| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naoto Tsuchiya, Masashi Izumiya, Hiroko Ogata-Kawata, Koji Okamoto, Yuko Fujiwara, Makiko Nakai, Atsushi Okabe, Aaron J Schetter, Elise D Bowman, Yutaka Midorikawa, Yasuyuki Sugiyama, Hiroyuki Aburatani, Curtis C Harris, Hitoshi Nakagam. Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21. Cancer research. vol 71. issue 13. 2011-09-29. PMID:21565979. |
selective activation of p53 target genes in response to various cellular stresses is a critical step in determining the ability to induce cell-cycle arrest or apoptosis. |
2011-09-29 |
2023-08-12 |
Not clear |
| Naoto Tsuchiya, Masashi Izumiya, Hiroko Ogata-Kawata, Koji Okamoto, Yuko Fujiwara, Makiko Nakai, Atsushi Okabe, Aaron J Schetter, Elise D Bowman, Yutaka Midorikawa, Yasuyuki Sugiyama, Hiroyuki Aburatani, Curtis C Harris, Hitoshi Nakagam. Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21. Cancer research. vol 71. issue 13. 2011-09-29. PMID:21565979. |
here we report the identification of the microrna mir-22 as a p53 target gene that selectively determines the induction of p53-dependent apoptosis by repressing p21. |
2011-09-29 |
2023-08-12 |
Not clear |
| Valentina Audrito, Tiziana Vaisitti, Davide Rossi, Daniela Gottardi, Giovanni D'Arena, Luca Laurenti, Gianluca Gaidano, Fabio Malavasi, Silvia Deagli. Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network. Cancer research. vol 71. issue 13. 2011-09-29. PMID:21565980. |
this agent blocks proliferation and promotes apoptosis selectively in leukemic cells that express wild-type (wt) p53. |
2011-09-29 |
2023-08-12 |
Not clear |
| Domagoj Vucic, Vishva M Dixit, Ingrid E Wert. Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nature reviews. Molecular cell biology. vol 12. issue 7. 2011-09-28. PMID:21697901. |
for example, ubiquitin e3 ligases, such as mdm2 (which ubiquitylates p53) and inhibitor of apoptosis (iap) proteins, and deubiquitinases, such as a20 and ubiquitin-specific protease 9x (usp9x) (which regulate the ubiquitylation and degradation of receptor-interacting protein 1 (rip1) and myeloid leukaemia cell differentiation 1 (mcl1), respectively), have important roles in apoptosis. |
2011-09-28 |
2023-08-12 |
Not clear |
| Andrea Rodrigues Gonçalves, Antonio Jose Vasconcellos Carneiro, Ivanir Martins, Paulo Antonio Silvestre de Faria, Maria Aparecida Ferreira, Eduardo Linhares Riello de Mello, Homero Soares Fogaça, Celeste Carvalho Siqueira Elia, Heitor Siffert Pereira de Souz. Prognostic significance of p53 protein expression in early gastric cancer. Pathology oncology research : POR. vol 17. issue 2. 2011-09-27. PMID:21116760. |
mutations of the p53 tumor suppressor gene have been associated with abnormalities in cell cycle regulation, dna repair and synthesis, apoptosis, and it has been implicated in the prognosis of advanced gastric cancer. |
2011-09-27 |
2023-08-12 |
Not clear |
| Chi Zhang, Yansheng Feng, Shunlin Qu, Xing Wei, Honglin Zhu, Qi Luo, Meidong Liu, Guangwen Chen, Xianzhong Xia. Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53. Cardiovascular research. vol 90. issue 3. 2011-09-27. PMID:21278141. |
resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through sirt1-mediated deacetylation of p53. |
2011-09-27 |
2023-08-12 |
mouse |
| Jyotsana Singhal, Sushma Yadav, Lokesh Dalasanur Nagaprashantha, Rit Vatsyayan, Sharad S Singhal, Sanjay Awasth. Targeting p53-null neuroblastomas through RLIP76. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 6. 2011-09-27. PMID:21411502. |
