| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valentina Turinetto, Paola Porcedda, Valentina Minieri, Luca Orlando, Erica Lantelme, Lisa Accomasso, Antonio Amoroso, Mario De Marchi, Laura Zannini, Domenico Delia, Claudia Giachin. A novel defect in mitochondrial p53 accumulation following DNA damage confers apoptosis resistance in Ataxia Telangiectasia and Nijmegen Breakage Syndrome T-cells. DNA repair. vol 9. issue 11. 2011-03-17. PMID:20947454. |
in accordance with the dependence of actd-induced apoptosis on a mitochondrial p53 function, in control t-cells specific inhibition of mitochondrial p53 translocation with μ pifithrin reduced apoptosis by 86%, whereas treatment with α pifithrin, which blocks p53-mediated transcription, had no effect. |
2011-03-17 |
2023-08-12 |
Not clear |
| Valentina Turinetto, Paola Porcedda, Valentina Minieri, Luca Orlando, Erica Lantelme, Lisa Accomasso, Antonio Amoroso, Mario De Marchi, Laura Zannini, Domenico Delia, Claudia Giachin. A novel defect in mitochondrial p53 accumulation following DNA damage confers apoptosis resistance in Ataxia Telangiectasia and Nijmegen Breakage Syndrome T-cells. DNA repair. vol 9. issue 11. 2011-03-17. PMID:20947454. |
our results disclose an undescribed defect in mitochondrial p53 accumulation in at and nbs t-cells that makes them resistant to apoptosis following unrepairable dna damage. |
2011-03-17 |
2023-08-12 |
Not clear |
| Alicja Sznarkowska, Robert Olszewski, Joanna Zawacka-Panka. [Pharmacological activation of tumor suppressor, wild-type p53 as a promising strategy to fight cancer]. Postepy higieny i medycyny doswiadczalnej (Online). vol 64. 2011-03-17. PMID:20966497. |
cellular stress induces stabilization of p53 and promotes, depending on the stress level, cell cycle arrest or apoptosis in the irreversibly damaged cells. |
2011-03-17 |
2023-08-12 |
human |
| Alicja Sznarkowska, Robert Olszewski, Joanna Zawacka-Panka. [Pharmacological activation of tumor suppressor, wild-type p53 as a promising strategy to fight cancer]. Postepy higieny i medycyny doswiadczalnej (Online). vol 64. 2011-03-17. PMID:20966497. |
numerous data indicate that low molecular weight compounds, identified by molecular modeling or in the functional, cell-based assays, efficiently activate non-mutated p53 in cancer cells which in consequence leads to their elimination due to p53-dependent apoptosis. |
2011-03-17 |
2023-08-12 |
human |
| Jin H Song, Karthikeyan Kandasamy, Marina Zemskova, Ying-Wei Lin, Andrew S Kraf. The BH3 mimetic ABT-737 induces cancer cell senescence. Cancer research. vol 71. issue 2. 2011-03-17. PMID:21084274. |
evidence indicates that the induction of senescence occurs as a result of reactive oxygen species elevation followed by low-level activation of the caspase cascade, insufficient to induce apoptosis, but sufficient to lead to minor dna damage and increases in p53, p21, il-6 and 8 proteins. |
2011-03-17 |
2023-08-12 |
Not clear |
| Jiening Xiao, Huixian Lin, Xiaobin Luo, Xiaoyan Luo, Zhiguo Wan. miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress. The EMBO journal. vol 30. issue 3. 2011-03-17. PMID:21217645. |
in response to cellular stress, p53 escapes the p53:mdm2 negative feedback to accumulate rapidly to induce cell cycle arrest and apoptosis. |
2011-03-17 |
2023-08-12 |
Not clear |
| Jiening Xiao, Huixian Lin, Xiaobin Luo, Xiaoyan Luo, Zhiguo Wan. miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress. The EMBO journal. vol 30. issue 3. 2011-03-17. PMID:21217645. |
mir-605 preferentially induced apoptosis in wt p53-expressing cells, an effect abolished by p53 inhibition. |
2011-03-17 |
2023-08-12 |
Not clear |
| Karina G Zecchin, Franco A Rossato, Helena F Raposo, Daniela R Melo, Luciane C Alberici, Helena C F Oliveira, Roger F Castilho, Ricardo D Coletta, Aníbal E Vercesi, Edgard Grane. Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis. Laboratory investigation; a journal of technical methods and pathology. vol 91. issue 2. 2011-03-16. PMID:20805790. |
further, apoptosis was preceded by an increase in both reactive oxygen species production and cytosolic calcium concentrations and independent of p53 activation and mitochondrial permeability transition. |
2011-03-16 |
2023-08-12 |
mouse |
| Sudhakar Veeranki, Divaker Choube. Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins. Immunology letters. vol 133. issue 1. 2011-03-15. PMID:20599558. |
the deletion is associated with defects in transcriptional activation of genes by p53 and inhibition of dna damage-induced apoptosis. |
2011-03-15 |
2023-08-12 |
mouse |
| Amit Man Joshi, Sanjeev Budhathoki, Keizo Ohnaka, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Takafumi Maekawa, Yohichi Yasunam. TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. Japanese journal of clinical oncology. vol 41. issue 2. 2011-03-15. PMID:21051533. |
tumor protein p53 gene and its negative regulator, murine double minute 2 homolog are important components for cell-cycle arrest and apoptosis. |
