
human |
| Mi Hee Lee, Dong-Wook Han, Suong-Hyu Hyon, Jong-Chul Par. Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3-O-gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB. Apoptosis : an international journal on programmed cell death. vol 16. issue 1. 2011-07-05. PMID:20963498. |
taken together, our data indicate that ht-1080 apoptosis may be mediated through the induction of p53 and caspases by the pro-oxidant activity of internalized egcg, as well as suppression of bcl-2 and phosphorylated nf-κb by the antioxidant activity of egcg. |
2011-07-05 |
2023-08-12 |
human |
| Eunkuk Park, Gi-Ja Lee, Samjin Choi, Seok-Keun Choi, Su-Jin Chae, Sung-Wook Kang, Youngmi Kim Pak, Hun-Kuk Par. The role of glutamate release on voltage-dependent anion channels (VDAC)-mediated apoptosis in an eleven vessel occlusion model in rats. PloS one. vol 5. issue 12. 2011-07-05. PMID:21203570. |
to confirm neuronal apoptosis, the brains were removed 72 h after ischemia to detect the neuron-specific nuclear protein and pro-apoptotic proteins (cleaved caspase-3, vdac, p53 and bax). |
2011-07-05 |
2023-08-12 |
rat |
| Huiping Yuan, Xiaoyong Zhang, Xiuqing Huang, Yonggang Lu, Weiqing Tang, Yong Man, Shu Wang, Jianzhong Xi, Jian L. NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways. PloS one. vol 5. issue 12. 2011-07-05. PMID:21209957. |
nadph oxidase 2-derived reactive oxygen species mediate ffas-induced dysfunction and apoptosis of β-cells via jnk, p38 mapk and p53 pathways. |
2011-07-05 |
2023-08-12 |
Not clear |
| Huiping Yuan, Xiaoyong Zhang, Xiuqing Huang, Yonggang Lu, Weiqing Tang, Yong Man, Shu Wang, Jianzhong Xi, Jian L. NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways. PloS one. vol 5. issue 12. 2011-07-05. PMID:21209957. |
we also found that palmitate and oleate stimulated apoptosis of nit-1 cells through p38mapk, p53 and nf-κb pathway. |
2011-07-05 |
2023-08-12 |
Not clear |
| Leonie Smeenk, Simon J van Heeringen, Max Koeppel, Bianca Gilbert, Eva Janssen-Megens, Hendrik G Stunnenberg, Marion Lohru. Role of p53 serine 46 in p53 target gene regulation. PloS one. vol 6. issue 3. 2011-07-05. PMID:21394211. |
interestingly, the extent of s46 phosphorylation of p53 bound to dna is considerably higher in cells directed towards apoptosis while the degree of phosphorylation at s15 remains highly similar. |
2011-07-05 |
2023-08-12 |
Not clear |
| Leonie Smeenk, Simon J van Heeringen, Max Koeppel, Bianca Gilbert, Eva Janssen-Megens, Hendrik G Stunnenberg, Marion Lohru. Role of p53 serine 46 in p53 target gene regulation. PloS one. vol 6. issue 3. 2011-07-05. PMID:21394211. |
moreover, our data suggest that following different chemotherapeutical treatments, the amount of chromatin-associated p53 phosphorylated at s46 but not at ps15 is higher on certain apoptosis related target genes. |
2011-07-05 |
2023-08-12 |
Not clear |
| Huan-Chih Chiu, Ding-Li Chou, Chin-Ting Huang, Wen-Hsing Lin, Tzu-Wen Lien, Kuei-Jung Yen, John T-A Hs. Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells. Biochemical pharmacology. vol 81. issue 11. 2011-07-05. PMID:21406185. |
in this study, we found that a small molecule, reactivation of p53 and induction of tumor cell apoptosis (rita), showed anti-cancer activity against gefitinib-resistant h1650 cells through a p53-independent pathway. |
2011-07-05 |
2023-08-12 |
Not clear |
| Brahmananda Reddy Chitteti, Yunlong Liu, Edward F Srou. Genomic and proteomic analysis of the impact of mitotic quiescence on the engraftment of human CD34+ cells. PloS one. vol 6. issue 3. 2011-07-05. PMID:21408179. |
system biology modeling indicated that the top four signaling pathways associated with these genes are integrin signaling, p53 signaling, cytotoxic t lymphocyte-mediated apoptosis, and myc mediated apoptosis signaling. |
2011-07-05 |
2023-08-12 |
human |