our studies on the drug-resistant p53-mutant as compared with drug-resistant p53 wild-type neuroblastoma revealed a novel mechanism for resistance to apoptosis: a direct role of p53 in regulating the cellular concentration of proapoptotic alkenals by functioning as a specific and saturable allosteric inhibitor of the alkenal-glutathione conjugate transporter, rlip76. |
2011-09-27 |
2023-08-12 |
Not clear |
| Jyotsana Singhal, Sushma Yadav, Lokesh Dalasanur Nagaprashantha, Rit Vatsyayan, Sharad S Singhal, Sanjay Awasth. Targeting p53-null neuroblastomas through RLIP76. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 6. 2011-09-27. PMID:21411502. |
taken together, these studies provide powerful evidence for a novel mechanism for drug and apoptosis resistance in p53-mutant neuroblastoma, based on a model of regulation of p53-induced apoptosis by rlip76, where p53 is a saturable and specific allosteric inhibitor of rlip76, and p53 loss results in overexpression of rlip76; thus, in the absence of p53, the drug and glutathione-conjugate transport activities of rlip76 are enhanced. |
2011-09-27 |
2023-08-12 |
Not clear |
| Kunyan He, Sung-Wuk Jang, Jayashree Joshi, Min-Heui Yoo, Keqiang Y. Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. Molecular biology of the cell. vol 22. issue 11. 2011-09-26. PMID:21460185. |
knocking down pike-a stabilizes p53, increases unc5b, and escalates uv-triggered apoptosis. |
2011-09-26 |
2023-08-12 |
mouse |
| Kunyan He, Sung-Wuk Jang, Jayashree Joshi, Min-Heui Yoo, Keqiang Y. Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. Molecular biology of the cell. vol 22. issue 11. 2011-09-26. PMID:21460185. |
hence our findings support the notion that akt--phosphorylated pike-a inhibits unc5b-elicited apoptosis and reduces its expression level through inactivation of p53. |
2011-09-26 |
2023-08-12 |
mouse |
| Nadine Rohwer, Thorsten Crame. Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 14. issue 3. 2011-09-26. PMID:21466972. |
specifically, we will highlight the multifaceted interaction of hif with apoptosis, senescence, autophagy, p53 and mitochondrial activity and outline how these are at the heart of hif-mediated therapy failure. |
2011-09-26 |
2023-08-12 |
human |
| M E Messina, R Halab. Does triptolide induce lysosomal-mediated apoptosis in human breast cancer cells? Medical hypotheses. vol 77. issue 1. 2011-09-26. PMID:21486687. |
it has been suggested that triptolide activates the p53 pathway to trigger apoptosis in these cells. |
2011-09-26 |
2023-08-12 |
human |
| K John, V Alla, C Meier, B M Pütze. GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria. Cell death and differentiation. vol 18. issue 5. 2011-09-23. PMID:21127500. |
p73, a member of the p53 family, shares high sequence homology with p53 and shows many p53-like properties: it binds to p53-dna target sites, transactivates p53-responsive genes and induces cell cycle arrest and apoptosis. |
2011-09-23 |
2023-08-12 |
Not clear |
| Il-Yeob Kim, Su-Young Park, Youra Kang, Dinesh Thapa, Han Gon Choi, Jung-Ae Ki. Role of nonsteroidal anti-inflammatory drug-activated gene-1 in docetaxel-induced cell death of human colorectal cancer cells with different p53 status. Archives of pharmacal research. vol 34. issue 2. 2011-09-23. PMID:21380817. |
it is not clear whether nag-1 induction is the responsible factor in cancer cell apoptosis with mutated p53. |
2011-09-23 |
2023-08-12 |
human |
