| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiayu Gao, Winston A Morgan, Alberto Sanchez-Medina, Olivia Corcora. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicology and applied pharmacology. vol 254. issue 3. 2011-09-06. PMID:21457722. |
the ethanol extract of scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and bax in human lung cancer cells. |
2011-09-06 |
2023-08-12 |
human |
| Jiayu Gao, Winston A Morgan, Alberto Sanchez-Medina, Olivia Corcora. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicology and applied pharmacology. vol 254. issue 3. 2011-09-06. PMID:21457722. |
following treatment, increased expression in the cancer cells of key proteins related to the enhancement of apoptosis was observed for p53 and bax. |
2011-09-06 |
2023-08-12 |
human |
| Jagat C Borah, Shiraz Mujtaba, Ioannis Karakikes, Lei Zeng, Michaela Muller, Jigneshkumar Patel, Natasha Moshkina, Keita Morohashi, Weijia Zhang, Guillermo Gerona-Navarro, Roger J Hajjar, Ming-Ming Zho. A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chemistry & biology. vol 18. issue 4. 2011-09-06. PMID:21513889. |
we show that ischemin alters post-translational modifications on p53 and histones, inhibits p53 interaction with cbp and transcriptional activity in cells, and prevents apoptosis in ischemic cardiomyocytes. |
2011-09-06 |
2023-08-12 |
human |
| A T Abdrashitova, T N Panova, I A Belolapenk. [Characteristics of cytokine state and processes of apoptosis under the influence of the combine action of production factors of the gas producing enterprise]. Advances in gerontology = Uspekhi gerontologii. vol 24. issue 1. 2011-09-06. PMID:21809637. |
people exposed to chronic influence of hydrogen sulphide gas demonstrate accelerated aging, increase of proinflammatory cytokine interleukin-8 level and the marker of apoptosis protein p53. |
2011-09-06 |
2023-08-12 |
Not clear |
| Sébastien Gillotin, Xin L. The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53. FEBS letters. vol 585. issue 12. 2011-09-05. PMID:21513714. |
in particular, the apoptotic pathway is regulated by p53 in cooperation with the apoptosis stimulating proteins of p53 (aspp) proteins. |
2011-09-05 |
2023-08-12 |
Not clear |
| Yuzhen Li, Xiuhua Liu, Fei Ron. PUMA mediates the apoptotic signal of hypoxia/reoxygenation in cardiomyocytes through mitochondrial pathway. Shock (Augusta, Ga.). vol 35. issue 6. 2011-09-02. PMID:21283058. |
p53 upregulated modulator of apoptosis (puma) plays an important role in mediating cell death. |
2011-09-02 |
2023-08-12 |
Not clear |
| Yuzhen Li, Xiuhua Liu, Fei Ron. PUMA mediates the apoptotic signal of hypoxia/reoxygenation in cardiomyocytes through mitochondrial pathway. Shock (Augusta, Ga.). vol 35. issue 6. 2011-09-02. PMID:21283058. |
interestingly, inhibition of endogenous puma expression by puma sirna or p53 inhibitor repressed h/r-induced cardiomyocyte apoptosis. |
2011-09-02 |
2023-08-12 |
Not clear |
| Shangming Liu, Qiuhuan Yuan, Shidou Zhao, Jingjing Wang, Yuji Guo, Fuwu Wang, Yanmin Zhang, Qian Liu, Shuai Zhang, Eng-Ang Ling, Aijun Ha. High glucose induces apoptosis in embryonic neural progenitor cells by a pathway involving protein PKCδ. Cellular signalling. vol 23. issue 8. 2011-09-02. PMID:21440619. |
furthermore, we found that interaction of pkcδ and c-abl played a crucial role in p53 accumulation in the nucleus, which was linked to the apoptosis of npcs in response to high glucose. |
2011-09-02 |
2023-08-12 |
Not clear |
| Sachin Verma, Amjad Ali, Sakshi Arora, Akhil C Banerje. Inhibition of β-TrcP-dependent ubiquitination of p53 by HIV-1 Vpu promotes p53-mediated apoptosis in human T cells. Blood. vol 117. issue 24. 2011-09-02. PMID:21521785. |
inhibition of β-trcp-dependent ubiquitination of p53 by hiv-1 vpu promotes p53-mediated apoptosis in human t cells. |
2011-09-02 |
2023-08-12 |
human |
| Sachin Verma, Amjad Ali, Sakshi Arora, Akhil C Banerje. Inhibition of β-TrcP-dependent ubiquitination of p53 by HIV-1 Vpu promotes p53-mediated apoptosis in human T cells. Blood. vol 117. issue 24. 2011-09-02. PMID:21521785. |
these findings establish a novel function of vpu in modulating the stability of p53 protein that correlates positively with apoptosis during late stages of hiv-1 infection. |
2011-09-02 |
2023-08-12 |
human |
| Baohua Sun, Hannah Wingate, Stephen G Swisher, Khandan Keyomarsi, Kelly K Hun. Absence of pRb facilitates E2F1-induced apoptosis in breast cancer cells. Cell cycle (Georgetown, Tex.). vol 9. issue 6. 2011-08-31. PMID:20237430. |
