| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle E Schober, Benjamin Block, Joanna C Beachy, Kimberly D Statler, Christopher C Giza, Robert H Lan. Early and sustained increase in the expression of hippocampal IGF-1, but not EPO, in a developmental rodent model of traumatic brain injury. Journal of neurotrauma. vol 27. issue 11. 2011-03-03. PMID:20822461. |
we used the controlled cortical impact (cci) model and measured hippocampal mrna levels of epo, igf-1, epor, igf-1r, and markers of caspase-dependent apoptosis (bcl2, bax, and p53) at post-injury days (pid) 1, 2, 3, 7, and 14. |
2011-03-03 |
2023-08-12 |
rat |
| R Vidya Priyadarsini, R Senthil Murugan, S Maitreyi, K Ramalingam, D Karunagaran, S Nagin. The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. European journal of pharmacology. vol 649. issue 1-3. 2011-03-03. PMID:20858478. |
the flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (hela) cells through p53 induction and nf-κb inhibition. |
2011-03-03 |
2023-08-12 |
human |
| El-Shaimaa A Arafa, Qianzheng Zhu, Zubair I Shah, Gulzar Wani, Bassant M Barakat, Ira Racoma, Mohamed A El-Mahdy, Altaf A Wan. Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Mutation research. vol 706. issue 1-2. 2011-03-03. PMID:21040738. |
our results reveal that up-regulation of the key upstream signaling factor, pten, in mcf-7/dox cells inhibited akt phosphorylation, which ultimately causes increase in their regulatory p53 levels affecting the induction of g2/m cell cycle arrest and apoptosis. |
2011-03-03 |
2023-08-12 |
human |
| Abhinav K Jain, Michelle Craig Barto. Making sense of ubiquitin ligases that regulate p53. Cancer biology & therapy. vol 10. issue 7. 2011-03-02. PMID:20930521. |
the functions of p53 most highly associated with the well-studied tumor suppressor are its abilities to induce cell cycle arrest and apoptosis in response to cellular stresses. |
2011-03-02 |
2023-08-12 |
Not clear |
| Chao Dai, Wei G. p53 post-translational modification: deregulated in tumorigenesis. Trends in molecular medicine. vol 16. issue 11. 2011-03-02. PMID:20932800. |
the p53 tumor suppressor protein has well-established roles in monitoring various types of stress signals by activating specific transcriptional targets that control cell cycle arrest and apoptosis, although some activities are also mediated in a transcription-independent manner. |
2011-03-02 |
2023-08-12 |
Not clear |
| Biswanath Maity, Jianqi Yang, Jie Huang, Ryan W Askeland, Soumen Bera, Rory A Fishe. Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity. The Journal of biological chemistry. vol 286. issue 2. 2011-03-02. PMID:21041304. |
rgs6 exhibited impressive antiproliferative actions in breast cancer cells, including inhibition of cell growth and colony formation and induction of cell cycle arrest and apoptosis by mechanisms independent of p53. |
2011-03-02 |
2023-08-12 |
mouse |
| Subash C Gupta, Simone Reuter, Kanokkarn Phromnoi, Byoungduck Park, Padmanabhan S Hema, Mangalam Nair, Bharat B Aggarwa. Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. The Journal of biological chemistry. vol 286. issue 2. 2011-03-02. PMID:21078664. |
in addition, nimbolide down-regulated cell survival proteins, including i-flice, ciap-1, ciap-2, bcl-2, bcl-xl, survivin, and x-linked inhibitor of apoptosis protein, and up-regulated the pro-apoptotic proteins p53 and bax. |
2011-03-02 |
2023-08-12 |
human |
| Subash C Gupta, Simone Reuter, Kanokkarn Phromnoi, Byoungduck Park, Padmanabhan S Hema, Mangalam Nair, Bharat B Aggarwa. Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. The Journal of biological chemistry. vol 286. issue 2. 2011-03-02. PMID:21078664. |
overall, our results indicate that nimbolide can sensitize colon cancer cells to trail-induced apoptosis through three distinct mechanisms: reactive oxygen species- and erk-mediated up-regulation of dr5 and dr4, down-regulation of cell survival proteins, and up-regulation of p53 and bax. |
2011-03-02 |
2023-08-12 |
human |
| N V Ryazantseva, V V Novitskii, O B Zhukova, A K Biktasova, O E Chechina, E V Sazonova, T T Radzivil, A N Wice, N Yu Chasovskik. Role of NF-kB, p53, and p21 in the regulation of TNF-α mediated apoptosis of lymphocytes. Bulletin of experimental biology and medicine. vol 149. issue 1. 2011-03-02. PMID:21113457. |
role of nf-kb, p53, and p21 in the regulation of tnf-α mediated apoptosis of lymphocytes. |
2011-03-02 |
2023-08-12 |
Not clear |