| Il-Yeob Kim, Su-Young Park, Youra Kang, Dinesh Thapa, Han Gon Choi, Jung-Ae Ki. Role of nonsteroidal anti-inflammatory drug-activated gene-1 in docetaxel-induced cell death of human colorectal cancer cells with different p53 status. Archives of pharmacal research. vol 34. issue 2. 2011-09-23. PMID:21380817. |
although docetaxel induced an increase in nag-1 and apoptosis in both hct-116 (wild-type p53) and ht-29 (mutant p53) colon cancer cells, nag-1 knockdown with sirna prevented docetaxel-induced cell death in only hct-116 cells. |
2011-09-23 |
2023-08-12 |
human |
| Jason E Stadanlick, Zhiqiang Zhang, Sang-Yun Lee, Mike Hemann, Matthew Biery, Michael O Carleton, Gerard P Zambetti, Stephen J Anderson, Tamas Oravecz, David L Wies. Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 2. 2011-09-23. PMID:21690328. |
surprisingly, co-elimination of the primary p53 regulators of cell cycle arrest (p21(waf)) and apoptosis (puma) actually abrogated the partial rescue caused by loss of puma alone, suggesting that the g1 checkpoint protein p21(waf) facilitates thymocyte development in some contexts. |
2011-09-23 |
2023-08-12 |
mouse |
| A V Kononov, S I Mosgovoĭ, M V Markelova, A G Shimanskai. [Morphogenesis of gastric mucosal atrophy as a basis of a phenotype of chronic gastritis]. Arkhiv patologii. vol 73. issue 3. 2011-09-23. PMID:21853920. |
the molecular characteristics of hyperproliferative metaplastic atrophy are varying: in some foci of metaplasia, the high proliferative activity of the epithelium is concomitant with the hyperexpression of p53, a marker of dna damage, the lower expression of the intestinal transcription factor cdx-2, and the low level of cpp32, an indicator of apoptosis. |
2011-09-23 |
2023-08-12 |
Not clear |
| Nam-Seok Kim, Seung-Il Jeong, Byung-Soon Hwang, Young-Eun Lee, Shin-Ho Kang, Hyung-Chul Lee, Chan-Ho O. Gallic acid inhibits cell viability and induces apoptosis in human monocytic cell line U937. Journal of medicinal food. vol 14. issue 3. 2011-09-22. PMID:21332403. |
in order to understand the mechanism by which ga induces apoptosis, we examined the gene expression of p53, nuclear factor κb (nf-κb), and inhibitor of nf-κb (i-κb) after treating the cells with ga and found that expression levels of the genes for p53 and nf-κb increased and that for i-κb decreased. |
2011-09-22 |
2023-08-12 |
human |
| Jaw-Ming Cherng, Kuen-Daw Tsai, Yu-Whay Yu, Jung-Chung Li. Molecular mechanisms underlying chemopreventive activities of glycyrrhizic acid against UVB-radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Radiation research. vol 176. issue 2. 2011-09-22. PMID:21545294. |
thus glycyrrhizic acid ameliorates uvb-radiation-induced tumorigenesis via downregulation of cell proliferation controls involving thymine dimer, pcna, apoptosis and transcription factor nf-κb and of inflammatory responses involving cox-2, pge2 and no while upregulating of p53 and p21/cip1 to prevent dna damage and facilitate dna repair. |
2011-09-22 |
2023-08-12 |
mouse |
| Marc S Mendonca, Helen Chin-Sinex, Ryan Dhaemers, Laura E Mead, Merv C Yoder, David A Ingra. Differential mechanisms of x-ray-induced cell death in human endothelial progenitor cells isolated from cord blood and adults. Radiation research. vol 176. issue 2. 2011-09-22. PMID:21663393. |
however, at high radiation doses (≥ 10 gy) cord blood ecfcs underwent p53 stabilization and bax-dependent apoptosis as well as p21-dependent g₁ and g₂/m cell cycle checkpoints. |
2011-09-22 |
2023-08-12 |
human |