| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diego F Calvisi, Maria M Simile, Sara Ladu, Maddalena Frau, Matthias Evert, Maria L Tomasi, Maria I Demartis, Lucia Daino, Maria A Seddaiu, Stefania Brozzetti, Francesco Feo, Rosa M Pascal. Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53. Hepatology (Baltimore, Md.). vol 53. issue 4. 2011-06-14. PMID:21480327. |
small interfering rna (sirna)-mediated mybl2/linc silencing reduced proliferation, induced apoptosis, and dna damage at similar levels in hcc cell lines, irrespective of p53 status. |
2011-06-14 |
2023-08-12 |
human |
| Diego F Calvisi, Maria M Simile, Sara Ladu, Maddalena Frau, Matthias Evert, Maria L Tomasi, Maria I Demartis, Lucia Daino, Maria A Seddaiu, Stefania Brozzetti, Francesco Feo, Rosa M Pascal. Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53. Hepatology (Baltimore, Md.). vol 53. issue 4. 2011-06-14. PMID:21480327. |
suppression of p53 or p21(waf1) genes abolished dna damage response, enhanced apoptosis, and inhibited growth in doxorubicin-treated cells harboring p53(+/+) . |
2011-06-14 |
2023-08-12 |
human |
| Ryoichi Imamura, Yoshitaka Isaka, Ruben M Sandoval, Asaf Ori, Swetlana Adamsky, Elena Feinstein, Bruce A Molitoris, Shiro Takahar. Intravital two-photon microscopy assessment of renal protection efficacy of siRNA for p53 in experimental rat kidney transplantation models. Cell transplantation. vol 19. issue 12. 2011-06-13. PMID:20719069. |
i/r-induced dna damage results in p53 activation in proximal tubule cells (ptc), leading to their apoptosis. |
2011-06-13 |
2023-08-12 |
rat |
| Lavinia Nardinocchi, Rosa Puca, Gabriella D'Oraz. HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation. Aging. vol 3. issue 1. 2011-06-13. PMID:21248371. |
here we show that hif-1α protects against drug-induced apoptosis by antagonizing the function of the tumor suppressor p53. |
2011-06-13 |
2023-08-12 |
human |
| Izumi Horikawa, Kaori Fujita, Curtis C Harri. p53 governs telomere regulation feedback too, via TRF2. Aging. vol 3. issue 1. 2011-06-13. PMID:21266744. |
uncapped or dysfunctional telomeres are an endogenous dna damage that activates atm kinase (ataxia telangiectasia mutated) and then p53 to induce cellular senescence or apoptosis. |
2011-06-13 |
2023-08-12 |
Not clear |
| Ying Zhang, Katharina Köhler, Jia Xu, Di Lu, Thomas Braun, Axel Schlitt, Michael Buerke, Ursula Müller-Werdan, Karl Werdan, Henning Ebel. Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture. Journal of molecular and cellular cardiology. vol 50. issue 3. 2011-06-09. PMID:21074539. |
inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture. |
2011-06-09 |
2023-08-12 |
mouse |
| Ying Zhang, Katharina Köhler, Jia Xu, Di Lu, Thomas Braun, Axel Schlitt, Michael Buerke, Ursula Müller-Werdan, Karl Werdan, Henning Ebel. Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture. Journal of molecular and cellular cardiology. vol 50. issue 3. 2011-06-09. PMID:21074539. |
cardiomyocyte apoptosis, partially mediated through p53 signaling pathway, plays a crucial role in the progression of pathological remodeling and heart failure following myocardial infarction (mi). |
2011-06-09 |
2023-08-12 |
mouse |
| Ying Zhang, Katharina Köhler, Jia Xu, Di Lu, Thomas Braun, Axel Schlitt, Michael Buerke, Ursula Müller-Werdan, Karl Werdan, Henning Ebel. Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture. Journal of molecular and cellular cardiology. vol 50. issue 3. 2011-06-09. PMID:21074539. |
we hypothesized that pifithrin-alpha (pfta), a synthetic p53 inhibitor, would suppress cardiac apoptosis through the disruption of p53-dependent transcriptional activation and thereby improve heart function in a mouse model of mi. |
2011-06-09 |
2023-08-12 |
mouse |
| Ying Zhang, Katharina Köhler, Jia Xu, Di Lu, Thomas Braun, Axel Schlitt, Michael Buerke, Ursula Müller-Werdan, Karl Werdan, Henning Ebel. Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture. Journal of molecular and cellular cardiology. vol 50. issue 3. 2011-06-09. PMID:21074539. |
in our experiments we show that pfta blocked p53 transcriptional activity and attenuated h(2)o(2)-induced cardiac apoptosis in cultured neonatal rat cardiomyocytes. |
2011-06-09 |
2023-08-12 |
mouse |
| Yasuhiro Sakamoto, Shunsuke Kato, Masahiro Takahashi, Yoshinari Okada, Katsuhiro Yasuda, Gou Watanabe, Hiroo Imai, Atsuko Sato, Chikashi Ishiok. Contribution of autophagic cell death to p53-dependent cell death in human glioblastoma cell line SF126. Cancer science. vol 102. issue 4. 2011-06-09. PMID:21214676. |
p53, the most extensively studied tumor suppressor, regulates apoptosis and autophagy by transactivating its downstream genes. |
2011-06-09 |
2023-08-12 |
human |
