| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoon-Jae Kim, Jin-Yong Chung, Seung Gee Lee, Ji Young Kim, Ji-Eun Park, Won Rok Kim, Bo Sun Joo, Seong Ho Han, Ki Soo Yoo, Young Hyun Yoo, Jong-Min Ki. Arsenic trioxide-induced apoptosis in TM4 Sertoli cells: the potential involvement of p21 expression and p53 phosphorylation. Toxicology. vol 285. issue 3. 2011-08-16. PMID:21565247. |
arsenic trioxide-induced apoptosis in tm4 sertoli cells: the potential involvement of p21 expression and p53 phosphorylation. |
2011-08-16 |
2023-08-12 |
Not clear |
| Yoon-Jae Kim, Jin-Yong Chung, Seung Gee Lee, Ji Young Kim, Ji-Eun Park, Won Rok Kim, Bo Sun Joo, Seong Ho Han, Ki Soo Yoo, Young Hyun Yoo, Jong-Min Ki. Arsenic trioxide-induced apoptosis in TM4 Sertoli cells: the potential involvement of p21 expression and p53 phosphorylation. Toxicology. vol 285. issue 3. 2011-08-16. PMID:21565247. |
asto-induced apoptosis was concomitant with the downregulation of p53, phosphorylation of p53 at serine residues, and g2/m cell cycle arrest. |
2011-08-16 |
2023-08-12 |
Not clear |
| Ahmed Malki, Amal Yousse. Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling. Oncology research. vol 19. issue 6. 2011-08-16. PMID:21776823. |
metformin induced apoptosis by arresting cells in g1 phase and reducing cyclin d level and increasing the expression of p21 and cyclin e. molecular and cellular studies indicated that metformin significantly elevated p53 and bax levels and reduced stat3 and bcl-2. |
2011-08-16 |
2023-08-12 |
human |
| Ahmed Malki, Amal Yousse. Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling. Oncology research. vol 19. issue 6. 2011-08-16. PMID:21776823. |
all these results suggested that metformin activated p53, bax, and induced tumor cell apoptosis through the erk signaling pathway. |
2011-08-16 |
2023-08-12 |
human |
| Ahmed Malki, Amal Yousse. Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling. Oncology research. vol 19. issue 6. 2011-08-16. PMID:21776823. |
this pathway has not been previously described for ir, p53, bax activation, or apoptosis. |
2011-08-16 |
2023-08-12 |
human |
| Hilary P Beck, Michael DeGraffenreid, Brian Fox, John G Allen, Yosup Rew, Stephen Schneider, Anne Y Saiki, Dongyin Yu, Jonathan D Oliner, Kevin Salyers, Qiuping Ye, Steven Olso. Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors. Bioorganic & medicinal chemistry letters. vol 21. issue 9. 2011-08-15. PMID:21123063. |
human murine double minute 2 (mdm2) is a negative regulator of p53, which plays an important role in cell cycle and apoptosis. |
2011-08-15 |
2023-08-12 |
human |
| Elena A Ostrakhovitch, Oleg A Semenikhi. p53-mediated regulation of neuronal differentiation via regulation of dual oxidase maturation factor 1. Neuroscience letters. vol 494. issue 1. 2011-08-15. PMID:21362455. |
the p53 transcription factor is involved in cell cycle, apoptosis and differentiation. |
2011-08-15 |
2023-08-12 |
mouse |
| Junhao Yan, Li Li, Nikan H Khatibi, Lei Yang, Ke Wang, Weiguang Zhang, Robert D Martin, Jingyan Han, John Zhang, Changman Zho. Blood-brain barrier disruption following subarchnoid hemorrhage may be faciliated through PUMA induction of endothelial cell apoptosis from the endoplasmic reticulum. Experimental neurology. vol 230. issue 2. 2011-08-15. PMID:21586287. |
as a result, in the present study, we investigated the role of puma (p53 upregulated modulator of apoptosis) following sah injury in rats. |
2011-08-15 |
2023-08-12 |
rat |
| Alan S Ma. p53 regulation of podosome formation and cellular invasion in vascular smooth muscle cells. Cell adhesion & migration. vol 5. issue 2. 2011-08-12. PMID:21164280. |
the p53 transcription factor, discovered in 1979 ( 1;2) , is well known as a potent suppressor of tumor development by inhibiting cell cycle progression, and promoting senescence or apoptosis, when the genome is compromised or under oncogenic stress ( 3) . |
2011-08-12 |
2023-08-12 |
Not clear |
| Yan Fang, Beihua Kong, Qifeng Yang, Daoxin Ma, Xun Q. The p53-HDM2 gene-gene polymorphism interaction is associated with the development of missed abortion. Human reproduction (Oxford, England). vol 26. issue 5. 2011-08-12. PMID:21339197. |
the interaction between p53 and human double minute 2 (hdm2) plays an important role in apoptosis; therefore, functional polymorphisms in these genes might have adverse effects in early pregnancy. |
2011-08-12 |
2023-08-12 |
human |
