| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ching-Hsein Chen, Yu-Jia Chang, Maurice S B Ku, King-Thom Chung, Jen-Tsung Yan. Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation. Journal of molecular medicine (Berlin, Germany). vol 89. issue 3. 2011-06-01. PMID:21340685. |
compared with the use of tmz or vpa alone, concurrent treatment with both drugs synergistically induced apoptosis in u87mg cells as evidenced by p53 and bax expression, mitochondrial transmembrane potential loss, reactive oxygen species production, and glutathione depletion. |
2011-06-01 |
2023-08-12 |
human |
| Wanrong Bao, Jingcheng Miao, Weihua Sheng, Yunbo Shan, Zhengyi Li, Xiaohua Wang, Yingying Jing, Yali Han, Jicheng Yan. [Adenovirus mediated IL-24 gene expression suppresses gastric cancer cell growth in vitro]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 25. issue 10. 2011-05-31. PMID:20112706. |
the expression of apoptosis-related genes was future determined by semi-quantification rt-pcr; we demonstrated that the moi of 100 was the optimal infective dose in the study on adenovirus-mediated il-24 gene transfer into sgc-7901 gastric cancer cell; il-24 gene mediated by adenovirus could successfully transcribe in sgc-7901 tumor cells; ad-il-24 could significantly inhibit sgc-7901 tumor cell growth and induce apoptosis, it also can up-regulate the express of bax, caspase-3 and p53 whilst down-regulate the bcl-2 expression. |
2011-05-31 |
2023-08-12 |
human |
| Wanrong Bao, Jingcheng Miao, Weihua Sheng, Yunbo Shan, Zhengyi Li, Xiaohua Wang, Yingying Jing, Yali Han, Jicheng Yan. [Adenovirus mediated IL-24 gene expression suppresses gastric cancer cell growth in vitro]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 25. issue 10. 2011-05-31. PMID:20112706. |
thus, adenovirus-mediated il-24 expression had marked anti-tumor effect in suppressing sgc-7901 human gastric cancer cell growth and inducing apoptosis, which may be closely associated with its up-regulation of bax/bcl-2, caspase-3 and p53. |
2011-05-31 |
2023-08-12 |
human |
| Darina Muthna, Tomas Soukup, Jirina Vavrova, Jaroslav Mokry, Jana Cmielova, Benjamin Visek, Alena Jiroutova, Radim Havelek, Jakub Suchanek, Stanislav Filip, Denis English, Martina Rezacov. Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis. Stem cells and development. vol 19. issue 12. 2011-05-31. PMID:20331357. |
irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis. |
2011-05-31 |
2023-08-12 |
human |
| Joydeep Das, Jyotirmoy Ghosh, Prasenjit Manna, Parames C Si. Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK. Biochemical pharmacology. vol 81. issue 7. 2011-05-31. PMID:21295553. |
taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of pi3-k/akt and inhibition of p53, p38-jnk. |
2011-05-31 |
2023-08-12 |
rat |
| Isabel Coutinho, Clara Pereira, Gil Pereira, Jorge Gonçalves, Manuela Côrte-Real, Lucília Saraiv. Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. Experimental cell research. vol 317. issue 8. 2011-05-31. PMID:21338602. |
distinct regulation of p53-mediated apoptosis by protein kinase cα, δ, ε and ζ: evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. |
2011-05-31 |
2023-08-12 |
human |
| Isabel Coutinho, Clara Pereira, Gil Pereira, Jorge Gonçalves, Manuela Côrte-Real, Lucília Saraiv. Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. Experimental cell research. vol 317. issue 8. 2011-05-31. PMID:21338602. |
using yeast cells co-expressing the human wild-type p53 and a single mammalian pkcα, δ, ε or ζ, we showed a differential regulation of p53-mediated apoptosis by these pkc isoforms. |
2011-05-31 |
2023-08-12 |
human |
| Isabel Coutinho, Clara Pereira, Gil Pereira, Jorge Gonçalves, Manuela Côrte-Real, Lucília Saraiv. Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. Experimental cell research. vol 317. issue 8. 2011-05-31. PMID:21338602. |
whereas pkcα and ζ had no effect on p53 activity, pkcδ and ε stimulated a p53-mediated mitochondria-dependent apoptosis. |
2011-05-31 |
2023-08-12 |
human |
| Isabel Coutinho, Clara Pereira, Gil Pereira, Jorge Gonçalves, Manuela Côrte-Real, Lucília Saraiv. Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. Experimental cell research. vol 317. issue 8. 2011-05-31. PMID:21338602. |
moreover, using pifithrin-α and -μ, selective inhibitors of p53 transcriptional activity and mitochondrial p53 translocation, respectively, we showed the activation of a transcription-dependent and -independent p53-mediated apoptosis by pkcδ and ε. |