to explore the role of prb in the e2f1-induced apoptosis of human breast cancer cells, we examined cell growth and apoptosis induction in isogenic cell systems of immortalized breast epithelial cells lacking either prb (76ne7) or p53 (76ne6). |
2011-08-31 |
2023-08-12 |
human |
| Baohua Sun, Hannah Wingate, Stephen G Swisher, Khandan Keyomarsi, Kelly K Hun. Absence of pRb facilitates E2F1-induced apoptosis in breast cancer cells. Cell cycle (Georgetown, Tex.). vol 9. issue 6. 2011-08-31. PMID:20237430. |
we found that e2f1 caused accumulation of cells in g2 and s phases of the cell cycle along with apoptosis in 76ne7 but not 76ne6 cells. variants of 76ne6 cells with functional p53 did not rescue the apoptotic response in these cells, whereas knocking down prb resulted in significant e2f1-induced apoptosis. |
2011-08-31 |
2023-08-12 |
human |
| Baohua Sun, Hannah Wingate, Stephen G Swisher, Khandan Keyomarsi, Kelly K Hun. Absence of pRb facilitates E2F1-induced apoptosis in breast cancer cells. Cell cycle (Georgetown, Tex.). vol 9. issue 6. 2011-08-31. PMID:20237430. |
we also determined that the effect of e2f1 overexpression in two breast cancer cell lines, mda-mb-436 and mda-mb-468, which lack prb and functional p53, was accumulation of cells in g2/s phase and apoptosis. |
2011-08-31 |
2023-08-12 |
human |
| Baohua Sun, Hannah Wingate, Stephen G Swisher, Khandan Keyomarsi, Kelly K Hun. Absence of pRb facilitates E2F1-induced apoptosis in breast cancer cells. Cell cycle (Georgetown, Tex.). vol 9. issue 6. 2011-08-31. PMID:20237430. |
therefore, we conclude that in the absence of rb, e2f1 overexpression results in apoptosis, not proliferation, and that this effect is independent of p53. |
2011-08-31 |
2023-08-12 |
human |
| Wei-Hsuan Hsu, Bao-Hong Lee, Tzu-Ming Pa. Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 6. 2011-08-30. PMID:21419818. |
the results demonstrated that rmde decreased nitric oxide (no), reactive oxygen species (ros), and prostaglandin e(2) (pge(2)) overexpression in hamster buccal pouches in the dmba treatment group and increased p53, serum tumor necrosis factor-α (tnf-α), and interleukin-1β (il-1β) to significantly stimulate caspase-8 and -3 activities, indicating that rmde reduced oxidative damage causing by dmba and induced apoptosis in oral cancer cells. |
2011-08-30 |
2023-08-12 |
Not clear |
| Brian J Leibowitz, Wei Qiu, Hongtao Liu, Tao Cheng, Lin Zhang, Jian Y. Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Molecular cancer research : MCR. vol 9. issue 5. 2011-08-30. PMID:21450905. |
loss of p53 blocks apoptosis in the intestinal crypts following irradiation but paradoxically accelerates gastrointestinal (gi) damage and death. |
2011-08-30 |
2023-08-12 |
mouse |
| Brian J Leibowitz, Wei Qiu, Hongtao Liu, Tao Cheng, Lin Zhang, Jian Y. Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Molecular cancer research : MCR. vol 9. issue 5. 2011-08-30. PMID:21450905. |
to better understand these two arms of p53 response in radiation-induced gi damage, we compared animal survival, as well as apoptosis, proliferation, cell-cycle progression, dna damage, and regeneration in the crypts of wt, p53 knockout (ko), puma ko, p21 ko, and p21/puma double ko (dko) mice in a whole body irradiation model. |
2011-08-30 |
2023-08-12 |
mouse |
| Matthias Gutekunst, Moshe Oren, Andrea Weilbacher, Michael A Dengler, Christiane Markwardt, Jürgen Thomale, Walter E Aulitzky, Heiko van der Kui. p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin. PloS one. vol 6. issue 4. 2011-08-30. PMID:21532991. |
the close relationship between p53 protein levels and induction of apoptosis is lost upon short-term differentiation, indicating that this predominant pro-apoptotic function of p53 is unique in pluripotent embryonal carcinoma (ec) cells. |
2011-08-30 |
2023-08-12 |
Not clear |
| Matthias Gutekunst, Moshe Oren, Andrea Weilbacher, Michael A Dengler, Christiane Markwardt, Jürgen Thomale, Walter E Aulitzky, Heiko van der Kui. p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin. PloS one. vol 6. issue 4. 2011-08-30. PMID:21532991. |
furthermore, in the very specific cellular context of germ cell-derived pluripotent ec cells, p53 function appears to be limited to induction of apoptosis. |
2011-08-30 |
2023-08-12 |
Not clear |
| Wakako Takabe, Noah Alberts-Grill, Hanjoong J. Disturbed flow: p53 SUMOylation in the turnover of endothelial cells. The Journal of cell biology. vol 193. issue 5. 2011-08-30. PMID:21624951. |
this leads to p53 sumoylation and its export to the cytosol, where it binds to the antiapoptotic protein bcl-2 to induce apoptosis. |
2011-08-30 |
2023-08-12 |
Not clear |