| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Li, Yongyi Cheng, Weixing Qu, Yi Sun, Zhiping Wang, Hanzhang Wang, Binqiang Tia. Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells. Basic & clinical pharmacology & toxicology. vol 108. issue 2. 2011-04-25. PMID:21054790. |
our study suggests that the activation of p53 and inhibition of the nf-kappa b system may play important roles in the fisetin-induced apoptosis in bladder cancer cells. |
2011-04-25 |
2023-08-12 |
human |
| Shinji Saiki, Yukiko Sasazawa, Yoko Imamichi, Sumihiro Kawajiri, Takahiro Fujimaki, Isei Tanida, Hiroki Kobayashi, Fumiaki Sato, Shigeto Sato, Ken-Ichi Ishikawa, Masaya Imoto, Nobutaka Hattor. Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy. vol 7. issue 2. 2011-04-25. PMID:21081844. |
all known mechanisms of apoptosis induced by caffeine act through cell cycle modulation or p53 induction. |
2011-04-25 |
2023-08-12 |
mouse |
| Jae-Sik Shin, Seung-Woo Hong, Jin-Gyun Lee, Young-Min Lee, Dae-Won Kim, Jee-Eun Kim, Da-Jung Jung, Sung-Kwan An, Nam-Joo Hong, Daejin Kim, Dong-Hoon Jin, Sok-Young Le. An ethanol extract of Iris nertschinskia induces p53-dependent apoptosis in the MCF7 human breast cancer cell line. International journal of molecular medicine. vol 27. issue 3. 2011-04-25. PMID:21240456. |
our results suggest that p53 sensitizes tumor cells to the ethanol extract of iris nertschinskia by bax protein induction and caspase-dependent apoptosis. |
2011-04-25 |
2023-08-12 |
human |
| R B Delston, K A Matatall, Y Sun, M D Onken, J W Harbou. p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis. Oncogene. vol 30. issue 5. 2011-04-22. PMID:20871633. |
these findings provide a mechanistic explanation as to how rb regulates cell division and apoptosis through different kinases, and reveal how hdm2 may functionally link the tumor suppressors rb and p53. |
2011-04-22 |
2023-08-12 |
human |
| Claudia Mayer, Odilia Popanda, Burkhard Greve, Eberhard Fritz, Thomas Illig, Friederike Eckardt-Schupp, Maria Gomolka, Axel Benner, Peter Schmeze. A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects. Cancer letters. vol 302. issue 1. 2011-04-22. PMID:21236564. |
pathway analysis revealed genes involved in p53 signalling, cell cycle control and apoptosis in response to radiation in primary lymphocytes. |
2011-04-22 |
2023-08-12 |
Not clear |
| Changwei Liu, Yu Wang, Sirou Xie, Yijing Zhou, Xiangmei Ren, Xiaoting Li, Yunqing Ca. Liquiritigenin induces mitochondria-mediated apoptosis via cytochrome c release and caspases activation in HeLa Cells. Phytotherapy research : PTR. vol 25. issue 2. 2011-04-21. PMID:20658471. |
the apoptosis induction with liquiritigenin is associated with the up-regulation of p53 and bax, along with down-regulation of bcl-2 and survivin. |
2011-04-21 |
2023-08-12 |
human |
| Changwei Liu, Yu Wang, Sirou Xie, Yijing Zhou, Xiangmei Ren, Xiaoting Li, Yunqing Ca. Liquiritigenin induces mitochondria-mediated apoptosis via cytochrome c release and caspases activation in HeLa Cells. Phytotherapy research : PTR. vol 25. issue 2. 2011-04-21. PMID:20658471. |
overall, the results indicate that liquiritigenin induces apoptosis in part via the mitochondrial pathway, which is associated with p53 up-regulation, release of cytochrome c and elevated activity of caspase-9 and -3 in hela cells. |
2011-04-21 |
2023-08-12 |
human |
| K Puszynski, R Bertolusso, T Lipniack. Crosstalk between p53 and nuclear factor-B systems: pro- and anti-apoptotic functions of NF-B. IET systems biology. vol 3. issue 5. 2011-04-21. PMID:21028926. |
nuclear factors p53 and nf-b control many physiological processes including cell cycle arrest, dna repair, apoptosis, death, innate and adaptive immune responses, and inflammation. |
2011-04-21 |
2023-08-12 |
Not clear |
| K Puszynski, R Bertolusso, T Lipniack. Crosstalk between p53 and nuclear factor-B systems: pro- and anti-apoptotic functions of NF-B. IET systems biology. vol 3. issue 5. 2011-04-21. PMID:21028926. |
the finding suggests that diverse roles of nf-b in apoptosis and cancer could be related to the dynamical context of activation of p53 and nf-b pathways. |
2011-04-21 |
2023-08-12 |
Not clear |
| Vijay Walia, Smita Kakar, Randolph Elbl. Micromanagement of the mitochondrial apoptotic pathway by p53. Frontiers in bioscience (Landmark edition). vol 16. 2011-04-21. PMID:21196200. |
perhaps the most potent weapon in p53's tumor suppressive arsenal is apoptosis, enacted as a last resort when all other remedies are exhausted. |
