| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ikuko Yokota, Yasushi Sasaki, Lisa Kashima, Masashi Idogawa, Takashi Tokin. Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene. International journal of oncology. vol 37. issue 6. 2011-02-24. PMID:21042708. |
tumor suppressor p53 is a transcription factor that induces growth arrest and/or apoptosis in response to cellular stress. |
2011-02-24 |
2023-08-12 |
human |
| Chompunoot Sinthupibulyakit, Wanida Ittarat, William H St Clair, Daret K St Clai. p53 Protects lung cancer cells against metabolic stress. International journal of oncology. vol 37. issue 6. 2011-02-24. PMID:21042727. |
in the presence of p53, increased ros from oxphos increases the expression of p53 target genes known to modulate metabolism, including synthesis of cytochrome c oxidase 2 (sco2) and tp53-induced glycolysis and apoptosis regulator (tigar). |
2011-02-24 |
2023-08-12 |
Not clear |
| Chunzhi Zhang, Junxia Zhang, Anlin Zhang, Yingyi Wang, Lei Han, Yongping You, Peiyu Pu, Chunsheng Kan. PUMA is a novel target of miR-221/222 in human epithelial cancers. International journal of oncology. vol 37. issue 6. 2011-02-24. PMID:21042732. |
bioinformatics and luciferase reporter assays showed that mir-221/222 co-modulated the p53 upregulated modulator of apoptosis (puma) expression by directly targeting the binding site within the 3'utr. |
2011-02-24 |
2023-08-12 |
human |
| David N Boone, Ying Qi, Zhaoliang Li, Stephen R Han. Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 2. 2011-02-24. PMID:21187408. |
although deregulated c-myc leads to tumor growth, it also triggers apoptosis in partnership with tumor suppressors such as arf and p53. |
2011-02-24 |
2023-08-12 |
human |
| David N Boone, Ying Qi, Zhaoliang Li, Stephen R Han. Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 2. 2011-02-24. PMID:21187408. |
oncogenic c-myc can indirectly induce the expression of the tumor suppressor arf, which leads to apoptosis through the stabilization of p53, but both c-myc and arf have apoptotic activities that are independent of p53. |
2011-02-24 |
2023-08-12 |
human |
| Wen-Yu Huang, Pei-Ming Yang, Yu-Fan Chang, Victor E Marquez, Ching-Chow Che. Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochemical pharmacology. vol 81. issue 4. 2011-02-23. PMID:21114963. |
the apoptosis and inhibition of cell viability induced by mtx were dependent on p53 and, partially, on p21. |
2011-02-23 |
2023-08-12 |
human |
| J C Su, K L Lin, C M Chien, C H Tseng, Y L Chen, L S Chang, S R Li. Furano-1,2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells. Cell biochemistry and function. vol 28. issue 8. 2011-02-22. PMID:21104938. |
the combined treatment of fnq with ag1478 (a specific egfr inhibitor) significantly enhanced the g(2)/m arrest and apoptosis, and also led to up-regulation in bax, p53, p21, p27, release of mitochondrial cytochrome c, and down-regulation of bcl-2, xiap, survivin, cyclin a, cyclin b, cdk1, and cdk2 in a549 cells. |
2011-02-22 |
2023-08-12 |
Not clear |
| Tathagata Choudhuri, Masanao Murakami, Rajeev Kaul, Sushil K Sahu, Suchitra Mohanty, Subhash C Verma, Pankaj Kumar, Erle S Robertso. Nm23-H1 can induce cell cycle arrest and apoptosis in B cells. Cancer biology & therapy. vol 9. issue 12. 2011-02-18. PMID:20448457. |
the genes with significant changes in expression patterns were clustered in groups which are responsible for regulating cell cycle, p53 activities and apoptosis. |
2011-02-18 |
2023-08-12 |
human |
| Tathagata Choudhuri, Masanao Murakami, Rajeev Kaul, Sushil K Sahu, Suchitra Mohanty, Subhash C Verma, Pankaj Kumar, Erle S Robertso. Nm23-H1 can induce cell cycle arrest and apoptosis in B cells. Cancer biology & therapy. vol 9. issue 12. 2011-02-18. PMID:20448457. |
bjab cells expressing nm23-h1 showed reduced proliferation rate and were susceptible to increased apoptosis which may in part be due to a direct interaction between nm23-h1 and p53. |
2011-02-18 |
2023-08-12 |
human |
| Cliona O'Driscoll, Joseph P Bressle. Hairless expression attenuates apoptosis in a mouse model and the COS cell line; involvement of p53. PloS one. vol 5. issue 9. 2011-02-18. PMID:20886113. |
hairless expression attenuates apoptosis in a mouse model and the cos cell line; involvement of p53. |
2011-02-18 |
2023-08-12 |
