| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Ahmed, J Yang, A Maya-Mendoza, D A Jackson, M Ashcrof. Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. Cell death & disease. vol 2. 2011-09-13. PMID:21593792. |
we have recently shown that induction of the p53 tumour suppressor protein by the small-molecule rita (reactivation of p53 and induction of tumour cell apoptosis; 2,5-bis(5-hydroxymethyl-2-thienyl)furan) inhibits hypoxia-inducible factor-1α and vascular endothelial growth factor expression in vivo and induces p53-dependent tumour cell apoptosis in normoxia and hypoxia. |
2011-09-13 |
2023-08-12 |
Not clear |
| Eun-Ryeong Hahm, Joomin Lee, Yi Huang, Shivendra V Sing. Withaferin a suppresses estrogen receptor-α expression in human breast cancer cells. Molecular carcinogenesis. vol 50. issue 8. 2011-09-12. PMID:21432907. |
wa treatment resulted in induction as well as increased s15 phosphorylation of p53 in mcf-7 cells, but rna interference of this tumor suppressor conferred modest protection at best against wa-induced apoptosis. |
2011-09-12 |
2023-08-12 |
human |
| Vasilis P Androutsopoulos, Ketan C Ruparelia, Athanasios Papakyriakou, Harilaos Filippakis, Aristeidis M Tsatsakis, Demetrios A Spandido. Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency. European journal of medicinal chemistry. vol 46. issue 6. 2011-09-12. PMID:21497957. |
we conclude that 2 inhibits hepg2 and mcf-7 cellular proliferation by inducing apoptosis and g2/m arrest through p53 and bax/bcl-xl upregulation. |
2011-09-12 |
2023-08-12 |
Not clear |
| Samah El Ghamrasni, Ashwin Pamidi, Marie Jo Halaby, Miyuki Bohgaki, Renato Cardoso, Li Li, Shriram Venkatesan, Swaminathan Sethu, Atsushi Hirao, Tak W Mak, Manoor Prakash Hande, Anne Hakem, Razqallah Hake. Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer. PLoS genetics. vol 7. issue 5. 2011-09-12. PMID:21625617. |
chk2 is an effector kinase important for the activation of cell cycle checkpoints, p53, and apoptosis in response to dna damage. |
2011-09-12 |
2023-08-12 |
mouse |
| Célia Floquet, Jean-Pierre Rousset, Laure Bido. [Rescue of nonsense mutated p53 by readthrough leads to apoptosis in cancers cells]. Medecine sciences : M/S. vol 27. issue 6-7. 2011-09-12. PMID:21718640. |
[rescue of nonsense mutated p53 by readthrough leads to apoptosis in cancers cells]. |
2011-09-12 |
2023-08-12 |
Not clear |
| Amanda S Coutts, Louise Weston, Nicholas B La Thangu. Actin nucleation by a transcription co-factor that links cytoskeletal events with the p53 response. Cell cycle (Georgetown, Tex.). vol 9. issue 8. 2011-09-09. PMID:20372063. |
despite its obvious importance in tumorigenesis, little information is available on the mechanisms that integrate cell motility and invasion with nuclear events. tumor suppressor p53 is a dna damage responsive transcription factor which initiates a checkpoint response culminating in cell cycle arrest or apoptosis. |
2011-09-09 |
2023-08-12 |
Not clear |
| X Chen, H Zhang, J P Aravindakshan, W H Gotlieb, M R Saira. Anti-proliferative and pro-apoptotic actions of a novel human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing and drug sensitization. Oncogene. vol 30. issue 25. 2011-09-09. PMID:21339736. |
although p53-pathway-dependent apoptotic agents could upregulate endogenous hotag-12b and p53 in uci-101/107 oc cells, hotag-12b could also induce apoptosis in p53-null and platinum-resistant skov3 oc cells and doxycycline-induced hotag-12b did not alter p53. |
2011-09-09 |
2023-08-12 |
mouse |
| Jagat J Mukherjee, Subodh Kumar, Ronald Gocinski, Jacquan William. Phenolic fraction of tobacco smoke inhibits BPDE-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 response. Chemical research in toxicology. vol 24. issue 5. 2011-09-09. PMID:21480602. |
phenolic fraction of tobacco smoke inhibits bpde-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 response. |
2011-09-09 |
2023-08-12 |
Not clear |
| Jagat J Mukherjee, Subodh Kumar, Ronald Gocinski, Jacquan William. Phenolic fraction of tobacco smoke inhibits BPDE-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 response. Chemical research in toxicology. vol 24. issue 5. 2011-09-09. PMID:21480602. |
increased cell transformation and decreased apoptosis by tscphfr were associated with attenuation of bpde-induced p53 accumulation. |
2011-09-09 |
2023-08-12 |
Not clear |
| Jagat J Mukherjee, Subodh Kumar, Ronald Gocinski, Jacquan William. Phenolic fraction of tobacco smoke inhibits BPDE-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 response. Chemical research in toxicology. vol 24. issue 5. 2011-09-09. PMID:21480602. |
jb6 cells transfected with p53 sirna showed significantly less apoptosis induction by bpde as compared to control cells. |