2011-04-21 |
2023-08-12 |
Not clear |
| Vijay Walia, Smita Kakar, Randolph Elbl. Micromanagement of the mitochondrial apoptotic pathway by p53. Frontiers in bioscience (Landmark edition). vol 16. 2011-04-21. PMID:21196200. |
more recently, evidence of a more rapid pathway emerged whereby p53 physically interacts with bcl-2 family members to tip the balance toward apoptosis. |
2011-04-21 |
2023-08-12 |
Not clear |
| Vijay Walia, Smita Kakar, Randolph Elbl. Micromanagement of the mitochondrial apoptotic pathway by p53. Frontiers in bioscience (Landmark edition). vol 16. 2011-04-21. PMID:21196200. |
this review details the multiple levels of regulation of mitochondrially-directed apoptosis by p53, including recent findings of how p53 translocation is regulated. |
2011-04-21 |
2023-08-12 |
Not clear |
| Amanda K Frank, Julia I-Ju Leu, Yan Zhou, Karthik Devarajan, Tatiana Nedelko, Andres Klein-Szanto, Monica Hollstein, Maureen E Murph. The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation. Molecular and cellular biology. vol 31. issue 6. 2011-04-21. PMID:21245379. |
in the thymus, we find that the p72 variant induces increased apoptosis following ionizing radiation, along with increased transactivation of a subset of p53 target genes, which includes murine caspase 4 (also called caspase 11), which we show is a direct p53 target gene. |
2011-04-21 |
2023-08-12 |
mouse |
| Maximilian Moergel, Eva Abt, Marcus Stockinger, Martin Kunke. Overexpression of p63 is associated with radiation resistance and prognosis in oral squamous cell carcinoma. Oral oncology. vol 46. issue 9. 2011-04-19. PMID:20656547. |
full length transcripts with transactivational domain (ta forms) present with homology to p53 and implicate functions governing cell proliferation, differentiation and apoptosis control. |
2011-04-19 |
2023-08-12 |
Not clear |
| Manujendra N Saha, Hua Jiang, Hong Chan. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. Cancer biology & therapy. vol 10. issue 6. 2011-04-18. PMID:20595817. |
our data show that nutlin-induced apoptosis correlated with reduction in cell viability, upregulation of p53, p21 and mdm2 protein levels with a simultaneous increase in pro-apoptotic targets puma, bax and bak and downregulation of anti-apoptotic targets bcl2 and survivin and activation of caspase in mm cells harboring wild type p53. |
2011-04-18 |
2023-08-12 |
Not clear |
| Manujendra N Saha, Hua Jiang, Hong Chan. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. Cancer biology & therapy. vol 10. issue 6. 2011-04-18. PMID:20595817. |
moreover, blocking the transcriptional arm of p53 by the p53-specific transcriptional inhibitor, pifithrin-α, not only inhibited nutlin-induced upregulation of p53-transcriptional targets but also augmented apoptosis in mm cells, suggesting an association of transcription-independent pathway of apoptosis. |
2011-04-18 |
2023-08-12 |
Not clear |
| Manujendra N Saha, Hua Jiang, Hong Chan. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. Cancer biology & therapy. vol 10. issue 6. 2011-04-18. PMID:20595817. |
however, inhibitor of mitochondrial translocation of p53, pft-μ, did not prevent nutlin-induced apoptosis, suggesting that the p53 transcription-dependent pathway was also operational in nutlin-induced apoptosis in mm. |
2011-04-18 |
2023-08-12 |
Not clear |
| A Abdi, H Sadraie, L Dargahi, L Khalaj, A Ahmadian. Apoptosis inhibition can be threatening in Aβ-induced neuroinflammation, through promoting cell proliferation. Neurochemical research. vol 36. issue 1. 2011-04-18. PMID:20848191. |
using caspase inhibitors, we inhibited apoptosis and assessed nf-kβ, hsp 70 (a hallmark of cancer), cmyc (proto-oncogene) and p53 (tumor suppressor protein). |
2011-04-18 |
2023-08-12 |
rat |
| Xia Li, William K K Wu, Bin Sun, Min Cui, Shanshan Liu, Jian Gao, Hongxiang Lo. Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells. Toxicology and applied pharmacology. vol 251. issue 2. 2011-04-18. PMID:21185854. |
dihydroptychantol a, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma u2os cells. |
2011-04-18 |
2023-08-12 |
human |
| Xia Li, William K K Wu, Bin Sun, Min Cui, Shanshan Liu, Jian Gao, Hongxiang Lo. Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells. Toxicology and applied pharmacology. vol 251. issue 2. 2011-04-18. PMID:21185854. |
furthermore, p53 was shown to be involved in dha-mediated autophagy and apoptosis. |
2011-04-18 |
2023-08-12 |
human |