2011-05-31 |
2023-08-12 |
human |
| Isabel Coutinho, Clara Pereira, Gil Pereira, Jorge Gonçalves, Manuela Côrte-Real, Lucília Saraiv. Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. Experimental cell research. vol 317. issue 8. 2011-05-31. PMID:21338602. |
furthermore, it gives mechanistic insights about the regulation of p53-mediated apoptosis by pkcδ and ε through modulation of p53 transcriptional activity and of its translocation to mitochondria. |
2011-05-31 |
2023-08-12 |
human |
| Tanveer Sharif, Cyril Auger, Christian Bronner, Mahmoud Alhosin, Thibaut Klein, Nelly Etienne-Selloum, Valérie B Schini-Kerth, Guy Fuhrman. Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell. Investigational new drugs. vol 29. issue 2. 2011-05-27. PMID:19943082. |
moreover, rwps treatment specifically triggered apoptosis of p19 ec cells in association with a dramatic upregulation of the tumor suppressor gene p53 and caspase-3 activation. |
2011-05-27 |
2023-08-12 |
Not clear |
| Claudio Celeghini, Rebecca Voltan, Erika Rimondi, Valter Gattei, Giorgio Zaul. Perifosine selectively induces cell cycle block and modulates retinoblastoma and E2F1 protein levels in p53 mutated leukemic cell lines. Investigational new drugs. vol 29. issue 2. 2011-05-27. PMID:20130960. |
perifosine promoted cytotoxicity with a combination of apoptosis induction in all cell lines and cell cycle block at the g(2)m checkpoint, which was selectively observed in p53(mutated) bjab and maver cell lines. |
2011-05-27 |
2023-08-12 |
Not clear |
| Gang Xu, Huai-Fu Wang, Gang He, Gang X. [Expression and significance of P53 and P21 in nasal NK/T-cell lymphoma]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 41. issue 1. 2011-05-26. PMID:20369488. |
to investigate the significance of p53 and p21 expressions in nasal nk/t-cell lymphoma (nktl) and their relationships with the clinical stage, prognosis, proliferation and apoptosis of tumor cells. |
2011-05-26 |
2023-08-12 |
Not clear |
| Binh T Vu, Lyubomir Vassile. Small-molecule inhibitors of the p53-MDM2 interaction. Current topics in microbiology and immunology. vol 348. 2011-05-26. PMID:21046355. |
treatment of cancer cells expressing wild-type p53 stabilize p53 and activate the p53 pathway, leading to cell cycle arrest and apoptosis. |
2011-05-26 |
2023-08-12 |
human |
| Yosef A Asir. Probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and Bax signal expression in rat cardiac tissues. Oxidative medicine and cellular longevity. vol 3. issue 5. 2011-05-26. PMID:21150336. |
probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and bax signal expression in rat cardiac tissues. |
2011-05-26 |
2023-08-12 |
rat |
| Diane L N Trinh, Adam N Elwi, Sung-Woo Ki. Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis. Oncotarget. vol 1. issue 6. 2011-05-26. PMID:21311096. |
direct interaction between p53 and tid1 proteins affects p53 mitochondrial localization and apoptosis. |
2011-05-26 |
2023-08-12 |
Not clear |
| Diane L N Trinh, Adam N Elwi, Sung-Woo Ki. Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis. Oncotarget. vol 1. issue 6. 2011-05-26. PMID:21311096. |
the p53 tumor suppressor induces apoptosis in response to genotoxic and environmental stresses. |
2011-05-26 |
2023-08-12 |
Not clear |
| Diane L N Trinh, Adam N Elwi, Sung-Woo Ki. Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis. Oncotarget. vol 1. issue 6. 2011-05-26. PMID:21311096. |
we previously demonstrated that tid1 interacts with p53, resulting in mitochondrial translocation of the complex and induction of intrinsic apoptosis [1]; however, the mechanism how they interact has been unknown. |
2011-05-26 |
2023-08-12 |
Not clear |
| Diane L N Trinh, Adam N Elwi, Sung-Woo Ki. Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis. Oncotarget. vol 1. issue 6. 2011-05-26. PMID:21311096. |
in breast cancer cells, depletion of tid1 by short hairpin rna (shrna) led to absence of p53 accumulation at mitochondria and resistance to apoptosis under hypoxic or genotoxic stresses. |
2011-05-26 |
2023-08-12 |
Not clear |
| Luca D'agostino, Antonio Giordan. NSP 5a3a: a potential novel cancer target in head and neck carcinoma. Oncotarget. vol 1. issue 6. 2011-05-26. PMID:21311098. |
molecular analysis indentified a novel p73 dependent mechanism independent of p53 and caspase 3 activity through which nsp 5a3a is inducing apoptosis. |
2011-05-26 |
2023-08-12 |
Not clear |