| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Zhang, Hong Shan, Dan Li, Zheng-Ran Li, Kang-Shun Zhu, Zai-Bo Jiang, Ming-Sheng Huan. Cisplatin sensitizes human hepatocellular carcinoma cells, but not hepatocytes and mesenchymal stem cells, to TRAIL within a therapeutic window partially depending on the upregulation of DR5. Oncology reports. vol 25. issue 2. 2011-05-09. PMID:21152876. |
the apoptosis of hcc cells only partially depended on the upregulation of dr5 and the status of p53. |
2011-05-09 |
2023-08-12 |
human |
| Marialaura Petroni, Veronica Veschi, Andrea Prodosmo, Cinzia Rinaldo, Isabella Massimi, Maurizio Carbonari, Carlo Dominici, Heather P McDowell, Christian Rinaldi, Isabella Screpanti, Luigi Frati, Armando Bartolazzi, Alberto Gulino, Silvia Soddu, Giuseppe Giannin. MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response. Molecular cancer research : MCR. vol 9. issue 1. 2011-05-06. PMID:21173028. |
here we show that mycn-dependent sensitization to apoptosis requires activation of p53 and its phosphorylation at serine 46. |
2011-05-06 |
2023-08-12 |
human |
| Marialaura Petroni, Veronica Veschi, Andrea Prodosmo, Cinzia Rinaldo, Isabella Massimi, Maurizio Carbonari, Carlo Dominici, Heather P McDowell, Christian Rinaldi, Isabella Screpanti, Luigi Frati, Armando Bartolazzi, Alberto Gulino, Silvia Soddu, Giuseppe Giannin. MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response. Molecular cancer research : MCR. vol 9. issue 1. 2011-05-06. PMID:21173028. |
the p53(s46) kinase hipk2 accumulates on mycn expression, and its depletion by rna interference impairs p53(s46) phosphorylation and apoptosis. |
2011-05-06 |
2023-08-12 |
human |
| Marialaura Petroni, Veronica Veschi, Andrea Prodosmo, Cinzia Rinaldo, Isabella Massimi, Maurizio Carbonari, Carlo Dominici, Heather P McDowell, Christian Rinaldi, Isabella Screpanti, Luigi Frati, Armando Bartolazzi, Alberto Gulino, Silvia Soddu, Giuseppe Giannin. MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response. Molecular cancer research : MCR. vol 9. issue 1. 2011-05-06. PMID:21173028. |
at variance from other tumor histotypes, in mycn-amplified neuroblastoma, nutlin-3 further induced hipk2 accumulation, p53(s46) phosphorylation, and apoptosis, and in combination with clastogenic agents purged virtually the entire cell population. |
2011-05-06 |
2023-08-12 |
human |
| Janina Seznec, Björn Silkenstedt, Ulrike Nauman. Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma. Journal of neuro-oncology. vol 101. issue 3. 2011-05-05. PMID:20556479. |
we demonstrate herein that the cell death sensitizing effects of mita are cell line specific, independent of the endogenous status of the tumor suppressor p53 as well as of the endogenous expression of x-linked inhibitor of apoptosis (xiap) or basal sensitivity towards death ligand-induced cell death. |
2011-05-05 |
2023-08-12 |
Not clear |
| Lymor Ringer, Paul Sirajuddin, Venkata Mahidhar Yenugonda, Anup Ghosh, Kyle Divito, Valerie Trabosh, Yesha Patel, Amanda Brophy, Scott Grindrod, Michael P Lisanti, Dean Rosenthal, Milton L Brown, Maria Laura Avantaggiati, Olga Rodriguez, Chris Albanes. VMY-1-103, a dansylated analog of purvalanol B, induces caspase-3-dependent apoptosis in LNCaP prostate cancer cells. Cancer biology & therapy. vol 10. issue 4. 2011-05-05. PMID:20574155. |