mouse |
| Lidia Feliu, Glòria Oliveras, Anna D Cirac, Emili Besalú, Cristina Rosés, Ramon Colomer, Eduard Bardají, Marta Planas, Teresa Pui. Antimicrobial cyclic decapeptides with anticancer activity. Peptides. vol 31. issue 11. 2011-02-17. PMID:20708052. |
we report here the cytotoxicity of a library of 66 antibacterial cyclodecapeptides on human carcinoma cell lines, and their effects on apoptosis [as assessed by cleavage of poly(adp-ribose) polymerase (parp)] and cell signaling proteins (p53 and erk1/2) in cultured human cervical carcinoma cells. |
2011-02-17 |
2023-08-12 |
human |
| Lidia Feliu, Glòria Oliveras, Anna D Cirac, Emili Besalú, Cristina Rosés, Ramon Colomer, Eduard Bardají, Marta Planas, Teresa Pui. Antimicrobial cyclic decapeptides with anticancer activity. Peptides. vol 31. issue 11. 2011-02-17. PMID:20708052. |
induction of apoptosis by these peptides was observed and the apoptotic effect of bpc88 and bpc96 caused a marked decrease on the activated form of erk1/2 kinase and an induction of p53. |
2011-02-17 |
2023-08-12 |
human |
| Kensuke Kojima, Jared K Burks, Janine Arts, Michael Andreef. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Molecular cancer therapeutics. vol 9. issue 9. 2011-02-17. PMID:20736344. |
jnj-26854165 treatment induced p53-mediated apoptosis in acute leukemia cells with wild-type p53, in which p53 rapidly drives transcription-independent apoptosis followed by activation of a transcription-dependent pathway. |
2011-02-17 |
2023-08-12 |
Not clear |
| Kensuke Kojima, Jared K Burks, Janine Arts, Michael Andreef. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Molecular cancer therapeutics. vol 9. issue 9. 2011-02-17. PMID:20736344. |
interestingly, jnj-26854165 induced s-phase delay and upregulated e2f1 expression in p53 mutant cells, resulting in apoptosis preferentially of s-phase cells. |
2011-02-17 |
2023-08-12 |
Not clear |
| Kensuke Kojima, Jared K Burks, Janine Arts, Michael Andreef. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Molecular cancer therapeutics. vol 9. issue 9. 2011-02-17. PMID:20736344. |
e2f1 knockdown blocked apoptosis induced by jnj-26854165 in p53 mutant cells. |
2011-02-17 |
2023-08-12 |
Not clear |
| Kensuke Kojima, Jared K Burks, Janine Arts, Michael Andreef. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Molecular cancer therapeutics. vol 9. issue 9. 2011-02-17. PMID:20736344. |
the presence of p53-independent apoptotic activity in addition to p53-mediated apoptosis induction, if operational in vivo, may prevent the selection of p53 mutant subclones during therapy. |
2011-02-17 |
2023-08-12 |
Not clear |
| Stefano Campaner, Mirko Doni, Alessandro Verrecchia, Giovanni Fagà, Lucia Bianchi, Bruno Amat. Myc, Cdk2 and cellular senescence: Old players, new game. Cell cycle (Georgetown, Tex.). vol 9. issue 18. 2011-02-17. PMID:20818171. |
other gene products like p53, suv39h1 or tgfβ promoted senescence, which together with apoptosis contributed to tumor suppression. |
2011-02-17 |
2023-08-12 |
mouse |
| L Matthew Arthur, Renee M Demarest, Lise Clark, Dmitri Gourevitch, Kamila Bedelbaeva, Rhonda Anderson, Andrew Snyder, Anthony J Capobianco, Paul Lieberman, Lionel Feigenbaum, E Heber-Kat. Epimorphic regeneration in mice is p53-independent. Cell cycle (Georgetown, Tex.). vol 9. issue 18. 2011-02-17. PMID:20855943. |
given the p53/p21 axis of control of dna damage, cell cycle arrest, apoptosis and senescence, we tested the role of p53 in the ear hole regenerative response. |
2011-02-17 |
2023-08-12 |
mouse |
| Masaru Watanabe, Hiroaki Naraba, Tomoko Sakyo, Takayuki Kitagaw. DNA damage-induced modulation of GLUT3 expression is mediated through p53-independent extracellular signal-regulated kinase signaling in HeLa cells. Molecular cancer research : MCR. vol 8. issue 11. 2011-02-17. PMID:20870738. |
the results suggest that dna-damaging agents reduce glut3 expression in cancer cells through activation of the mek-erk pathway independently of p53, leading to cell death or apoptosis. |
2011-02-17 |
2023-08-12 |
Not clear |
| M Xia, D Knezevic, L T Vassile. p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation. Oncogene. vol 30. issue 3. 2011-02-17. PMID:20871630. |
p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation. |
2011-02-17 |
2023-08-12 |
Not clear |