| Wei Tang, Weiyi Fan, Quanhong Liu, Jing Zhang, Xiaofei Qi. The role of p53 in the response of tumor cells to sonodynamic therapy in vitro. Ultrasonics. vol 51. issue 7. 2011-08-11. PMID:21616517. |
p53 plays a pivotal role in apoptosis. |
2011-08-11 |
2023-08-12 |
Not clear |
| Wei Tang, Weiyi Fan, Quanhong Liu, Jing Zhang, Xiaofei Qi. The role of p53 in the response of tumor cells to sonodynamic therapy in vitro. Ultrasonics. vol 51. issue 7. 2011-08-11. PMID:21616517. |
these results primarily demonstrated that: (1) p53 was activated to promote sdt-induced apoptosis through extrinsic and intrinsic signaling pathways in the s180 and h-22 cells; (2) cellular responses of different cells to sdt were distinct, the aggressive s180 cells were much more sensitive than h-22, whereas eac cells were relatively less sensitive. |
2011-08-11 |
2023-08-12 |
Not clear |
| Tsutomu Yoshida, Tsukasa Sekine, Ken-ichi Aisaki, Tetuo Mikami, Jun Kanno, Isao Okayas. CITED2 is activated in ulcerative colitis and induces p53-dependent apoptosis in response to butyric acid. Journal of gastroenterology. vol 46. issue 3. 2011-08-10. PMID:21165656. |
in ulcerative colitis (uc), fusobacterium varium is significantly detected in patients' mucosa, and butyric acid (ba), abundantly produced by the bacterium, activates the p53 system and induces epithelial apoptosis, as we previously reported. |
2011-08-10 |
2023-08-12 |
Not clear |
| Emil Rudolf, Miroslav Cervink. Stress responses of human dermal fibroblasts exposed to zinc pyrithione. Toxicology letters. vol 204. issue 2-3. 2011-08-10. PMID:21557991. |
cells further upregulate the expression of p53 which increases its transcriptional activity while mitogenic signaling exemplified by mtor (mammalian target of rapamycin) expression is suppressed and these steps lead to mitochondrial, caspase-dependent apoptosis. |
2011-08-10 |
2023-08-12 |
human |
| L F Peterson, E Mitrikeska, D Giannola, Y Lui, H Sun, D Bixby, S N Malek, N J Donato, S Wang, M Talpa. p53 stabilization induces apoptosis in chronic myeloid leukemia blast crisis cells. Leukemia. vol 25. issue 5. 2011-08-09. PMID:21350558. |
p53 stabilization induces apoptosis in chronic myeloid leukemia blast crisis cells. |
2011-08-09 |
2023-08-12 |
human |
| L F Peterson, E Mitrikeska, D Giannola, Y Lui, H Sun, D Bixby, S N Malek, N J Donato, S Wang, M Talpa. p53 stabilization induces apoptosis in chronic myeloid leukemia blast crisis cells. Leukemia. vol 25. issue 5. 2011-08-09. PMID:21350558. |
in this study, we show that human homolog double minute 2 (hdm2) inhibition, with mi-219-a novel compound, and consequently p53 stabilization induce chronic myeloid leukemia (cml) blast crisis cells to undergo apoptosis regardless of the presence of the t315i mutation in the bcr-abl kinase domain. |
2011-08-09 |
2023-08-12 |
human |
| L F Peterson, E Mitrikeska, D Giannola, Y Lui, H Sun, D Bixby, S N Malek, N J Donato, S Wang, M Talpa. p53 stabilization induces apoptosis in chronic myeloid leukemia blast crisis cells. Leukemia. vol 25. issue 5. 2011-08-09. PMID:21350558. |
in addition, p53 protein accumulates in the mitochondrial fraction of treated cells involved in transcription-independent induction of apoptosis. |
2011-08-09 |
2023-08-12 |
human |
| Xiangdong Lu, Chunyu Yang, Chaoying Yin, Terry Van Dyke, Karl Simi. Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression. Molecular cancer research : MCR. vol 9. issue 4. 2011-08-09. PMID:21385880. |
apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression. |
2011-08-09 |
2023-08-12 |
mouse |
| Xiangdong Lu, Chunyu Yang, Chaoying Yin, Terry Van Dyke, Karl Simi. Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression. Molecular cancer research : MCR. vol 9. issue 4. 2011-08-09. PMID:21385880. |
it is well established that the p53 regulates multiple, distinct cellular functions such as cell-cycle arrest and apoptosis. |
2011-08-09 |
2023-08-12 |
mouse |
| Xiangdong Lu, Chunyu Yang, Chaoying Yin, Terry Van Dyke, Karl Simi. Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression. Molecular cancer research : MCR. vol 9. issue 4. 2011-08-09. PMID:21385880. |
using a mouse brain carcinoma model that shows high selective pressure for p53 inactivation, we found that even partially abolishing p53-dependent apoptosis by bax inactivation was sufficient to significantly reduce the selective pressure for p53 loss. |
2011-08-09 |
2023-08-12 |
mouse |