at higher concentrations (5 μm or 10 μm), vmy-1-103 induced apoptosis via decreased mitochondrial membrane polarity and induction of p53 phosphorylation, caspase-3 activity and parp cleavage. |
2011-05-05 |
2023-08-12 |
mouse |
| Hongzhuan Xuan, Jing Zhao, Junying Miao, Yajing Li, Yafang Chu, Fuliang H. Effect of Brazilian propolis on human umbilical vein endothelial cell apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 1. 2011-05-05. PMID:20933568. |
furthermore, we investigated the molecular mechanisms of huvec apoptosis induced by eebp by testing the levels of integrin β4, p53, reactive oxygen species (ros) and mitochondrial membrane potential. |
2011-05-05 |
2023-08-12 |
human |
| Juhong Liu, Hye-Jung Chung, Matthew Vogt, Yetao Jin, Daniela Malide, Liusheng He, Miroslav Dundr, David Leven. JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress. The EMBO journal. vol 30. issue 5. 2011-05-05. PMID:21285945. |
c-myc and p53 networks control proliferation, differentiation, and apoptosis and are responsive to, and cross-regulate a variety of stresses and metabolic and biosynthetic processes. |
2011-05-05 |
2023-08-12 |
Not clear |
| Juhong Liu, Hye-Jung Chung, Matthew Vogt, Yetao Jin, Daniela Malide, Liusheng He, Miroslav Dundr, David Leven. JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress. The EMBO journal. vol 30. issue 5. 2011-05-05. PMID:21285945. |
the accumulated p53 quickly induces apoptosis. |
2011-05-05 |
2023-08-12 |
Not clear |
| Fang Yuan, Qi Xie, Junbing Wu, Yujie Bai, Beibei Mao, Yongli Dong, Wenzhi Bi, Guangju Ji, Wufan Tao, Yan Wang, Zengqiang Yua. MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation. The Journal of biological chemistry. vol 286. issue 9. 2011-05-04. PMID:21212262. |
mst1 promotes apoptosis through regulating sirt1-dependent p53 deacetylation. |
2011-05-04 |
2023-08-12 |
Not clear |
| Fang Yuan, Qi Xie, Junbing Wu, Yujie Bai, Beibei Mao, Yongli Dong, Wenzhi Bi, Guangju Ji, Wufan Tao, Yan Wang, Zengqiang Yua. MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation. The Journal of biological chemistry. vol 286. issue 9. 2011-05-04. PMID:21212262. |
it has been reported that overexpression of mst1 initiates apoptosis by activating p53. |
2011-05-04 |
2023-08-12 |
Not clear |
| Fang Yuan, Qi Xie, Junbing Wu, Yujie Bai, Beibei Mao, Yongli Dong, Wenzhi Bi, Guangju Ji, Wufan Tao, Yan Wang, Zengqiang Yua. MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation. The Journal of biological chemistry. vol 286. issue 9. 2011-05-04. PMID:21212262. |
collectively, these findings define a novel regulatory mechanism involving the phosphorylation of sirt1 by mst1 kinase which leads to p53 activation, with implications for our understanding of signaling mechanisms during dna damage-induced apoptosis. |
2011-05-04 |
2023-08-12 |
Not clear |
| Won-Hyung Choi, Jong-Phil Chu, Mei-Hua Jiang, Seung-Hwa Baek, Hyun-do Par. Effects of fraction obtained from Korean Corni Fructus extracts causing anti-proliferation and p53-dependent apoptosis in A549 lung cancer cells. Nutrition and cancer. vol 63. issue 1. 2011-05-03. PMID:21132604. |
consistently, cm/f3 effectively induced the activation of bax, cytochrome-c, caspase-3, -8, -9, p53, and p21 causing apoptosis, and caused the suppression of cdk2, prb, and e2f1 related to cell arrest in a549 cells. |
2011-05-03 |
2023-08-12 |
Not clear |