2011-09-09 |
2023-08-12 |
Not clear |
| Jagat J Mukherjee, Subodh Kumar, Ronald Gocinski, Jacquan William. Phenolic fraction of tobacco smoke inhibits BPDE-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 response. Chemical research in toxicology. vol 24. issue 5. 2011-09-09. PMID:21480602. |
in p53 impaired cells (which are observed to have a faster growth rate as compared to normal cells), tscphfr has a practically negligible effect on apoptosis induction in response to bpde. |
2011-09-09 |
2023-08-12 |
Not clear |
| Jagat J Mukherjee, Subodh Kumar, Ronald Gocinski, Jacquan William. Phenolic fraction of tobacco smoke inhibits BPDE-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 response. Chemical research in toxicology. vol 24. issue 5. 2011-09-09. PMID:21480602. |
also, in p53 null hct116 p53(-/-) cells, bpde-induced apoptosis is unresponsive to tscphfr. |
2011-09-09 |
2023-08-12 |
Not clear |
| Jagat J Mukherjee, Subodh Kumar, Ronald Gocinski, Jacquan William. Phenolic fraction of tobacco smoke inhibits BPDE-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 response. Chemical research in toxicology. vol 24. issue 5. 2011-09-09. PMID:21480602. |
our observations indicate that attenuation of bpde-induced p53 response has a role in apoptosis inhibition and increased cell transformation by tscphfr. |
2011-09-09 |
2023-08-12 |
Not clear |
| Wendell S Fortson, Shubhalaxmi Kayarthodi, Yasuo Fujimura, Huali Xu, Roland Matthews, William E Grizzle, Veena N Rao, Ganapathy K Bhat, E Shyam P Redd. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. International journal of oncology. vol 39. issue 1. 2011-09-09. PMID:21519790. |
histone deacetylase inhibitors, valproic acid and trichostatin-a induce apoptosis and affect acetylation status of p53 in erg-positive prostate cancer cells. |
2011-09-09 |
2023-08-12 |
Not clear |
| Wendell S Fortson, Shubhalaxmi Kayarthodi, Yasuo Fujimura, Huali Xu, Roland Matthews, William E Grizzle, Veena N Rao, Ganapathy K Bhat, E Shyam P Redd. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. International journal of oncology. vol 39. issue 1. 2011-09-09. PMID:21519790. |
we found that vpa and tsa induce apoptosis, upregulate p21/waf1/cip1, repress tmprss2-erg expression and affect acetylation status of p53 in vcap cells. |
2011-09-09 |
2023-08-12 |
Not clear |
| Judith T M L Paridaen, Esther Janson, Kagistia Hana Utami, Tamara C Pereboom, Paul B Essers, Carina van Rooijen, Danica Zivkovic, Alyson W MacInne. The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish. Developmental biology. vol 355. issue 2. 2011-09-09. PMID:21565180. |
our models demonstrate that the loss of gnl2 or ns induces p53 stabilization and p53-mediated apoptosis. |
2011-09-09 |
2023-08-12 |
zebrafish |
| Cheng-Chang Yeh, Hsiao-Ling Hsieh, Jihjong Lee, Yi-Hua Jan, Tsung-Ching Lai, Chi-Yuan Hong, Michael Hsiao, Mark Y P Ku. Polyethylenimine-mediated PUMA gene delivery to orthotopic oral cancer: suppression of tumor growth through apoptosis induction in situ and prolonged survival. Head & neck. vol 33. issue 6. 2011-09-08. PMID:20737492. |
puma (a p53 up-regulated modulator of apoptosis) is induced by p53 tumor suppressor and other apoptotic stimuli. |
2011-09-08 |
2023-08-12 |
Not clear |
| Kyung Pyo Kang, Sung Kwang Park, Duk Hoon Kim, Mi Jeong Sung, Yu Jin Jung, Ae Sin Lee, Jung Eun Lee, Kunka Mohanram Ramkumar, Sik Lee, Moon Hyang Park, Si-Gyun Roh, Won Ki. Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 26. issue 3. 2011-09-08. PMID:20817674. |
the causative mechanisms of cisplatin-induced acute kidney injury include renal inflammation, activation of p53 tumour suppressor protein and tubular apoptosis. |
2011-09-08 |
2023-08-12 |
mouse |
| Gabriela Mustata, Mei Li, Nicki Zevola, Ahmet Bakan, Lin Zhang, Michael Epperly, Joel S Greenberger, Jian Yu, Ivet Baha. Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death. Current topics in medicinal chemistry. vol 11. issue 3. 2011-09-08. PMID:21320058. |
puma (p53 upregulated modulator of apoptosis) is a bcl-2 homology 3 (bh3)-only bcl-2 family member and a key mediator of apoptosis induced by a wide variety of stimuli. |
2011-09-08 |
2023-08-12 |
Not clear |
| Sang Hoon Jung, Beum Jin Kim, Eun Ha Lee, Neville N Osborn. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochemistry international. vol 57. issue 7. 2011-09-07. PMID:20708054. |
it was found that an insult of h(2)o(2) to rgc-5 cells caused them to die by apoptosis, demonstrated not only by staining dead cells for phosphatidylserine but also by the up-regulation (cleaved parp, aif, p53) and down-regulation (bcl-2) of proteins associated with apoptosis and survival. |
2011-09-07 |
2023-08-12 |
rat |