| Wei-Ting Lee, Chia-Wen Chan. Bax is upregulated by p53 signal pathway in the SPE B-induced apoptosis. Molecular and cellular biochemistry. vol 343. issue 1-2. 2011-03-01. PMID:20567883. |
bax is upregulated by p53 signal pathway in the spe b-induced apoptosis. |
2011-03-01 |
2023-08-12 |
Not clear |
| Wei-Ting Lee, Chia-Wen Chan. Bax is upregulated by p53 signal pathway in the SPE B-induced apoptosis. Molecular and cellular biochemistry. vol 343. issue 1-2. 2011-03-01. PMID:20567883. |
in addition, p38 and p53 sirnas inhibit spe b-induced apoptosis. |
2011-03-01 |
2023-08-12 |
Not clear |
| I Kostic, B Toffoletto, M Toller, C A Beltrami, F S Ambesi-Impiombato, F Curci. UVC radiation-induced effect on human primary thyroid cell proliferation and HLA-DR expression. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 42. issue 12. 2011-03-01. PMID:20886415. |
apoptosis was detected measuring annexin v, proteins involved in apoptotic process (p53, bax, bcl-2, caspase 3, and 9) by immunoblot analysis and hla-dr expression by facs. |
2011-03-01 |
2023-08-12 |
human |
| A S Azmi, P A Philip, F W J Beck, Z Wang, S Banerjee, S Wang, D Yang, F H Sarkar, R M Mohamma. MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy. Oncogene. vol 30. issue 1. 2011-02-28. PMID:20818437. |
zncl(2) enhanced mi-219 activity (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt), apoptosis and colony formation), and chelation of zinc not only blocked the activity of mi-219, but also suppressed reactivation of the p53 and its downstream effector molecules p21(waf1) and bax. |
2011-02-28 |
2023-08-12 |
Not clear |
| Toshikatsu Okumur. Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs. Journal of gastroenterology. vol 45. issue 11. 2011-02-28. PMID:20824291. |
tzds induce apoptosis through increased levels of apoptotic molecules, such as p53 and pten and/or decreased level of anti-apoptotic molecules, such as bcl-2 and survivin. |
2011-02-28 |
2023-08-12 |
Not clear |
| Ricardo J S Viana, Maria B Fonseca, Rita M Ramalho, Ana F Nunes, Cecília M P Rodrigue. Organelle stress sensors and cell death mechanisms in neurodegenerative diseases. CNS & neurological disorders drug targets. vol 9. issue 6. 2011-02-28. PMID:20942793. |
in addition, nuclear dna damage triggers cell death, where p53 is activated to modulate the expression of selected apoptosis target genes. |
2011-02-28 |
2023-08-12 |
Not clear |
| Crissy Dudgeon, Peng Wang, Xiameng Sun, Rui Peng, Quanhong Sun, Jian Yu, Lin Zhan. PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01. Molecular cancer therapeutics. vol 9. issue 11. 2011-02-28. PMID:20978166. |
in this study, we found that ucn-01, a staurosporine analogue and broad-range kinase inhibitor used in clinical trials, inhibits colon cancer cell growth by inducing apoptosis via puma, a bh3-only bcl-2 family member and a p53 target. |
2011-02-28 |
2023-08-12 |
Not clear |
| Manujendra N Saha, Hua Jiang, Asuka Mukai, Hong Chan. RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses. Molecular cancer therapeutics. vol 9. issue 11. 2011-02-28. PMID:21062913. |
here, we found that rita activates the p53 pathway and induces apoptosis in mm cell lines and primary mm samples, preferentially killing myeloma cells. |
2011-02-28 |
2023-08-12 |
Not clear |
| Binghui Li, Jiong Zhao, Chong-Zhi Wang, Jennifer Searle, Tong-Chuan He, Chun-Su Yuan, Wei D. Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer letters. vol 301. issue 2. 2011-02-28. PMID:21194832. |
ginsenoside rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. |
2011-02-28 |
2023-08-12 |
Not clear |
| Fatih Eren, Mustafa Akkiprik, Ozlen Atuğ, Ozgür Sönmez, Gülgün Tahan, Filiz Ozdemir, Hülya Over Hamzaoğlu, Ciğdem Ataizi Celikel, Neşe Imeryüz, Erol Avşar, Ayşe Oze. R72P polymorphism of TP53 in ulcerative colitis patients is associated with the incidence of colectomy, use of steroids and the presence of a positive family history. Pathology oncology research : POR. vol 16. issue 4. 2011-02-24. PMID:20309662. |
p53 tumor suppressor protein is one of the pivotal regulators for genome integrity, cell cycle and apoptosis. |
2011-02-24 |
2023-08-12 |
Not clear |
| Liming Wu, Chi A Ma, Yongge Zhao, Ashish Jai. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. The Journal of biological chemistry. vol 286. issue 3. 2011-02-24. PMID:20959462. |
functionally, overexpression of aurora b or nir suppresses p53 transcriptional activity, and depletion of aurora b or nir causes p53-dependent apoptosis and cell growth arrest, due to the up-regulation of p21 and bax. |
2011-02-24 |
2023-08-12 |
Not clear |