| Michal Mincberg, Jacob Gopas, Jacov Ta. Minute virus of mice (MVMp) infection and NS1 expression induce p53 independent apoptosis in transformed rat fibroblast cells. Virology. vol 412. issue 1. 2011-05-03. PMID:21295324. |
minute virus of mice (mvmp) infection and ns1 expression induce p53 independent apoptosis in transformed rat fibroblast cells. |
2011-05-03 |
2023-08-12 |
mouse |
| Michal Mincberg, Jacob Gopas, Jacov Ta. Minute virus of mice (MVMp) infection and NS1 expression induce p53 independent apoptosis in transformed rat fibroblast cells. Virology. vol 412. issue 1. 2011-05-03. PMID:21295324. |
in this work, we show that mvmp infection and/or ns1 protein expression in permissive transformed rat fibroblast cells leads to apoptosis in wild type and p53(-/-) cells. |
2011-05-03 |
2023-08-12 |
mouse |
| Darina Gromyko, Thomas Arnesen, Anita Ryningen, Jan Erik Varhaug, Johan R Lillehau. Depletion of the human Nα-terminal acetyltransferase A induces p53-dependent apoptosis and p53-independent growth inhibition. International journal of cancer. vol 127. issue 12. 2011-05-03. PMID:21351257. |
cells harboring wild-type tp53 were also prone to apoptosis via the p53 pathway after hnata downregulation. |
2011-05-03 |
2023-08-12 |
human |
| Youya Nakazawa, Hiroyuki Arai, Naoya Fujit. The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis. Cancer research. vol 71. issue 3. 2011-05-02. PMID:21148752. |
zac1 can induce apoptosis through its ability to transcriptionally coactivate p53, which regulates apoptosis in the vasculature and is often downregulated in metastasis. |
2011-05-02 |
2023-08-12 |
mouse |
| Rintaro Okoshi, Natsumi Kubo, Kumiko Nakashima, Osamu Shimozato, Akira Nakagawara, Toshinori Ozak. CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose deprivation. Biochemical and biophysical research communications. vol 406. issue 1. 2011-05-02. PMID:21295542. |
creb represses p53-dependent transactivation of mdm2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose deprivation. |
2011-05-02 |
2023-08-12 |
Not clear |
| J J Merino, M L Montes, A Blanco, M J Bustos, C Oreja-Guevara, C Bayon, A Cuadrado, G Lubrini, I Cambron, A Munoz, S Cebolla, M Gutierrez-Fernandez, J I Bernardino, J R Arribas, M Fial. [HIV-1 neuropathogenesis: therapeutic strategies against neuronal loss induced by gp120/Tat glycoprotein in the central nervous system]. Revista de neurologia. vol 52. issue 2. 2011-04-29. PMID:21271550. |
furthermore, the aberrant interaction of glycoprotein gp120 with the cxcr4 chemokine receptor causes caspase-3-dependent apoptosis (ceramide is also released) activating apoptotic proteins (p53 and retinoblastoma), which are part of the neurotoxic mechanisms associated to neuronal dysfunction in neuroaids. |
2011-04-29 |
2023-08-12 |
Not clear |
| Rong Tang, Qiaoling Zhou, Jinyong Shu, Tianfeng Tang, Xiang Ao, Weisheng Peng, Yide Zhan. [Effect of cordyceps sinensis extract on Klotho expression and apoptosis in renal tubular epithelial cells induced by angiotensin II]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 34. issue 4. 2011-04-28. PMID:19411745. |
to investigate the effect of cordyceps sinensis (cs) extract and losartan (los) on the expression of klotho (kl), p53, p21, and apoptosis in renal tubular epithelial cell nrk-52e induced by angiotensin ii (ang ii), and to elucidate its therapeutical mechanism in ang ii induced renal tubular epithelial cell apoptosis. |
2011-04-28 |
2023-08-12 |
Not clear |