| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xia Li, William K K Wu, Bin Sun, Min Cui, Shanshan Liu, Jian Gao, Hongxiang Lo. Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells. Toxicology and applied pharmacology. vol 251. issue 2. 2011-04-18. PMID:21185854. |
dha-mediated autophagy and apoptosis are associated with the cytoplasmic and nuclear functions of p53. |
2011-04-18 |
2023-08-12 |
human |
| Hongmei Jing, Jing Wang, Ping Yang, Xiaoyan Ke, Guohua Xia, Baoan Che. Magnetic Fe₃O₄ nanoparticles and chemotherapy agents interact synergistically to induce apoptosis in lymphoma cells. International journal of nanomedicine. vol 5. 2011-04-18. PMID:21187919. |
interestingly, increased apoptosis in raji lymphoma cells was accompanied by upregulation of p53 protein and downregulation of nf-κb protein. |
2011-04-18 |
2023-08-12 |
Not clear |
| Bulbul Pandit, Andrei L Garte. Proteasome inhibitors induce p53-independent apoptosis in human cancer cells. The American journal of pathology. vol 178. issue 1. 2011-04-18. PMID:21224072. |
we reevaluated the role of p53 in proteasome inhibitor-induced apoptosis by using isogenic human cancer cell lines with different p53 status. |
2011-04-18 |
2023-08-12 |
human |
| Bulbul Pandit, Andrei L Garte. Proteasome inhibitors induce p53-independent apoptosis in human cancer cells. The American journal of pathology. vol 178. issue 1. 2011-04-18. PMID:21224072. |
notably, thiostrepton induced more potent apoptosis in hepg2 cells with p53 knockdown than in parental cells with wild-type p53. |
2011-04-18 |
2023-08-12 |
human |
| Kazunari Iwamoto, Hiroyuki Hamada, Yukihiro Eguchi, Masahiro Okamot. Mathematical modeling of cell cycle regulation in response to DNA damage: exploring mechanisms of cell-fate determination. Bio Systems. vol 103. issue 3. 2011-04-15. PMID:21095219. |
after dna damage, cells activate p53, a tumor suppressor gene, and select a cell fate (e.g., dna repair, cell cycle arrest, or apoptosis). |
2011-04-15 |
2023-08-12 |
Not clear |
| Kathrin Scheckenbach, Galatia Papadopoulou, Thomas K Hoffmann, Adam Chaker, Henning Bier, Jörg Schipper, Vera Balz, Martin Wagenman. The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN). Journal of negative results in biomedicine. vol 9. 2011-04-15. PMID:21184685. |
the tumor suppressor p53, its activation leads to cell cycle arrest and apoptosis. |
2011-04-15 |
2023-08-12 |
Not clear |
| Jean-Christophe Marin. MDM2 and MDMX in cancer and development. Current topics in developmental biology. vol 94. 2011-04-15. PMID:21295684. |
the p53 tumor suppressor pathway is active in cells that are subjected to stress and/or damaged, where it promotes cell cycle arrest or apoptosis. |
2011-04-15 |
2023-08-12 |
Not clear |
| X Wang, L Zeng, J Wang, J F L Chau, K P Lai, D Jia, A Poonepalli, M P Hande, H Liu, G He, L He, B L. A positive role for c-Abl in Atm and Atr activation in DNA damage response. Cell death and differentiation. vol 18. issue 1. 2011-04-14. PMID:20798688. |
here we show that c-abl deficiency resulted in a broad spectrum of defects in cell response to genotoxic stress, including activation of chk1 and chk2, activation of p53, nuclear foci formation, apoptosis, and dna repair, suggesting that c-abl might also act upstream of the dna damage-activated signaling cascades in addition to its role in p73 and p53 regulation. |
2011-04-14 |
2023-08-12 |
Not clear |
| Zhongbin Lai, Satyan Kalkunte, Surendra Sharm. A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice. Hypertension (Dallas, Tex. : 1979). vol 57. issue 3. 2011-04-14. PMID:21263114. |
hypoxia-induced elevation of p53 was associated with marked induction of proapoptotic protein bax, downregulation of bcl-2, and trophoblast-specific apoptosis in utero-placental tissue. |
2011-04-14 |
2023-08-12 |
mouse |
| Sakhila K Banu, Jone A Stanley, Jehoon Lee, Sam D Stephen, Joe A Arosh, Patricia B Hoyer, Robert C Burghard. Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53. Toxicology and applied pharmacology. vol 251. issue 3. 2011-04-13. PMID:21262251. |
hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of bcl-2 members, erk1/2 and p53. |
2011-04-13 |
2023-08-12 |
rat |
| Sakhila K Banu, Jone A Stanley, Jehoon Lee, Sam D Stephen, Joe A Arosh, Patricia B Hoyer, Robert C Burghard. Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53. Toxicology and applied pharmacology. vol 251. issue 3. 2011-04-13. PMID:21262251. |