2011-03-15 |
2023-08-12 |
Not clear |
| Seung Bae Rho, Jeong Heon Lee, Mi Sun Park, Hyun-Jung Byun, Sokbom Kang, Sang-Soo Seo, Joo-Young Kim, Sang-Yoon Par. Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53. FEBS letters. vol 585. issue 1. 2011-03-15. PMID:21081126. |
overexpression of tctp in lung carcinoma cells reversed p53 mediated apoptosis and inhibition of tctp expression by small interfering rna increased apoptosis of lung carcinoma cells. |
2011-03-15 |
2023-08-12 |
Not clear |
| Seung Bae Rho, Jeong Heon Lee, Mi Sun Park, Hyun-Jung Byun, Sokbom Kang, Sang-Soo Seo, Joo-Young Kim, Sang-Yoon Par. Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53. FEBS letters. vol 585. issue 1. 2011-03-15. PMID:21081126. |
these results clearly indicate that the interaction between tctp and p53 prevents apoptosis by destabilizing p53. |
2011-03-15 |
2023-08-12 |
Not clear |
| Alicja Sznarkowska, Katarzyna Maleńczyk, Leszek Kadziński, Krzysztof P Bielawski, Bogdan Banecki, Joanna Zawacka-Panka. Targeting of p53 and its homolog p73 by protoporphyrin IX. FEBS letters. vol 585. issue 1. 2011-03-15. PMID:21146529. |
we previously reported that protoporphyrin ix (ppix) disrupts the p53/murine double minute 2 (mdm2) complex and leads to p53 accumulation and activation of apoptosis in hct 116 cells. |
2011-03-15 |
2023-08-12 |
Not clear |
| A Bender, D Opel, I Naumann, R Kappler, L Friedman, D von Schweinitz, K-M Debatin, S Fuld. PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis. Oncogene. vol 30. issue 4. 2011-03-14. PMID:20856197. |
although mcl-1 knockdown enhances doxorubicin- and pi103-induced apoptosis, silencing of noxa, bax/bak or p53 reduces apoptosis, underscoring the functional relevance of the doxorubicin- and pi103-mediated modulation of these proteins for chemosensitization. |
2011-03-14 |
2023-08-12 |
Not clear |
| Jian Liu, Guowu Yu, Yanyan Zhao, Dengpan Zhao, Ying Wang, Lu Wang, Jiang Liu, Lei Li, Yu Zeng, Yongyan Dang, Chuangui Wang, Guang Gao, Weiwen Long, David M Lonard, Shanlou Qiao, Ming-Jer Tsai, Bianhong Zhang, Honglin Luo, Xiaotao L. REGgamma modulates p53 activity by regulating its cellular localization. Journal of cell science. vol 123. issue Pt 23. 2011-03-14. PMID:21084564. |
depletion of regγ sensitizes cells to stress-induced apoptosis, validating its crucial role in the control of apoptosis, probably through regulation of p53 function. |
2011-03-14 |
2023-08-12 |
mouse |
| Y Shao, Y Liu, C Shao, J Hu, X Li, F Li, L Zhang, D Zhao, L Sun, X Zhao, D J Kopecko, D V Kalvakolanu, Y Li, D Q X. Enhanced tumor suppression in vitro and in vivo by co-expression of survivin-specific siRNA and wild-type p53 protein. Cancer gene therapy. vol 17. issue 12. 2011-03-10. PMID:20706288. |
when p53 was expressed along with a survivin-specific short hairpin rna (shrna), tumor cell proliferation was significantly suppressed and apoptosis occurred. |
2011-03-10 |
2023-08-12 |
mouse |
| Y Shao, Y Liu, C Shao, J Hu, X Li, F Li, L Zhang, D Zhao, L Sun, X Zhao, D J Kopecko, D V Kalvakolanu, Y Li, D Q X. Enhanced tumor suppression in vitro and in vivo by co-expression of survivin-specific siRNA and wild-type p53 protein. Cancer gene therapy. vol 17. issue 12. 2011-03-10. PMID:20706288. |
these studies revealed evidence of an interaction between p53 and survivin proteins plus a complex signaling network operating downstream of the wtp53-survivin pathway that actively controls tumor cell proliferation, survival and apoptosis. |
2011-03-10 |
2023-08-12 |
mouse |
| S-E Chow, J-S Wang, S-F Chuang, Y-L Chang, W-K Chu, W-S Chen, Y-W Che. Resveratrol-induced p53-independent apoptosis of human nasopharyngeal carcinoma cells is correlated with the downregulation of ΔNp63. Cancer gene therapy. vol 17. issue 12. 2011-03-10. PMID:20725098. |
by using small-interfering rna (sirna) technology, we found that the targeted silencing of Δnp63 induced apoptosis and sensitized the npc cells to rsv-induced apoptosis through caspase-3 activation, whereas suppression of p53 by sirna did not inhibit rsv-induced apoptosis. |
2011-03-10 |
2023-08-12 |
human |
| S-E Chow, J-S Wang, S-F Chuang, Y-L Chang, W-K Chu, W-S Chen, Y-W Che. Resveratrol-induced p53-independent apoptosis of human nasopharyngeal carcinoma cells is correlated with the downregulation of ΔNp63. Cancer gene therapy. vol 17. issue 12. 2011-03-10. PMID:20725098. |
these results suggested that Δnp63, but not p53, is a molecular target of rsv-induced apoptosis and the regulation of Δnp63 expression by rsv may provide a therapeutic effect of rsv in human npc. |
2011-03-10 |
2023-08-12 |
human |
| Hung-Yun Lin, Heng-Yuan Tang, Faith B Davis, Paul J Davi. Resveratrol and apoptosis. Annals of the New York Academy of Sciences. vol 1215. 2011-03-10. PMID:21261644. |
resveratrol treatment in vitro causes activation and nuclear translocation of mitogen-activated protein kinase (erk1/2), consequent phosphorylation of ser-15 of p53, and apoptosis. |
2011-03-10 |
2023-08-12 |
Not clear |