| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Li, Shuyong Zhang, Linghuan Gao, Ying Chen, Xin Xi. A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction. Journal of biomolecular screening. vol 16. issue 4. 2011-08-01. PMID:21471462. |
the p53 tumor suppressor is a potent transcription factor that regulates cell growth inhibition and apoptosis. |
2011-08-01 |
2023-08-12 |
human |
| Vicente Molina, Sergi Papiol, Javier Sanz, Araceli Rosa, Bárbara Arias, Mar Fatjó-Vilas, Julia Calama, Ana I Hernández, Joemir Bécker, Lourdes Fañaná. Convergent evidence of the contribution of TP53 genetic variation (Pro72Arg) to metabolic activity and white matter volume in the frontal lobe in schizophrenia patients. NeuroImage. vol 56. issue 1. 2011-07-29. PMID:21296169. |
protein p53, encoded by tp53 gene, has a central role in the control of apoptosis and is involved in oligodendrocyte development. |
2011-07-29 |
2023-08-12 |
human |
| Peiju Qiu, Huashi Guan, Ping Dong, Shiming Li, Chi-Tang Ho, Min-Hsiung Pan, David Julian McClements, Hang Xia. The p53-, Bax- and p21-dependent inhibition of colon cancer cell growth by 5-hydroxy polymethoxyflavones. Molecular nutrition & food research. vol 55. issue 4. 2011-07-29. PMID:21462329. |
herein, using isogenic variants of hct116 human colon cancer cells, we investigated the effects of p53, bax and p21 on the apoptosis and cell-cycle arrest induced by different 5oh-pmfs. |
2011-07-29 |
2023-08-12 |
human |
| Hongbo Wang, Xujun Ma, Shumei Ren, John K Buolamwini, Chunhong Ya. A small-molecule inhibitor of MDMX activates p53 and induces apoptosis. Molecular cancer therapeutics. vol 10. issue 1. 2011-07-28. PMID:21075910. |
a small-molecule inhibitor of mdmx activates p53 and induces apoptosis. |
2011-07-28 |
2023-08-12 |
human |
| Hongbo Wang, Xujun Ma, Shumei Ren, John K Buolamwini, Chunhong Ya. A small-molecule inhibitor of MDMX activates p53 and induces apoptosis. Molecular cancer therapeutics. vol 10. issue 1. 2011-07-28. PMID:21075910. |
importantly, this novel small-molecule p53 activator caused mcf-7 cells to undergo apoptosis and acted additively with nutlin-3a to activate p53 and decrease the viability of cancer cells. |
2011-07-28 |
2023-08-12 |
human |
| Sujoy Bhattacharya, Ramesh M Ray, Edward Chaum, Dianna A Johnson, Leonard R Johnso. Inhibition of Mdm2 sensitizes human retinal pigment epithelial cells to apoptosis. Investigative ophthalmology & visual science. vol 52. issue 6. 2011-07-28. PMID:21345989. |
because recent studies indicate that blocking the interaction between p53 and mdm2 results in the nongenotoxic activation of p53, the authors sought to investigate whether the inhibition of p53-mdm2 binding activates p53 and sensitizes human retinal epithelial cells to apoptosis. |
2011-07-28 |
2023-08-12 |
human |
| Jin-Yun Liu, Zhong Liu, Dong-Mei Wang, Man-Mei Li, Shao-Xiang Wang, Rui Wang, Jian-Ping Chen, Yi-Fei Wang, De-Po Yan. Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chemico-biological interactions. vol 190. issue 2-3. 2011-07-26. PMID:21376709. |
treated cells were arrested at the g1 phase of the cell cycle and the expression of p53 and p27(kip1), two key regulators related to cell cycle and apoptosis, was up-regulated. |
2011-07-26 |
2023-08-12 |
Not clear |
| Jenna Scotcher, David J Clarke, Stefan K Weidt, C Logan Mackay, Ted R Hupp, Peter J Sadler, Pat R R Langridge-Smit. Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry. Journal of the American Society for Mass Spectrometry. vol 22. issue 5. 2011-07-26. PMID:21472523. |
the tumor suppressor p53 is a redox-regulated transcription factor involved in cell cycle arrest, apoptosis and senescence in response to multiple forms of stress, as well as many other cellular processes such as dna repair, glycolysis, autophagy, oxidative stress and differentiation. |
2011-07-26 |
2023-08-12 |
Not clear |
| Jin Woo Choi, Dae Gyu Kim, Al-Eum Lee, Hye Rim Kim, Jin Young Lee, Nam Hoon Kwon, Young Kee Shin, Soon-Kyung Hwang, Seung-Hee Chang, Myung-Haing Cho, Yoon-La Choi, Jhingook Kim, Seung Hyun Oh, Bora Kim, Soo-Youl Kim, Hyo-Sung Jeon, Jae Yong Park, Hyunseok Peter Kang, Bum Joon Park, Jung Min Han, Sunghoon Ki. Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis. PLoS genetics. vol 7. issue 3. 2011-07-26. PMID:21483803. |
upon dna damage, aimp2 promotes apoptosis through the protective interaction with p53. |
2011-07-26 |
2023-08-12 |
mouse |
| Christian Tovar, Brian Higgins, Kenneth Kolinsky, Mingxuan Xia, Kathryn Packman, David C Heimbrook, Lyubomir T Vassile. MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer. Molecular cancer. vol 10. 2011-07-26. PMID:21539745. |