| Hirokazu Shiheido, Hideaki Takashima, Nobuhide Doi, Hiroshi Yanagaw. mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction. PloS one. vol 6. issue 3. 2011-07-05. PMID:21423613. |
p53 is a tumor suppressor protein that prevents tumorigenesis through cell cycle arrest or apoptosis of cells in response to cellular stress such as dna damage. |
2011-07-05 |
2023-08-12 |
Not clear |
| S K Nayak, P S Panesar, H Kuma. Non-genotoxic p53-activators and their significance as antitumor therapy of future. Current medicinal chemistry. vol 18. issue 7. 2011-07-04. PMID:21254973. |
the tumor suppressor protein p53 mediates critical cellular functions including regulation of cell cycle, apoptosis, dna repair, and senescence. |
2011-07-04 |
2023-08-12 |
Not clear |
| Radek Jorda, Libor Havlícek, Iain W McNae, Malcolm D Walkinshaw, Jirí Voller, Antonín Sturc, Jana Navrátilová, Marek Kuzma, Martin Mistrík, Jirí Bártek, Miroslav Strnad, Vladimír Krysto. Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity. Journal of medicinal chemistry. vol 54. issue 8. 2011-07-04. PMID:21417417. |
protein kinase selectivity profile of compound 7 and its biological effects (cell cycle arrest, dephosphorylation of the retinoblastoma protein, accumulation of the tumor suppressor protein p53, induction of apoptosis, inhibition of homologous recombination) are consistent with cdk inhibition as a primary mode of action. |
2011-07-04 |
2023-08-12 |
human |
| Kurinji Singaravelu, Babu J Padanila. p53 target Siva regulates apoptosis in ischemic kidneys. American journal of physiology. Renal physiology. vol 300. issue 5. 2011-07-01. PMID:21307125. |
p53 target siva regulates apoptosis in ischemic kidneys. |
2011-07-01 |
2023-08-12 |
mouse |
| Kurinji Singaravelu, Babu J Padanila. p53 target Siva regulates apoptosis in ischemic kidneys. American journal of physiology. Renal physiology. vol 300. issue 5. 2011-07-01. PMID:21307125. |
the role of p53 in inducing apoptosis following acute kidney injury is well-established; however, the molecular mechanisms remain largely unknown. |
2011-07-01 |
2023-08-12 |
mouse |
| Sung Ho An, Jung Hoon Kang, Dong Heui Kim, Myeong Seon Le. Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells. BMB reports. vol 44. issue 3. 2011-07-01. PMID:21429301. |
vitamin c increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells. |
2011-07-01 |
2023-08-12 |
human |
| Sung Ho An, Jung Hoon Kang, Dong Heui Kim, Myeong Seon Le. Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells. BMB reports. vol 44. issue 3. 2011-07-01. PMID:21429301. |
using cell growth assays, morphological methods, western blotting, flow cytometry, and dna fragmentation analysis, we measured the expression of p53 level involved in the effect of vc on cddp-induced apoptosis of hct116, a human colon cancer cell line. |
2011-07-01 |
2023-08-12 |
human |
| Sung Ho An, Jung Hoon Kang, Dong Heui Kim, Myeong Seon Le. Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells. BMB reports. vol 44. issue 3. 2011-07-01. PMID:21429301. |
cddp plus vc treatment resulted in significantly increased apoptosis along with upregulation of p53 compared to untreated cells and/or cddp-treated cells. |
2011-07-01 |
2023-08-12 |
human |
| Sung Ho An, Jung Hoon Kang, Dong Heui Kim, Myeong Seon Le. Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells. BMB reports. vol 44. issue 3. 2011-07-01. PMID:21429301. |
these results suggest that vc enhanced cddp sensitivity and apoptosis via upregulation of p53. |
2011-07-01 |
2023-08-12 |
human |
| Yanhong Zhang, Wensheng Yan, Xinbin Che. Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions. The Journal of biological chemistry. vol 286. issue 18. 2011-07-01. PMID:21454711. |
here, we found that endogenous wild-type p53 in mcf-10a cells was not required for acinus formation, but knockdown of endogenous wild-type p53 (p53-kd) led to partial clearance of cells in the lumen due to decreased apoptosis. |
2011-07-01 |
2023-08-12 |
mouse |