our data indicated that crvi: (i) induced dna fragmentation and increased apoptosis, (ii) increased cytochrome c release from the mitochondria to cytosol, (iii) downregulated anti-apoptotic bcl-2, bcl-xl, hsp70 and hsp90; upregulated pro-apoptotic bax and bad, (iv) altered translocation of bcl-2, bcl-xl, bax, bad, hsp70 and hsp90 to the mitochondria, (v) upregulated p-erk and p-jnk, and selectively translocated p-erk to the mitochondria and nucleus, (vi) activated caspase-3 and parp, and (vii) increased phosphorylation of p53 at ser-6, ser-9, ser-15, ser-20, ser-37, ser-46 and ser-392, increased p53 transcriptional activation, and downregulated mdm-2. |
2011-04-13 |
2023-08-12 |
rat |
| Markus Vogt, Johanna Munding, Martha Grüner, Sven-Thorsten Liffers, Berlinda Verdoodt, Jennifer Hauk, Lars Steinstraesser, Andrea Tannapfel, Heiko Hermekin. Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas. Virchows Archiv : an international journal of pathology. vol 458. issue 3. 2011-04-12. PMID:21225432. |
the microrna encoding genes mir-34a and mir-34b/c represent direct p53 target genes and possess tumor suppressive properties as they mediate apoptosis, cell cycle arrest, and senescence. |
2011-04-12 |
2023-08-12 |
human |
| Yandong Nan, Faguang Jin, Shuanying Yang, Yingxuan Tian, Yonghong Xie, Enqing Fu, Hong Y. Discovery of a set of biomarkers of human lung adenocarcinoma through cell-map proteomics and bioinformatics. Medical oncology (Northwood, London, England). vol 27. issue 4. 2011-04-08. PMID:20041319. |
further searching against kegg pathways found that six proteins were involved in wnt signaling pathway, apoptosis pathway, erb-2 signaling pathway, p53 signaling pathway, ubiquitin-mediated proteolysis and were might be hopefully screened as candidate markers of lung adenocarcinoma. |
2011-04-08 |
2023-08-12 |
human |
| M Kumar, Z Lu, A A L Takwi, W Chen, N S Callander, K S Ramos, K H Young, Y L. Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene. vol 30. issue 7. 2011-04-08. PMID:20935678. |
inhibition of either mir-25 or mir-30d expression increases endogenous p53 expression and elevates cellular apoptosis in several cell lines, including one from multiple myeloma that has little tp53 mutations. |
2011-04-08 |
2023-08-12 |
human |
| Aren van Waarde, Anna A Rybczynska, Nisha Ramakrishnan, Kiichi Ishiwata, Philip H Elsinga, Rudi A J O Dierck. Sigma receptors in oncology: therapeutic and diagnostic applications of sigma ligands. Current pharmaceutical design. vol 16. issue 31. 2011-04-07. PMID:21050178. |
sigma ligands induce apoptosis not only in drug-sensitive but also in drug-resistant cancer cells (e.g., cells with p53 mutations, or caspase dysfunction). |
2011-04-07 |
2023-08-12 |
Not clear |
| Irena Porebska, Ewa Sobańska, Monika Kosacka, Renata Jankowsk. Apoptotic regulators: P53 and survivin expression in non-small cell lung cancer. Cancer genomics & proteomics. vol 7. issue 6. 2011-04-05. PMID:21156966. |
survivin and p53 are proteins that take part in cell cycle and apoptosis regulation. |
2011-04-05 |
2023-08-12 |
Not clear |
| Irena Porebska, Ewa Sobańska, Monika Kosacka, Renata Jankowsk. Apoptotic regulators: P53 and survivin expression in non-small cell lung cancer. Cancer genomics & proteomics. vol 7. issue 6. 2011-04-05. PMID:21156966. |
the p53 protein is known to be a guardian of the genome and alterations in its structure enhance resistance to apoptosis. |
2011-04-05 |
2023-08-12 |
Not clear |
| Najuan Zhang, Fei Pei, Huaying Wei, Tongtong Zhang, Chao Yang, Gang Ma, Chunlei Yan. Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 63. issue 1-2. 2011-04-04. PMID:19815400. |
corresponding to the reduced apoptosis rate in the i/r+/isor+ group, western blotting assay showed increased amount of bcl-2 and p53, decreased amount of bax, and nuclear accumulation of nf-κb/p65. |
2011-04-04 |
2023-08-12 |
rat |
| Junko Kimura, Takuya Kudoh, Yoshio Miki, Kiyotsugu Yoshid. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage. International journal of cancer. vol 128. issue 7. 2011-04-04. PMID:20499313. |
following genotoxic insults, the protein level of p53 is increased, and p53 functions as a sequence-specific transcription factor that regulates the expression of downstream target genes required for cell cycle arrest, dna repair or apoptosis. |
2011-04-04 |
2023-08-12 |
Not clear |
| Junko Kimura, Takuya Kudoh, Yoshio Miki, Kiyotsugu Yoshid. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage. International journal of cancer. vol 128. issue 7. 2011-04-04. PMID:20499313. |
to search novel downstream targets of p53 on apoptosis, we had carried out microarray analysis. |
2011-04-04 |
2023-08-12 |
Not clear |