| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyung-Sun Heo, Hakjoo Lee, Patrizia Nigro, Tamlyn Thomas, Nhat-Tu Le, Eugene Chang, Carolyn McClain, Cynthia A Reinhart-King, Michael R King, Bradford C Berk, Keigi Fujiwara, Chang-Hoon Woo, Jun-ichi Ab. PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. The Journal of cell biology. vol 193. issue 5. 2011-08-30. PMID:21624955. |
pkcζ mediates disturbed flow-induced endothelial apoptosis via p53 sumoylation. |
2011-08-30 |
2023-08-12 |
mouse |
| Kyung-Sun Heo, Hakjoo Lee, Patrizia Nigro, Tamlyn Thomas, Nhat-Tu Le, Eugene Chang, Carolyn McClain, Cynthia A Reinhart-King, Michael R King, Bradford C Berk, Keigi Fujiwara, Chang-Hoon Woo, Jun-ichi Ab. PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. The Journal of cell biology. vol 193. issue 5. 2011-08-30. PMID:21624955. |
we tested the hypothesis that pkcζ activation by d-flow induces endothelial cell (ec) apoptosis by regulating p53. |
2011-08-30 |
2023-08-12 |
mouse |
| Kyung-Sun Heo, Hakjoo Lee, Patrizia Nigro, Tamlyn Thomas, Nhat-Tu Le, Eugene Chang, Carolyn McClain, Cynthia A Reinhart-King, Michael R King, Bradford C Berk, Keigi Fujiwara, Chang-Hoon Woo, Jun-ichi Ab. PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. The Journal of cell biology. vol 193. issue 5. 2011-08-30. PMID:21624955. |
we found that d-flow-mediated peroxynitrite (onoo(-)) increased pkcζ activation, which subsequently induced p53 sumoylation, p53-bcl-2 binding, and ec apoptosis. |
2011-08-30 |
2023-08-12 |
mouse |
| Kyung-Sun Heo, Hakjoo Lee, Patrizia Nigro, Tamlyn Thomas, Nhat-Tu Le, Eugene Chang, Carolyn McClain, Cynthia A Reinhart-King, Michael R King, Bradford C Berk, Keigi Fujiwara, Chang-Hoon Woo, Jun-ichi Ab. PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. The Journal of cell biology. vol 193. issue 5. 2011-08-30. PMID:21624955. |
en face confocal microscopy revealed increases in nonnuclear p53 expression, nitrotyrosine staining, and apoptosis in aortic ec located in d-flow areas in wild-type mice, but these effects were significantly decreased in p53(-/-) mice. |
2011-08-30 |
2023-08-12 |
mouse |
| Kyung-Sun Heo, Hakjoo Lee, Patrizia Nigro, Tamlyn Thomas, Nhat-Tu Le, Eugene Chang, Carolyn McClain, Cynthia A Reinhart-King, Michael R King, Bradford C Berk, Keigi Fujiwara, Chang-Hoon Woo, Jun-ichi Ab. PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. The Journal of cell biology. vol 193. issue 5. 2011-08-30. PMID:21624955. |
we propose a novel mechanism for p53 sumoylation mediated by the pkcζ-piasy interaction during d-flow-mediated ec apoptosis, which has potential relevance to early events of atherosclerosis. |
2011-08-30 |
2023-08-12 |
mouse |
| Zhi-Fang Wang, Xiong Gu. Arsenite-induced apoptosis is prevented by selenite in A375 cell line. Biological trace element research. vol 140. issue 1. 2011-08-29. PMID:20390378. |
thus, our results indicate upregulation of p53 and bcl-2 play acrucial role in the naaso2-induced g1 arrest and apoptosis of a375 cells and that downregulation p53 appears to contribute to the inhibition by na2seo3 of the effects induced by naaso2. |
2011-08-29 |
2023-08-12 |
human |
| Jyotirmoy Ghosh, Joydeep Das, Prasenjit Manna, Parames C Si. The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis. Biomaterials. vol 32. issue 21. 2011-08-29. PMID:21486680. |
blockage of p53 and p38-jnk by pharmacological inhibitors also suppressed the doxorubicin-induced apoptosis with the concomitant inhibition of anti-apoptotic bcl-2 family proteins. |
2011-08-29 |
2023-08-12 |
rat |
| Nou-Ying Tang, Ya-Ting Huang, Chun-Shu Yu, Yang-Ching Ko, Shin-Hwar Wu, Bin-Chuan Ji, Jai-Sing Yang, Jiun-Long Yang, Te-Chun Hsia, Ya-Yin Chen, Jing-Gung Chun. Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells. Anticancer research. vol 31. issue 5. 2011-08-29. PMID:21617228. |
phenethyl isothiocyanate (peitc) promotes g2/m phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer du 145 cells. |
2011-08-29 |
2023-08-12 |
human |
| Ye Ji, Yi-Cai Zhang, Liu-Bao Pei, Li-Li Shi, Jing-Long Yan, Xue-Hua M. Anti-tumor effects of dihydroartemisinin on human osteosarcoma. Molecular and cellular biochemistry. vol 351. issue 1-2. 2011-08-26. PMID:21234653. |
the p53 gene may play a certain role in the dha-induced human osteosarcoma apoptosis and cell cycle arrest. |
2011-08-26 |
2023-08-12 |
human |
| Isabelle Soubeyran, Isabelle Mahouche, Aude Grigoletto, Thierry Leste-Lasserre, Guillaume Drutel, Christophe Rey, Stephane Pedeboscq, France Blanchard, Veronique Brouste, Jean-Christophe Sabourin, Yves Bécouarn, Josy Reiffers, François Ichas, Francesca De Giorg. Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function. The American journal of pathology. vol 178. issue 5. 2011-08-26. PMID:21514416. |
although p53 function appears important for proliferation arrest and apoptosis induced by cancer therapeutics, the prognostic significance of p53 mutations remains elusive. |