| Yasuhiro Sakamoto, Shunsuke Kato, Masahiro Takahashi, Yoshinari Okada, Katsuhiro Yasuda, Gou Watanabe, Hiroo Imai, Atsuko Sato, Chikashi Ishiok. Contribution of autophagic cell death to p53-dependent cell death in human glioblastoma cell line SF126. Cancer science. vol 102. issue 4. 2011-06-09. PMID:21214676. |
using wild-type (wt) and mutant (mt) p53 inducible cell lines in tp53-null sf126 glioblastoma cells, we examined the apoptosis and autophagic cell death induced by p53. |
2011-06-09 |
2023-08-12 |
human |
| Yasuhiro Sakamoto, Shunsuke Kato, Masahiro Takahashi, Yoshinari Okada, Katsuhiro Yasuda, Gou Watanabe, Hiroo Imai, Atsuko Sato, Chikashi Ishiok. Contribution of autophagic cell death to p53-dependent cell death in human glioblastoma cell line SF126. Cancer science. vol 102. issue 4. 2011-06-09. PMID:21214676. |
wt p53 expression in sf126 cells induced apoptosis and autophagy, and reduced the cell number. |
2011-06-09 |
2023-08-12 |
human |
| Prem Khanal, Won-Keun Oh, Hyo Jeong Yun, Gwang Mo Namgoong, Sang-Gun Ahn, Seong-Min Kwon, Hoo-Kyun Choi, Hong Seok Cho. p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis. Carcinogenesis. vol 32. issue 4. 2011-06-09. PMID:21216846. |
p-hpea-eda-induced activation of caspase-3 and poly-adenosine diphosphate-ribose polymerase, phosphorylation of p53 (ser15) and dna fragmentation in ht-29 cells, leading to apoptosis. |
2011-06-09 |
2023-08-12 |
Not clear |
| H Hasegawa, Y Yamada, K Tsukasaki, N Mori, K Tsuruda, D Sasaki, T Usui, A Osaka, S Atogami, C Ishikawa, Y Machijima, S Sawada, T Hayashi, Y Miyazaki, S Kamihir. LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway. Leukemia. vol 25. issue 4. 2011-06-09. PMID:21242994. |
analyses, including with a dna microarray, revealed that neither death receptors nor p53 pathways contributed to the apoptosis. |
2011-06-09 |
2023-08-12 |
mouse |
| Louise Y Y Fong, Yubao Jiang, Maysoon L Rawahneh, Karl J Smalley, Carlo M Croce, John L Farber, Kay Huebne. Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. Carcinogenesis. vol 32. issue 4. 2011-06-09. PMID:21245412. |
immunohistochemical analysis of carcinomas showed that zn supplementation caused a shift to a less proliferative/aggressive cancer phenotype by reducing cell proliferation, stimulating apoptosis and decreasing expression of the key tumor markers cyclin d1, p53 and cox-2. |
2011-06-09 |
2023-08-12 |
human |
| I Mendilcioglu, S Karaveli, G Erdogan, M Simsek, O Taskin, M Ozekinc. Apoptosis and expression of Bcl-2, Bax, p53, caspase-3, and Fas, Fas ligand in placentas complicated by preeclampsia. Clinical and experimental obstetrics & gynecology. vol 38. issue 1. 2011-06-07. PMID:21485723. |
apoptosis and expression of bcl-2, bax, p53, caspase-3, and fas, fas ligand in placentas complicated by preeclampsia. |
2011-06-07 |
2023-08-12 |
Not clear |
| I Mendilcioglu, S Karaveli, G Erdogan, M Simsek, O Taskin, M Ozekinc. Apoptosis and expression of Bcl-2, Bax, p53, caspase-3, and Fas, Fas ligand in placentas complicated by preeclampsia. Clinical and experimental obstetrics & gynecology. vol 38. issue 1. 2011-06-07. PMID:21485723. |
to determine whether preeclampsia is associated with an increase in placental apoptosis and altered expression of mediators of apoptosis such as fas, fas ligand, caspase-3, p53, bcl-2 and bax. |
2011-06-07 |
2023-08-12 |
Not clear |
| Raffaele Frazzi, Bruno Casali, Mauro Iori, Davide Nicoli, Caterina Mammi, Francesco Merl. Increase in clusterin forms part of the stress response in Hodgkin's lymphoma. International journal of oncology. vol 38. issue 3. 2011-06-06. PMID:21240462. |
p53 up-regulation accompanies increases in clusterin levels accordingly with the onset of apoptosis. |
2011-06-06 |
2023-08-12 |
Not clear |
| Charlotte Hinault, Dan Kawamori, Chong Wee Liew, Bernhard Maier, Jiang Hu, Susanna R Keller, Raghavendra G Mirmira, Heidi Scrable, Rohit N Kulkarn. Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice. Diabetes. vol 60. issue 4. 2011-06-06. PMID:21357466. |
p53, a key regulator of the cell cycle and apoptosis, has mostly been a focus of investigation as a tumor suppressor. |
2011-06-06 |
2023-08-12 |
mouse |
| Hongxia Wang, Fengchun Zhang, Fei Ye, Yuan Ma, David Y Zhan. The effect of coptis chinensis on the signaling network in the squamous carcinoma cells. Frontiers in bioscience (Elite edition). vol 3. 2011-06-03. PMID:21196313. |
coptis chinensis has a wide effect on cell signaling, including cell cycle regulation (cdk6, cdk4, cyclin b1, cyclin e, cyclin d1, p27), cell adhesion (e-cadherin, osteopontin), differentiation, apoptosis(p-stat3, p53, brca1), cytoskeleton (p-pkc α/β ii, vimentin, p-pkcα), mapk signaling (raf-1, erk1/2, p-p38, p-erk), and the phosphatidylinositol 3-kinase signaling pathway (p-akt, akt, p-pten). |
2011-06-03 |
2023-08-12 |
mouse |