the p53 tumor suppressor controls a major pathway that can block cell proliferation or induce apoptosis in response to diverse forms of oncogenic stress. |
2011-07-26 |
2023-08-12 |
Not clear |
| P Pratheeshkumar, Girija Kutta. Oleanolic acid induces apoptosis by modulating p53, Bax, Bcl-2 and caspase-3 gene expression and regulates the activation of transcription factors and cytokine profile in B16F. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 30. issue 1. 2011-07-26. PMID:21609313. |
oleanolic acid induces apoptosis by modulating p53, bax, bcl-2 and caspase-3 gene expression and regulates the activation of transcription factors and cytokine profile in b16f. |
2011-07-26 |
2023-08-12 |
Not clear |
| Victor C Y Mak, Lee Lee, Michelle K Y Siu, Oscar G W Wong, Xin Lu, Hextan Y S Ngan, Esther S Y Wong, Annie N Y Cheun. Downregulation of ASPP1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 24. issue 4. 2011-07-25. PMID:21102414. |
aspp1, a member of apoptosis-stimulating proteins of p53 (aspps), is a proapoptotic protein that can stimulate apoptosis through its interaction with p53. |
2011-07-25 |
2023-08-12 |
Not clear |
| Majid Ebrahimi, Karin Nylander, Isaäc van der Waa. Oral lichen planus and the p53 family: what do we know? Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 40. issue 4. 2011-07-25. PMID:21138483. |
the coordinated stabilization of p53 and decreased expression of p63 seen in olp cause induction of apoptosis enabling removal of dna-damaged cells. |
2011-07-25 |
2023-08-12 |
human |
| Yong-Yu Liu, Gauri A Patwardhan, Kaustubh Bhinge, Vineet Gupta, Xin Gu, S Michal Jazwinsk. Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells. Cancer research. vol 71. issue 6. 2011-07-25. PMID:21278235. |
suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells. |
2011-07-25 |
2023-08-12 |
human |
| Yong-Yu Liu, Gauri A Patwardhan, Kaustubh Bhinge, Vineet Gupta, Xin Gu, S Michal Jazwinsk. Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells. Cancer research. vol 71. issue 6. 2011-07-25. PMID:21278235. |
tumor suppressor p53 plays an essential role in protecting cells from malignant transformation by inducing cell-cycle arrest and apoptosis. |
2011-07-25 |
2023-08-12 |
human |
| Yong-Yu Liu, Gauri A Patwardhan, Kaustubh Bhinge, Vineet Gupta, Xin Gu, S Michal Jazwinsk. Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells. Cancer research. vol 71. issue 6. 2011-07-25. PMID:21278235. |
human ovarian cancer cells expressing mutant p53 displayed resistance to apoptosis induced by dna damage. |
2011-07-25 |
2023-08-12 |
human |
| Yong-Yu Liu, Gauri A Patwardhan, Kaustubh Bhinge, Vineet Gupta, Xin Gu, S Michal Jazwinsk. Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells. Cancer research. vol 71. issue 6. 2011-07-25. PMID:21278235. |
gcs silencing increased the levels of phosphorylated p53 and p53-responsive genes, including p21(waf1/cip1), bax, and puma, consistent with a redirection of the mutant p53 cells to apoptosis. |
2011-07-25 |
2023-08-12 |
human |
| Colleen A Brady, Dadi Jiang, Stephano S Mello, Thomas M Johnson, Lesley A Jarvis, Margaret M Kozak, Daniela Kenzelmann Broz, Shashwati Basak, Eunice J Park, Margaret E McLaughlin, Anthony N Karnezis, Laura D Attard. Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell. vol 145. issue 4. 2011-07-22. PMID:21565614. |
microarray analysis reveals that one mutant, p53(25,26), is severely compromised for transactivation of most p53 target genes, and, moreover, p53(25,26) cannot induce g(1)-arrest or apoptosis in response to acute dna damage. |
2011-07-22 |
2023-08-12 |
mouse |
| Yu Zhao, Shaoping Wu, Junhua Wu, Peiyuan Jia, Shan Gao, Xiangdong Yan, Yuxia Wan. Introduction of hypoxia-targeting p53 fusion protein for the selective therapy of non-small cell lung cancer. Cancer biology & therapy. vol 11. issue 1. 2011-07-20. PMID:21248471. |
we provide the evidence that this p53 fusion protein could significantly induce the cell-cycle arrest and/or apoptosis to inhibit h1299 cells' growth via p53-dependent pathways, including up-regulation of p21 expression and activation of pro-caspase-3, especially under hypoxia in vitro. |
2011-07-20 |
2023-08-12 |
Not clear |
| Ruth Villalonga-Planells, Llorenç Coll-Mulet, Fina Martínez-Soler, Esther Castaño, Juan-Jose Acebes, Pepita Giménez-Bonafé, Joan Gil, Avelina Tortos. Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme. PloS one. vol 6. issue 4. 2011-07-20. PMID:21483692. |
activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme. |
2011-07-20 |
2023-08-12 |
human |