2011-08-26 |
2023-08-12 |
human |
| Manasi Das, Fahima Dilnawaz, Sanjeeb K Saho. Targeted nutlin-3a loaded nanoparticles inhibiting p53-MDM2 interaction: novel strategy for breast cancer therapy. Nanomedicine (London, England). vol 6. issue 3. 2011-08-26. PMID:21542687. |
the objective of the present study is to prepare and characterize nutlin-3a loaded polymeric poly(lactide-co-glycolide) nanoparticles (nps) surface functionalized with transferrin ligand, to deliver the encapsulated drug in a targeted manner to its site of action and to evaluate the efficacy of the nanoformulation in terms of its cellular uptake, cell cytotoxicity, cell cycle arrest, apoptosis and activation of p53 pathway at molecular level in mcf-7 breast cancer cell line. |
2011-08-26 |
2023-08-12 |
Not clear |
| Caiping Guo, Kewei Liu, Yi Zheng, Haibo Luo, Hongbo Chen, Laiqiang Huan. Apoptosis induced by an antagonist peptide against HPV16 E7 in vitro and in vivo via restoration of p53. Apoptosis : an international journal on programmed cell death. vol 16. issue 6. 2011-08-25. PMID:21475994. |
apoptosis induced by an antagonist peptide against hpv16 e7 in vitro and in vivo via restoration of p53. |
2011-08-25 |
2023-08-12 |
mouse |
| Caiping Guo, Kewei Liu, Yi Zheng, Haibo Luo, Hongbo Chen, Laiqiang Huan. Apoptosis induced by an antagonist peptide against HPV16 E7 in vitro and in vivo via restoration of p53. Apoptosis : an international journal on programmed cell death. vol 16. issue 6. 2011-08-25. PMID:21475994. |
in contrast, the induction of apoptosis and p53 reactivation effects by the selected peptide were abolished after e7 knocked down with sirna. |
2011-08-25 |
2023-08-12 |
mouse |
| Caiping Guo, Kewei Liu, Yi Zheng, Haibo Luo, Hongbo Chen, Laiqiang Huan. Apoptosis induced by an antagonist peptide against HPV16 E7 in vitro and in vivo via restoration of p53. Apoptosis : an international journal on programmed cell death. vol 16. issue 6. 2011-08-25. PMID:21475994. |
these results demonstrate that the selected peptide can induce e7 degradation and lead to marked apoptosis in hpv16-related cancer cells by activating cellular p53 and its target genes, such as p21. |
2011-08-25 |
2023-08-12 |
mouse |
| Xiao-Gang Yang, Xiao-Lin Li, Yi-Jian Chen, Zhao-Xia Xie, Min-Yuan Peng, Xiao-Chun Huang, Ran-Xin Huan. [Apoptosis of Burkitt's lymphoma Raji cell line induced by bortezomib]. Zhongguo shi yan xue ye xue za zhi. vol 17. issue 3. 2011-08-24. PMID:19549370. |
cell morphology was observed under light microscope; flow cytometry was used to analyze cell apoptosis; rt-pcr was used to detect the expressions of nf-kappab and p53 gene mrnas. |
2011-08-24 |
2023-08-12 |
Not clear |
| Xiao-Gang Yang, Xiao-Lin Li, Yi-Jian Chen, Zhao-Xia Xie, Min-Yuan Peng, Xiao-Chun Huang, Ran-Xin Huan. [Apoptosis of Burkitt's lymphoma Raji cell line induced by bortezomib]. Zhongguo shi yan xue ye xue za zhi. vol 17. issue 3. 2011-08-24. PMID:19549370. |
nf-kappab and p53 gene are supposed to participate in the bortezomib induced apoptosis of raji cells. |
2011-08-24 |
2023-08-12 |
Not clear |
| Martine M Kloster, Elin H Naderi, Harald Carlsen, Heidi K Blomhoff, Soheil Nader. Hyperactivation of NF-κB via the MEK signaling is indispensable for the inhibitory effect of cAMP on DNA damage-induced cell death. Molecular cancer. vol 10. 2011-08-24. PMID:21510868. |
we have recently shown that p53 is critical for the inhibitory effect of camp on genotoxic agents-mediated apoptosis in bcp-alls. |
2011-08-24 |
2023-08-12 |
Not clear |
| Martine M Kloster, Elin H Naderi, Harald Carlsen, Heidi K Blomhoff, Soheil Nader. Hyperactivation of NF-κB via the MEK signaling is indispensable for the inhibitory effect of cAMP on DNA damage-induced cell death. Molecular cancer. vol 10. 2011-08-24. PMID:21510868. |
importantly, pharmacological or genetic ablation of nf-κb reversed the inhibitory effect of camp on dna damage-induced apoptosis, demonstrating that, in addition to p53, camp relies on the activity of nf-κb to provide cells with a survival advantage in the face of dna damage. |
2011-08-24 |
2023-08-12 |
Not clear |
| Alexander E P Heazell, Andrew N Sharp, Philip N Baker, Ian P Crocke. Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast. Apoptosis : an international journal on programmed cell death. vol 16. issue 2. 2011-08-23. PMID:21052841. |
intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast. |
2011-08-23 |
2023-08-12 |
human |
| Alexander E P Heazell, Andrew N Sharp, Philip N Baker, Ian P Crocke. Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast. Apoptosis : an international journal on programmed cell death. vol 16. issue 2. 2011-08-23. PMID:21052841. |
the intrinsic pathway of apoptosis, particularly p53, is important in regulating placental cell turnover in response to damage. |
2011-08-23 |
2023-08-12 |
human |